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Scarfase
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Taking shrooms while on paxil?
#7961906 - 01/31/08 08:10 PM (16 years, 1 day ago) |
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I am going to be purchasing my first batch of shrooms this weekend, and I was wondering if it was dangerous to take shrooms while on an SSRI. I have been on it for about a year now, would it just not make me trip at all, or could it be dangerous?
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doitagain
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Re: Taking shrooms while on paxil? [Re: Scarfase]
#7961911 - 01/31/08 08:12 PM (16 years, 1 day ago) |
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if it is an ssri you should be fine, it may lower your response but thats not known for sure, if it an ssri you will be fine with shrooms.
-------------------- now i hear the police comin after me
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Scarfase
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Re: Taking shrooms while on paxil? [Re: doitagain]
#7961934 - 01/31/08 08:20 PM (16 years, 1 day ago) |
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Do you have any idea on how much I would need? I am buying an 1/8, 35 bucks, i don't know if that's a good price or not around here.
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MorphMan
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Re: Taking shrooms while on paxil? [Re: doitagain]
#7961946 - 01/31/08 08:22 PM (16 years, 1 day ago) |
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It will be fine, but just as doitagain said, it's going to reduce the mushrooms' effectiveness. Some would argue that it's not really worth it because the amount you'd need to take is going to be larger than normal and thus you will end up spending more money to get the same intensity trip as someone would take while not on paxil. What I don't know is how long paxil stays in your system or how long you'd have to abstain from it in order to get the full effects from the psilocin.
But the answer to your question is definitely yes, it's safe to eat the shrooms.
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Scarfase
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Re: Taking shrooms while on paxil? [Re: MorphMan]
#7961952 - 01/31/08 08:23 PM (16 years, 1 day ago) |
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This is such a great relief, I have been worrying about this for so long though, looks like I came to the right place for my answer
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MorphMan
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Re: Taking shrooms while on paxil? [Re: Scarfase]
#7961958 - 01/31/08 08:24 PM (16 years, 1 day ago) |
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Yeah man, I'm glad that it's a relief.
Welcome to the shroomery, if you have any questions about anything else feel free to ask.
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Scarfase
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Re: Taking shrooms while on paxil? [Re: MorphMan]
#7962083 - 01/31/08 08:54 PM (16 years, 1 day ago) |
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Sorry for all the questions, I know I'm probably just worrying too much, but there is no chance in this..killing me? haha
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MorphMan
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Re: Taking shrooms while on paxil? [Re: Scarfase]
#7962146 - 01/31/08 09:12 PM (16 years, 1 day ago) |
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No, I'm certain this is not going to kill you. The only reason the whole paxil issue is going to even interact is because the two drugs both interact with the serotonin receptor(s). The paxil is an SSRI meaning that it's going to inhibit the body's ability to metabolize the serotonin. For some reason it causes the body to have trouble intaking the psilocin and it's not as efficient (you'll need more mushrooms to have the same trip as someone that isn't taking it).
I understand the paranoia, and I'd actually say it's good, you should always be aware of the possible consequences of your drug use. However, I know people that have taken mushrooms that are on an SSRI and they were absolutely fine. You don't have to worry about any lethal interactions between the drugs. The only adverse effect the paxil will have on the psilocin is that it will make it less effective. You'll just need a higher dose.
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weephar
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Re: Taking shrooms while on paxil? [Re: MorphMan]
#7962322 - 01/31/08 09:45 PM (16 years, 1 day ago) |
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I have personal experience with this and I have some bad news...eating an 1/8 of shrooms for me while on paxil provided almost no effect...it sucks waiting to trip and having nothing happen.
However, if you quit the Paxil, then you will be able to trip. The only question is how long you need to quit for. I quit and never went back...and didn't have shrooms until like 3 months later, so my length of time experience is not very relevant. I quit because of a couple of reasons, but one was that mdma (something else effected by paxil) did nothing for me...and then I got some LSD (after quitting) about a month later and I got a full on trip. I have heard that you need to quit anywhere between a week and a month...though I have no good personal evidence if the time is less than a month.
I was on effexor and then paxil for a long time (like years) and ate shrooms a few times(over a few years) and had no effects...it really is frustrating. It was very nice to finally be able to trip on shrooms, though I preferred the LSD.
