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InvisibleveggieM

Registered: 07/25/04
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Libido-enhancing root in global dispute
    #6428537 - 01/05/07 03:49 PM (17 years, 1 month ago)

Libido-enhancing root in global dispute
January 5, 2007 - MSNBC

Timotea Cordova , 80, prepares a traditional elixir to ward off the breathless effect of the high altitude in Junin, Peru. For hundreds of years, Quechua Indians have grown maca, the frost-resistant root that grows in these frigid Andean highlands, to boost stamina and sex drive. The root, they believe, is nature's bounty and belongs to everyone and to no one in particular.









JUNIN, Peru — In a small storefront on a bleak, wind-swept Andean plateau, Timotea Cordova offers an oxygen-deprived visitor a traditional elixir to ward off the breathless effect of the high altitude.

Dropping a few shriveled tuber roots into a blender, the 80-year-old, Quechua Indian shopkeeper promises with a playful glance that the concoction will also provide a leg up later in the bedroom.

For hundreds of years, Quechua Indians have grown maca, the frost-resistant root that thrives in these frigid Andean highlands, to boost stamina and sex drive. The root, they believe, is nature's bounty and belongs to everyone and to no one in particular.

Maca growers and indigenous organizations were outraged when, in 2001, a New Jersey-based company, PureWorld Botanicals, received a U.S. patent for exclusive commercial distribution of an extract of maca's active libido-enhancing compounds that it branded as MacaPure.

Peruvian officials called the patent an "emblematic case" of biopiracy and are preparing to challenge it in U.S. courts.

The maca dispute is just the latest collision between indigenous people and commercial interests over so-called biological prospecting, the growing practice of scouring the globe for exotic plants, microbes and other living things ripe for commercial exploitation.

Bioprospecting has huge potential for good, say researchers who go to sea, climb mountains and trek to obscure corners of the world in search of exotic and undiscovered life.

A 2005 U.N. University report concluded that 62% of all cancer drugs were created from bioprospecting discoveries.

The venom of a deadly sea snail found off the coast of the Philippines led Elan Pharmaceuticals to develop the painkiller Prialt, which U.S. regulators approved in 2004. The key ingredient in the breast cancer drug Taxol owned by Bristol-Myers Squibb is taken from the bark of the yew tree, and Wyeth's kidney transplant drug Rapamune comes from Easter Island soil.

But bioprospecting is mostly unregulated and there are mounting calls to establish legal frameworks for such work.

The Convention on Biological Diversity produced at the 1992 Earth Summit in Rio de Janeiro entitled nations to a share of the profits from substances yielded by their flora and fauna. It was ratified by 188 countries — but not the United States, which argues that such a requirement stifles innovation and would undermine the patent system.

That hasn't stopped some of the world's poorest countries, which also hold the richest pockets of natural biodiversity, from fighting to apply the convention to international patent law.

India has had the most success, most recently persuading the European Patent Board of Appeals to invalidate a 1994 patent granted to U.S.-based W.R. Grace & Co. for an insecticide derived from neem seeds.

Peru and Brazil, both at the forefront of the biopiracy debate, have been less persuasive.

Brazil, which has some of the world's strictest regulations to prevent the removal of genetic materials from the Amazon, has been hard-pressed to demonstrate a single case of biopiracy before the World Trade Organization.

Attempts by Peruvian indigenous groups, meanwhile, ultimately failed to overturn U.S. patents based on ayahuasca, a hallucinogenic plant used for centuries in religious and healing ceremonies, and nuna, a nutritious Andean bean that pops when toasted.

Peru hopes the MacaPure dispute will become a pivotal case in attempts to require all patent applications to disclose the source of genetic materials.

Alejandro Argumedo, a Quechua Indian agronomist and activist, says the French company that bought PureWorld in 2005, Naturex, has no right to "privatize knowledge that belongs to an entire region."

Naturex's marketing manager, Antoine Dauby, says the company acknowledges that maca's beneficial properties were long ago discovered by indigenous Peruvians. He says its patent lets them "grow, sell and use maca as they have for centuries."

"Our patent is for the extraction and isolation of maca's key ingredient — and nothing else," said Dauby. As a good faith gesture, he said, Naturex is offering to grant free licenses to Peruvian companies to use MacaPure in their products.

Qun Yi Zheng, PureWorld's former president and chief scientist, says the company invested more than $1 million and three years of research in the endeavor and that it popularized maca as a worldwide Peruvian export.

Peruvians "should not be so narrow-minded," Zheng said, but should instead be grateful. "After we studied it, put money into the research, (maca) has become a useful commodity."

A wide range of potency peddling maca-based products — from powders and pills to jams and candies — have helped triple Peru's exports of the plant from $1.3 million in 2000 to more than $3 million annually since 2003, according to the Exporters Association of Peru.

Japan was Peru's biggest maca customer in 2005, followed by the United States, Germany, Belgium and Canada.

Zheng's peer-reviewed study, published in the journal Urology in April 2000, showed that MacaPure greatly improved penile dysfunction in castrated rats. Also, lab mice fed the stuff for 22 days engaged in sexual intercourse up to 67 times in a three-hour period, compared with 16 times by less randy rodents deprived of the extract.

Peru contends PureWorld's alcohol-based extraction process simply mimics the centuries-old practice by Andean people of soaking dried maca root in Andean moonshine to release the libido boosters.

But providing scientific proof to show PureWorld's formula falls short of a "novel" and "useful" invention has proven elusive.

"We don't have the technology for this analysis and we have had to turn to a scientist in the United States who offered to do the analysis for free," said Manuel Ruiz, a director at the non-profit Peruvian Society for Environmental Law and a member of Peru's National Anti-Biopiracy Commission.

