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InvisibleveggieM

Registered: 07/25/04
Posts: 17,504
Hybrid THC Molecules May Give a Longer, Stronger High
    #7596237 - 11/04/07 08:26 PM (16 years, 2 months ago)

Hybrid THC Molecules May Give a Longer, Stronger High
November 4, 2007 - Wired Science

Chemists have created a collection of molecules that may have effects superior to marijuana. They are hybrids of tetrahydrocannabinol (THC), the psychoactive ingredient in weed, and anandamide, the euphoria-causing chemical found in sea urchin roe.

Researchers intend to use the hybrids as tools to better understand the endocannabinoid system, which partially controls pleasure and pain signals.

In the December issue of Bioorganic and Medicinal Chemistry, scientists from Organix, a small research and development firm, explained that THC and anandamide each have their own unique advantages and disadvantages.

Anandamide starts working faster than its marijuana-derived counterpart, but it is more quickly destroyed by the body. A fusion of the two chemicals may last longer while maintaining an equal or stronger effect.

At the beginning of the project, organic chemists made a bunch of slightly different molecules that resembled both of their natural inspirations -- THC and anandamide. Once those chemicals had been synthesized, other researchers tested them on the proteins that are stimulated by marijuana.

Checking the effects of slight tweaks to the shape of a molecule is called SAR -- a structure-activity relationship study. Although the researchers at Organix did not comment on the recreational potential of their new chemicals, their SAR data makes it very clear that the new drugs push the same pleasure buttons as THC and anandamide.

Toward the end of the study, they gave the best experimental chemicals to mice. Small amounts of the most potent molecule prevented them from pulling their tails away from a hot surface. That test, called a tail-flick assay, showed that the new drug is a rather powerful painkiller.


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Offlinelearningtofly
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Registered: 05/21/07
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Re: Hybrid THC Molecules May Give a Longer, Stronger High [Re: veggie]
    #7596327 - 11/04/07 08:41 PM (16 years, 2 months ago)

finally! now I can get super high with crazy mutant sea urchin-pot HIGHbrids.


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Offlinemakaveli8x8
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Re: Hybrid THC Molecules May Give a Longer, Stronger High [Re: learningtofly]
    #7596395 - 11/04/07 08:52 PM (16 years, 2 months ago)

:smilingpuppy:


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We were sent to hell for eternity :hellfire: Ø:omgawesome:h®
We play on earth to pass the time :foreheadslap:

Over-population the root of all Evil-brings the Elites Closer to the gates.


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Offlineaaei67
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Registered: 01/30/07
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Re: Hybrid THC Molecules May Give a Longer, Stronger High [Re: makaveli8x8]
    #7596496 - 11/04/07 09:12 PM (16 years, 2 months ago)

How long until these new molecules become illegal? A new psychedelic revolution may be born if they stay legal long nough for the masses to get a hold of. I want some sea urchin-marijuanna hybrid


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"LSD is really baby blood"

danlennon3 said:
whoever isn't permanently tripping just isn't paying attention


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Offlinemakaveli8x8
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Re: Hybrid THC Molecules May Give a Longer, Stronger High [Re: aaei67]
    #7596510 - 11/04/07 09:16 PM (16 years, 2 months ago)

by the way you can click on the puppy :smile:


--------------------
We were sent to hell for eternity :hellfire: Ø:omgawesome:h®
We play on earth to pass the time :foreheadslap:

Over-population the root of all Evil-brings the Elites Closer to the gates.


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Offlinelearningtofly
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Re: Hybrid THC Molecules May Give a Longer, Stronger High [Re: makaveli8x8]
    #7596735 - 11/04/07 10:19 PM (16 years, 2 months ago)

okay so the question thats on everyones mind is can we or can we not plug this stuff?


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Offlineelmanimal
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Registered: 11/15/06
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Re: Hybrid THC Molecules May Give a Longer, Stronger High [Re: learningtofly]
    #7596765 - 11/04/07 10:26 PM (16 years, 2 months ago)

Quote:

learningtofly said:
okay so the question thats on everyones mind is can we or can we not plug this stuff?




If by everyone one you mean crystal g.

:wink:


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Invisibleusg543
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Registered: 02/11/07
Posts: 5,192
Re: Hybrid THC Molecules May Give a Longer, Stronger High [Re: elmanimal]
    #7596881 - 11/04/07 11:05 PM (16 years, 2 months ago)

what the hell is in sea urchin roe?

and where can i buy them :laugh:


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OfflineGroomies
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Re: Hybrid THC Molecules May Give a Longer, Stronger High [Re: usg543]
    #7597134 - 11/05/07 12:32 AM (16 years, 2 months ago)

is it a strong feeling like MDMA? can you tell that your on something? and how long does it last?


