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Anonymous

Re: Genetically Mutated Mushrooms [Re: mycofile]
    #90275 - 12/19/99 10:42 AM (24 years, 3 months ago)

All Colchicinoids such as Colchicine and Demecolcine have this effect on cells. Cytochalasin B also has an effect on cells but I'm still unsure as to what exactly that effect is but it's probably the same as colchicine. What other chemicals produces this effect or an effect that may be more or less useful.

-PsiliPharm


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Anonymous

Re: Genetically Mutated Mushrooms [Re: mycofile]
    #90278 - 12/21/99 08:01 PM (24 years, 3 months ago)

Here are some sources for colchicine:

Alfa Aesar
http://www.alpha.com/

Molecular Biosciences
http://www.molbio.com/

Acros Organics
http://www.acros.be/

ICN Biomedical Research Products
http://www.icnbiomed.com/

Alchem International Ltd.
http://www.alchemdlh.com/

Inga Pharmaceuticals
http://www.ingapharma.com/

Leeward Resources, Inc.
http://www.leeward.com/

Rokem
http://www.rokem.com/

Transo-Pharm Homepage
http://www.transopharm.de/engl/index.htm

AMPAK CO.
http://www.ampaku.com/

Worldwide Pharmaceutical
http://www.wwpharmaceutical.com/

Vital-Chem
http://www.vital-chem.com/

International Rx Specialty Company
http://www.irxsc.com/

United Tel Inc.
http://www.unitedt.com/

CHEMINPEX International
http://www.cheminpex.com/

Flavine International, Inc.
http://www.flavine-usa.com/

INDOWORLD TRADING CORPORATION
http://www.indo-world.com/

-PsiliPharm


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Anonymous

Re: Genetically Mutated Mushrooms [Re: mycofile]
    #90279 - 12/21/99 11:55 PM (24 years, 3 months ago)

Here is a list of resources that I've found so far. I'm not finished with this list. I know, it's long enough. Here it is:

Pharmacology of Colchicine
http://biotech.icmb.utexas.edu/botany/colch.html

MedChem Feature Molecule - Colchicine
http://www.phc.vcu.edu/feature/colchicine/colchicine.html

Approaches to the Diterpene Colchicine
http://www.chem.ohiou.edu/~mcmills/colchicine.html

Scorecard Chemical Profile: Colchicine
http://www.scorecard.org/chemical-profiles/summary.tcl?edf_substance_id=64-86-8

PubMed QUERY: Colchicine
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db= m&form=4&term=Colchicine&dopt=d&relpubdate=1+Year&dispmax=5000

Colchicine
http://www.nursespdr.com/members/database/ndrhtml/colchicine.html

Treatment of Severe Colchicine Overdose with Colchicine-Specific Fab Fragments
http://www.nejm.org/content/1995/0332/0010/0642.asp

information please: colchicine
http://cbs.infoplease.com/ce5/CE011792.html

Colchicine and Orchids.
http://www.oncil.demon.co.uk/CSMColchicine.htm

DRUGSTORE.COM - DRUG INTERACTIONS: Colchicine
http://www.drugstore.com/guide/Drug/Colchicine.asp

Polyploidy In Plants
http://gnome.agrenv.mcgill.ca/breeding/polypld.htm

Cannabis Growing For Medicinal Marijuana
http://www.jaxshirt.com/99grow.htm

Marijuana Botany: Chapter 3 - An Advanced Study: The Propagation and Breeding of Distinctive Cannabis
http://www.coastnet.com/~bcga/MJBotany/botany3.htm
http://www.mellowgold.com/grow/mjbotany/marijuanabotany3.html

How To Grow Marijuana (Jolly Roger Tek)
http://www.overthrow.com/marijuana.html
http://internettrash.com/users/qaz/mjgrow2.htm
http://www.plokm.com/drugs/mjgrow2.htm
http://www.freespeech.org/bandit710/grow.html
http://www.tamcotec.com/freestyle/growing.htm
http://www.angelfire.com/pe/hemp/
http://www.erowid.org/plants/cannabis/cannabis_cultivation14.shtml
http://members.xoom.com/DominoMF/Dope.html
http://nepenthes.lycaeum.org/Plants/Cannabis/potgrow-1.html
http://concept420.hypermart.net/general_growing.htm
http://www.lycaeum.org/drugs/Cannabis/potgrow-1
http://www.angelfire.com/on/Chronic/AnarchistsCookBook.txt
http://www.newpower.org/chn/order/cookbook/072.txt
http://www.marijuana-hemp.com/cin/growing/mjgrow3.shtml
http://www.psa1.net/grow_bud/grow_bud.html
http://www.totse.com/files/FA048/potgrow_.htm
http://www.marijuana.org.il/Mjgrow3.htm
http://hacking.iwarp.com/072.htm

