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Offlineshroom_daddy
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Registered: 08/23/07
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Last seen: 16 years, 2 months
Drugs that affect functionality of the brain?
    #7417092 - 09/16/07 04:33 PM (16 years, 4 months ago)

Which drugs have a long term affect on the user?
Which affect ability to produce serotonin, dopamine, etc?


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Offlineclemens
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Re: Drugs that affect functionality of the brain? [Re: shroom_daddy]
    #7417170 - 09/16/07 04:52 PM (16 years, 4 months ago)

Most drugs don't really affect the brains functionality unless abused.


--------------------

Take it easy dude, but take it!


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Offlineyageman
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Re: Drugs that affect functionality of the brain? [Re: shroom_daddy]
    #7417615 - 09/16/07 07:21 PM (16 years, 4 months ago)

Quote:

shroom_daddy said:
Which drugs have a long term affect on the user?





All of them *can.....dude
If you dont want to learn anything, then I guess that sucks for you.

You know what "learning" does im sure.

Mind-to chemical-back to mind. The origin is chemical in this relationship.

Its a Teeter-Totter.
Its also a fractal.
If you dont want it to be a part of your fractal, dont use these additives.
Psychedelics can effect mood for better or worse.
The chemical trends may change.

All of these psychedelics can do this.


--------------------
[quote]Me_Roy said:
You moron. Material is material is material.  No 'thing' fixes any situation.  If anything were so simple we would be living in a much better world.[/quote] <-----the dumbest thing I have ever read in my life.
Thanks shroomery.


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Offlinef0rce
^.^


Registered: 01/19/07
Posts: 79
Last seen: 8 years, 2 months
Re: Drugs that affect functionality of the brain? [Re: yageman]
    #7417688 - 09/16/07 07:50 PM (16 years, 4 months ago)

I'm getting the feeling yage is trippin.

But anywho, in my opinon if something doesn't alter the functionality of your brain then it isn't a drug. I have found that if you use any substance to much for to long then its gonna have some negative affects.


--------------------
big said it first
more money more problems
the way i see it
more problems more money


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Offlineporcupine
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Re: Drugs that affect functionality of the brain? [Re: shroom_daddy]
    #7417701 - 09/16/07 07:54 PM (16 years, 4 months ago)

all of them.


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Offlineshroom_daddy
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Re: Drugs that affect functionality of the brain? [Re: porcupine]
    #7417719 - 09/16/07 08:01 PM (16 years, 4 months ago)

Compare the long term effects of psychedelics vs. physically dependent drugs, namely cocaine and heroin. I'll leave speed out of this b/c it eventually fries your brain beyond repair.


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Offlineyageman
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Re: Drugs that affect functionality of the brain? [Re: f0rce]
    #7417779 - 09/16/07 08:14 PM (16 years, 4 months ago)

Quote:

f0rce said:
I'm getting the feeling yage is trippin.

But anywho, in my opinon if something doesn't alter the functionality of your brain then it isn't a drug. I have found that if you use any substance to much for to long then its gonna have some negative affects.




I have not tripped in 2 years.

I agree with what you said though.

That was just the hppd talking.
Hope you liked it.

It actually made sense. I was just trying to paint a picture with words.

In all seriousness though.........
I was talking about the chemicals in your brain.

They all effect you permanently in their own special way.
Hopefully its in a good way.
Thats most often how it turns out. But I have seen otherwise.

You cant just extract a memory or a chemical reaction in your brain and throw it away. You can forget about it. Thats the best you have got though.

The psychedelic becomes a part of the grand neuro-system.

In some ways you could say that it is inherently permanent even after the drug is fully metabolized and exits the body.
No Im not tripping.......lol


--------------------
[quote]Me_Roy said:
You moron. Material is material is material.  No 'thing' fixes any situation.  If anything were so simple we would be living in a much better world.[/quote] <-----the dumbest thing I have ever read in my life.
Thanks shroomery.


