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JunkFood
Stranger

Registered: 10/02/06
Posts: 7,258
Loc: NYC
Last seen: 2 years, 8 months

Why they had so many grapefruits in Fear and Loathing

#7289343 - 08/12/07 10:26 PM (16 years, 8 months ago)

Grapefruit juice (as well as pummelos, tangelos, and Seville oranges) can inhibit enteric cytochrome P3A4, a cytochrome P450 enzyme in the intestine that helps to break down toxic substances, including drugs.

The reaction between grapefruit juice and the enzymes does not wear off. To get the protection back, you have to wait for the enzymes to be resynthesized by the body, which can take 72 hours.

In addition to grapefruit juice decreasing the breakdown of some drugs, it can also change the absorption of others through interference with two other systems. These are P-glycoprotein and organic anion transporting polypeptide (OATP), which are involved with how drugs get out of the intestine and into the body.

http://www.shroomery.org/forums/showflat.php/Cat/0/Number/7287481/an/0/page/0

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Coaster
Baʿal

Registered: 05/22/06
Posts: 33,501
Loc: Deep in the Valley
Last seen: 12 years, 6 months

Re: Why they had so many grapefruits in Fear and Loathing

[Re: JunkFood]
#7289375 - 08/12/07 10:36 PM (16 years, 8 months ago)

i h8 how they exagerate the drugs soooo much
they made Adrenochrome seem like datura
and its more like ginger beer

--------------------

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Ogla

Registered: 02/16/04
Posts: 11,335

Re: Why they had so many grapefruits in Fear and Loathing

[Re: Coaster]
#7289384 - 08/12/07 10:37 PM (16 years, 8 months ago)

because they are healthy and feel good to eat. You gotta stay hydrated now

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mikeytro
Stranger

Registered: 01/28/07
Posts: 2,532
Last seen: 13 years, 8 months

Re: Why they had so many grapefruits in Fear and Loathing

[Re: Coaster]
#7289397 - 08/12/07 10:39 PM (16 years, 8 months ago)

ever seen bong water?
when luke wilson drops acid...now that makes acid look like datura
good movie nonetheless

--------------------
"Reality is merely an illusion, albeit a very persistent one." - Einstein

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Ogla

Registered: 02/16/04
Posts: 11,335

Re: Why they had so many grapefruits in Fear and Loathing

[Re: Coaster]
#7289399 - 08/12/07 10:39 PM (16 years, 8 months ago)

Quote:

Coaster said:
i h8 how they exagerate the drugs soooo much
they made Adrenochrome seem like datura
and its more like ginger beer

yeah, i've never seen reptiles neither

Extras:

JunkFood
Stranger

Registered: 10/02/06
Posts: 7,258
Loc: NYC
Last seen: 2 years, 8 months

Re: Why they had so many grapefruits in Fear and Loathing

[Re: Coaster]
#7289449 - 08/12/07 10:54 PM (16 years, 8 months ago)

Quote:

Coaster said:
i h8 how they exagerate the drugs soooo much
they made Adrenochrome seem like datura
and its more like ginger beer

I hate how fucking cheap and corny the special effects for the tripping scenes are. Looks like some dudes got together and dressed up in costumes and shot themselves with a camcorder and applied some video effects :smirk:

:smirk:

There were THREE instances of good effects in that fucking movie: 1.) the valet's face stretching when they check into the first hotel 2.) the carpet moving when Duke's online 3.) The hotel clerk's head turning into a moray eel

Extras:

KilroyMilosevik
Swiss Ego

Registered: 02/14/07
Posts: 989
Loc: Northwest of Nowhere

Re: Why they had so many grapefruits in Fear and Loathing

[Re: Ogla]
#7289458 - 08/12/07 10:55 PM (16 years, 8 months ago)

Quote:

losfreddy said:
Quote:

Coaster said:
i h8 how they exagerate the drugs soooo much
they made Adrenochrome seem like datura
and its more like ginger beer

yeah, i've never seen reptiles neither

Indeed

I believe just as Depp and Del Toro(?) are getting their room right before the bar scene and reptiles is best - the carpet and choppy vision is the best rendition of an acid come up I have seen in a movie thus far, but still...