Marijuana Cultivation (German)
http://www.lycaeum.org/drugs/Cannabis/nederwiet

Ohio List of Extremely Hazardous Substances
http://www.epa.ohio.gov/derr/cepps/cepd/hazard.html

Geriatric Drug Review -- Colchicine
http://www.agenet.com/drugs_general/colchicine.html

Colchicine Toxicity Prompts Dosage Change
http://www.medsafe.govt.nz/Profs/Safety/colchicinetoxicity.htm

Vitamin Buzz - Colchicine
http://www.vitaminbuzz.com/Drug/Colchicine-F.htm

COLCHICINE
http://www.theberries.ns.ca/Archives/colchicine.html

CASE REPORT: Colchicine Poisoning: Report of a Fatal Case and Presentation of an HPLC Procedure for Body Fluid and Tissue Analyses
http://www.jatox.com/abstracts/1997/jan-feb/kinjabs.htm

COLCHICINE, N-BENZOYL-DEACETYL Benzamide, N-(5,6,7,9-tetrahydro-1,2,3, 10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)- (9CI)
http://dtp.nci.nih.gov/docs/static_pages/compounds/33410.html

Drug Database Entry: Colchicine
http://www.allhealth.com/meds/kb/0,4383,6743_156660,00.html

MSDS for Colchicine
http://physchem.ox.ac.uk/MSDS/C/colchicine

Cutaneous Drug Reaction Database: Colchicine
gopher://gopher.dartmouth.edu/00/Research/BioSci/CDRD/C/COLCHICINE

Environmental Science Center: Colchicine
http://esc.syrres.com/~esc/lookup.exe?CAS=64-86-8

NTP Chemical Repository: Colchicine
http://ntp-db.niehs.nih.gov/NTP_Reports/NTP_Chem_H&S/NTP_Chem6/Radian64-86-8.txt

COLCHICINE
http://matrix.ucdavis.edu/rxderm-archives/colchicine

Picatinny Arsenal
http://www.pica.army.mil/infomenu/p3/ai/right2know_chems.html

Wheeless' Textbook of Orthopaedics: Colchicine
http://www.medmedia.com/meda1/147.htm

Partial List of Mutagens
http://www.inform.umd.edu/CampusInfo/Departments/EnvirSafety/os/ch/mutagen.html

Colchicine Overdose
http://www.geocities.com/Athens/Parthenon/3616/#_Toc395896282

Colchicine used in plant breeding work to induce mutations (polyploidy).
http://www.geocities.com/RainForest/Vines/2259/colchicine.htm

Suicide FAQ Part 2 - Methods: Poisons
http://www.dead.org/suicide/part2.html

Colchicine (Oral)
http://home.clara.co.uk/alexknight/behcets-syndrome/medication/colchicine.html

RxMed: Colchicine
http://www.rxmed.com/monographs2/colchi.html

In Vitro Colchicine Application of Haploid Cucumber Plants
http://ars-genome.cornell.edu/cgc/cgc20/97cuke11.htm

Colchicine, an efficient genome-doubling agent for maize (Zea mays L.) microspores cultured in anthero
http://link.springer.de/link/service/journals/00299/bibs/9018010/90180858.htm

Colchicine-mediated chromosome doubling during anther culture of maize (Zea mays L.)
http://link.springer.de/link/service/journals/00122/bibs/6092008/60921017.htm

Improved production of doubled haploids by colchicine application to wheat (Triticum aestivum L.) anther culture
http://link.springer.de/link/service/journals/00299/bibs/8017012/80170974.htm

Somatic chromosome number doubling of selected potato genotypes using callus culture or the colchicine treatment of shoot nodes in vitro
http://www.hri.ac.uk/aab/98-075.htm

