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OfflineEcho7
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A question about psilocybin and serotonin
    #8818300 - 08/23/08 11:29 PM (15 years, 6 months ago)

It is my understanding that the psychedelic effects of mushrooms occur as a result of psilocybin (funny how this forum's spell check underlines that word) binding with serotonin receptors.  I am also of the understanding that brain receptors can be saturated so that every available receptor is filled with a chemical of some kind (I believe this is why high-dose LSD trips last so long, the chemical floats around in synapse because nothing can uptake it).'

My question is, if receptors can saturate and psilocybin operates on serotonin receptors, assuming this occurs in a high-dose subject, would serotonin (the chemical itself) stop being active in the body, at least until there were available receptors for it to bind to?


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OfflineZinglons Acolyte
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Re: A question about psilocybin and serotonin [Re: Echo7]
    #8818312 - 08/23/08 11:34 PM (15 years, 6 months ago)

no, there are many types of seretonin rtecepotors, and psilocybin only binds to one, the 5ht-2a seretonin receptor

btw the spellcheck is in firefox itsself and not the forum, thats why its underlined :wink:


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OfflineEcho7
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Re: A question about psilocybin and serotonin [Re: Echo7]
    #8818340 - 08/23/08 11:42 PM (15 years, 6 months ago)

Hmmm... so what effect does that have on the way serotonin operates endogenously?  It must do something...


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OfflineZinglons Acolyte
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Re: A question about psilocybin and serotonin [Re: Echo7]
    #8818368 - 08/23/08 11:50 PM (15 years, 6 months ago)

it makes you trip :macdre:


--------------------
And they wandered off.. nine ways till bedfast.
-----
"And lets pray that there's intelligent life somewhere up in space 'cause theres bugger-all down here on earth!"  -Monty Python's "The Universe Song" from The Meaning of Life
"In the beginning, the universe was created. This has made a lot of people very angry and has been widely considered as a bad move."  -Douglas Adams "The Hitchhikers Guide to the Galaxy"
"If the words 'life, liberty and the pursuit of happiness' don't include the right to experiment with your own consciousness, then the Declaration of Independence isn't worth the hemp it was written on." -Terence McKenna

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OfflineEcho7
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Re: A question about psilocybin and serotonin [Re: Zinglons Acolyte]
    #8818465 - 08/24/08 12:13 AM (15 years, 6 months ago)

Quote:

Zinglons Acolyte said:
it makes you trip :macdre:




Well duh, but what actually goes on?


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OfflineZinglons Acolyte
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Re: A question about psilocybin and serotonin [Re: Echo7]
    #8818477 - 08/24/08 12:17 AM (15 years, 6 months ago)

thats not very well established... mainly because the fucktard government doesnt allow legitimate research on drugs


--------------------
And they wandered off.. nine ways till bedfast.
-----
"And lets pray that there's intelligent life somewhere up in space 'cause theres bugger-all down here on earth!"  -Monty Python's "The Universe Song" from The Meaning of Life
"In the beginning, the universe was created. This has made a lot of people very angry and has been widely considered as a bad move."  -Douglas Adams "The Hitchhikers Guide to the Galaxy"
"If the words 'life, liberty and the pursuit of happiness' don't include the right to experiment with your own consciousness, then the Declaration of Independence isn't worth the hemp it was written on." -Terence McKenna

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OfflineEcho7
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Re: A question about psilocybin and serotonin [Re: Zinglons Acolyte]
    #8818482 - 08/24/08 12:17 AM (15 years, 6 months ago)

Quote:

Zinglons Acolyte said:
thats not very well established... mainly because the fucktard government doesnt allow legitimate research on drugs




Makes sense... hmm... thanks for helping out.


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