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OfflineAsanteA
low dose - high adventure
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Re: Researchers work on cocaine vaccine [Re: badchad]
    #7831509 - 01/04/08 11:41 AM (13 years, 25 days ago)

Quote:

The obvious problem (which you mentioned) is addiction. Anything that produces euphoria is likely to have a high abuse liability because face it, why wouldn't you want to feel good all the time?





If there are no negative consequences to the drug, if it didn't lead to escalating use, comedowns and stuff, would addiction potential be that big of a concern?

It would be strictly psychological addiction, but without a comedown.

Instead what you would get is that neuroplasticity makes a slightly elevated mood the new norm, if you take it for a couple of months or so.

If the drug doesn't actually downregulate, your brain will become accustomed to being upregulated and over time define that as the new baseline state.

If your brain is used to episodes of :crankey: you will become more capable of feeling :crankey: due to neuroplasticity. If you're accustomed to :smile2: however, your :crankey: pathways will atrophy as your brain gears towards the :smile2: state in exactly the same way. Short of neurosurgery perpetual :smile2: isn't possible, but you sure can elevate the general feeling tone and experience your psychologic highs and lows from that elevated level.

If you can keep yourself happier somehow for a few years, your brain will be predisposed to making you feel happy. To a limited extent you can unlearn suffering or become very good at it.


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Invisiblebadchad
Mad Scientist

Registered: 03/02/05
Posts: 13,029
Re: Researchers work on cocaine vaccine [Re: Asante]
    #7831577 - 01/04/08 12:05 PM (13 years, 25 days ago)

Quote:

Wiccan_Seeker said:
If there are no negative consequences to the drug, if it didn't lead to escalating use, comedowns and stuff, would addiction potential be that big of a concern?




No. But the difficulty in achieving all that is what makes it a pipe dream.


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...the whole experience is (and is as) a profound piece of knowledge.  It is an indellible experience; it is forever known.  I have known myself in a way I doubt I would have ever occurred except as it did.

Smith, P.  Bull. Menninger Clinic (1959) 23:20-27; p. 27.

...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.

Osmond, H.  Annals, NY Acad Science (1957) 66:418-434; p.436


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Offlinejasonpwnd
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Re: Researchers work on cocaine vaccine [Re: Asante]
    #7831790 - 01/04/08 01:32 PM (13 years, 25 days ago)

Quote:

Wiccan_Seeker said:
If there are no negative consequences to the drug, if it didn't lead to escalating use, comedowns and stuff, would addiction potential be that big of a concern?

It would be strictly psychological addiction, but without a comedown.




Sounds like THC? Minus the escalating use, you'd have to use it a lot to get the constantly happy effects. Too bad you can build tolerance so easily though..


--------------------

Disclaimer: Everything I say is a lie intended to make my e-reputation more prestigious.


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OfflineInfrared
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Registered: 07/15/02
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Re: Researchers work on cocaine vaccine [Re: Asante]
    #7832624 - 01/04/08 05:40 PM (13 years, 25 days ago)

they put up a piece of paper at the methadone clinic i go to about this... apparently they are looking for volunteers for their clinical trial.. and not just cocaine addicts.. but pretty much addicts of all kinds


fuck this shit.. i hope it fails miserably.. or it kills everyone who takes it.


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When chemistry is outlawed.. Only outlaws have chemistry:rainbowdrink:


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Offlinesmokescreen
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Re: Researchers work on cocaine vaccine [Re: Asante]
    #10856061 - 08/13/09 10:37 PM (11 years, 5 months ago)

consider the implications of a psychedelic "vaccine".  This shot or whatever form it may be in would have to cover alot of chemicals!  Look at how many shulgin made.. then consider how many more possibilities are out there.  Ok let's just figure it "blocks" LSD, psilocin, and MDMA - the three major ones.  Psilocin is basically an orally active form of DMT, an indigenous and important neural transmitter involved in dreaming and who knows what else.  You can kind of group LSD with that also, though nowhere near as close to DMT as shrooms.  Think about the possibility of NEVER dreaming again... we're talking insanity.  I don't know where MDMA chimes in here, but what if the vaccine somehow blocked the empathy emotion somewhat as a side-effect.  What would a human be without that emotion.  This is scary shit.


--------------------
:ganja: "Let's get together and feel alright" :ganja:                  :cubie: :mushroom2::tripping:


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OfflineMichiaelJackson
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Registered: 06/27/09
Posts: 175
Last seen: 11 years, 4 months
Re: Researchers work on cocaine vaccine [Re: smokescreen]
    #10856159 - 08/13/09 10:51 PM (11 years, 5 months ago)

Am I the only person who finds this shit scary as fucking hell?


--------------------
Wanna hear something depressing? One out of four Shroomerites wants to lock me in a government cage for using a substance they don't like.

Hard to believe, right? Read it for yourself:

http://www.shroomery.org/forums/showflat.php/Number/7874721#Post7874721


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OfflineAsanteA
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Re: Researchers work on cocaine vaccine [Re: CosmicFool]
    #10857858 - 08/14/09 06:39 AM (11 years, 5 months ago)

Wait, wait, wait..

Somebody snorts 100mg of cocaine and every single cocaine molecule will be attacked by the immune system?

That sounds very dangerous to me in itself. The number of virus particles in the most severe flu is millions upon millions of times smaller than the number of cocaine molecules in 100mg of blow.

Directly or indirectly, this will cost lives.


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