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badchad
Mad Scientist

Registered: 03/02/05
Posts: 13,372
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Re: The case against marijuana [Re: JunkFood]
#7615916 - 11/09/07 04:03 PM (16 years, 2 months ago) |
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And if you were to look, that might be a well-done study. You would have to look into the compound (HU210) and see what else is known about it. It's a "cannabinoid", which means it acts on cannabinoid receptors.
It may be much different than marijuana in terms of second messenger signaling and efficacy.
The bottom line is the same however: the quality of the study is assured (at least to some degree) by the process of peer-review. It is not infallible, but much more rigorous than simply posting up a random website.
-------------------- ...the whole experience is (and is as) a profound piece of knowledge. It is an indellible experience; it is forever known. I have known myself in a way I doubt I would have ever occurred except as it did. Smith, P. Bull. Menninger Clinic (1959) 23:20-27; p. 27. ...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely. Osmond, H. Annals, NY Acad Science (1957) 66:418-434; p.436
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freddurgan
Techgnostic



Registered: 01/11/04
Posts: 3,648
Last seen: 11 years, 8 months
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Re: Negative physiological affects of marijuana - peer reviewed scientific study abstracts [Re: VisionsToReality]
#7615923 - 11/09/07 04:06 PM (16 years, 2 months ago) |
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Quote:
VisionsToReality said: 8. MJ can cause hypotension and bradycardia Author/Editor/Inventor Kunos, George [Reprint author]; Jarai, Zoltan [Author]; Varga, Karoly [Author]; Liu, Jie [Author]; Wang, Lei [Author]; Wagner, Jens A. [Author]. Institution Department of Pharmacology and Toxicology, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA, 23298, USA. Title Cardiovascular effects of endocannabinoids: The plot thickens Source Prostaglandins & Other Lipid Mediators. 61(1-2). April, 2000. 71-84. Abstract Cannabinoids, the bioactive ingredients of the marijuana plant, are best known for their psychoactive properties, but they also influence other physiological processes, such as cardiovascular variables. Endocannabinoids are recently identified lipid mediators that act as natural ligands at cannabinoid receptors and mimic most of the biological effects, including the cardiovascular actions, of plant-derived cannabinoids. In experimental animals, the most prominent component of the cardiovascular effects of cannabinoids is prolonged hypotension and bradycardia. This review focuses on the possible mechanisms underlying these effects. The emerging evidence suggesting that endocannabinoids may be involved in the peripheral regulation of vascular tone under certain conditions is also discussed.
I can vouch for that. I've developed what the doctor said was bradycardia in the last 4 years. And super super low blood pressure. Like passing out when I stand low. It's weak.
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sinenomine
Stranger
Registered: 12/02/06
Posts: 557
Last seen: 10 years, 8 months
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Re: The case against marijuana [Re: JunkFood]
#7615941 - 11/09/07 04:11 PM (16 years, 2 months ago) |
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http://www.washingtonpost.com/wp-dyn/content/article/2006/05/25/AR2006052501729_pf.html
Not only is there no positive correlation between cannabis use and cancer, there is actually a NEGATIVE correlation.
"What we found instead was no association at all, and even a suggestion of some protective effect."
Your chance of getting cancer is LOWER if you smoke weed.
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badchad
Mad Scientist

Registered: 03/02/05
Posts: 13,372
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Re: The case against marijuana [Re: sinenomine]
#7615969 - 11/09/07 04:19 PM (16 years, 2 months ago) |
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But the results never reached statistical significance, which is an entirely different from the keyword: suggestion.
The actual study is here: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17035389&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Another example of peer-review. There is a big difference between objectively reporting scientific findings, and sensationalizing a story for the Washington Post.
-------------------- ...the whole experience is (and is as) a profound piece of knowledge. It is an indellible experience; it is forever known. I have known myself in a way I doubt I would have ever occurred except as it did. Smith, P. Bull. Menninger Clinic (1959) 23:20-27; p. 27. ...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely. Osmond, H. Annals, NY Acad Science (1957) 66:418-434; p.436
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freddurgan
Techgnostic