--------------------
-The door.
-The door is closed.
-Why is the door closed?
*Gasps*
-Why DOES the door close!?

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JunkFood
Stranger

Registered: 10/02/06
Posts: 7,258
Loc: NYC
Last seen: 2 years, 8 months

Re: Why they had so many grapefruits in Fear and Loathing

[Re: KilroyMilosevik]
#7289467 - 08/12/07 10:57 PM (16 years, 8 months ago)

Quote:

KilroyMilosevik said:
I believe just as Depp and Del Toro(?) are getting their room right before the bar scene and reptiles is best - the carpet and choppy vision is the best rendition of an acid come up I have seen in a movie thus far, but still...

Yeah, too bad the effects end there :smirk:

:smirk:

Fucking lazy bastard, Gilliam.

Extras:

imachavel
I loved and lost but I loved-ftw

Registered: 06/06/07
Posts: 31,488
Loc: You get banned for saying that

Last seen: 4 hours, 8 minutes

Re: Why they had so many grapefruits in Fear and Loathing

[Re: JunkFood]
#7289483 - 08/12/07 11:01 PM (16 years, 8 months ago)

hey junkfood, you know a lot about this shit, ever thought about enzymes in plants creating different psychedelics? do you think it could be done?
peace

--------------------
:kingcrankey:

:kingcrankey:

I did not say to edit my signature soulidarity! Now forever I will never remember what I said about understanding the secrets of the universe by paying attention to subtleties!

:facepalm:

:facepalm:

I'm never giving you the password again. Jerk

Extras:

JunkFood
Stranger

Registered: 10/02/06
Posts: 7,258
Loc: NYC
Last seen: 2 years, 8 months

Re: Why they had so many grapefruits in Fear and Loathing

[Re: imachavel]
#7289493 - 08/12/07 11:04 PM (16 years, 8 months ago)

Oh I just copied and pasted that from the newspaper.

--------------------
HOW'S MY POSTING? CLICK HERE

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Seventy
equanimitor

Registered: 05/24/07
Posts: 912
Loc: Canada (PNW)
Last seen: 9 months, 13 days

Re: Why they had so many grapefruits in Fear and Loathing

[Re: JunkFood]
#7289557 - 08/12/07 11:25 PM (16 years, 8 months ago)

Quote:

JunkFood said:
Oh I just copied and pasted that from the newspaper.

:lol:

--------------------

[Easiest Glove Box Ever] - [Beginner Friendly LC Method] - [Hyphae's Pinning Strategy]

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Sophistic Radiance
Free sVs!

Registered: 07/11/06
Posts: 43,135
Loc: Center of the Universe

Re: Why they had so many grapefruits in Fear and Loathing

[Re: Seventy]
#7290043 - 08/13/07 04:19 AM (16 years, 8 months ago)

You guys take that film way too literally.

--------------------
Enlil said:
You really are the worst kind of person.

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Bridgeburner
Not spiritual at all.

Registered: 09/16/06
Posts: 20,010

Re: Why they had so many grapefruits in Fear and Loathing

[Re: Sophistic Radiance]
#7290046 - 08/13/07 04:23 AM (16 years, 8 months ago)

Quote:

Tchan909 said:
You guys take that film way too literally.

and the effects were great. the film was about the book, not about drugs. so go whine about "bad effects" elsewhere, hardc0re tripperzzz.

--------------------

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indica

Registered: 08/17/05
Posts: 18,905

Re: Why they had so many grapefruits in Fear and Loathing

[Re: JunkFood]
#7290048 - 08/13/07 04:26 AM (16 years, 8 months ago)

Quote:

JunkFood said:
Quote:

Coaster said:
i h8 how they exagerate the drugs soooo much
they made Adrenochrome seem like datura
and its more like ginger beer

I hate how fucking cheap and corny the special effects for the tripping scenes are. Looks like some dudes got together and dressed up in costumes and shot themselves with a camcorder and applied some video effects There were THREE instances of good effects in that fucking movie: 1.) the valet's face stretching when they check into the first hotel 2.) the carpet moving when Duke's online 3.) The hotel clerk's head turning into a moray eel

you are a faggot and obviously didn't understand the movie.

there is a thread that argues your same dumb, uneducated un-appreciative retard autistic spaz-wad question a few months ago,

find it and get an enema and then go listen to some Shirley Wang-Fag or something, hippie.

