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P. Flux
Grasshopper




Registered: 05/08/08
Posts: 84
Loc: Midwest
Last seen: 12 years, 1 month
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Effects of Psilocybin on Time Perception
#8523881 - 06/14/08 03:05 PM (15 years, 11 months ago) |
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January 1st, 2007
Effects of psilocybin on time perception and temporal control of behaviour in humans
Hallucinogenic psilocybin is known to alter the subjective experience of time. However, there is no study that systematically investigated objective measures of time perception under psilocybin. Therefore, we studied dose-dependent effects of the serotonin (5-HT)2A/1A receptor agonist psilocybin (4-phosphoryloxy-N, N-dimethyltryptamine) on temporal processing, employing tasks of temporal reproduction, sensorimotor synchronization and tapping tempo. To control for cognitive and subjective changes, we assessed spatial working memory and conscious experience. Twelve healthy human volunteers were tested under placebo, medium (115µg/kg), and high (250µg/kg) dose conditions, in a double-blind experimental design. Psilocybin was found to significantly impair subjects’ ability to (1) reproduce interval durations longer than 2.5 sec, (2) to synchronize to inter-beat intervals longer than 2 sec and (3) caused subjects to be slower in their preferred tapping rate. These objective effects on timing performance were accompanied by working-memory deficits and subjective changes in conscious state, namely increased reports of ‘depersonalization’ and ‘derealization’ phenomena including disturbances in subjective ‘time sense.’ Our study is the first to systematically assess the impact of psilocybin on timing performance on standardized measures of temporal processing. Results indicate that the serotonin system is selectively involved in duration processing of intervals longer than 2 to 3 seconds and in the voluntary control of the speed of movement. We speculate that psilocybin’s selective disruption of longer intervals is likely to be a product of interactions with cognitive dimensions of temporal processing -presumably via 5-HT2A receptor stimulation.
Old, but interesting, nonetheless. Peace
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Nature Boy
Stranger than most



Registered: 07/09/07
Posts: 8,246
Loc: Samsara
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Re: Effects of Psilocybin on Time Perception [Re: P. Flux]
#8524377 - 06/14/08 05:41 PM (15 years, 11 months ago) |
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I remember reading this study when it was first published. I agree...it was interesting.
I just wish they had studied a larger population of subjects. Twelve individuals is, arguably, barely adequate a cohort for drawing valid conclusions. Fifty or more would have been more statistically significant and therefore persuasive, IMHO.
N.B.
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TypicalTripper
CannabisCuddling Canuck



Registered: 03/24/07
Posts: 396
Loc: Canada
Last seen: 12 years, 3 months
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Re: Effects of Psilocybin on Time Perception [Re: Nature Boy]
#8525642 - 06/15/08 12:53 AM (15 years, 11 months ago) |
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Yeah twelve people might be small but it must be hard to get approval for large scale drug testing regarding illegal drugs, in the United States at least.
I liked how the third discovery was that it slowed down your tapping rythm. People on mushroom think so fast they see everything else be slower , so they slow down their movements ? Who knows...
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Groomies
Ghost



Registered: 08/16/07
Posts: 1,119
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Re: Effects of Psilocybin on Time Perception [Re: TypicalTripper]
#8526074 - 06/15/08 07:06 AM (15 years, 11 months ago) |
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thats awesome.. it explains why when i'm on mushies. i can fight my friends just standing perfectly still and with only one hand. i can see every punch come at me in slow motion. i've once even caught a fly, flying by me in midair, while on mushies.
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Konyap


Registered: 06/30/07
Posts: 33,945
Loc: Planet Piss
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Re: Effects of Psilocybin on Time Perception [Re: Groomies]
#8526270 - 06/15/08 09:46 AM (15 years, 11 months ago) |
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dang lol when im sober you can ask me what time it is and im usually not off more then 15 min, but on mush i run faster then a crack addict
but i think the test is sayin people had to make up for feeling slower so they went on a second guess and thats why they got the slower results
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veggie

Registered: 07/25/04
Posts: 17,538
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Re: Effects of Psilocybin on Time Perception [Re: P. Flux]
#8527326 - 06/15/08 04:09 PM (15 years, 11 months ago) |
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This thread has been closed.
Reason: Posts in News is limited to current news stories.
(If you would like this post moved to another forum, let me know)
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