EXERCISES IN CELL BIOLOGY FOR THE UNDERGRADUATE LABORATORY
http://www.faseb.org/ascb/pubs/exercises.html

GAPS IN PENROSE'S TOILINGS
http://www.pitt.edu/~grush/papers/penrose/penrosehtml/penrose-text.html

Relationship between frequency of autodiploid corn inbred occurrence and origin of initial stock.
http://www.agron.missouri.edu/mnl/66/105shatskaya.html

Chemicals Known to the State (of California) to Cause Cancer
http://www.oehha.ca.gov/prop65/12999ls2.html

Chromosome doubling in haploids through colchicine
http://www.agron.missouri.edu/mnl/68/101gayen.html

7 Genetic Research and Chromosome Number
http://www.nal.usda.gov/pgdic/Strawberry/book/bokseve.htm

Alkaloids from Phenylalanine and Tyrosine: Colchicine
http://www.life.uiuc.edu/plantbio/363/lecture34.html

Emergency First Aid Treatment Guide for Colchicine
http://www.epa.gov/swercepp/ehs/firstaid/64868.txt

Chromosome Doubling with Colchicine
http://fastplants.cals.wisc.edu/crgc/ids/t1.html

Colchicine
http://www.emedline.com/lexicomp/datasets/anes_f/html/chapter/mono/fc032000.htm

Discovery of Novel Anti-Tubulin Agents
http://dtp.nci.nih.gov/docs/compare/novel_compounds/newtub.html

Polyploids and Haploids
http://www.css.orst.edu/classes/css530/UNIT13.HTM

Nuclear Structure and Function: 2nd Year Physiologists: 'Investigation of the cytoskeleton'
http://atlas.path.ox.ac.uk/~prc/CYTOSK99/cytosk99.html

Centre for Molecular Genetics and Toxicology
http://www.swan.ac.uk/cget/ejgt/article3.htm

Sustainable Organic Plant Breeding Appendix 4.
http://www.anth.org/ifgene/breedap4.htm

INTRODUCTION TO PLANT BREEDING: CHROMOSOME REMODELING
http://ianrwww.unl.edu/ianr/agronomy/815/cremdl.htm

Heptalene Chemistry
http://www.unizh.ch/oci/group.pages/hansen/publ/heptalene.html

Pharmacology of Vinblastine, Vincristine, Vindesine and Vinorelbine
http://biotech.icmb.utexas.edu/botany/vvv.html

Neurotoxicity of CI-980, a Novel Mitotic Inhibitor
http://aacr.edoc.com/ccr/v3n3/df000419.html

Blokhin, A.V., Yoo, H.-D., Geralds, R.S., Nagle, D.G., Gerwick, W.H., and Hamel, E. "Characterization of the interaction of the marine cyanobacterial natural product curacin A with the colchicine site of tubulin and initial structure-activity studies with analogs." Molecular Pharmacology 1995, 48, 523-531.

-PsiliPharm


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Anonymous

Re: Genetically Mutated Mushrooms [Re: mycofile]
    #90280 - 12/22/99 12:04 AM (24 years, 3 months ago)

What would the effects of these other substances be?:

Actinomycin D
Benzylbenzodioxole derivatives
Carbamates
CI-980
Colcemid
Combretastatin A-4
Curacin A
Cycloheximide
Cytochalasin D
Dolastatin 10
Dolastatin 15
E7010
Halichondrin B
Homohalichondrin B
Maytansine
Paclitaxel
Podophyllotoxin
Rhizoxin
Tritylcysteine
Vinblastine
Vincristine
Vindesine
Vinorelbine

If you actually start looking you'll find many different types of anti-mitotic substances.

-PsiliPharm

[This message has been edited by PsiliPharm (edited December 22, 1999).]


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Anonymous

Re: Genetically Mutated Mushrooms [Re: mycofile]
    #90281 - 12/22/99 03:57 PM (24 years, 3 months ago)

Since we are talking about Genetically Mutated or/Altered Mushrooms and in relevence to my first post about the bioluminescent mushroom idea. I thought that these posts are worth looking at:

Bioluminescent Pictures? http://www.shroomery.org/ubbnoncgi/Forum4/HTML/000534.html

Glowing Shrooms-- Tek? http://www.shroomery.org/ubbnoncgi/Forum4/HTML/000535.html

The second one is the one that I put my two cents worth of information into.

