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Offlinejenerikcairet
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what is psilocin
    #6613228 - 02/26/07 04:15 PM (16 years, 11 months ago)

i know what it is but i have read both that it is in magic mushrooms, and also that your body breaks psilocybin down into psilocin. are both true?


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Offlinenotapillow
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Re: what is psilocin [Re: jenerikcairet]
    #6613247 - 02/26/07 04:18 PM (16 years, 11 months ago)

yes.


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OfflineFucked
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Re: what is psilocin [Re: jenerikcairet]
    #6613304 - 02/26/07 04:36 PM (16 years, 11 months ago)

When psilocybin, which is not in itself pharmacologically active, enter the bady, it gets it's phosphate group broken off through dephosphorylization, which is hydrolysis removing a phophate group.

This allows it to fit snugly into your 5-ht receptors and start you trippin'.


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Offlineturkeyphant
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Re: what is psilocin [Re: Fucked]
    #6613525 - 02/26/07 05:41 PM (16 years, 11 months ago)

Psilocin is 4-HO-DMT or 4-hydroxy-N,N-dimethyltryptamine. It looks like this:

The -OH group at the top is on the carbon in the 4-position on the DMT. The two methyl groups on the nitrogen on the right are the N,N-dimethyl part of the DMT.

Psilocybin is 4-phosphoryloxy-N,N-dimethyltryptamine or 4-phosphoryloxy-DMT. It looks like this:

The only difference is a phosphoryloxy group at the 4-position instead of the hydroxy group. Psilocybin is a prodrug that is converted into psilocin in the body by hydrolysis.

Both psilocin and psilocybin are found in most species of magic mushrooms.


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Edited by turkeyphant (02/26/07 05:53 PM)


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InvisibleBrainiac
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Re: what is psilocin *DELETED* [Re: turkeyphant]
    #6613537 - 02/26/07 05:45 PM (16 years, 11 months ago)

Post deleted by Brainiac

Reason for deletion: D.P.



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Edited by Brainiac (02/26/07 05:52 PM)


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InvisibleBrainiac
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Re: what is psilocin [Re: Brainiac]
    #6613550 - 02/26/07 05:50 PM (16 years, 11 months ago)

Psilocin, sometimes called psilocine or psilotsin, is a psychedelic (hallucinogenic) mushroom alkaloid. It is found in most psychedelic mushrooms together with its close congener psilocybin. Psilocin is a Schedule I drug under the Convention on Psychotropic Substances.[1]

Psilocin is almost identical to the chemical structure of the chemical of another known hallucinogen, bufotenin. The only difference is the position of the hydroxyl (OH-) group on the benzene ring - in psilocin, the hydroxyl group is at the 4-position in the indole ring, and in bufotenin, the hydroxyl group is at the 5-position on the indole ring.

Psilocybin (also known as psilocybine), is a psychedelic alkaloid of the tryptamine family. It is present in many species of fungi, including those of the genus Psilocybe, such as Psilocybe cubensis and Psilocybe semilanceata, but also reportedly isolated from a dozen or so other genera. Psilocybin-containing mushrooms are commonly called magic mushrooms or more simply "shrooms". The intensity and duration of recreational and entheogenic use of psilocbyin mushrooms vary depending on species of mushroom, dosage, individual physiology, and set and setting.

Dimethyltryptamine (DMT), also known as N,N-dimethyltryptamine, not to be confused with 5-MeO-DMT, is a psychedelic tryptamine, similar in structure to the neurotransmitter serotonin. DMT is created in small amounts by the human body during normal metabolism[1] by the enzyme Tryptamine-N-methyltransferase. Pure DMT at room temperature is a clear or white crystalline solid. DMT was first chemically synthesized in 1931. It also occurs naturally in many species of plants. DMT-containing plants are used in several South American shamanic practices. It is one of the main active constituents of snuffs like yopo and of the drink ayahuasca.

DMT is generally not active orally unless it is combined with a monoamine oxidase inhibitor (MAOI), such as harmaline. Without an MAOI, the body quickly metabolizes orally-administered DMT, and it therefore has no hallucinogenic effect unless the dose exceeds monoamine oxidase's metabolic capacity (very rare). Other means of ingestion such as smoking or injecting the drug can produce powerful hallucinations and entheogenic activity for a short time (usually less than half an hour).


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Offlinecalgone47
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Re: what is psilocin [Re: Brainiac]
    #6613571 - 02/26/07 05:56 PM (16 years, 11 months ago)

I could've sworn psilocin was 4-HO-DMT (4-hydroxy-N,N-dimethyltryptamine)


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InvisibleBrainiac
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Re: what is psilocin [Re: calgone47]
    #6613576 - 02/26/07 05:59 PM (16 years, 11 months ago)

Theres more then psilocin and psilocybin in some mushrooms.


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:cool: Fair is Fair :devil:


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OfflineFucked
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Re: what is psilocin [Re: Brainiac]
    #6613584 - 02/26/07 06:02 PM (16 years, 11 months ago)

way to copy from wikipedia.


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InvisibleBrainiac
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Re: what is psilocin [Re: Fucked]
    #6613589 - 02/26/07 06:04 PM (16 years, 11 months ago)

Wikipedia is kown to wrong.


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:Awesketch:

:cool: Fair is Fair :devil:


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InvisibleKoala Koolio
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Registered: 01/07/04
Posts: 7,752
Re: what is psilocin [Re: Fucked]
    #6613634 - 02/26/07 06:21 PM (16 years, 11 months ago)

Quote:

Fucked said:
When psilocybin, which is not in itself pharmacologically active, enter the bady, it gets it's phosphate group broken off through dephosphorylization, which is hydrolysis removing a phophate group.





My understanding is that while the removal of the phosphate group is proven to be true, there's not actually evidence that psilocybin, if it does reach the receptors, is not active itself.

Anyone have more info on that?


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OfflineChesh


Registered: 01/21/07
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Re: what is psilocin [Re: Koala Koolio]
    #6613855 - 02/26/07 07:19 PM (16 years, 11 months ago)

There's no way that phosphate group would fit into a 5-HT receptor.

Psilocybin must be metabolized to psilocin before it can affect consciousness.


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