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Offlinef0rce
^.^


Registered: 01/19/07
Posts: 79
Last seen: 8 years, 2 months
Re: Drugs that affect functionality of the brain? [Re: yageman]
    #7418155 - 09/16/07 10:06 PM (16 years, 4 months ago)

Sorry, didn't know you no longer tripped. I did understand what you where saying but it seemed to make logical jumps that I would normally only make when not in this reality :P


--------------------
big said it first
more money more problems
the way i see it
more problems more money


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InvisibleFecalDildo
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Re: Drugs that affect functionality of the brain? [Re: shroom_daddy]
    #7418174 - 09/16/07 10:12 PM (16 years, 4 months ago)

Quote:

shroom_daddy said:
Compare the long term effects of psychedelics vs. physically dependent drugs, namely cocaine and heroin. I'll leave speed out of this b/c it eventually fries your brain beyond repair.




Sorry to burst your bubble but cocaine is not physically addictive.

And no, speed does not eventually fry your brain beyond repair.


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Offlinelearningtofly
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Re: Drugs that affect functionality of the brain? [Re: FecalDildo]
    #7418192 - 09/16/07 10:16 PM (16 years, 4 months ago)

How is cocaine not addictive? Why does a friend of mine go to Narcotics Anonymous meetings and drug tests twice a week yet she still does it in between (leaves the system just in time). I'm pretty sure thats addicted.


--------------------


Edited by learningtofly (09/16/07 10:17 PM)


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InvisibleFecalDildo
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Re: Drugs that affect functionality of the brain? [Re: learningtofly]
    #7418197 - 09/16/07 10:17 PM (16 years, 4 months ago)

Learn the difference between psychological and physical addictions.


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Offlinelearningtofly
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Re: Drugs that affect functionality of the brain? [Re: FecalDildo]
    #7418207 - 09/16/07 10:21 PM (16 years, 4 months ago)

My bad, more like read the entire post.


--------------------


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Offlineyageman
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Re: Drugs that affect functionality of the brain? [Re: f0rce]
    #7418208 - 09/16/07 10:21 PM (16 years, 4 months ago)

logic is pliable when attached to language.

What sounds logical to one person might just sound ridiculous to the other.

Such short-hand, and "skips in logic" are very important while tripping.

You get shit done alot faster that way when with the right person.

Teeter-Totter-------> to fractals.
Mood-------> to chemical reactions and back to the mood.


I totally understand why you said that.
I was just having some fun with those who could read it.
Its all for fun.


--------------------
[quote]Me_Roy said:
You moron. Material is material is material.  No 'thing' fixes any situation.  If anything were so simple we would be living in a much better world.[/quote] <-----the dumbest thing I have ever read in my life.
Thanks shroomery.


Edited by yageman (09/16/07 10:34 PM)


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Offlineshroom_daddy
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Registered: 08/23/07
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Last seen: 16 years, 2 months
Re: Drugs that affect functionality of the brain? [Re: FecalDildo]
    #7418313 - 09/16/07 10:42 PM (16 years, 4 months ago)

Quote:

FecalDildo said:
Quote:

shroom_daddy said:
Compare the long term effects of psychedelics vs. physically dependent drugs, namely cocaine and heroin. I'll leave speed out of this b/c it eventually fries your brain beyond repair.




Sorry to burst your bubble but cocaine is not physically addictive.

And no, speed does not eventually fry your brain beyond repair.




I guess speed is pretty safe then, huh? If you want to be nit-picky and argue that it doesn't fry "beyond repair" I guess it just depends how much and over what time period. But it does fry your brain and if you use over any lengthy period of time, you won't be the same. Have you ever met someone who's been on meth for 5+ years? They're lunatics. 10+, you may not find many. The average life of an addict is somewhere around five years. But if you want to defend it, be my guest.


Edited by shroom_daddy (09/16/07 10:44 PM)


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InvisibleFecalDildo
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Re: Drugs that affect functionality of the brain? [Re: shroom_daddy]
    #7418471 - 09/16/07 11:24 PM (16 years, 4 months ago)

I'm 36 now. I've used amphetamines recreationally since I was 17.

Just what is it you're trying to tell me? Do you have any first hand knowledge of this topic or are you just telling me the things that officer Dare told you in school?


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Offlinespammaps
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Registered: 06/28/07
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Last seen: 16 years, 1 month
Re: Drugs that affect functionality of the brain? [Re: FecalDildo]
    #7418968 - 09/17/07 07:27 AM (16 years, 4 months ago)

drugs that definitely have:
MDMA (ecstasy), (meth)amphetamines, cocaine, heroin


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Offlinesuave
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Re: Drugs that affect functionality of the brain? [Re: spammaps]
    #7418980 - 09/17/07 07:34 AM (16 years, 4 months ago)

MDMA and meth seem to "hurt" the body/brain the most if you will.