-PsiliPharm


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Anonymous

Re: Genetically Mutated Mushrooms [Re: mycofile]
    #90282 - 12/23/99 05:07 PM (24 years, 2 months ago)

I've created a new thread relating to the use of colchicine on marijuana plants at Cannabis.com:

Using Colchicine To Produce Polyploidy Marijauna!

-PsiliPharm


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Anonymous

Re: Genetically Mutated Mushrooms [Re: mycofile]
    #90283 - 12/26/99 10:02 PM (24 years, 2 months ago)

Recently, I was told about a substance called ethyl methanesulfonate (EMS) which causes mutations in cells in relation to it's environment. Some other mutagens that are compared to this one:

methyl methanesulfonate
N-nitroso-N-ethylurea
N-methyl-N-nitrosourea

-PsiliPharm


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Anonymous

Re: Genetically Mutated Mushrooms [Re: mycofile]
    #90284 - 12/28/99 12:48 PM (24 years, 2 months ago)

Since it was said that colchicine can be used to cross two species that were incompatable before, I started thinking of some interesting Psilocybe species that would be interesting to cross. Here's my list:

Equador x Mazatapec
Equador x Cambodia
Mazatapec x Cambodia
Mazatapec x B+
Equador x B+
Cambodia x B+
Cambodia x Treasure Coast
Treasure Coast x B+
Treasure Coast x Equador
Treasure Coast x Mazatapec
Treasure Coast x Phantasia Mystery
Phantasia Mystery x Equador
Phantasia Mystery x Mazatapec
Phantasia Mystery x B+
B+ x A
B+ x B
B+ x Cyanescens
Cyanescens x Phantasia Mystery
Cyanescens x Equador
Cyanescens x Mazatapec
Cyanescens x Cambodia
Cyanescens x Treasure Coast
Cyanescens x Azurescens
Azurescens x B+
Azurescens x Phantasia Mystery
Azurescens x Equador
Azurescens x Mazatapec
Azurescens x Cambodia
Azurescens x Treasure Coast
Azurescens x Australian
Australian x B+
Australian x Equador
Australian x Mazatapec
Australian x Cambodia
Australian x Treasure Coast
Australian x Phantasia Mystery
Australian x Cyanescens
Australian x A
A x Equador
A x Mazatapec
A x Cambodia
A x Treasure Coast
A x Phantasia Mystery
A x Cyanescens
A x Azurescens
A x B
B x Equador
B x Mazatapec
B x Cambodia
B x Treasure Coast
B x Phantasia Mystery
B x Cyanescens
B x Azurescens
B x Australian
B x Gulf Coast
Gulf Coast x Azurescens
Gulf Coast x Cyanescens
Gulf Coast x Phantasia Mystery
Gulf Coast x Treasure Coast
Gulf Coast x Cambodia
Gulf Coast x Mazatapec
Gulf Coast x Equador
Gulf Coast x Australian
Gulf Coast x B+
Gulf Coast x A
Gulf Coast x Mexican
Mexican x A
Mexican x B
Mexican x B+
Mexican x Equador
Mexican x Mazatapec
Mexican x Cambodia
Mexican x Australian
Mexican x Treasure Coast
Mexican x Phantasia Mystery
Mexican x Cyanescens
Mexican x Azurescens
Mexican x Hispanica
Hispanica x Azurescens
Hispanica x Cyanescens
Hispanica x Phantasia Mystery
Hispanica x Treasure Coast
Hispanica x Gulf Coast
Hispanica x Australian
Hispanica x Equador
Hispanica x Cambodia
Hispanica x Mazatapec
Hispanica x A
Hispanica x B
Hispanica x B+
Panaeolus Tropicalis x Panaeolus Cyanescens

Also, what if Panaeolus became compatable with Psylocybe through this method? Another thought is that any one of the cross breeds may be breed again with another strain or another cross breed. All of the above strains were obtained from The Hawk's Eye. There are many other strains that could be breed to create a new strain.
In fact, I'm going to create a new thread on this very subject. Here:

Creating New Strains of Psychedelic Mushrooms

-PsiliPharm

[This message has been edited by PsiliPharm (edited December 28, 1999).]


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