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Anonymous

whats acid made from?
    #957387 - 10/13/02 06:27 PM (18 years, 11 months ago)

im newb when it comes to anything other than pot and even then i know not much about it, other than if i smoke it ill get stoned...and im wondering what acid is made from.....my friends say its something with shrooms...but i dunno, they are pretty retarded most the time....


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OfflineJeroen198
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Re: whats acid made from? [Re: ]
    #957418 - 10/13/02 06:36 PM (18 years, 11 months ago)

"im wondering what acid is made from.....my friends say its something with shrooms"

heh.. time to go out and get some new friends  :wink: 


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OfflinePoogi
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Re: whats acid made from? [Re: Jeroen198]
    #957426 - 10/13/02 06:40 PM (18 years, 11 months ago)

I share that sentiment.


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Anonymous

Re: whats acid made from? [Re: Poogi]
    #957429 - 10/13/02 06:42 PM (18 years, 11 months ago)

no, i think im gunna keep the same ones even if they are retarded.... :frown: :crazy:


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InvisiblePapaverS
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Re: whats acid made from? [Re: ]
    #957436 - 10/13/02 06:44 PM (18 years, 11 months ago)

It's made with peanut butter (see other thread)! :grin:

Seriously, d-LySergic acid Diethylamide is a hallucinogenic indolamine which is active at serotonin (5-hydroxy tryptamine) receptor sites in the central nervous system.

While chemically similar to the active ingredient in mushrooms, psilocybin, it actually is derived from synthetically modifying the extracts of a grain fungus called ergot.

It is not something that can be easily made by just anyone. Not only is advanced organic chemistry methods and lab techniques required, but the precursors and chemicals needed are beyond the ability of most lay people to obtain.


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Anonymous

Re: whats acid made from? [Re: Papaver]
    #957462 - 10/13/02 06:55 PM (18 years, 11 months ago)

......


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InvisiblePapaverS
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Re: whats acid made from? [Re: ]
    #957472 - 10/13/02 06:57 PM (18 years, 11 months ago)

What's that mean? Was I helpful or not? :crazy:

I've seen that business before with just dots in a post, but I must confess, I have no idea what it means...

:confused:


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Anonymous

Re: whats acid made from? [Re: Papaver]
    #957484 - 10/13/02 07:03 PM (18 years, 11 months ago)

I somehow think he has no idea what you just said..

By the way.. My acidhead friend is always telling me that "not even scientists know how it works in your brain, its still a mystery." About the receptor sites, is that proven? Or just theory?


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InvisiblePapaverS
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Re: whats acid made from? [Re: ]
    #957497 - 10/13/02 07:08 PM (18 years, 11 months ago)

> About the receptor sites, is that proven? Or just theory?

Mostly theory really, and I'm not up on the latest, but last time I checked some of the dominant theories that made sense to me was that LSD acted as a mixed agonist/antagonist across a range of 5HT receptor sub-types. There was also a slight dopaminergic component, either through direct Dx receptor binding, or through collateral pre-synaptic dopamine release.

It is an area that I've been meaning to freshen up on. Perhaps this winter, I will...


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InvisibleGumby
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Re: whats acid made from? [Re: Papaver]
    #957888 - 10/13/02 09:31 PM (18 years, 11 months ago)

Thats the same receptor site that Psilocybin is active at, no?

I've got a friend who said he know's these guys who are going to make LSD. I said hell no, it wont happen. They don't have the knowledge or resources to do it. Getting the precursors is hard enough, much less actualy making it.


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Invisibledee_N_ae
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Re: whats acid made from? [Re: ]
    #958028 - 10/13/02 10:23 PM (18 years, 11 months ago)

LSD was tested extensivly in the CIA, on it's own agents.  I'm sure the exact reactions that occur in the brain once the substance enters are well documented with the latest in 3D MRI technology, or whatever  :tongue:
Maybe not though... I would at least like to think that a group of scientists, whether they're government ones or not, has done research like this recently.  Anyone got links?  Would the information even be readily available to the public since hallucinogens are illegal? 


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Anonymous

Re: whats acid made from? [Re: dee_N_ae]
    #958042 - 10/13/02 10:29 PM (18 years, 11 months ago)

Thats the thing, NO ONE is doing LSD research anymore, not with the actual substance... or at least thats how it was a while ago, I'm not to fresh on this subject myself.. But I would think that if there were any studies going on, someone here at the Shroomery would know..