I know mushrooms can be seriously dangerous. I'd be more worried about me getting myself killed on high doses of them then the actual psilocin chemical doing anything to my brain.

Then again, that's from eating alot of them fresh instead of a controlled dry dosage.


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OfflineTHEBats
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Re: Drugs that affect functionality of the brain? [Re: suave]
    #7419058 - 09/17/07 08:36 AM (16 years, 4 months ago)

well both ecstasy and cocaine if abused can deplete your reserves of their respective neuraltransmitter. However even more harmful are inhalants. And heroin isn't all that damaging. The only real negative physical effect is the addiction. I suppose that can be damaging enough. Meth, alcohol and mdma are also neuraltoxins so they're all damaging in that way.

You should have added permanently to the end of your question because all drugs work by changing the functioning of your brain. However I assume you meant permanently.



Edited by THEBats (09/17/07 08:43 AM)


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Offlineshroom_daddy
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Re: Drugs that affect functionality of the brain? [Re: THEBats]
    #7419244 - 09/17/07 10:22 AM (16 years, 4 months ago)

To fecaldildo, the real reason i left speed out of the discussion is because i wouldn't do it myself. All I'm saying is with prolonged use, it is very damaging. No, I'm not an expert, but I do know people(not my close friends thankfully) that have become addicts. But then again, you don't have to be an expert on the effects of methamphetamines to be able to see what it does to people. When I think about the addicts before Meth, they are totally different people. Not to say that these guys were destined for greatness, but they had some potential to be upstanding citizens or nonetheless normal people.

I can believe that you used speed and now you're fine. But to imply that speed isn't detrimental is absurd.

To suave, I've heard that it is extremely hard to overdose on shrooms. Do you have any links or facts about any OD cases? Some say you would have to eat your own body weight in fresh shrooms. However, considering all the variables, I doubt this to be true, believing that a given person could OD on much less that their body weight.

To thebats, yes I suppose permanently would have been a better wording.


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Offlinesuave
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Registered: 04/23/07
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Re: Drugs that affect functionality of the brain? [Re: shroom_daddy]
    #7419701 - 09/17/07 01:13 PM (16 years, 4 months ago)

I've aten close to 100 grams wet before. Feels like your brains going to melt...


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Offlineporcupine
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Re: Drugs that affect functionality of the brain? [Re: suave]
    #7419915 - 09/17/07 02:27 PM (16 years, 4 months ago)

cocaine is physically addictive, it does produce some physical withdrawal symptoms when stopping. it's like marijuana, there is a physical withdrawal when you stop but it's not serious. opiates and CNS depressants produce the most severe type of physical dependence.


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OfflineTHEBats
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Re: Drugs that affect functionality of the brain? [Re: porcupine]
    #7419937 - 09/17/07 02:31 PM (16 years, 4 months ago)

Quote:

porcupine said:
cocaine is physically addictive, it does produce some physical withdrawal symptoms when stopping. it's like marijuana, there is a physical withdrawal when you stop but it's not serious. opiates and CNS depressants produce the most severe type of physical dependence.




wrong. cocaine is not physically addictive and neither is marijuana. Learn the difference between physically addicting and mentally addicting. Physical withdrawal symptoms from cocaine or marijuana do not have a physical cause therefore they're still psychological. However with either alcohol or heroin the way your body functions is altered once one is addicted causing physical symptoms with a physical root cause.


Edited by THEBats (09/17/07 02:32 PM)


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OfflineCoaster
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Re: Drugs that affect functionality of the brain? [Re: THEBats]
    #7420022 - 09/17/07 02:55 PM (16 years, 4 months ago)

Insane in the membrane
Insane in the brain!
Insane in the membrane
Insane in the brain!

Insane in the membrane
Plenty insane
Got no brain!
Insane in the membrane
Insane in the brain!

