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InvisibleBridgeburner
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Brookhaven scientists explore brain's reaction to potent hallucinogen
    #8502490 - 06/09/08 04:27 AM (15 years, 11 months ago)

http://www.newsrx.com/articles/996975.html

Brain-imaging studies performed in animals at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory provide researchers with clues about why an increasingly popular recreational drug that causes hallucinations and motor-function impairment in humans is abused. Using trace amounts of Salvia divinorum – also known as "salvia," a Mexican mint plant that can be smoked in the form of dried leaves or serum – Brookhaven scientists found that the drug's behavior in the brains of primates mimics the extremely fast and brief "high" observed in humans. Their results are now published online in the journal NeuroImage.

Quickly gaining popularity among teenagers and young adults, salvia is legal in most states, but is grabbing the attention of municipal lawmakers. Numerous states have placed controls on salvia or salvinorin A – the plant's active component – and others, including New York, are considering restrictions.

"This is probably one of the most potent hallucinogens known," said Brookhaven chemist Jacob Hooker, the lead author of the study, which is the first to look at how the drug travels through the brain. "It's really important that we study drugs like salvia and how they affect the brain in order to understand why they are abused and to investigate their medicinal relevance, both of which can inform policy makers."

Hooker and fellow researchers used positron emission tomography, or PET scanning, to watch the distribution of salvinorin A in the brains of anesthetized primates. In this technique, the scientists administer a radioactively labeled form of salvinorin A (at concentrations far below pharmacologically active doses) and use the PET scanner to track its site-specific concentrations in various brain regions.

Within 40 seconds of administration, the researchers found a peak concentration of salvinorin A in the brain – nearly 10 times faster than the rate at which cocaine enters the brain. About 16 minutes later, the drug was essentially gone. This pattern parallels the effects described by human users, who experience an almost immediate high that starts fading away within 5 to 10 minutes.

High concentrations of the drug were localized to the cerebellum and visual cortex, which are parts of the brain responsible for motor function and vision, respectively. Based on their results and published data from human use, the scientists estimate that just 10 micrograms of salvia in the brain is needed to cause psychoactive effects in humans.

Salvia doesn't cause the typical euphoric state associated with other hallucinogens like LSD, Hooker said. The drug targets a receptor that is known to modulate pain and could be important for therapies as far reaching as mood disorders.

"Most people don't find this class of drugs very pleasurable," Hooker said. "So perhaps the main draw or reason for its appeal relates to the rapid onset and short duration of its effects, which are incredibly unique. The kinetics are often as important as the abused drug itself."

The Brookhaven team plans to conduct further studies related to salvia's abuse potential. The scientists also hope to develop radioactive tracers that can better probe the brain receptors to which salvia binds. Such studies could possibly lead to therapies for chronic pain and mood disorders.


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Offlineperosiste
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Re: Brookhaven scientists explore brain's reaction to potent hallucinogen [Re: Bridgeburner]
    #8502503 - 06/09/08 04:37 AM (15 years, 11 months ago)

well Ill be damned actual medical research on a hallucinogen.


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Risk Management will be the downfall of western civilization

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OfflineNature Boy
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Re: Brookhaven scientists explore brain's reaction to potent hallucinogen [Re: perosiste]
    #8502511 - 06/09/08 04:44 AM (15 years, 11 months ago)

Quote:

perosiste said:
well Ill be damned actual medical research on a hallucinogen.




I hate to be a cynic, but since the GOVERNMENT is footing the bill, it is highly likely this study is in preparation for justifying making salvia a schedule 1 drug.

Better stock up while you can.  Once that's gone, the youtube assholes will switch to DMT, and MHRB will be the next target for sheduling.

N.B.


--------------------
All submitted posts under this user name are works of pure fiction or outright lies.  Any information, statement, or assertion contained therein should be considered pure unadulterated bullshit.  Note well:  Sorry, but I do not answer PM's unless you are a long-time trusted friend.  If you have a question, ask it in the appropriate thread.

                                                                               

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Offlineperosiste
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Re: Brookhaven scientists explore brain's reaction to potent hallucinogen [Re: Nature Boy]
    #8502531 - 06/09/08 05:01 AM (15 years, 11 months ago)

yeah I think its time to plant some around the house.