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InvisiblePapaverS
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Re: whats acid made from? [Re: ]
    #958083 - 10/13/02 10:50 PM (18 years, 11 months ago)

It's also that this whole area of brain chemistry in highly complex, and not fully understood, at this time. Ultimately, you are getting into areas of proteomics, and then into areas of advanced logic -- in terms of how these different neuronal-synaptic sites interact with other neuronal-synaptic sites.

We?re talking what here, 100 Trillion neurons, each of which may have up to several thousand synaptic connections. Each synapse has a plethora of varying proteins which afford it function (i.e. different types of inhibitory and excitatory post synaptic receptors, pre-synaptic uptake pumps, vesicles, and varying pre-synaptic receptors).

We are just beginning to grasp how little we truly know in these areas, and how far we have to go before we even start asking the right questions, or developing sophisticated enough tools to study these things.


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OfflineChemical_Smile
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Re: whats acid made from? [Re: Papaver]
    #958184 - 10/13/02 11:23 PM (18 years, 11 months ago)

Thats what I love about this branch of science.  I can walk in without a fucking clue and be right up there with the best of them.  :grin:


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InvisiblePapaverS
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Re: whats acid made from? [Re: Chemical_Smile]
    #958217 - 10/13/02 11:31 PM (18 years, 11 months ago)

How True! :grin:

Besides, the personal experimentation and research is a gas! :grin: :cool:


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Edited by papaver (10/13/02 11:32 PM)


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OfflineKoOs
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Re: whats acid made from? [Re: ]
    #958656 - 10/14/02 01:51 AM (18 years, 11 months ago)

It's made with CP.


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InvisiblePapaverS
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Re: whats acid made from? [Re: KoOs]
    #958851 - 10/14/02 03:27 AM (18 years, 11 months ago)

LMAO! :grin:


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OfflineBaby_Hitler
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Re: whats acid made from? [Re: Papaver]
    #958876 - 10/14/02 03:40 AM (18 years, 11 months ago)

I thought it was made with Morning glory seeds and tartar sauce.


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InvisiblePapaverS
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Re: whats acid made from? [Re: Baby_Hitler]
    #958893 - 10/14/02 03:58 AM (18 years, 11 months ago)

LMAO! :grin:


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Invisiblesir tripsalot
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Re: whats acid made from? [Re: Papaver]
    #959077 - 10/14/02 06:16 AM (18 years, 11 months ago)

Deja vu..


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InvisibleShroomismM
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Re: whats acid made from? [Re: sir tripsalot]
    #959145 - 10/14/02 07:13 AM (18 years, 11 months ago)

Someone once said Deja Vu is made of dead kittens


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InvisibleDreaMaTrix
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Re: whats acid made from? [Re: Shroomism]
    #959241 - 10/14/02 08:42 AM (18 years, 11 months ago)

>Someone once said Deja Vu is made of dead kittens

No, thats where the 5-meow-rigomortis-CP extract comes from :grin:

 


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"We are the one's we have been waiting for" - Hopi saying


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InvisibleDreaMaTrix
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Re: whats acid made from? [Re: DreaMaTrix]
    #959242 - 10/14/02 08:43 AM (18 years, 11 months ago)

>No, thats where the 5-meow-rigomortis-CP extract comes from

BTW, don't try to do this extract, it's like flogging a dead cat :wink:



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"We are the one's we have been waiting for" - Hopi saying


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Offlinefrogsheath
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Re: whats acid made from? [Re: ]
    #959245 - 10/14/02 08:50 AM (18 years, 11 months ago)

Another fun acid-fact:  phenylalanine (the stuff found in aspartame --I believe-- it's in sugarless candy and soda-pop) can have a similar effect, chemically, on your nuerotransmitters, to some of the effects of LSD.  On every product with this stuff in it there is a disclaimer on the bottom of the ingredients list.  Correct me if I'm wrong on this --it's just something I heard from an uncertified source. :laugh: 


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OfflinePhluck
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Re: whats acid made from? [Re: frogsheath]
    #959464 - 10/14/02 12:50 PM (18 years, 11 months ago)

Interesting aspartame fact: It's been shown to cause Olney's lesions in some studies.

