Home | Community | Message Board

Mycohaus
This site includes paid links. Please support our sponsors.


Welcome to the Shroomery Message Board! You are experiencing a small sample of what the site has to offer. Please login or register to post messages and view our exclusive members-only content. You'll gain access to additional forums, file attachments, board customizations, encrypted private messages, and much more!

Shop: Unfolding Nature Unfolding Nature: Being in the Implicate Order   Kraken Kratom Kratom Capsules for Sale, Red Vein Kratom

Jump to first unread post Pages: 1
InvisibleveggieM

Registered: 07/25/04
Posts: 17,504
Snorting a Brain Chemical Could Replace Sleep
    #7806973 - 12/28/07 09:54 AM (16 years, 1 month ago)

Snorting a Brain Chemical Could Replace Sleep
December 28, 2007 - Wired

In what sounds like a dream for millions of tired coffee drinkers, Darpa-funded scientists might have found a drug that will eliminate sleepiness.

A nasal spray containing a naturally occurring brain hormone called orexin A reversed the effects of sleep deprivation in monkeys, allowing them to perform like well-rested monkeys on cognitive tests. The discovery's first application will probably be in treatment of the severe sleep disorder narcolepsy.

The treatment is "a totally new route for increasing arousal, and the new study shows it to be relatively benign," said Jerome Siegel, a professor of psychiatry at UCLA and a co-author of the paper. "It reduces sleepiness without causing edginess."

Orexin A is a promising candidate to become a "sleep replacement" drug. For decades, stimulants have been used to combat sleepiness, but they can be addictive and often have side effects, including raising blood pressure or causing mood swings. The military, for example, administers amphetamines to pilots flying long distances, and has funded research into new drugs like the stimulant modafinil (.pdf) and orexin A in an effort to help troops stay awake with the fewest side effects.

The monkeys were deprived of sleep for 30 to 36 hours and then given either orexin A or a saline placebo before taking standard cognitive tests. The monkeys given orexin A in a nasal spray scored about the same as alert monkeys, while the saline-control group was severely impaired.

The study, published in the Dec. 26 edition of The Journal of Neuroscience, found orexin A not only restored monkeys' cognitive abilities but made their brains look "awake" in PET scans.

Siegel said that orexin A is unique in that it only had an impact on sleepy monkeys, not alert ones, and that it is "specific in reversing the effects of sleepiness" without other impacts on the brain.

Such a product could be widely desired by the more than 70 percent of Americans who the National Sleep Foundation estimates get less than the generally recommended eight hours of sleep per night (.pdf).

The research follows the discovery by Siegel that the absence of orexin A appears to cause narcolepsy. That finding pointed to a major role for the peptide's absence in causing sleepiness. It stood to reason that if the deficit of orexin A makes people sleepy, adding it back into the brain would reduce the effects, said Siegel.

"What we've been doing so far is increasing arousal without dealing with the underlying problem," he said. "If the underlying deficit is a loss of orexin, and it clearly is, then the best treatment would be orexin."

Dr. Michael Twery, director of the National Center on Sleep Disorders Research, said that while research into drugs for sleepiness is "very interesting," he cautioned that the long-term consequences of not sleeping were not well-known.

Both Twery and Siegel noted that it is unclear whether or not treating the brain chemistry behind sleepiness would alleviate the other problems associated with sleep deprivation.

"New research indicates that not getting enough sleep is associated with increased risk of cardiovascular disease and metabolic disorders," said Twery.

Still, Siegel said that Americans already recognize that sleepiness is a problem and have long treated it with a variety of stimulants.

"We have to realize that we are already living in a society where we are already self-medicating with caffeine," he said.

He also said that modafinil, which is marketed as Provigil by Cephalon and Alertec in Canada, has become widely used by healthy individuals for managing sleepiness.

"We have these other precedents, and it's not clear that you can't use orexin A temporarily to reduce sleep," said Siegel. "On the other hand, you'd have to be a fool to advocate taking this and reducing sleep as much as possible."