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Risk Management will be the downfall of western civilization

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InvisibleEgo Death
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Re: Brookhaven scientists explore brain's reaction to potent hallucinogen [Re: Bridgeburner]
    #8502579 - 06/09/08 05:26 AM (15 years, 11 months ago)

Quote:

It's really important that we study drugs like salvia and how they affect the brain in order to understand why they are abused




I've never heard of salvia being abused.  Its not crack, its not something people get addicted to and crave everyday.

The reason why salvia is USED is obvious.  Humans seek to alter their state of mind, we have done since the dawn of time.  Equally, so do many other animals.  We do it to push the boundaries of understanding.  To experience things beyond the norm.  One of the first ways of altering my perceptions, I found as a child, was to spin round really fast in the playground at school.

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Offlineperosiste
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Re: Brookhaven scientists explore brain's reaction to potent hallucinogen [Re: Ego Death]
    #8502587 - 06/09/08 05:30 AM (15 years, 11 months ago)

I guess that they are calling any drug use
"abuse"


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InvisibleEgo Death
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Re: Brookhaven scientists explore brain's reaction to potent hallucinogen [Re: perosiste]
    #8502596 - 06/09/08 05:32 AM (15 years, 11 months ago)

We best start calling fat people "food abusers" and people that drink coffee everyday "drug addicts".

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Offlineperosiste
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Re: Brookhaven scientists explore brain's reaction to potent hallucinogen [Re: Ego Death]
    #8502610 - 06/09/08 05:39 AM (15 years, 11 months ago)

well according to technical definitions..........


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OfflineShroomNinja
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Re: Brookhaven scientists explore brain's reaction to potent hallucinogen [Re: perosiste]
    #8502834 - 06/09/08 08:05 AM (15 years, 11 months ago)

Quote:

perosiste said:
I guess that they are calling any drug use
"abuse"




That seems to be the case with most drugs.

I am happy that they are doing studies into it. I'm interested in learning how that stuff works in the mind.

It's also good that they are looking to use it as a medicine and not just jumping straight to "its dangerous and will kill you"

I do tend to agree that its probably just gonna be used for leverage at some point in the future.


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Welcome To The Realm of The Unknown!!

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InvisibleMush 4 Brains
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Re: Brookhaven scientists explore brain's reaction to potent hallucinogen [Re: ShroomNinja]
    #8504019 - 06/09/08 03:48 PM (15 years, 11 months ago)

They consider it abuse when you don't have a need for the drug, if there is no known use for the drug, or if you take over an amount of a prescribed drug in order to get high.  I too am interested in it's effects on body and mind, and i find it very intriguing that it may possibly have use as a "pain modifier."  Salvia personally isn't my cup of tea, though i have had a good time on it before.  Either people have a smile ear to ear or they freak the fuck out after smoking it, Ive experienced both.

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InvisibleInvisible_Woe


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Re: Brookhaven scientists explore brain's reaction to potent hallucinogen [Re: Nature Boy]
    #8505908 - 06/10/08 12:51 AM (15 years, 11 months ago)

Quote:

Nature Boy said:
Quote:

perosiste said:
well Ill be damned actual medical research on a hallucinogen.




I hate to be a cynic, but since the GOVERNMENT is footing the bill, it is highly likely this study is in preparation for justifying making salvia a schedule 1 drug.

Better stock up while you can.  Once that's gone, the youtube assholes will switch to DMT, and MHRB will be the next target for sheduling.

N.B.




exactky what i am saying...then they will go to datura then morning glories and forever untill there is no mind expansion left to be had


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These are not the answers you should be questioning.

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OfflineNature Boy
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Re: Brookhaven scientists explore brain's reaction to potent hallucinogen [Re: ShroomNinja]
    #8506343 - 06/10/08 05:30 AM (15 years, 11 months ago)

Quote:

ShroomNinja said:
I am happy that they are doing studies into it. I'm interested in learning how that stuff works in the mind.





Which brain receptors it selectively inhibits has already been fully studied and identified.  No need to do the Brookhaven study, unless there is some possibility of policy propaganda to be gained by it.

Quote:

It's also good that they are looking to use it as a medicine and not just jumping straight to "its dangerous and will kill you"




Yes, but they will get to the proscribing of salvia shortly thereafter.  It's like doing a whitewashed environmental impact study.  "No creatures will be harmed.  Go ahead put up your mega-mall, Mr. Builder.  Oh, by the way, thanks for the bag full of cash."