Do my shit undercover
Now it's time for the blubba
Blabba
To watch that belly get fatter
Fat boy on a diet
Don't try it
I'll jack your ass like a looter in a riot
My shit's fat like a sumo slammin' that ass
Leavin' your face in the grass
You know
I don't take a dulo
Lightly
Punks just jealous `cause they can't outwrite me
So kick that style: wicked, wild
Happy face nigga never seen me smile
Rip that mainframe
I'll explain
A nigga like me is goin' insane


--------------------


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InvisibleRobo
R Series 66Y
Registered: 05/08/07
Posts: 14,861
Re: Drugs that affect functionality of the brain? [Re: shroom_daddy]
    #7420033 - 09/17/07 02:58 PM (16 years, 4 months ago)

 


Edited by Robo (11/08/13 01:08 PM)


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Offlineporcupine
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Re: Drugs that affect functionality of the brain? [Re: Coaster]
    #7420070 - 09/17/07 03:07 PM (16 years, 4 months ago)

Quote:


wrong. cocaine is not physically addictive and neither is marijuana. Learn the difference between physically addicting and mentally addicting. Physical withdrawal symptoms from cocaine or marijuana do not have a physical cause therefore they're still psychological. However with either alcohol or heroin the way your body functions is altered once one is addicted causing physical symptoms with a physical root cause.





wrong. stop telling me to learn the difference between physically addicting and mentally addicting. some of the withdrawal symptoms from cocaine and marijuana do have a physiological cause. the mind and body are linked, you cannot separate them.

The neurobiological basis for cannabis withdrawal has been established via discovery of an endogenous cannabinoid system, identification of cannabinoid receptors, and demonstrations of precipitated withdrawal with cannabinoid receptor antagonists. Laboratory studies have established the reliability, validity, and time course of a cannabis withdrawal syndrome and have begun to explore the effect of various medications on such withdrawal

http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16612207&query_hl=7&itool=pubmed_docsum

Chronic exposure to psychostimulants induces neuro-adaptations in ion channel function of dopamine (DA)-innervated cells localized within the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc). Although neuroplasticity in ion channel function is initially found in drug-sensitized animals, it has recently been believed to underlie the withdrawal effects of cocaine, including craving that leads to relapse in human addicts. Recent studies have also revealed remarkable differences in altered ion channel activities between mPFC pyramidal neurons and medium spiny NAc neurons in cocaine-withdrawn animals. In response to psychostimulant or certain "excitatory" stimuli, increased intrinsic excitability is found in mPFC pyramidal neurons, whereas decreased excitability is observed in medium spiny NAc cells in drug-withdrawn animals compared to drug-free control animals. These changes in ion channel function are modulated by interrupted DA/Ca2+ signaling with decreased DA D2 receptor function but increased D1 receptor signaling. More importantly, they are correlated to behavioral changes in cocaine-withdrawn human addicts and sensitized animals. Based on growing evidence, researchers have proposed that cocaine-induced neuro-adaptations in ion channel activity and DA/Ca2+ signaling in mPFC pyramidal neurons and medium spiny NAc cells may be the fundamental cellular mechanism underlying the cocaine withdrawal effects observed in human addicts.

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17519508&ordinalpos=19&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum


Edited by porcupine (09/17/07 03:10 PM)


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Invisiblebadchad
Mad Scientist

Registered: 03/02/05
Posts: 13,372
Re: Drugs that affect functionality of the brain? [Re: porcupine]
    #7420087 - 09/17/07 03:13 PM (16 years, 4 months ago)

Quote:

porcupine said:
the mind and body are linked, you cannot separate them.





Very true.

Nearly all forms of "addiction" contain an underlying psychological component. This is why "addiction" is diagnosed on behavioral symptoms, rather than physical.

There is no objective, single, physical cause of "addiction". If you look into the literature, there are tons of physical correlates and causes of addiction. Searching pubmed for the physiological basis of "addiction" is like going to Barnes and Noble and asking for a book about "weight loss". There are some good leads, but everyone has there own opinion.


--------------------
...the whole experience is (and is as) a profound piece of knowledge.  It is an indellible experience; it is forever known.  I have known myself in a way I doubt I would have ever occurred except as it did.

Smith, P.  Bull. Menninger Clinic (1959) 23:20-27; p. 27.

...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.