Basically though, SNRI's (effexor) and SRRI's (paxil) kill a trip and it sucks. Quitting them also sucks...you really need to wean yourself off of them...and it is best to do with a doctor's supervision. There is some withdrawl going cold turkey (probably the effexor moreso than paxil, but still). I wish I had kept better records but I had a lot going on(good stuff like college graduation...I wouldn't do it if bad stuff is going on) when I was weaning myself off, so I don't really remember how much I lowered my dose nor the exact amount of time between my last dose of paxil and my first dose of L. I just know I would take a little less paxil for a few days before relowering my dose. Sometimes I would go two days between doses. I was really unscientific about it, which isn't usually my style (though I had been planning on quitting and would usually fail at it due to not having a good enough reason to quit, and the same thing happened with effexor...after several tries I finally did quit) and I would strongly suggest talking to a doctor about it if you really want to do it.
Another thing to think about, is that are you sure you want to quit the Paxil to trip. If the paxil is really helping then you may want to consider that...I keep planning to go back on it (though I am unsure if it is really helping, though it definetly was at one time), but keep pushing it back because there are other things I want to trip on and I don't know if I want to take it anymore. Just something to think about. I think some day I may go back on...but I am in no hurry to and am unsure if I need to. Also, the physical dependence on them sucks. Though I have had no problem quitting these drugs with self-weaning...I have heard stories of ex-heroin addicts who had more trouble getting off of effexor...probably hearsay...but still.
Anyway, I wish you the best of luck...I have found tripping to be amazing and I hope you get something really special out of it. I really wish I could remember the length of time between my last dose of paxil and the first dose of lsd, but I have so much paxil saved up that I can't even figure it out if I tried. I believe the half-life is about 24 hours(wikipedia)...so you can use that as a starting point to figure out how long it takes to get out of your system...but I weaned myself off over the course of a month and it was probably a week before my trip that I took my last dose of paxil (I have been thinking more and lookin at a calendar, so I am guessing this).
Anyway, I highly recommend talking to your doctor and thinking about it carefully if you really want to quit. Some people have trouble after quitting, and it takes a while to start working in the first place, so going back on might take a little while.
For the safety aspects, I had no physical or psychological problems after doing it, besides being very frustrated that I had wasted more shrooms, haha.
Please tell us how it goes and how long you quit for if you decide to do that. (the more info people have the better). Feel free to ask me any questions...though remember I am not a doctor.
Be careful, and Have a nice trip!
(sorry, that was really long and rambled on)
-------------------- Life is good! (and it is also a journey) Free Rudd!
Edited by weephar (01/31/08 09:57 PM)
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mandelbrah
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Re: Taking shrooms while on paxil? [Re: weephar]
#7962716 - 01/31/08 11:08 PM (16 years, 1 day ago) |
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SSRIs work by inhibiting the chemical regulators in your synapses that mop up seratonin.
The result is that there is more seratonin in your synapses, and therefore more seratonin finds its way to the next neuron.
This is a molecule of seratonin.

Many psychedelic drugs such as psilocin, psilocybin, LSD-25, etc., are extremely similar in structure to neurotransmitters, especially seratonin.
This is a molecule of psilocin.

Psychedelic drugs, since they are very similar in structure to seratonin, compete to bind to the same receptors on the postsynaptic neurons.
If there is an elevated level of seratonin in your synapses, it will be a stronger competitor for receptors, reducing the number of receptors available to accept a psychedelic drug. More seratonin will bind to the next neuron when using SSRIs, resulting in diminished effect when using seratonin-mimic type psychedelics.
If you take the risk of using psychedelic drugs, avoid MAOI (monoamine oxidase inhibitors) or tricyclic antidepressants in general, as they have very serious interactions with a variety of drugs.
SSRIs/SNRIs will make it much more difficult for you to trip, but not impossible. Never jack up the dose of a drug to compensate for an antidepressant.
