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OfflineExplosiveMango
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Forcing precursor uptake
    #6382458 - 12/18/06 08:48 AM (17 years, 5 months ago)

Since the last thread about the psilocybin pathway was closed due to animal testing being suggested... I will start this one!

I was a bit surprised to hear how little DMT a psilocybe could uptake, and I was wondering if there were ways to increase this. If anyone has anyone has any information about any of the things I'm about to suggest I would be glad to hear it.

Physical method-

Bottlenecking: if a substrate were developed such that only one small hole existed connecting the mycelium to air, and the hole was covered with a large amount of DMT, perhaps this would force the mycelium to grow THROUGH the DMT, thus absorbing more than it would 'want'?



Chemical methods-

Forced absorption: If a culture were established (the intentional creation of overlay might help here) and a saturated solution of DMT in a solvent were obtained, perhaps the mycelium could be made more permeable and the DMT could simply be dissolved in. A small amount of ethanol perhaps? DMSO?

Disrupting the pathway early: If a chemical existed which would prevent the decarboxylation of tryptophan in mycelium (or maybe the methylation of tryptamines), perhaps the the rates of absorption of more complex precursors would increase? This is based on the idea that a psilocybe having less available material to phosphorylate might "try harder" and thus produce more phosphorylation enzymes.
(not too sure this one makes sense)


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Invisiblefastfred
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Re: Forcing precursor uptake *DELETED* [Re: ExplosiveMango]
    #6382745 - 12/18/06 10:47 AM (17 years, 5 months ago)

Post deleted by fastfred

Reason for deletion: DP


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Invisiblefastfred
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Re: Forcing precursor uptake [Re: fastfred]
    #6383064 - 12/18/06 12:40 PM (17 years, 5 months ago)

Just to reference the last thread...
http://www.shroomery.org/forums/showflat.php/Cat/0/Number/6368972/an/0/page/0

I think the DMSO is a good idea. DMSO is great at transporting molecules through otherwise impermeable membranes.


-FF

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