Peru has also enlisted the pro bono help of Washington attorney Jorge Goldstein to prepare a legal challenge. He is examining, among other things, archives from rural Peruvian universities to demonstrate that the U.S. Patent and Trademark Office failed to consider "prior art" — pre-existing knowledge that could be used to overturn the patent.

Chris Kilham, who conducted the initial field research for MacaPure in the Peruvian highlands, says he can see the issue from both sides.

"PureWorld, which did all of this work, found compounds that nobody knew existed before," said Kilham, a professor of ethnobotany at the University of Massachusetts at Amherst.

"On the other hand, the native people from whom the knowledge of especially the sexual applications of maca arise were not at all considered in these patents."

The specter of biopiracy in Peru dates back to the 1630s, when Jesuit priests took bark from the Peruvian cinchona tree — the original source of quinine — back to Europe, where it was hailed as a miracle cure for malaria.

Peru never got wealthy from the discovery.

Cinchona seeds were smuggled by the Dutch from Peru in the 19th century and planted in Java. Indonesia became the world's primary source of quinine.

The image of the cinchona tree was put on the Peruvian flag — a constant reminder of Peru's unrewarded contribution to one of the most important breakthroughs in medical history.

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Invisibleelsig
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Re: Libido-enhancing root in global dispute [Re: veggie]
    #6428714 - 01/05/07 05:18 PM (17 years, 1 month ago)

thanks for posting this article. I feel im getting pissed off when i read stuff like this. pre existing knowledge yes, so he shouldnt be able to m have a patent like this, lets hope things works out.

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Invisiblefastfred
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Re: Libido-enhancing root in global dispute [Re: elsig]
    #6429924 - 01/06/07 01:40 AM (17 years, 1 month ago)

You can't prevent people from making money from bio-prospecting or most of this stuff never would be found.

Don't try to put a bad spin on this it is a good thing. The company patented an extract process that they spent money researching and that they developed. The indians didn't invent it, they've never even made that type of extract before and now they're pissed?

They can still make their tea and eat and sell the root just like always. Without the patent NOBODY would be getting the extract.

Calling research, discovery, and production of bioproducts "biopiracy" is complete bullshit.


-FF

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Invisibleelsig
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Re: Libido-enhancing root in global dispute [Re: fastfred]
    #6429952 - 01/06/07 02:11 AM (17 years, 1 month ago)

yes sure, i have no problem seeing that point of view myeslef. but thats not what i reacted on most when i read this, this plant was handet over to this person by the indians because the couldnt 7afford , has the knowledge or equipment to do this theirself.. so it would be only fair to give something back like a small percentage, or perhaps purchase the plant material from peru, as a good gesture, i know if someone handet over something to me i wouldnt take that thing and make something of my own without involving those I owe it to in the first place. if this guy was travelling peru and came across this plant I would have looked on this matter completly diffrent.. and he did not exactly invent plant extraction either.. now did he, just a protocol on probably allready existing knowledge, improving something is not inventing something. but i do agree that its a good thing that this product gets availble for other parts of the world also.

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Invisiblefastfred
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Re: Libido-enhancing root in global dispute [Re: elsig]
    #6430041 - 01/06/07 03:03 AM (17 years, 1 month ago)

Extraction for standardized extracts is not like just pouring some solvent on the plant material and then evaporating it. They discovered what solvent would extract the active(s), then they probably run it through a chromatography column. They then have to discover what fraction from the column contains the actives. Then they have to find a preservative effective at preserving the actives, plus the binders and other stuff to make it into a useful product.

> it would be only fair to give something back like a small percentage

Maybe they will. But it seems that the indians are out for a big settlement or to deny the company their patent entirely.

> improving something is not inventing something.

You can patent inventions, improvements upon inventions, processes, and improvements on processes.

I'm sure the whole thing is going to be good for the indians in the long run. They have the market on the root cornered at the moment, so I'm sure that if the product sells well then company will be paying big bucks to the indians for the raw ingredient. The company is also going to promote this root extract, which will not only increase interest in their product but also the whole root, the ground root, and teas made from the root. The indians will be sure to make a profit from all the interest generated in the root. I'm sure almost nobody had heard of the root until the company patented the extract, so this is a situation where everyone wins.

Unless, of course, the whole thing gets tied up in litigation for years to come. That might well be what the indians are trying to do... Prevent the extract from being marketed while the publicity from the lawsuit lets them make a killing on the raw root sales which they already have cornered.


-FF

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OfflineThreePieceSuit
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Re: Libido-enhancing root in global dispute [Re: fastfred]
    #6430724 - 01/06/07 10:50 AM (17 years, 1 month ago)

Slightly off topic, but they mentioned that Ayahuasca was patented?

By whom, and for what purpose?


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Invisiblefastfred
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Re: Libido-enhancing root in global dispute [Re: ThreePieceSuit]
    #6431953 - 01/06/07 05:17 PM (17 years, 1 month ago)

One more point... If the indians don't think the patent is valid they don't have to do anything. They can make and sell all the extract that they want. It would fall on the company to sue them for patent infringement. If they feel that they really have a prior art case then they could do that no problem.


-FF

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InvisibleDNKYD
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Registered: 09/23/04
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Re: Libido-enhancing root in global dispute [Re: ThreePieceSuit]
    #6432025 - 01/06/07 05:40 PM (17 years, 1 month ago)

Maybe they mean this patent on a B. caapi cultivar:
http://www.google.com/patents?vid=USPATPP5751&id=sWg-AAAAEBAJ&dq=ayahuasca

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