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InvisibleveggieM

Registered: 07/25/04
Posts: 17,504
Researchers Work on Cocaine Vaccine [TX]
    #7820997 - 01/01/08 06:12 PM (16 years, 1 month ago)

Researchers Work on Cocaine Vaccine
January 1, 2008 - Associated Press

HOUSTON (AP) — Two Baylor College of Medicine researchers in Houston are working on a cocaine vaccine they hope will become the first-ever medication to treat people hooked on the drug. "For people who have a desire to stop using, the vaccine should be very useful," said Dr. Tom Kosten, a psychiatry professor who is being assisted in the research by his wife, Therese, a psychologist and neuroscientist. "At some point, most users will give in to temptation and relapse, but those for whom the vaccine is effective won't get high and will lose interest."

The vaccine, currently in clinical trials, stimulates the immune system to attack the real thing when it's taken.

The immune system — unable to recognize cocaine and other drug molecules because they are so small — can't make antibodies to attack them.

To help the immune system distinguish the drug, Kosten attached inactivated cocaine to the outside of inactivated cholera proteins.

In response, the immune system not only makes antibodies to the combination, which is harmless, but also recognizes the potent naked drug when it's ingested. The antibodies bind to the cocaine and prevent it from reaching the brain, where it normally would generate the highs that are so addictive.

"It's a very clever idea," says David Eagleman, a Baylor neuroscientist. "Scientists have spent the last few decades figuring out reward pathways in the brain and how drugs like cocaine hijack the system. It turns out those pathways are difficult to rewire once they've seen the drug. But the vaccine just circumvents all that."

Kosten asked the Food and Drug Administration in December to green-light a multi-institutional trial to begin in the spring and is awaiting a response.

Approval would mark a breakthrough in the treatment of cocaine addiction, which now mostly involves psychiatric counseling and 12-step programs. It presumably would be the final clinical hurdle before the vaccine — more than a decade in the making — might be approved for treatment. But one expert warns against expecting too much.

"Addiction vaccines are a promising advance, but it's unlikely any treatment in this field will work for everyone," said Dr. David Gorelick, a senior investigator at the National Institute on Drug Abuse. "Still, if they prove successful, they will give those working in drug addiction an important option."


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OfflineSubstance D
Smurfed Up
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Registered: 11/25/07
Posts: 239
Loc: Inside my Head
Last seen: 15 years, 6 months
Re: Researchers Work on Cocaine Vaccine [Re: veggie]
    #7821096 - 01/01/08 06:36 PM (16 years, 1 month ago)

i been hearing about this for awhile now ,as a former coke addict i found it so hard to get past the 3 or 4 month clean mark ,i was having so many dreams about it ,an i slowly let my self get closer an closer to relapse by hanging out again with people i used to do it with ,go back to the same bars an with in 6 months i would be hooked again,its been over a year clean for me an my girl ,we actually moved from NY to Florida to get away from that shit,an ive been offered it down here a few times but never done it ,once i got over the coke dreams i flat out hate the shit now.the desire is gone!but if this was a one time deal with the vaccine ,that after taking it you'll never get high off of coke again it will work. but if its in a pill form were you need to keep taking it,it wont work. coke heads would stop taking it an start sniffing again


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You can turn your back on a person, but, never turn your back on a drug. Especially when it's waving a razor-sharp hunting knife in your eye.


Edited by Substance D (01/01/08 06:38 PM)


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Offlinedelafonze19
Old school vet
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Registered: 03/28/07
Posts: 73
Loc: where the aminitas grow
Last seen: 14 years, 1 month
Re: Researchers Work on Cocaine Vaccine [Re: Substance D]
    #7822392 - 01/02/08 01:12 AM (16 years, 1 month ago)

Yeah, sounds great until it becomes one of those required vacine to go to school or get a job or whatever.


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OfflineSeussA
Error: divide byzero


Folding@home Statistics
Registered: 04/27/01
Posts: 23,480
Loc: Caribbean
Last seen: 2 months, 20 days
Re: Researchers Work on Cocaine Vaccine [Re: delafonze19]
    #7822679 - 01/02/08 05:35 AM (16 years, 30 days ago)

> sounds great until it becomes one of those required

My thoughts as well... how long before "addictive drug vaccines" are required for all school children?


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Just another spore in the wind.


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