God I hate how people expect the fucking universe in movies. If you don;t like it, try and do a better job yourself

:crankey:

:crankey:

Extras:

Psilobuds
₪

Registered: 03/23/07
Posts: 1,775
Loc:

Re: Why they had so many grapefruits in Fear and Loathing

[Re: Bridgeburner]
#7290060 - 08/13/07 04:35 AM (16 years, 8 months ago)

Quote:

b0red5tiff said:

and the effects were great. the film was about the book, not about drugs. so go whine about "bad effects" elsewhere, hardc0re tripperzzz.

Extras:

Individual
Bass Addict

Registered: 12/20/06
Posts: 6,666
Loc: Reality Loophole

Re: Why they had so many grapefruits in Fear and Loathing

[Re: Ogla]
#7290065 - 08/13/07 04:39 AM (16 years, 8 months ago)

Quote:

losfreddy said:
Quote:

Coaster said:
i h8 how they exagerate the drugs soooo much
they made Adrenochrome seem like datura
and its more like ginger beer

yeah, i've never seen reptiles neither

But I've seen people with :crankey:

:crankey:

faces on acid. :razz:

:razz:

--------------------
THE PHILOSOPHY OF LIBERTY <---

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johnm214

Registered: 05/31/07
Posts: 17,582
Loc: Americas

Re: Why they had so many grapefruits in Fear and Loathing

[Re: Individual]
#7290749 - 08/13/07 11:48 AM (16 years, 8 months ago)

Well I'm not aware that cyp3a4 does much for the drugs that Duke was doing ( I think benzo's though are metabolized via this route)- it's possible. CYP2d6 is much more important in alot of the drug pathways though, and common valerian and ginko can induce (arguably) with cimetidine, prozac, and others inhibiting.

I think the real reason is that Hunter likes grapefruit. He's got them in alot of his writings that don't mention drugs. I've seen him drink whisky out of grapefruits too, in an interview.

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Bridgeburner
Not spiritual at all.

Registered: 09/16/06
Posts: 20,010

Re: Why they had so many grapefruits in Fear and Loathing

[Re: johnm214]
#7290786 - 08/13/07 12:02 PM (16 years, 8 months ago)

yeah it makes for an instant coctail: pour rum into a grapefruit sliced in half and emptied. excellent.

--------------------

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Fraggin
Multi-Faceted

Registered: 01/05/05
Posts: 8,707
Last seen: 8 years, 2 months

Re: Why they had so many grapefruits in Fear and Loathing

[Re: Bridgeburner]
#7291382 - 08/13/07 03:21 PM (16 years, 8 months ago)

Grapefruits inhibit the activity of cytochrome P450 enzymes of the 3A and 1A groups. Some substances, including drugs, are converted by this enzyme. Specifically DXM. DXM is converted to DXO by this same enzyme, only with different groups. Using grapefruit in conjunction with DXM allows one to metabolize (or absorb if that words is better) dxm before it's converted to DXO, resulting in a more efficient trip.
Users have reported their trips are augmented by quicker come ups and trips in faster duration.

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FoodOfTheGods
worst poster onthe boards

Registered: 08/06/07
Posts: 267
Loc: south
Last seen: 16 years, 4 months

Re: Why they had so many grapefruits in Fear and Loathing

[Re: mikeytro]
#7291551 - 08/13/07 04:12 PM (16 years, 8 months ago)

Quote:

mikeytro said:
ever seen bong water?
when luke wilson drops acid...now that makes acid look like datura
good movie nonetheless

rim drabba rim drim rim drabba rim drim rin drima rim dim daahhhh!!

--------------------
The DEA's the Joker, the FDA's the joke, and the joke is on the USA.

Extras:

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Mushrooms, Mycology and Psychedelics > The Psychedelic Experience

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