A friend of my family is a neuroscientist, and one of his colleagues was involved in a study on this. Apparently the guy was cornered in the bathroom by a NutraSweet representative, trying to get him to sign a deal not to release the study or something like that. Pretty slimy when you think about it.

So I don't drink diet pop.



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"I have no valid complaint against hustlers. No rational bitch. But the act of selling is repulsive to me. I harbor a secret urge to whack a salesman in the face, crack his teeth and put red bumps around his eyes." -Hunter S Thompson
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OfflinePhluck
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Re: whats acid made from? [Re: Phluck]
    #959473 - 10/14/02 12:52 PM (18 years, 11 months ago)

Here's a nifty article on the topic.

http://www.vegsource.com/davis/sweeteners.htm


--------------------
"I have no valid complaint against hustlers. No rational bitch. But the act of selling is repulsive to me. I harbor a secret urge to whack a salesman in the face, crack his teeth and put red bumps around his eyes." -Hunter S Thompson
http://phluck.is-after.us


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OfflinePhluck
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Re: whats acid made from? [Re: Phluck]
    #959475 - 10/14/02 12:54 PM (18 years, 11 months ago)

Oh, and one more, this one talks about research done by Olney himself, on lesions caused by aspartame.

http://www.swankin-turner.com/lawof.html

Olney, a conservative scientist, is adamant when he says "there is no margin of safety for aspartame in a child's diet."



--------------------
"I have no valid complaint against hustlers. No rational bitch. But the act of selling is repulsive to me. I harbor a secret urge to whack a salesman in the face, crack his teeth and put red bumps around his eyes." -Hunter S Thompson
http://phluck.is-after.us


Edited by Phluck (10/14/02 12:55 PM)


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InvisiblePapaverS
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Re: whats acid made from? [Re: Phluck]
    #959596 - 10/14/02 01:55 PM (18 years, 11 months ago)

Yeah, phenylalanine is one of two amino acid precursors (the other, and more common one, being tyrosine) to epinephrine, norepinephrine, and dopamine. I do know that phenylalanine is bad news for those with a rare genetic disorder called phenylketonuria [sp?].

I also image that excess phenylalanine in the system can really gum up the various bio-pathways associated with the construction and degradation of the various catecholaminergic neurotransmitters.

I personally never saw what was so bad about sugar, that we had to start screwing around with potentially dangerous substitutes like saccharine and aspartame? :crazy:


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Invisibleshroomerylurker
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Re: whats acid made from? [Re: ]
    #964518 - 10/16/02 12:01 AM (18 years, 11 months ago)



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Offlinericyjo
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Re: whats acid made from? [Re: shroomerylurker]
    #965110 - 10/16/02 04:16 AM (18 years, 11 months ago)

LSD is a semisynthetic preparation derived from "ergot", an extract of the fungus "Claviceps Purpurea", which grows as a parasite on rye wheat.

Here's what that fungus looks like:



Don't even think about it....


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"Re-examine all that you have been told...
dismiss that which insults your soul." -Walt Whitman


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Invisibleshroomerylurker
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Re: whats acid made from? [Re: shroomerylurker]
    #965462 - 10/16/02 10:08 AM (18 years, 11 months ago)

For the most part people make LSD out of LSA!


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OfflinePhluck
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Re: whats acid made from? [Re: shroomerylurker]
    #966688 - 10/16/02 07:22 PM (18 years, 11 months ago)

Actually, not usually. They make it from ergotamine.


--------------------
"I have no valid complaint against hustlers. No rational bitch. But the act of selling is repulsive to me. I harbor a secret urge to whack a salesman in the face, crack his teeth and put red bumps around his eyes." -Hunter S Thompson
http://phluck.is-after.us


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InvisiblePapaverS
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Re: whats acid made from? [Re: Phluck]
    #968058 - 10/17/02 04:13 AM (18 years, 11 months ago)

Good call! :cool:

HBWR and MG seeds are not good precursors for large scale LSD production, nor are any existing pharmaceuticals. I was going to post this elsewhere, but it seems like this is as good a place as any...