Registered: 01/11/04
Posts: 3,648
Last seen: 11 years, 8 months
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Re: The case against marijuana [Re: sinenomine]
#7615972 - 11/09/07 04:20 PM (16 years, 2 months ago) |
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Quote:
sinenomine said: http://www.washingtonpost.com/wp-dyn/content/article/2006/05/25/AR2006052501729_pf.html
Not only is there no positive correlation between cannabis use and cancer, there is actually a NEGATIVE correlation.
"What we found instead was no association at all, and even a suggestion of some protective effect."
Your chance of getting cancer is LOWER if you smoke weed.
That is so vague since there are approximately TONS of different cancers. Which one is protected against? How so?
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the human abstract
malaka the werewolf


Registered: 11/30/09
Posts: 8,817
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Re: The case against marijuana [Re: freddurgan]
#15099107 - 09/19/11 12:42 AM (12 years, 4 months ago) |
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A lot of weed is sprayed with pesticides
--------------------
★ ★★ ★
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Konyap


Registered: 06/30/07
Posts: 33,945
Loc: Planet Piss
Last seen: 4 years, 2 months
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http://www.growery.org/3151/Cannibis-Notice
theres even a times artical where they said guys and girls get weaker in the subjects they arent good at then everything jus goes back to normal even after ten years use
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obaku
student of theuniverse


Registered: 01/31/03
Posts: 142
Loc: Northwest Oregon
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Re: The case against marijuana [Re: Konyap]
#15099646 - 09/19/11 06:35 AM (12 years, 4 months ago) |
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Don't forget to mention that cannabis use will make men grow gigantic breasts. I was in Jamaica and Afghanistan, and all the men there have teats just like Dolly Parton. You have been warned! Pot also lowers sperm counts, so Jamaica and Afghanistan's birth rates are so low that soon there will be no people in those countries left at all!
-------------------- The master's gone herb gathering, somewhere on the mountain, cloud-hidden, whereabouts unknown.
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Rexter
Tripper


Registered: 05/03/09
Posts: 10,047
Loc: Florida
Last seen: 10 years, 5 months
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Re: The case against marijuana [Re: obaku]
#15099783 - 09/19/11 08:03 AM (12 years, 4 months ago) |
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Marijuana has never affected my learning. Ive passed AP classes in highschool, while being baked. Although there are exceptions to every rule.
Right now I'm about to take my pre-GED test. With no marijuana. Lets see how this goes
And great job providing this information.
-------------------- new trade list my own WCA V: I "Ha! Marshall you're so funny man You should be a comedian, god damn!" Unfortunately I am I just hide behind the tears of a clown" Meteloides said: Stick to naturally occurring substances! Like Shrooms! And DMT! And Datura! And Amanita Phalloides! And Nutmeg! And Hemlock! That'll expand the shit out of your DNA.
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Kada
Asha'man


Registered: 02/15/05
Posts: 12,394
Loc: Buckeye
Last seen: 2 months, 21 days
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Re: The case against marijuana [Re: Rexter]
#15099830 - 09/19/11 08:21 AM (12 years, 4 months ago) |
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Quote:
Marijuana impairs both learning and memory Author/Editor/Inventor Sullivan, Jane M. [Reprint author]. Institution Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA, 92037, USA. Title Cellular and molecular mechanisms underlying learning and memory impairments produced by cannabinoids Source Learning & Memory (Cold Spring Harbor). 7(3). May-June, 2000. 132-139. Abstract Why does smoking marijuana impair learning and memory? Behavioral studies suggest that a disruption of normal hippocampal function contributes to these deficits. In vitro experiments find that cannabinoid receptor activation reduces neurotransmitter release below the levels required to trigger long-term changes in synaptic strength in the hippocampus. Cannabinoids reduce glutamate release through a G-protein-mediated inhibition of the calcium channels responsible for neurotransmitter release from hippocampal neurons. These mechanisms likely play a role in the learning and memory impairments produced by cannabinoids and by endogenous cannabinoid receptor ligands.
I know this is crap. I have a friend who smoked 24/7 and got 3rd in his class. He smoked when he studied and smoked when he took tests. I think lazy, stupid people love weed just as much as a smart person does. I know a lot of people who smoke weed daily and they are not impaired mentally at all. I'm high right now and I can function just as well as I can when I'm sober. Practice makes perfect I guess.
-------------------- ~The Cultivators Motherload~ "I am free, no matter what rules surround me. If I find them tolerable, I tolerate them; if I find them too obnoxious, I break them. I am free because I know that I alone am morally responsible for everything I do." -Robert A. Heinlein "There is no need for temples, no need for complicated philosophies. My brain and my heart are my temples; my philosophy is kindness."-Dalai Lama Live long and prosper.
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blewmeanie