/the more you know
Edited by mandelbrah (02/01/08 12:16 AM)
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Skeeblix
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Re: Taking shrooms while on paxil? [Re: mandelbrah]
#7962760 - 01/31/08 11:17 PM (16 years, 1 day ago) |
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It's one of the main reasons I'm real susceptible to the effects of hallucinogens. I have seasonal depression, and in the wintertime, it becomes real apparent that my brain isn't doing all the shit it should be with my serotonergic system, and if I dose in the winter months I have to make sure I remember to cut my dosage back a bit because without a normal level of seratonin it doesn't take a very large dose to catapult me into outer space.
Even though I can really tell when my chemicals are out of whack, the best thing I ever did was quit eating SSRIs. Learning to cope with the change in mood on your own takes a bit of effort, but you get the added benefit of not feeling quite so listless and blank, like how SSRIs made me feel.
-------------------- This post approved by:
Premedman1 said:
I just shat my pants.
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doitagain
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Re: Taking shrooms while on paxil? [Re: mandelbrah]
#7962767 - 01/31/08 11:18 PM (16 years, 1 day ago) |
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yeah not everybody is the same, i tripped hard off of a half-eigth my first time, they were very good shrooms though, but I was on an SSRI, so for me it hasn't really had a noticeable effect but it can on some people.
-------------------- now i hear the police comin after me
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RaMboZo
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Re: Taking shrooms while on paxil? [Re: doitagain]
#7963520 - 02/01/08 05:53 AM (16 years, 20 hours ago) |
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Well I've eaten a bunch of shrooms and felt nothing, and then ate about the same amount and saw the meaning of life. These were from the same strain but different flushes. I don't think I was on Paxil at the time but it is possible. 10 years ago and my recollection is a bit rusty. I think you'll be fine. About an eight is perfect. Just don't worry yourself to death, thats what gets ya.
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weephar
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Re: Taking shrooms while on paxil? [Re: doitagain]
#7963543 - 02/01/08 06:04 AM (16 years, 20 hours ago) |
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Just out of curiosity, which ssri were you on?
-------------------- Life is good! (and it is also a journey) Free Rudd!
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donvliet
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Re: Taking shrooms while on paxil? [Re: weephar] 1
#7963660 - 02/01/08 06:53 AM (16 years, 19 hours ago) |
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here's a lot of info on anti-depressants and psychedelics: http://www.bluelight.ru/vb/showthread.php?s=&threadid=108959&r=10
I have used Paxil and was able to trip while on it. I needed slightly more but nothing extreme. I recommend against quitting you antidepressant just to take drugs. It can take weeks before your system returns to normal after quiting. Plus there's the risk of falling back into depression not to mention withdrawal symptoms if you don't build down the dose of the antidepressant gradually.
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MorphMan
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Re: Taking shrooms while on paxil? [Re: mandelbrah]
#7964664 - 02/01/08 12:21 PM (16 years, 14 hours ago) |
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Quote:
mandelbrah said: SSRIs work by inhibiting the chemical regulators in your synapses that mop up seratonin.
The result is that there is more seratonin in your synapses, and therefore more seratonin finds its way to the next neuron.
This is a molecule of seratonin.

Many psychedelic drugs such as psilocin, psilocybin, LSD-25, etc., are extremely similar in structure to neurotransmitters, especially seratonin.
This is a molecule of psilocin.

Psychedelic drugs, since they are very similar in structure to seratonin, compete to bind to the same receptors on the postsynaptic neurons.
If there is an elevated level of seratonin in your synapses, it will be a stronger competitor for receptors, reducing the number of receptors available to accept a psychedelic drug. More seratonin will bind to the next neuron when using SSRIs, resulting in diminished effect when using seratonin-mimic type psychedelics.
If you take the risk of using psychedelic drugs, avoid MAOI (monoamine oxidase inhibitors) or tricyclic antidepressants in general, as they have very serious interactions with a variety of drugs.
SSRIs/SNRIs will make it much more difficult for you to trip, but not impossible. Never jack up the dose of a drug to compensate for an antidepressant.
