Auto-SummaryA Scientific American article explores how psilocybin, the active compound in magic mushrooms, alters consciousness to create a profound sense of "oneness" by changing brain activity. Researchers found that psilocybin causes brain networks that typically process the self and the external world separately to become integrated, leading to a "hidden order" in what appears to be chaotic brain activity. The study, published in Nature, involved 62 participants who experienced a sense of unity with their surroundings, described as "embeddedness." Using functional MRI and machine learning, scientists observed that brain networks responsible for sensory input became less connected, while those involved in higher-level processing became more connected. This shift suggests a reorganization of how the brain processes internal and external information. The findings highlight the role of context in shaping the psychedelic experience and suggest that the brain actively manages the boundary between self and the world, which psilocybin may temporarily reduce. The research offers a neurobiological basis for the meaningful experiences reported by users and raises questions about the therapeutic potential of psychedelics.
How psilocybin alters consciousness to create a sense of ‘oneness’
Psychedelics can create a new “hidden order” in brain activity that could explain how these drugs alter our sense of self
By Allison Parshall edited by Claire Cameron
August 19, 2026 [Source: Scientific American]
 Taking psychedelics can dissolve the boundary between you and the rest of the world, leaving a profound feeling of “oneness.” Now scientists have revealed that specific changes to the brain may cause this altered sense of consciousness. The results, published in Nature, show how taking psilocybin—an active ingredient in magic mushrooms—causes brain networks that typically process the self and the outside world separately to become integrated.
“It reframes our understanding of the psychedelic experience by providing a biological basis for some of the meaning and coherence people report,” says lead author Devon Stoliker, a computational neuroscientist at Monash University in Melbourne, Australia.
During a psilocybin trip, brain activity becomes more random or chaotic. Networks of neurons that usually fire together become desynchronized, and new connections can form. This shake-up of the brain’s existing patterns of connectivity may contribute to psilocybin’s potential therapeutic effect for certain mental health conditions. But the experience is also paradoxical, Stoliker says: “If the brain becomes more disorganized, then why do some people have highly meaningful and coherent experiences?”
In their study, Stoliker and his colleagues purported to find a “hidden order” in this chaos. Curiously, this order emerged in people whose conscious experience had been most strongly altered by psilocybin.
The researchers gave 62 healthy adults with no psychedelic experience a dose of psilocybin, then used functional magnetic resonance imaging to scan their brains in varying contexts: resting, meditating and listening to music—all with their eyes closed—and while watching a movie. Many participants experienced a blissful state of oneness, which the researchers call “embeddedness.” One participant reported, “I melded with the MRI machine, floor, walls, air. It was like nothing existed except for me or me as part of something bigger.”
The scientists measured how synchronized different brain networks were with one another. They reported that systems responsible for processing sensory input from the outside world became less connected with the rest of the brain, whereas those responsible for higher-level processing became more connected. “Broadly, [this result] suggests a shift in the balance between internally generated and sensory processing,” Stoliker says.
Next, the researchers used machine learning to identify patterns hiding in the data. Specifically, they analyzed individual participants’ brain activity while the trip evolved and as the participants did different tasks. People who had less profound experiences had widely variable brain activity—even if they were engaged in the same actions as their peers. But for those who felt a strong sense of oneness, key dimensions of their brain activity tended to look the same across the group, forming distinct patterns for each activity they performed.
In other words, Stoliker explains, “network activity became more similar when participants experienced less separation between self and world.” The findings offer a neurobiological explanation for why the context of a psychedelic trip—where and when it happens or what someone does during it—can so greatly influence the experience.
“Context sensitivity is a double-edged sword,” says Nico Dosenbach, a neurologist at Washington University in St. Louis, who was not involved in the study. The results highlight the importance of having a “controlled, positive setting, which would make therapy more expensive and difficult to deliver—but not unrealistic,” he says. Computational neuroscientist Adeel Razi, the study’s senior author, notes that using machine learning to study individual brains during a trip could help reveal why the same drug produces such different experiences in different people.
Investigators are currently split on whether the apparent benefits of psychedelics stem from the conscious experience of tripping or from the underlying changes in brain connectivity, explains Lorenzo Pasquini, a neuroscientist at the University of California, San Francisco, who wasn’t involved in the study. The new work doesn’t answer that question, he says, but it hints at the importance of people’s conscious experience.
On a more philosophical level, the findings suggest that the division we typically perceive between ourselves and the world is actively managed by the brain, Stoliker says. “Rather than psychedelics simply creating an illusion that the self and the world are one,” he says, “they may temporarily reduce the brain processes that normally maintain this separation.”
Perhaps the illusion is not the sense of oneness but our perceived separation from the world to begin with. “Psychedelics may offer a temporary glimpse of a bigger picture,” Stoliker says.
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