Quote:

I do tend to agree that its probably just gonna be used for leverage at some point in the future.




Yep.  I'm neither the first, nor will I be the last to say it:  Hallucinogenic drug use needs to be out of the public eye. YouTube assholes are going to kill it all.  It is so very, very easy for the parents and policy makers to point to that source as rationale for outlawing EVERYTHING psychoactive that finds its way there.

We're in deep trouble thanks to a handful of a-holes....but isn't that always the way??  A few spoil it for all.  GRRRRRRR...

N.B.


--------------------
All submitted posts under this user name are works of pure fiction or outright lies.  Any information, statement, or assertion contained therein should be considered pure unadulterated bullshit.  Note well:  Sorry, but I do not answer PM's unless you are a long-time trusted friend.  If you have a question, ask it in the appropriate thread.

                                                                               

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Invisiblebadchad
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Re: Brookhaven scientists explore brain's reaction to potent hallucinogen [Re: Nature Boy]
    #8506525 - 06/10/08 08:16 AM (15 years, 11 months ago)

This was a peer-reviewed research study.  Thus, the findings and outcomes are open to positive interpretations (as well as negative).  The vast majority of academic research in the U.S. is dunded by the government (since academic research is usually non-profit) so to say it's propoganda is a stretch. 

Lastly, while the binding profile of Salvinorin-A is known, I don't believe its pharmacokinetic properties haven't been studied, making it worthwhile (although the results are intuitive).


--------------------
...the whole experience is (and is as) a profound piece of knowledge.  It is an indellible experience; it is forever known.  I have known myself in a way I doubt I would have ever occurred except as it did.

Smith, P.  Bull. Menninger Clinic (1959) 23:20-27; p. 27.

...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.

Osmond, H.  Annals, NY Acad Science (1957) 66:418-434; p.436

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Invisiblecreekfreek
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Re: Brookhaven scientists explore brain's reaction to potent hallucinogen [Re: Invisible_Woe]
    #8509394 - 06/10/08 10:51 PM (15 years, 11 months ago)

Quote:

Invisible_Woe said:
Quote:

Nature Boy said:
Quote:

perosiste said:
well Ill be damned actual medical research on a hallucinogen.




I hate to be a cynic, but since the GOVERNMENT is footing the bill, it is highly likely this study is in preparation for justifying making salvia a schedule 1 drug.

Better stock up while you can.  Once that's gone, the youtube assholes will switch to DMT, and MHRB will be the next target for sheduling.

N.B.




exactky what i am saying...then they will go to datura then morning glories and forever untill there is no mind expansion left to be had





This is exactly the reason that everyone who uses pot or any other substance that they have deemed illegal needs to stand up and open their mouths and tell the government what they think.
We need to stop the government before they take everything we enjoy away from us.
GET UP, STAND UP, STAND UP FOR YOUR RIGHTS!!!
Peace.

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Invisiblejohnm214
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Re: Brookhaven scientists explore brain's reaction to potent hallucinogen [Re: badchad]
    #8509618 - 06/10/08 11:58 PM (15 years, 11 months ago)

Quote:

badchad said:
This was a peer-reviewed research study.  Thus, the findings and outcomes are open to positive interpretations (as well as negative).  The vast majority of academic research in the U.S. is dunded by the government (since academic research is usually non-profit) so to say it's propoganda is a stretch. 

Lastly, while the binding profile of Salvinorin-A is known, I don't believe its pharmacokinetic properties haven't been studied, making it worthwhile (although the results are intuitive).




Thank's for that.

I'm sick of folks who probably haven't read the studyh claim its all just a pack of lies.  What in the article re: the study was wrong?

And all we need to know is some receptors a drug works on?  Nevermind any other effects or charecteristics?  Guess I'll go drink my methanol coctail now ya fools

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OfflineGroomies
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Re: Brookhaven scientists explore brain's reaction to potent hallucinogen [Re: johnm214]
    #8509989 - 06/11/08 03:23 AM (15 years, 11 months ago)

drugs is like sex.. its bad but it feels so good!


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:hotidea::hotidea::hotidea:

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OfflineNature Boy
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Re: Brookhaven scientists explore brain's reaction to potent hallucinogen [Re: johnm214]
    #8511828 - 06/11/08 03:40 PM (15 years, 11 months ago)

Quote:

johnm214 said:
Thank's for that.