Registered: 10/01/06
Posts: 28,984
Loc:
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Re: The case against marijuana [Re: Rexter]
#15099953 - 09/19/11 09:00 AM (12 years, 4 months ago) |
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Quote:
Rexter said: Marijuana has never affected my learning......Right now I'm about to take my pre-GED test.
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blewmeanie




Registered: 10/01/06
Posts: 28,984
Loc:
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Re: The case against marijuana [Re: Kada]
#15099960 - 09/19/11 09:01 AM (12 years, 4 months ago) |
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Quote:
Kada said:
Quote:
Marijuana impairs both learning and memory Author/Editor/Inventor Sullivan, Jane M. [Reprint author]. Institution Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA, 92037, USA. Title Cellular and molecular mechanisms underlying learning and memory impairments produced by cannabinoids Source Learning & Memory (Cold Spring Harbor). 7(3). May-June, 2000. 132-139. Abstract Why does smoking marijuana impair learning and memory? Behavioral studies suggest that a disruption of normal hippocampal function contributes to these deficits. In vitro experiments find that cannabinoid receptor activation reduces neurotransmitter release below the levels required to trigger long-term changes in synaptic strength in the hippocampus. Cannabinoids reduce glutamate release through a G-protein-mediated inhibition of the calcium channels responsible for neurotransmitter release from hippocampal neurons. These mechanisms likely play a role in the learning and memory impairments produced by cannabinoids and by endogenous cannabinoid receptor ligands.
I know this is crap. I have a friend who smoked 24/7 and got 3rd in his class. He smoked when he studied and smoked when he took tests. I think lazy, stupid people love weed just as much as a smart person does. I know a lot of people who smoke weed daily and they are not impaired mentally at all. I'm high right now and I can function just as well as I can when I'm sober. Practice makes perfect I guess.
I can't remember shit when I'm high.
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birdland

Registered: 07/24/11
Posts: 2,202
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Re: The case against marijuana [Re: Kada]
#15100248 - 09/19/11 10:32 AM (12 years, 4 months ago) |
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Quote:
Kada said: I know this is crap. I have a friend who smoked 24/7 and got 3rd in his class. He smoked when he studied and smoked when he took tests. I think lazy, stupid people love weed just as much as a smart person does. I know a lot of people who smoke weed daily and they are not impaired mentally at all. I'm high right now and I can function just as well as I can when I'm sober. Practice makes perfect I guess.
I know for a fact my short term memory and learning abilities are impaired while I'm high. Without a doubt. Does this make me stupid and lazy?
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Konyap


Registered: 06/30/07
Posts: 33,945
Loc: Planet Piss
Last seen: 4 years, 2 months
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Re: The case against marijuana [Re: birdland]
#15102655 - 09/19/11 06:50 PM (12 years, 4 months ago) |
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shrooms are like being high x30
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AnonymousRabbit
Comrade


Registered: 01/10/08
Posts: 8,993
Last seen: 1 year, 4 months
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.
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Edited by AnonymousRabbit (05/19/22 12:37 AM)
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morrowasted
Worldwide Stepper



Registered: 10/30/09
Posts: 31,377
Loc: House of Mirrors
Last seen: 4 days, 4 hours
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I support the OP. I smoke every day. I have for years. I want to stop.
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AnonymousRabbit
Comrade


Registered: 01/10/08
Posts: 8,993
Last seen: 1 year, 4 months
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.
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Edited by AnonymousRabbit (05/19/22 12:37 AM)
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morrowasted
Worldwide Stepper



Registered: 10/30/09
Posts: 31,377
Loc: House of Mirrors
Last seen: 4 days, 4 hours
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Speak for yourself. Marijuana is the most addictive drug for me. And I have used them all.
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AnonymousRabbit
Comrade


Registered: 01/10/08
Posts: 8,993
Last seen: 1 year, 4 months
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.
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Edited by AnonymousRabbit (05/19/22 12:37 AM)
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d0urd3n
Just call me "D"


Registered: 09/15/10
Posts: 5,237
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Now I'm scared about my heart getting fucked up Does anyone have evidence of it not being bad for the heart?
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