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imachavel
I loved and lost but I loved-ftw


Registered: 06/06/07
Posts: 31,414
Loc: You get banned for saying that
Last seen: 10 hours, 52 minutes
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Re: natural lsd [Re: imachavel]
#7220666 - 07/25/07 12:29 AM (16 years, 7 months ago) |
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I found this: "In a previous report, Gartz (3) was unable to detect baeocystin in P. cubensis. But Repke et al. (14) reported traces of baeocystin in other strains of Psilocybe cubensis about 10 years ago. They suggested that many non-specific enzyme systems exist in fungi which have the ability to oxidise exogenously added compounds, as well as normal, obligatory intermediates (14)."
Is there any research on ergot or woodrose enzymes
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I did not say to edit my signature soulidarity! Now forever I will never remember what I said about understanding the secrets of the universe by paying attention to subtleties!
I'm never giving you the password again. Jerk
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imachavel
I loved and lost but I loved-ftw


Registered: 06/06/07
Posts: 31,414
Loc: You get banned for saying that
Last seen: 10 hours, 52 minutes
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Re: natural lsd [Re: imachavel]
#7220761 - 07/25/07 01:34 AM (16 years, 7 months ago) |
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check this out, it's about dmt biosynthesis AND synthesis:
http://www.thechemblog.com/?p=37
my main question is, the synthesis is way different than the biosynthesis. This is because the aromatic amino acid reduction can't happen unless it's being made between living components, correct? See, those things are way different.
i don't know why i've been skipping over that. Anyway, chemical reactions which would create lysergic acid amide is way different when produced by a chemical reaction in a living organism and a chemical reaction in a laboratory. The main difference being that organisms are building themselves from subtle chemical reactions, and since there is now growth in a laboratory, the reactions must be more severe and definite. However, there must be similarities, to produce the same molecule, right?
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I did not say to edit my signature soulidarity! Now forever I will never remember what I said about understanding the secrets of the universe by paying attention to subtleties!
I'm never giving you the password again. Jerk
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Acyl
cyanidepoisoning


Registered: 12/13/05
Posts: 4,472
Loc: N.W.T.
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Re: natural lsd [Re: imachavel]
#7220850 - 07/25/07 02:45 AM (16 years, 7 months ago) |
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You're missing quite a bit pal... synthesis in nature happens under compeltely different mediums than synthesis in labs.
There are a large number of enzymes that are responsible for the conversion of many regular molecules into the psychedelic ones, its a slow biochemical process that has come about through evolution over thousands of years. Its nothing like the quick and dirty lab synthesis.
Take cocaine for example.
First notice that its got two ester groups, the benzyl and the methyl.. To produce cocaethylene you would only want to replace the methyl group with the ethyl.
If you tried to create cocaethylene from cocaine in the lab by a transesterification with ethanol you would end up converting the methyl group as well as the benzyl group into the ethyl ester. It would take several steps to get it right, infact id be willing to bet that the only efficient way of producing cocaethylene in the lab is to start from a compound that isnt even cocaine.
Now.. when alcohol (ethanol) is drunk while cocaine is in your system your body converts this to cocaethylene in the liver. This is done enzymatically, the enzyme only targets the methyl group. So, in the lab ethanol + cocaine =/= cocaethylene but in the body ethanol + cocaine = cocaethylene.
See the power of enzymes and biochemistry?
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Acyl
cyanidepoisoning


Registered: 12/13/05
Posts: 4,472
Loc: N.W.T.
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Re: natural lsd [Re: Acyl]
#7220853 - 07/25/07 02:48 AM (16 years, 7 months ago) |
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Didnt read your last post (only read the first after my last post), glad you finally realized it .
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imachavel
I loved and lost but I loved-ftw