Sleep advocates probably won't have to worry about orexin A reaching drugstore shelves for many years. Any commercial treatment using the substance would need approval from the Food and Drug Administration, which can take more than a decade.


Extras: Filter Print Post Top
OfflineSCleROTiUM_LICK
ResearchedFiction Writer


Registered: 11/08/06
Posts: 884
Last seen: 4 years, 5 months
Re: Snorting a Brain Chemical Could Replace Sleep [Re: veggie]
    #7806994 - 12/28/07 10:04 AM (16 years, 1 month ago)

Great. Now they can cut our wages in half and expect us to work 2-3 times longer each day.


--------------------


Extras: Filter Print Post Top
OfflineDave Bowman
Albert Hoffmans Apprentice
Male User Gallery


Folding@home Statistics
Registered: 08/30/07
Posts: 2,104
Loc: Your Imagination
Last seen: 3 months, 23 days
Re: Snorting a Brain Chemical Could Replace Sleep [Re: SCleROTiUM_LICK]
    #7807057 - 12/28/07 10:33 AM (16 years, 1 month ago)

Quote:

SCleROTiUM_LICK said:
Great. Now they can cut our wages in half and expect us to work 2-3 times longer each day.




Fuck that.


Extras: Filter Print Post Top
Offlinehighdroponics
Professional Deadhead
Male User Gallery


Registered: 11/14/06
Posts: 5,574
Loc: Earth, Milky Way Galaxy Flag
Last seen: 11 years, 3 days
Re: Snorting a Brain Chemical Could Replace Sleep [Re: SCleROTiUM_LICK]
    #7807209 - 12/28/07 11:47 AM (16 years, 1 month ago)

Quote:

SCleROTiUM_LICK said:
Great. Now they can cut our wages in half and expect us to work 2-3 times longer each day.




that probably will be what they will expect of us soon enough.


--------------------
Dr :ronpaul: says to stop trying to treat the side-effects of big government and focus on the core issues. End the Federal Reserve/audit the gold reserves at Fort Knox, abolish the IRS, end all wars and occupancies, stop the building of an empire that will inevitably fail, and cut all unconstitutional federal programs. Put the power back in the peoples' hands by ending this nanny-state.


Extras: Filter Print Post Top
InvisibleEgo Death
Justadropofwaterinanendlesssea
 User Gallery

Registered: 04/27/03
Posts: 10,447
Loc: The War Machine
Re: Snorting a Brain Chemical Could Replace Sleep [Re: highdroponics]
    #7807281 - 12/28/07 12:29 PM (16 years, 1 month ago)

I am a robot...

That drugs bound to have some bad side effects though.


Extras: Filter Print Post Top
Offlinemoon_glue
Orwell's Post9/11 Era
Male


Registered: 01/20/07
Posts: 2,264
Loc: Earth, today...
Last seen: 8 years, 10 months
Re: Snorting a Brain Chemical Could Replace Sleep [Re: Ego Death]
    #7807323 - 12/28/07 12:49 PM (16 years, 1 month ago)

LOLOL this is a horrible discovery for a world thats embraced coffee so openly. it's also another drug they are selling you that your body provides for you free of charge.

people are gonna look 60 at age 20 if we give up our right to sleep


Extras: Filter Print Post Top
OfflineGrylls
Male User Gallery


Registered: 10/15/07
Posts: 394
Loc: East of the Continental D...
Last seen: 1 year, 5 months
Re: Snorting a Brain Chemical Could Replace Sleep [Re: Ego Death]
    #7807359 - 12/28/07 01:02 PM (16 years, 1 month ago)

I don't even want to start about how bad this could be for our mental health.

But, I'll mention some points anyway.

