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A 20 years old male was admitted to the Emergency Room, with confusion and profound sweating. His initial laboratory tests were normal. Soon thereafter a right hemiparesis, dysarthria, and subsequent deterioration of consciousness level were established. Babinski sign was positive in both legs. During the episode flumazenil, naloxone and corticosteroids were administered. Ophtalmoplegia, dysarthria, temperature of 39°C, cardiac arrhythmias, and rhabdomyolysis were also present. Urine analysis was proved positive for methylenedioxymethamphetamine cannabinoids and benzodiazepines. Until that time the patient denied any use of illegal narcotics. A head computed tomography scan (CT) upon his admission showed no abnormalities, but subsequent Magnetic Resonance Imaging (MRI) revealed an ischemic infarct in the brainstem. The patient has been transferred to the ICU. Two days later, a new CT scan confirmed the presence of the infarct. During his stay in the ICU the patient has been monitored for arrhythmias, was hydrated and rhabdomyolysis was appropriately managed. Five days latter following a partial recovery the patient was discharged. No other obvious causes that may have led to cerebral infarction, including potential cardiovascular pathology, abnormalities of blood coagulation or collagen vascular disease or others were found in extensive laboratory work up.

Because of its worldwide illicit use, MDMA merits a better understanding. The postmortem findings in deaths associated with ecstasy, include liver abnormalities, varying from foci of individual cell necrosis to hepatic necrosis, myocardial injuries consistent with catecholamine induced damage, whilst perivascular haemorrhagic and hypoxic changes have been identified in the brain4. MDMA has been associated with cerebrovascular accidents, and although this fact is widely accepted, there are only few case reports described. From our search in bibliography we found only six relevant case reports of ischaemic stroke following ecstasy use. A possible interpretation of these incidents has been proposed from the work of Reneman and al who were based on single photon emission CT and have concluded that there is an altered regulation of 5HT2A receptors in MDMA users implicating that they may be at risk for cerebrovascular accidents due to abnormal vascular reactions. 5

Available data imply a strong association between MDMA abuse and cerebral infraction. Our presentation, added to the previous relevant case reports on ecstasy adverse effects, aims at underlining the importance of drug abuse inclusion in the differential diagnosis of cerebral infraction in young adults.

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Shins said:

Delt shitty hands? She died of complications from a drug overdose.

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Regardless of how the stroke happened, it is shitty what happened in the ER that led up to her death. That part was out of her direct control and yes, she was "Dealt a bad hand" in that situation


I am super sorry to hear this op, my condolences

searching said:

Thanks guys.  Yeah, I know a lot of people on here and in real life that push the dosage of mdma.  It's made me re-think how much I take a night.  Hopefully people on here re-think it as well.  Just think, she was just trying to have a good time and took one too many molly pills and it ended up killing her.

I also found out that when she collapsed at the festival, her "friend" picked her up and wouldn't take her to get medical attention.  At the end of the night he brought her back to the hotel and didn't tell anyone in fear of getting in trouble for giving her the drugs.  He waited until the next morning when she couldn't even talk or walk to get help.  Time lost is brain lost when it comes to strokes.

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searching said:

Thanks guys.  Yeah, I know a lot of people on here and in real life that push the dosage of mdma.  It's made me re-think how much I take a night.  Hopefully people on here re-think it as well.  Just think, she was just trying to have a good time and took one too many molly pills and it ended up killing her.

I also found out that when she collapsed at the festival, her "friend" picked her up and wouldn't take her to get medical attention.  At the end of the night he brought her back to the hotel and didn't tell anyone in fear of getting in trouble for giving her the drugs.  He waited until the next morning when she couldn't even talk or walk to get help.  Time lost is brain lost when it comes to strokes.

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