Osmond, H.  Annals, NY Acad Science (1957) 66:418-434; p.436


Edited by badchad (09/17/07 03:16 PM)


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Offlinejeanpignon
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Re: Drugs that affect functionality of the brain? [Re: Coaster]
    #7420094 - 09/17/07 03:14 PM (16 years, 4 months ago)

YOU ARE NOT IN RIGHT TO SAY THAT MAD THING!!!
BOOOO BAD BOY!!!!!


--------------------
bonjour les shroom!!!


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Offlinejeanpignon
frenshchampignon
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Registered: 08/07/07
Posts: 115
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Re: Drugs that affect functionality of the brain? [Re: Coaster]
    #7420099 - 09/17/07 03:15 PM (16 years, 4 months ago)

Quote:

Coaster said:
Insane in the membrane
Insane in the brain!
Insane in the membrane
Insane in the brain!

Insane in the membrane
Plenty insane
Got no brain!
Insane in the membrane
Insane in the brain!

Do my shit undercover
Now it's time for the blubba
Blabba
To watch that belly get fatter
Fat boy on a diet
Don't try it
I'll jack your ass like a looter in a riot
My shit's fat like a sumo slammin' that ass
Leavin' your face in the grass
You know
I don't take a dulo
Lightly
Punks just jealous `cause they can't outwrite me
So kick that style: wicked, wild
Happy face nigga never seen me smile
Rip that mainframe
I'll explain
A nigga like me is goin' insane






BOOOOOOO!!! BAD BOY!!!!


--------------------
bonjour les shroom!!!


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OfflineTHEBats
FuturePsychopharmacologist
Male

Registered: 03/18/05
Posts: 1,268
Loc: Florida
Last seen: 12 years, 7 months
Re: Drugs that affect functionality of the brain? [Re: porcupine]
    #7422530 - 09/18/07 06:36 AM (16 years, 4 months ago)

Quote:

porcupine said:
Quote:


wrong. cocaine is not physically addictive and neither is marijuana. Learn the difference between physically addicting and mentally addicting. Physical withdrawal symptoms from cocaine or marijuana do not have a physical cause therefore they're still psychological. However with either alcohol or heroin the way your body functions is altered once one is addicted causing physical symptoms with a physical root cause.





wrong. stop telling me to learn the difference between physically addicting and mentally addicting. some of the withdrawal symptoms from cocaine and marijuana do have a physiological cause. the mind and body are linked, you cannot separate them.

The neurobiological basis for cannabis withdrawal has been established via discovery of an endogenous cannabinoid system, identification of cannabinoid receptors, and demonstrations of precipitated withdrawal with cannabinoid receptor antagonists. Laboratory studies have established the reliability, validity, and time course of a cannabis withdrawal syndrome and have begun to explore the effect of various medications on such withdrawal

http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16612207&query_hl=7&itool=pubmed_docsum

Chronic exposure to psychostimulants induces neuro-adaptations in ion channel function of dopamine (DA)-innervated cells localized within the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc). Although neuroplasticity in ion channel function is initially found in drug-sensitized animals, it has recently been believed to underlie the withdrawal effects of cocaine, including craving that leads to relapse in human addicts. Recent studies have also revealed remarkable differences in altered ion channel activities between mPFC pyramidal neurons and medium spiny NAc neurons in cocaine-withdrawn animals. In response to psychostimulant or certain "excitatory" stimuli, increased intrinsic excitability is found in mPFC pyramidal neurons, whereas decreased excitability is observed in medium spiny NAc cells in drug-withdrawn animals compared to drug-free control animals. These changes in ion channel function are modulated by interrupted DA/Ca2+ signaling with decreased DA D2 receptor function but increased D1 receptor signaling. More importantly, they are correlated to behavioral changes in cocaine-withdrawn human addicts and sensitized animals. Based on growing evidence, researchers have proposed that cocaine-induced neuro-adaptations in ion channel activity and DA/Ca2+ signaling in mPFC pyramidal neurons and medium spiny NAc cells may be the fundamental cellular mechanism underlying the cocaine withdrawal effects observed in human addicts.

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17519508&ordinalpos=19&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum




You still fail to see the difference and nit picking to find literature that suits your needs means shit when there is plenty of research that says otherwise; that cocaine is psychologically addicting and nothing more.

Also bad boy! :mad2:  Confusing correlation with causation.  Shame on you.

With that I do agree in the subjectivity of the term.


Edited by THEBats (09/18/07 06:44 AM)


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