/the more you know
This is a very good, interesting post. I knew that SSRI's inhibited your body from getting rid of the excess serotonin, but this puts everything into perspective. Good post
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tyler_0_durden
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Re: Taking shrooms while on paxil? [Re: Scarfase]
#7965068 - 02/01/08 02:01 PM (16 years, 12 hours ago) |
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Quote:
Scarfase said: I am going to be purchasing my first batch of shrooms this weekend, and I was wondering if it was dangerous to take shrooms while on an SSRI. I have been on it for about a year now, would it just not make me trip at all, or could it be dangerous?
you're thinking of certain MAOIs. SSRI's are fine when you take them with mushrooms, but they are known to affect the trip. Some people report increased effects, some report decreased effects. This is because the molecules of psilocybin and the molecule responsible for paxil or prozac are really similar. So they can act in tamden or against each other. There is no danger here in mixing the two, but I say, if you're gonna dose, you might as well stop taking your Paxil a week before so you won't be disappointed with your trip.
-------------------- "As a man who has devoted his whole life to the most clear headed science, to the study of matter, I can tell you as a result of my research about atoms this much: There is no matter as such. All matter originates and exists only by virtue of a force which brings the particle of an atom to vibration and holds this most minute solar system of the atom together. We must assume behind this force the existence of a conscious and intelligent mind. This mind is the matrix of all matter." --Max Planck
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Scarfase
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Re: Taking shrooms while on paxil? [Re: weephar]
#7965078 - 02/01/08 02:03 PM (16 years, 12 hours ago) |
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Quote:
weephar said: I have personal experience with this and I have some bad news...eating an 1/8 of shrooms for me while on paxil provided almost no effect...it sucks waiting to trip and having nothing happen.
However, if you quit the Paxil, then you will be able to trip. The only question is how long you need to quit for. I quit and never went back...and didn't have shrooms until like 3 months later, so my length of time experience is not very relevant. I quit because of a couple of reasons, but one was that mdma (something else effected by paxil) did nothing for me...and then I got some LSD (after quitting) about a month later and I got a full on trip. I have heard that you need to quit anywhere between a week and a month...though I have no good personal evidence if the time is less than a month.
I was on effexor and then paxil for a long time (like years) and ate shrooms a few times(over a few years) and had no effects...it really is frustrating. It was very nice to finally be able to trip on shrooms, though I preferred the LSD.
Basically though, SNRI's (effexor) and SRRI's (paxil) kill a trip and it sucks. Quitting them also sucks...you really need to wean yourself off of them...and it is best to do with a doctor's supervision. There is some withdrawl going cold turkey (probably the effexor moreso than paxil, but still). I wish I had kept better records but I had a lot going on(good stuff like college graduation...I wouldn't do it if bad stuff is going on) when I was weaning myself off, so I don't really remember how much I lowered my dose nor the exact amount of time between my last dose of paxil and my first dose of L. I just know I would take a little less paxil for a few days before relowering my dose. Sometimes I would go two days between doses. I was really unscientific about it, which isn't usually my style (though I had been planning on quitting and would usually fail at it due to not having a good enough reason to quit, and the same thing happened with effexor...after several tries I finally did quit) and I would strongly suggest talking to a doctor about it if you really want to do it.
Another thing to think about, is that are you sure you want to quit the Paxil to trip. If the paxil is really helping then you may want to consider that...I keep planning to go back on it (though I am unsure if it is really helping, though it definetly was at one time), but keep pushing it back because there are other things I want to trip on and I don't know if I want to take it anymore. Just something to think about. I think some day I may go back on...but I am in no hurry to and am unsure if I need to. Also, the physical dependence on them sucks. Though I have had no problem quitting these drugs with self-weaning...I have heard stories of ex-heroin addicts who had more trouble getting off of effexor...probably hearsay...but still.
Anyway, I wish you the best of luck...I have found tripping to be amazing and I hope you get something really special out of it. I really wish I could remember the length of time between my last dose of paxil and the first dose of lsd, but I have so much paxil saved up that I can't even figure it out if I tried. I believe the half-life is about 24 hours(wikipedia)...so you can use that as a starting point to figure out how long it takes to get out of your system...but I weaned myself off over the course of a month and it was probably a week before my trip that I took my last dose of paxil (I have been thinking more and lookin at a calendar, so I am guessing this).
Anyway, I highly recommend talking to your doctor and thinking about it carefully if you really want to quit. Some people have trouble after quitting, and it takes a while to start working in the first place, so going back on might take a little while.
