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Inhaling HCN (hydrogen Cyanide, which is what the cyanide in the plant is converted to when you burn it) in a concentration of 600 to 700 ppm for five minutes or approximately 200 ppm for 30 minutes may be fatal. Survival in any specific case often depends on the rapidity and scope of treatment.

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http://www.mdidea.com/products/proper/proper080.html
Phytochemicals and Constituents:

Root contains total alkaliods 0.1% around, including febrifugin(Beta-dichroine),isofebrifugin(alpha-dichroine,and gamma-dichroine, these are effect content for Malaria treatment. Other phytochemicals including dichroidine,4-quinazolone,unbeliferone(dichrin A,7- hydroxycoumarin) and dichrin B.

Hydrangea Extract.Hydrangea Root Extract.Hydrangea Root extract.Radix Dichroae Extract.10:1.Dichroa febrifuga Lour.root extract.

  Pharmacology and Efficacy:

Quinazolinone type alkaloids, febrifugine (1) and isofebrifugine (2), isolated from Dichroa febrifuga roots, show powerful antimalarial activity against Plasmodium falciparum. Unfortunately, their emetic effect and other undesirable side effects have precluded their clinical use for malaria. Because of their antimalarial potency, analogues were searched for, with the goal of preserving the strong antimalarial activity, while dramatically reducing side effects. We expected that compounds useful in drug development would exist in metabolites derived from 1 and Df-1 (3), the condensation product of 1 with acetone, by mouse liver S9. Feb-A and -B (4 and 5) were isolated as the major metabolites of 1. In addition to 4 and 5, feb-C and -D (6 and 7) were also purified from the metabolic mixture of 3. Compounds 4 and 5 were compounds oxidized at C-6 and C-2 of the quinazolinone ring of 1, respectively. Compounds 6 and 7, derived from 3, also bear febrifugine type structures in which the 4' '- and 6' '-positions of the piperidine ring of 1 were oxidized. In vitro antimalarial and cytotoxic tests using synthetically obtained racemic 4-6 and enantiomerically pure 7 demonstrated that 4 and 6 had antimalarial activity against P. falciparum, of similar potency to that of 1, with high selectivity. The antimalarial activity of 5 and 7, however, was dramatically decreased in the test. The in vitro antimalarial activity of analogues 22 and 43, which are stereoisomers of 4 and 6, was also evaluated, showing that 22 is active. The results suggest that basicity of both the 1- and the 1' '-nitrogen atoms of 1 is crucial in conferring powerful antimalarial activity. Racemic 4 and 6 exhibited powerful in vivo antimalarial activity against mouse malaria P. berghei, and especially, no serious side effects were observed with 4. Thus, the metabolite 4 appears to be a promising lead compound for the development of new types of antimalarial drugs. (source)
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  Medicinal Uses:

Antiperiodic; Emetic; Expectorant; Febrifuge; Purgative.

This plant is commonly used in Chinese herbalism, where it is considered to be one of the 50 fundamental herbs. The leaves are purgative. They are used in the treatment of stomach cancer. The juice of the leaves is used in Nepal to treat coughs, colds and bronchitis. A decoction of the stem bark is used in the treatment of fevers. a decoction of the leaves is used to treat malarial fever. The root contains several alkaloids and is emetic, expectorant, febrifuge and purgative. The juice of the root is used in Nepal to treat fevers and indigestion. This plant is 26 times more powerful than quinine in the treatment of malaria but causes vomiting. Substances in the plant are 100 times more powerful than quinine, but they are poisonous.

The wood is used as a fuel.
Hydrangea Extract.Hydrangea Root Extract.Hydrangea Root extract.Radix Dichroae Extract.10:1.Dichroa febrifuga Lour.root extract.Hydrangea arborescens extract photo picture image img

Hydrangea's greatest use is in the treatment of inflamed or enlarged prostate glands. This herb may also be used for urinary stones or gravel associated with infections such as cystitis. It soothes irritated mucus membranes, and will relieve backache caused by kidney trouble.

Hydrangea is also known as Seven Bark. Hydrangea grows up to 9 feet tall, and is found in woodlands and along stream banks in southeastern and central North America. Hydrangeas are marsh or aquatic plants, and hence the name is derived from a Greek compound signifying "water-vessel". The folk name "Seven Bark" was used in reference to the fact that when the bark peels off, it does so in several layers of various colors. The parts of this plant used medicinally are the dried root, rhizome, and leaves. Cherokee Indians used a root decoction or tea as a diuretic, cathartic, and emetic. They also scraped the bark, and made a poultice for wounds, burns, sore muscles, sprains and tumors. They chewed the bark for stomach problems & heart trouble. A decoction of Hydrangea was also used by early American settlers for calculus. The primary chemical constituents of Hydrangea include glycosides (hydrangin), saponins, resins, rutin, essential oils, and flavonoids. It contains no tannins. Hydrangea is well recognized in the treatment of inflamed or enlarged prostate glands. This herb is valued for its solvent properties that help break down and prevent further formation of stones & deposits in the urinary system. Hydrangea has been used for hundreds of years in folk medicine to contribute to the elimination of deposits in the bladder and kidneys. It soothes irritated mucus membranes. This herb will also relieve backache caused by kidney problems. For kidney stones, Hydrangea is often combined with Stone Root, Bearberry and Gravel Root. For prostate problems, it combines well with Horsetail and Saw Palmetto. Indications for which Hydrangea is typically prescribed include frequent urination, accompanied by a sense of burning and sharp, quick pain in the urethra. Other possible symptoms include pain from the irritation of passing renal sand, and aching in the back with irritation and partial suppression of urine.

  Action:  To stop malarial attacks.

  Indications:  Malaria.

  Precaution:  It causes vomiting as a side effect; overdosage should be avoided. Used with caution in pregnancy

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Now, there is little to no documentation of effects on people when smoked, experience-wise...*If anyone here has ever tried...

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"USES: Diuretic and Soothant. Hydrangea paniculata has been smoked to produce cannabis-like effects, but many species from this genus are dangerous if smoked, as they contain a cyanide compound when burned".

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hydrangea is used to treat bladder problems and kidney stones. This means that it is possible to avoid or remove the cyanide, otherwise this would not be an effective remedy for these sicknesses ( this just leaves more questions).

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The primary chemical constituents of Hydrangea include glycosides (hydrangin)...

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