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InvisibleveggieM

Registered: 07/25/04
Posts: 17,504
Study backs use of cannabis-based Sativex to treat MS
    #14058601 - 03/03/11 07:02 AM (12 years, 10 months ago)

Study backs use of cannabis-based Sativex to treat MS
March 3, 2011 - PharmaTimes.com

Results of a Phase III trial have shown the ability of GW Pharmaceuticals' cannabinoid-based medicine Sativex to reduce severe spasticity associated with multiple sclerosis.

According to the data, published in the European Journal of Neurology, about half of MS patients who had failed to respond to standard therapy experienced an improvement in spasticity after taking Sativex Oromucosal Spray (delta-9-tetrahydrocannabinol and cannabidiol).

The trial hit its primary goal of demonstrating that Sativex induced a significant improvement in scores of spasticity, spasm frequency and sleep disturbance related to spasticity compared to a placebo.

Following a four-week, single-blind therapeutic trial period involving 572 patients, Sativex was shown to have reduced the mean score for spasticity, with 48% of patients achieving a clinically meaningful improvement of ≥20% in spasticity severity.

Of these responders, 241 took part in a 12-week, randomised, placebo-controlled trial phase, at the end of which the number of patients reporting an improvement in spasticity scores of ≥30% was significantly greater in the Sativex group (74%) than in the control arm (51%).

"We have been aware for a long time that cannabinoid medicines can significantly improve spasticity, which is a common, complex symptom of MS, and now the results from this study prove the positive impact they can have on patients’ symptoms, and ultimately their lives," said Professor John Zajicek, Honorary Consultant in Neurology, Derriford Hospital and Chair of Clinical Neurosciences at PCMD, University of Plymouth, commenting on the findings.

MS affects around 100,000 people in the UK, and spasticity is a common symptom that is considered to be a major cause of disability, interfering with many every day activities such as walking, picking up objects, washing or dressing.

Sativex was approved by health regulators in the UK and Spain last year, but only in patients who have not responded to other medication and who show a clinically significant improvement in symptoms during a trial run of therapy.


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Invisiblenopalero
dirt worshipper

Registered: 08/04/10
Posts: 946
Loc: up in ya
Re: Study backs use of cannabis-based Sativex to treat MS [Re: veggie]
    #14063603 - 03/03/11 10:38 PM (12 years, 10 months ago)

mj is a stimulant and triggers spasms, it might help deal with the pain and stress but i doubt they are really finding it stops spasms from occurring.

to say it might help people with MS without stating that it might also trigger an attack is :facepalm:

:pipesmoke:



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the dinosaurs will be back.
only that which has passed can be predicted.
life is both a mirror and a window.

THE GRAYS HOPE TO WIN. STOP. RAINBOW NEEDED URGENTLY.


Edited by nopalero (03/03/11 10:39 PM)


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Offlineuser1837483975
Male

Registered: 10/18/09
Posts: 2,161
Last seen: 3 years, 10 months
Re: Study backs use of cannabis-based Sativex to treat MS [Re: nopalero]
    #14064727 - 03/04/11 04:56 AM (12 years, 10 months ago)

Marijuana is a depressant dude


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OfflineHumility
Working on it
 User Gallery


Registered: 10/07/08
Posts: 6,745
Last seen: 6 years, 11 months
Re: Study backs use of cannabis-based Sativex to treat MS [Re: user1837483975]
    #14065034 - 03/04/11 08:06 AM (12 years, 10 months ago)

THC has stimulant properties

CBDs and other associated chems have depressant qualities.

They are both in cannabis.  Different plants have different profiles.

I don't know nor do I care to look up right now what exactly Sativex is composed of.


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