There is something going on more when we sleep than just the chemical recovery of our body. We dream FOR A REASON. To put it very simple, our dreams are subconscious expressions in the form of symbols. These symbols contain our very thoughts that are either subconscious concerns, fears and beliefs, or our everyday concerns or events. When interpreted correctly, these symbols unlock the meaning to a lot of our personal issues, or subconscious 'stuff' that may not be apparent or suppressed in our waking state consciousness.

I doubt this chemical sleep will ever work. If so, it will further envelop the modern, materialistic consumer in physical/mental malfunction, opening up a whole new niche in which pharmacologists can develop drugs for.

We already know of one condition that can be a result of modern a lifestyle that is replete with processed, animal based diets and lack of sleep and relaxtion. It has no specific cause, but once you evaluate the patient and their lifestyle, it is only obvious why they are having this particular condition. Its name is fibromyalgia.

I don't think this is moving forward in technology at all, but rather a degeneration of it. There are some things you just cannot develop, invent or improve.


--------------------
Alone in the clouds all blue.  Lying on an eiderdown.  You can't see me, but I can you.


Extras: Filter Print Post Top
Offlinefapjack
Title
 User Gallery


Registered: 07/26/07
Posts: 16,574
Loc: Central New Jersey
Last seen: 3 years, 10 months
Re: Snorting a Brain Chemical Could Replace Sleep [Re: Grylls]
    #7807503 - 12/28/07 01:58 PM (16 years, 1 month ago)

I for one wouldn't mind taking this chemical to help stay up entire weekends while partying. I like sleeping too much to use it reguarly though.


--------------------


Extras: Filter Print Post Top
InvisibleCracka_X
Spiritual Dirt Worshipper
Male User Gallery


Folding@home Statistics
Registered: 01/25/03
Posts: 8,808
Loc: Swamp
Re: Snorting a Brain Chemical Could Replace Sleep [Re: veggie]
    #7807591 - 12/28/07 02:42 PM (16 years, 1 month ago)

interesting


--------------------
The best way to live
is to be like water
For water benefits all things
and goes against none of them
It provides for all people
and even cleanses those places
a man is loath to go
In this way it is just like Tao        ~Daodejing


Extras: Filter Print Post Top
OfflinesyntheticTHC
mind detergent


Registered: 12/29/02
Posts: 72
Last seen: 8 years, 9 months
Re: Snorting a Brain Chemical Could Replace Sleep [Re: Grylls]
    #7807617 - 12/28/07 02:53 PM (16 years, 1 month ago)

You study Jung much?


--------------------


Extras: Filter Print Post Top
OfflineGrylls
Male User Gallery


Registered: 10/15/07
Posts: 394
Loc: East of the Continental D...
Last seen: 1 year, 5 months
Re: Snorting a Brain Chemical Could Replace Sleep [Re: syntheticTHC]
    #7808738 - 12/28/07 09:44 PM (16 years, 1 month ago)

Me?


--------------------
Alone in the clouds all blue.  Lying on an eiderdown.  You can't see me, but I can you.


Extras: Filter Print Post Top
OfflineGenesis
Dr.
Male
Registered: 12/18/07
Posts: 24
Loc: Australia
Last seen: 15 years, 7 months
Re: Snorting a Brain Chemical Could Replace Sleep [Re: Grylls]
    #7809392 - 12/29/07 12:36 AM (16 years, 1 month ago)

This sounds fantastic! I am going to keep an eye out for this bessa. Hopefully it will be put on the market in the next ten years. Gen


Extras: Filter Print Post Top
Offlinechubbycharley
the chubbiest ofthe charleys
Male

Registered: 04/02/04
Posts: 525
Loc: everywhere
Last seen: 13 years, 9 months
Re: Snorting a Brain Chemical Could Replace Sleep [Re: Grylls]
    #7809557 - 12/29/07 01:55 AM (16 years, 1 month ago)

Quote:

Grylls said:
We dream FOR A REASON. To put it very simple, our dreams are subconscious expressions in the form of symbols. These symbols contain our very thoughts that are either subconscious concerns, fears and beliefs, or our everyday concerns or events. When interpreted correctly, these symbols unlock the meaning to a lot of our personal issues, or subconscious 'stuff' that may not be apparent or suppressed in our waking state consciousness.