Registered: 06/06/07
Posts: 31,414
Loc: You get banned for saying that
Last seen: 10 hours, 52 minutes
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Re: natural lsd [Re: Acyl]
#7223058 - 07/25/07 04:58 PM (16 years, 7 months ago) |
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acyl, i think that's exactly what I'm trying to say, I don't see why that's different from what I'm saying. That's a fascinating bit of research, you drink alchohol and take cocaine and your liver makes coca-ethylene or whatever. Anyway......
Do you HAVE any information of enzymatic experiments with psychedelics plants? peace
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I did not say to edit my signature soulidarity! Now forever I will never remember what I said about understanding the secrets of the universe by paying attention to subtleties!
I'm never giving you the password again. Jerk
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Greenport
Stranger
Registered: 09/03/07
Posts: 3
Last seen: 15 years, 7 months
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Re: natural lsd [Re: imachavel]
#8448835 - 05/26/08 10:16 PM (15 years, 9 months ago) |
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Well, there have been scientific advances allowing us to genetically alter the proteins of plants, fungi and bacteria to force them to produce pharmaceuticals (yeah, drugs). It's been done with corn and tobacco certainly.
What would happen if we spliced the genes from a cannabis plant with a corn plant? Hmmmmm?! 
On the other hand, as far as genetically altering plants to produce LSD from the other ergotamine alkaloids it naturally produces would be a bit tricky. One can't just feed the plant Diethylamine and cross her fingers . It would probably be possible in a scientific bio-lab but since that would be highly illegal today, that won't happen.
Perhaps if a person could find a plant/bacteria that actually forms small amounts of LSD - they could cultivate strains selectively choosing the ones that produce the most. Over a long period of selective breeding, who knows maybe that would be possible. But as of now do we even know of any plants/bacteria that directly produce LSD anyways?
It'd be a tricky change of genetics either way, whether one wanted to do it directly by splicing genes or selectively via breeding. As cool of an idea as it is, there is likely to be no following to it as of its complexity and lack of funding/research ability. We're likely to see DMT-containing pot first, or DMT-contining shrooms even...
Maybe years and years down the line somebody will achieve this goal. Not yet, though. We're not scientifically advanced enough yet (although we're getting there!)
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Entropymancer


Registered: 07/16/05
Posts: 10,207
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Re: natural lsd [Re: Greenport]
#8448846 - 05/26/08 10:19 PM (15 years, 9 months ago) |
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You're too late, imachavel has since been banned and is peddling his nonsense elsewhere. Good post though.
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doitagain
He-Bro



Registered: 02/22/07
Posts: 1,947
Loc: Land of Milk and Honey
Last seen: 13 years, 8 months
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Quote:
Entropymancer said: You're too late, imachavel has since been banned and is peddling his nonsense elsewhere. Good post though.
what did that 'tard finally get the ban for?
-------------------- now i hear the police comin after me
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Entropymancer


Registered: 07/16/05
Posts: 10,207
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Re: natural lsd [Re: doitagain]
#8448862 - 05/26/08 10:25 PM (15 years, 9 months ago) |
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I think he left smeone a trade rating instead of a general (because he was cracked out and pissed off and had already given them a zero general rating). He'd recently had a major meltdown in the Pub, got banned from there, then continued his meltdown in the OTD. The mods happily jumped at the excuse to ban him.
Then he had a puppet for about a week not long after... I saw it got banned, I'm not sure what for though.
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doitagain
He-Bro



Registered: 02/22/07
Posts: 1,947
Loc: Land of Milk and Honey
Last seen: 13 years, 8 months
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they finally made it.
-------------------- now i hear the police comin after me
Edited by doitagain (06/14/08 03:59 PM)
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Acyl
cyanidepoisoning



Registered: 12/13/05
Posts: 4,472
Loc: N.W.T.
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Re: natural lsd [Re: doitagain]
#8527217 - 06/15/08 03:31 PM (15 years, 8 months ago) |
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jetpackjake
Brisketball Champion



Registered: 03/18/08
Posts: 224
Loc: Fortuna, California
Last seen: 13 years, 2 months
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Re: natural lsd [Re: Acyl]
#8527238 - 06/15/08 03:37 PM (15 years, 8 months ago) |
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lmao
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