Someone once told me that:

Laboratory cultivation of ergot is extremely difficult, at best! Claviceps purpurea requires sophisticated submersed-liquid cultivation techniques to produce the correct ergo-alkaloids. Whereas, Claviceps paspali can be successfully surface cultivated on a substrate, but the ergo-alkaloids are different (i.e. paspalic acid), so you must adjust your subsequent extraction and synth procedures accordingly. :laugh:

Wild collection is still a highly viable source? :crazy:


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Invisiblezeta
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Re: whats acid made from? [Re: Papaver]
    #968119 - 10/17/02 05:17 AM (18 years, 11 months ago)

In reply to:

HBWR and MG seeds are not good precursors for large scale LSD production, nor are any existing pharmaceuticals.




Ergotamine tartrate tablets prescribed for migraine headaches are the ultimate precursor for LSD production!


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InvisibleLallafa
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Re: whats acid made from? [Re: zeta]
    #968159 - 10/17/02 05:44 AM (18 years, 11 months ago)

im almost positive that no one syths lsd from ergotamine tablets.

the ultimate precursor for lsd would be pure lsa, or pure ergotamine.


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Invisiblezeta
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Re: whats acid made from? [Re: Lallafa]
    #968160 - 10/17/02 05:45 AM (18 years, 11 months ago)



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InvisibleLallafa
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Re: whats acid made from? [Re: zeta]
    #968173 - 10/17/02 06:07 AM (18 years, 11 months ago)

ok..
am i missing something?

isolating ergotamine from tablets to use as a precursor would be about as economical as using morning glory seed extract

defiantly not the "ultimate precursor"


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OfflineShroomSkin
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Re: whats acid made from? [Re: Papaver]
    #968387 - 10/17/02 10:02 AM (18 years, 11 months ago)

Why is ergot so damn hard to get?  Is it just because its a good precursor for LSD, or is it used for something else, too?  And anyone remember Shroomy McPot's method for making acid?  :grin:


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OfflineRemy
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Re: whats acid made from? [Re: Gumby]
    #968699 - 10/17/02 12:48 PM (18 years, 11 months ago)

In reply to:

Thats the same receptor site that Psilocybin is active at, no?





All psychedelics are active at the 5HT receptor sites. Its what classifies this type of drug as psychedelics.


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Offlinerfgdxm
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Re: whats acid made from? [Re: Remy]
    #971095 - 10/18/02 01:59 AM (18 years, 11 months ago)

>All psychedelics are active at the 5HT receptor sites. Its what classifies this type of drug as psychedelics.

Wrong, and I defy you to cite a dictionary using that definition.


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InvisiblePapaverS
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Re: whats acid made from? [Re: rfgdxm]
    #972144 - 10/18/02 01:46 PM (18 years, 10 months ago)

Maybe we should state it as: most psychoactive indolamines have a high degree of activety at 5HT receptor sites, whereas some psychoactive phenethylamines have some degree of activity at 5HT receptor sites.

In other words?

"You can bind some of the serotonergics some of the times, but you can't bind all of the catecholaminerics all of the time." :crazy: :grin:

Or, perhaps?

"I never met a drugs I didn?t like!" :grin: :crazy:


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InvisibleGumby
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Re: whats acid made from? [Re: ShroomSkin]
    #972566 - 10/18/02 04:49 PM (18 years, 10 months ago)

>Why is ergot so damn hard to get?

1. It can destroy entire crops of wheat, it's bad stuff.
2. It's deadly poisonous by itself.
3. Its a precursor to LSD.


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OfflineShroomSkin
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Re: whats acid made from? [Re: Gumby]
    #972613 - 10/18/02 05:14 PM (18 years, 10 months ago)

I guess that explains it!  :grin:


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Offlinerfgdxm
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Re: whats acid made from? [Re: Papaver]
    #973091 - 10/18/02 09:01 PM (18 years, 10 months ago)

And then what about those psychedelics that aren't active at this receptor? This is just a silly definition.


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InvisiblePapaverS
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Re: whats acid made from? [Re: rfgdxm]
    #973191 - 10/18/02 09:41 PM (18 years, 10 months ago)

I was simply referring to indolamines and certain phenethylamines. There is, of course, broad range, including cannabis which is active primarily at CB1 receptor sites in the CNS, and CB2 peripherally. Cannabinoid receptors only having been discovered in 1992.

It's a big, broad, world out there! Neurochemistry is the March Hare's "Rabbit Hole" of science! Welcome to the machine, Alice, doesn?t live here anymore... :grin:


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