if we need our dreams to tell us what we're thinking than how do you account for lucid dreaming? i think when we spend our time in a barely conscious state (what is commonly referred to as our waking state but is only the 3rd of 7 states of consciousness according to some Hindu texts, i believe the Yoga Sutras of Patanjali is one) then the thoughts we are barely aware of surface as symbols in our dreams.

when our time is spent in a more aware state of consciousness, one where thoughts don't just happen but are actively observed and refined, eventually devoid of all modern dysfunction that is presently considered normal, our dreams become the only feasible method of time travel, of space exploration, of inter dimensional communication and commerce. i think the reason we dream is to lucidly control our experience and explore the unknown.

with that out of the way, from what this article is saying, if the drug truly reduces all of the effects of sleep deprivation, then why not? but what are the chances there will be no side effects?


--------------------
if i'm just a stoned stoner, sayin some stoned ass shit, please correct me :smile:


Extras: Filter Print Post Top
OfflineanarchOi
Ellenalien is fat.
Male User Gallery


Registered: 08/06/07
Posts: 2,293
Loc: ASE Flag
Last seen: 12 years, 11 months
Re: Snorting a Brain Chemical Could Replace Sleep [Re: chubbycharley]
    #7810362 - 12/29/07 11:52 AM (16 years, 1 month ago)

i bet orexin A gets you high


--------------------


Extras: Filter Print Post Top
Invisibleenlightened seed
Utopia is a state of mind
Male User Gallery


Registered: 05/04/07
Posts: 2,117
Loc: amongst civilization
Re: Snorting a Brain Chemical Could Replace Sleep [Re: anarchOi]
    #7824755 - 01/02/08 06:31 PM (16 years, 30 days ago)

http://www.wired.com/science/discoveries/news/2007/12/sleep_deprivation?mbid=yhp
before we know it "they'll" be pushing their new dope upon the masses... :snort:
& thanks to a monopoly on airwaves, it'll be a success!


Edited by enlightened seed (01/02/08 06:40 PM)


Extras: Filter Print Post Top
Jump to top Pages: 1

Shop: Unfolding Nature Unfolding Nature: Being in the Implicate Order   Kraken Kratom Kratom Capsules for Sale, Red Vein Kratom


Similar ThreadsPosterViewsRepliesLast post
* Natural marijuana compounds in the brain suppress pain veggieM 1,786 2 07/10/05 08:35 PM
by XMAN
* This Is Your Brain on Meth ivi 1,180 2 07/23/04 08:22 AM
by Fade_To_Black
* Brain May Repair Itself When Meth Users Quit veggieM 1,459 1 04/06/05 01:37 PM
by cricket
* Cannabinol helps against brain trauma cybrbeast 2,278 2 11/18/03 02:22 PM
by Seuss
* Cannabis' brain tumour drug hope Le_Canard 964 0 08/15/04 07:33 PM
by Le_Canard
* Cannabinoids shown to halt brain cancer. adrug 937 0 09/26/04 11:50 PM
by adrug
* Snorting cocaine off toilet lids in bars. Lana 3,494 9 01/23/05 09:43 AM
by JacquesSauniere
* Machine aims to replace drug dogs motamanM 2,684 4 11/22/03 02:16 PM
by DailyPot

Extra information
You cannot start new topics / You cannot reply to topics
HTML is disabled / BBCode is enabled
Moderator: motaman, veggie, Alan Rockefeller, Mostly_Harmless
2,169 topic views. 0 members, 8 guests and 10 web crawlers are browsing this forum.
[ Show Images Only | Sort by Score | Print Topic ]
Search this thread:

Copyright 1997-2024 Mind Media. Some rights reserved.

Generated in 0.028 seconds spending 0.007 seconds on 14 queries.