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OnlineFreedom
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A fun paper for those interested in biosynthesis of tryptamines
    #7551492 - 10/23/07 03:56 PM (16 years, 3 months ago)

This is a fun thought provoking paper to read. Nothing super practical, but give me millions of dollars and an army of psychonauts and I swear I'd make some new psychedelics with the method;)

Here is a nice little picture from the paper:



http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17884630&ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

The abstract:

The highly substrate-specific strictosidine synthase (EC 4.3.3.2) catalyzes the biological Pictet-Spengler condensation between tryptamine and secologanin, leading to the synthesis of about 2000 monoterpenoid indole alkaloids in higher plants. The crystal structure of Rauvolfia serpentina strictosidine synthase (STR1) in complex with strictosidine has been elucidated here, allowing the rational site-directed mutation of the active center of STR1 and resulting in modulation of its substrate acceptance. Here, we report on the rational redesign of STR1 by generation of a Val208Ala mutant, further describing the influence on substrate acceptance and the enzyme-catalyzed synthesis of 10-methyl- and 10-methoxystrictosidines. Based on the addition of strictosidine to a crude strictosidine glucosidase preparation from Catharanthus cells, a combined chemoenzymatic approach to generating large alkaloid libraries for future pharmacological screenings is presented.


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Offlinenoobballer
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Registered: 10/19/07
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Re: A fun paper for those interested in biosynthesis of tryptamines [Re: Freedom]
    #7551762 - 10/23/07 04:52 PM (16 years, 3 months ago)

looks interesting


--------------------
Insanity is doing the exact same thing and expecting different results.


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