For the safety aspects, I had no physical or psychological problems after doing it, besides being very frustrated that I had wasted more shrooms, haha.
Please tell us how it goes and how long you quit for if you decide to do that. (the more info people have the better). Feel free to ask me any questions...though remember I am not a doctor.
Be careful, and Have a nice trip!
(sorry, that was really long and rambled on)
thank you, that was very helpful and everyone else, it's making me feel more at ease with doing these. i've also read somewhere that shrooms can decrease symptoms of OCD and depression, which is what i'm prescribed to paxil in the first place for.
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tyler_0_durden
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Re: Taking shrooms while on paxil? [Re: Scarfase]
#7965092 - 02/01/08 02:08 PM (16 years, 12 hours ago) |
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yes, you're absolutely right, shrooms can decrease or eliminate symptoms of OCD, depression as well. If the half-life of paxil (paroxetine) is 24 hours, not taking it for one week should leave you golden for your trip.
-------------------- "As a man who has devoted his whole life to the most clear headed science, to the study of matter, I can tell you as a result of my research about atoms this much: There is no matter as such. All matter originates and exists only by virtue of a force which brings the particle of an atom to vibration and holds this most minute solar system of the atom together. We must assume behind this force the existence of a conscious and intelligent mind. This mind is the matrix of all matter." --Max Planck
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Scarfase
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that's what i'm on, the 30mg of paroxetine. if i don't take it for a few days, i start feeling really..i don't know how to put it, but i start feeling like i'm losing a grip on reality, or like i'm going crazy.
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MorphMan
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Re: Taking shrooms while on paxil? [Re: Scarfase]
#7965166 - 02/01/08 02:25 PM (16 years, 12 hours ago) |
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Quote:
Scarfase said: that's what i'm on, the 30mg of paroxetine. if i don't take it for a few days, i start feeling really..i don't know how to put it, but i start feeling like i'm losing a grip on reality, or like i'm going crazy.
SSRI's are, in my opinion, very dangerous drugs to fuck around with. The withdrawal symptoms can be pretty bad; reactions vary from some reporting increased suicidal thoughts while others complain about "brain zaps" which are basically these electric shocks that one feels inside their skull.. like your brain is being zapped. Scientists don't know what these zaps are at the time, though. Really, SSRI's can have some very bad side effects.
Some withdrawal symptoms of Paxil: - intense insomnia - extraordinarily vivid dreams - extreme confusion during waking hours - intense fear of losing your sanity - steady feeling of existing outside of reality as you know it (referred to as depersonalization at times) - memory and concentration problems - Panic Attacks (even if you never had one before) - severe mood swings, esp. heightened irritability / anger. - suicidal thoughts (in extreme cases) - an unconventional dizziness/ vertigo - the feeling of shocks, similar to mild electric one, running the length of your body - an unsteady gait - slurred speech - headaches - profuse sweating, esp. at night - muscle cramps - blurred vision - breaking out in tears - hypersensitivity to motion, sounds, smells - decreased appetite - nausea - abdominal cramping, diarrhea - loss of appetite - chills/ hot flashes
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doitagain
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Re: Taking shrooms while on paxil? [Re: MorphMan]
#7965761 - 02/01/08 05:05 PM (16 years, 9 hours ago) |
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yeah i would not recommend quitting ssri's cold-turkey, titrate the dose down to nothing, and smoke some bud to help with the withdrawl symptoms.
Those brain zaps are fricken annoying.
-------------------- now i hear the police comin after me
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Poppy B
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Re: Taking shrooms while on paxil? [Re: Scarfase]
#25407621 - 08/23/18 02:17 PM (5 years, 5 months ago) |
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Older post, but very relevant for my current experiences. I started on a 10mg dose of paroxetine around 18 months ago, and it worked so well I have remained on the same dose. I recently started micro dosing(1 gram dried cube)after not using psilocybin for many, many years. Potency variances aside, I feel that the visuals are muted from the SSRI. From my past experiences with dried cubes, I used to get much better threshold visuals from a gram as I recall. A few things that may be noteworthy. I still yawn a little at first, and the energy boost sets in around 45 minutes. Insight, and an overall sense of good vibes will persist for a few days afterwards.
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