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:hotidea::hotidea::hotidea:


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Offlinebuddhahoodlum
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Re: Hybrid THC Molecules May Give a Longer, Stronger High [Re: usg543]
    #7597212 - 11/05/07 01:16 AM (16 years, 2 months ago)

Wow thats amazing I heard about something like this along time ago. They said something along the lines of sea urchin's being related to humans through the cannabinoid receptors in the brain. The sea urchins were the first creatures to establish this ability and thus we ended up with it too far down the road go figure lol.


Edited by buddhahoodlum (11/05/07 01:20 AM)


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OfflineEllezdey
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Registered: 02/08/07
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Re: Hybrid THC Molecules May Give a Longer, Stronger High [Re: buddhahoodlum]
    #7597248 - 11/05/07 01:47 AM (16 years, 2 months ago)

If you dont mind wikipedia, go to this url that is about the sea urchin. In the "Culinary" section, it talks about sea urchin "roe" (which is apparently the gonads or testiclies of sea urchins) and how it is considered an aphrodisiac in some countries to be eaten with a meal. The anandamide, within the roe, is a cannabinod neurotransmitter found in many species of animals. A cannabinoid neurotransmitter is a molecule that fits the same synaptic "key-lock" as cannabinols (THC).

Damn, even sea urchins need some pain relief.

http://en.wikipedia.org/wiki/Sea_urchin


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OfflineVisionary Tools
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Registered: 06/23/07
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Re: Hybrid THC Molecules May Give a Longer, Stronger High [Re: Groomies]
    #7597366 - 11/05/07 04:25 AM (16 years, 2 months ago)

Quote:

Groomies said:
is it a strong feeling like MDMA? can you tell that your on something? and how long does it last?




Anandamide is released by the body during orgasm. So there you go, like sex? Like bud.


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Offlinemonstermush
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Registered: 10/22/07
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Re: Hybrid THC Molecules May Give a Longer, Stronger High [Re: Visionary Tools]
    #7600560 - 11/05/07 09:47 PM (16 years, 2 months ago)

this is going to lead to a crazy weedmonster who when touched inflicts massive doses of THC so your high for like 9 days


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OfflineGroomies
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Re: Hybrid THC Molecules May Give a Longer, Stronger High [Re: monstermush]
    #7602057 - 11/06/07 10:58 AM (16 years, 2 months ago)

awesome! I'll be growing that in my aquarium


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:hotidea::hotidea::hotidea:


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OfflineVisionary Tools
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Re: Hybrid THC Molecules May Give a Longer, Stronger High [Re: monstermush]
    #7602655 - 11/06/07 01:19 PM (16 years, 2 months ago)

Quote:

monstermush said:
this is going to lead to a crazy weedmonster who when touched inflicts massive doses of THC so your high for like 9 days




I remember broaching the topic of modifying algae or bacteria to produce THC, and just think about that. Having a modified e.coli colony in your GI tract, making all the THC you'll ever, ever need.


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Offlinea_guy_named_ai
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Registered: 09/24/07
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Re: Hybrid THC Molecules May Give a Longer, Stronger High [Re: veggie]
    #7611029 - 11/08/07 12:39 PM (16 years, 2 months ago)

What's wrong with just plain weed?? Leave the sea urchins alone! Leave the weed alone!


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Invisiblepoke smot!
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Registered: 01/08/03
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Re: Hybrid THC Molecules May Give a Longer, Stronger High *DELETED* [Re: makaveli8x8]
    #7613345 - 11/09/07 12:04 AM (16 years, 2 months ago)

Post deleted by poke smot!

Reason for deletion: x



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Offlinemakaveli8x8
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Re: Hybrid THC Molecules May Give a Longer, Stronger High [Re: poke smot!]
    #7613513 - 11/09/07 01:18 AM (16 years, 2 months ago)

one could look at it as eating with the benifit of getting high :yesnod:

and whats wrong with eating gonads?  some people on this site do that already just look in otd!:lol:


--------------------
We were sent to hell for eternity :hellfire: Ø:omgawesome:h®
We play on earth to pass the time :foreheadslap:

Over-population the root of all Evil-brings the Elites Closer to the gates.


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InvisibleLucidDream
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Re: Hybrid THC Molecules May Give a Longer, Stronger High [Re: veggie]
    #7615396 - 11/09/07 01:51 PM (16 years, 2 months ago)

Better living through chemistry. :cool:

http://www.starvinmarvinsseafoods.com/sea-urchin.htm


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Sarcasm just one of my many talents.



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InvisibleLeftyBurnz
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Re: Hybrid THC Molecules May Give a Longer, Stronger High [Re: LucidDream]
    #7617644 - 11/10/07 05:11 AM (16 years, 2 months ago)

you guys think this might be an attempt to get a super strain of weed into circulation, in the attempt to keep pot illegal like the other "hard" drugs?

you know what i want? for them to create some psilomescaline-tetrahydrocannabinol. THAT would be the shit.


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