I'm sick of folks who probably haven't read the studyh claim its all just a pack of lies.  What in the article re: the study was wrong?

And all we need to know is some receptors a drug works on?  Nevermind any other effects or charecteristics?  Guess I'll go drink my methanol coctail now ya fools




I don't think anyone said anything of the kind.  No one is calling into question the findings, motivations, accuracy, or veracity of the study.  In fact, it's highly likely it is quite well done (if not redundant).

What >>IS<< of concern is the purpose to which it will be put, namely as evidence of the psychoactive speed, potency, strength and unpredicability of salvinorin's effects on the human brain, thereby warranting immediate scheduling.

THAT's what the real problem will be in the very near future.  Feds following several states in proscribing the possession, sale and use, and putting people in JAIL for it.

N.B.


--------------------
All submitted posts under this user name are works of pure fiction or outright lies.  Any information, statement, or assertion contained therein should be considered pure unadulterated bullshit.  Note well:  Sorry, but I do not answer PM's unless you are a long-time trusted friend.  If you have a question, ask it in the appropriate thread.

                                                                               

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Invisiblejohnm214
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Re: Brookhaven scientists explore brain's reaction to potent hallucinogen [Re: Nature Boy]
    #8513636 - 06/11/08 11:48 PM (15 years, 11 months ago)

Quote:

Nature Boy said:
Quote:

johnm214 said:
Thank's for that.

I'm sick of folks who probably haven't read the studyh claim its all just a pack of lies.  What in the article re: the study was wrong?

And all we need to know is some receptors a drug works on?  Nevermind any other effects or charecteristics?  Guess I'll go drink my methanol coctail now ya fools




I don't think anyone said anything of the kind.  No one is calling into question the findings, motivations, accuracy, or veracity of the study.  In fact, it's highly likely it is quite well done (if not redundant).

N.B.




Nature Boy said:

Which brain receptors it selectively inhibits has already been fully studied and identified.  No need to do the Brookhaven study, unless there is some possibility of policy propaganda to be gained by it.





I hate to be a cynic, but since the GOVERNMENT is footing the bill, it is highly likely this study is in preparation for justifying making salvia a schedule 1 drug.

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Invisiblebadchad
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Re: Brookhaven scientists explore brain's reaction to potent hallucinogen [Re: Nature Boy]
    #8514512 - 06/12/08 09:09 AM (15 years, 11 months ago)

Quote:

Nature Boy said:


What >>IS<< of concern is the purpose to which it will be put, namely as evidence of the psychoactive speed, potency, strength and unpredicability of salvinorin's effects on the human brain, thereby warranting immediate scheduling.






And this would be an incorrect assumption.  An inactive, benign, lipophilic drug (e.g. a receptor antagonist) could show the same profile if given intravenously.


--------------------
...the whole experience is (and is as) a profound piece of knowledge.  It is an indellible experience; it is forever known.  I have known myself in a way I doubt I would have ever occurred except as it did.

Smith, P.  Bull. Menninger Clinic (1959) 23:20-27; p. 27.

...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.

Osmond, H.  Annals, NY Acad Science (1957) 66:418-434; p.436

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OfflineNature Boy
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Re: Brookhaven scientists explore brain's reaction to potent hallucinogen [Re: badchad]
    #8521409 - 06/13/08 08:08 PM (15 years, 11 months ago)

Quote:

badchad said:

And this would be an incorrect assumption.  An inactive, benign, lipophilic drug (e.g. a receptor antagonist) could show the same profile if given intravenously.




Huh?  If a compound is INACTIVE, then there would be no concern whatsoever of it beccoming a scheduled drug.  I think we're misunderstanding one another.  I'll try to be clearer:

I have no doubt the researchers are doing their study in good faith, and their information will be accurate, etc.

The concern I have is that the study will be utilized by overly zealous anti-drug czars as justification for immediate scheduling.

N.B.


--------------------
All submitted posts under this user name are works of pure fiction or outright lies.  Any information, statement, or assertion contained therein should be considered pure unadulterated bullshit.  Note well:  Sorry, but I do not answer PM's unless you are a long-time trusted friend.  If you have a question, ask it in the appropriate thread.

                                                                               

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Invisiblejohnm214
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Re: Brookhaven scientists explore brain's reaction to potent hallucinogen [Re: Nature Boy]
    #8523516 - 06/14/08 01:15 PM (15 years, 11 months ago)

Then say that in the future.

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