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Syrian Rue and mushrooms
    #6359278 -

I have some Syrain rue extract (10x), but I am curious how to take it.. and when before my trip? I think you just swallow it.. But should I take it a hour before hand or a day or right when I take my shrooms?


--------------------
Junkies United we stand , Devided we're sick as fuck.
-                  -                -
"Hallucinations are something heroin users are not at all accustomed to," said Const. Conor King, Victoria police drug expert. "They react like you or I would react if we took Aspirin and all of a sudden the TV got up and started walking across the room."
-                  -                -
Make drugs legal, or alcohol and tobacco illegal. Either way it's more fair.

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Re: Syrian Rue and mushrooms [Re: MustNotBe]
    #6359362 -

If you are doing Rue, *PLEASE* READ AND MAKE NOTE OF THE DIETARY RESTRICTIONS.

Not following these COULD possibly lead to death (seriously, not meida-BS scare people away from drugs propaganda), last thing we need is a 'some kid heard eating this would make mushrooms more potent and he ended up dead' news stories.

I've added the list of foods/etc at the bottom of this post, CHECK EROWID FOR MORE INFO.

That being said, I asked this question about dosages on another message board awhile ago, and the response I got was 1g of mush for 3-5g of Rue, full respone I got is below.

Quote:



For purely informational purposes, harmaline and harmala are very hallucinogenic by themselves(syrian rue).
Most people who know how to get really into 1.5 grams of shrooms due to years of useing hallucinogens might not care to mix maois even if they only have one gram for themselves. 1 gram of shrooms with 3-5 grams of rue could be a VERY INTENSE and long lasting trip. Try 24 hours.
Even 2.5 rue adds more potency to the shrooms and another very interesting set of elements. Its a very serious mix, cognatively and physically.
caapi, like rue is the original ayahuasca





Another response on the topic.

Quote:



Looks like they are giving me some time before I get narced out for other peoples texting issues.

In short:
3 grams of rue and 2 grams of shrooms is far more intense than 2 grams of shrooms by themselves.
For some people this is 2 times as potent for some its 4 times as potent. Most dont notice anything other than an elongated and intensified shroom trip.
SOme people really have a hard time with it because it is a bit like taking ayahuasca. The end all be all of hallucinogens.
In my experiences which I will report at a later date Im sure, It is deeper and guided by waves you cant really controll. Shrooms are hard enough on my mind and body but this is something special.
The first time I took aya I thought I might pass out or die. I was scared.
3 grams rue and 2 grams of shrooms can do this easily.
3 grams rue boiled/eaten over 30 min.-1 hours time, then eat the shrooms.
If I could do it again Id try 4 grams of rue without any other drug. That would have told me the most about what I was in for.
T. Mckenna ate about 6 grams rue and 2 grams shrooms after an already, week long psilo-excursion. His brother didnt come back totally untill one week and a half later. People were afraid for him.
This is for the people who want to go the furthest. The visuals become very 3-d and real and every manifestation of the trip that you thought deserved more analytical contact is accentuated.
Rue by its self at around 3 grams can take on some increadible visual forms.
Rue causes the fattest tracers known to science as well as the growing and shrinking of objects. It is one hell of a load if you take dmtayahuasca or shrooms mixed with maois.





In short: You'll need atleast around 1.5g-2g of Rue to activate the MAOI, you'll also start to trip off of the Rue along, going above that much Rue, and you'll start to trip intensly off of that. It will also make the mushrooms upto 2x as intense - if not more. It can make the trip last ALOT longer also, and can be intense past the point of comfort.

Unless you are expierenced with doing /VERY/ high doses of mushrooms, this isnt really recomended. This just isnt like the lemon juice 'get more bang for your buck', - this is potenitatly turning the mushroom expiernce into something else eniterly.

Research and be carefull - this has the potential to knock you on you're ass and then some. And remeber

- You can always take more, but you can NEVER take less.

I'd say taking 3g of mushrooms would be *WAY* too much for this for you're first time - I'd start with 2g of Rue, what about ~30 mins before eating the Mushrooms, and start with 1g of mushrooms. See how this goes, wait an hour - if you feel like you want to bump it up, add some more mushrooms - Yes, re-dosing may be less effective then taking all 2g at once. But, I'd rather have a less-effective re-dose, then ending up in a trip that is too comofortable for me to handle.

When mixing in something like Rue, it's not just an 'ok, this will be over in 6 hours' like you can assume with normal mush - it may be lasting a MUCH longer time.




Quote:



Among the materials which may be dangerous in combination with MAO inhibitors are:-

Sedatives, tranquilizers, antihistamines, narcotics and alcohol) any of which can cause hypotensive crisis (severe blood pressure drop); and amphetamines (even diet pills), mescaline, asarone, nutmeg (active doses), macromerine, ephedrine, oils of dill, parsley or wild fennel, beer, wine, cocoa, aged cheese and other tyrosine containing foods (tyrosine is converted into tyramine by bacteria in the bowel) ) any of which can cause hypertensive crises (severe blood pressure rise).


ALCOHOLIC BEVERAGES - avoid Chianti wine and vermouth. Consumption of red, white, and port WINE in quantities less than 120mL present little risk (Anon, 1989; Da Prada et al, 1988; McCabe, 1986).

BEER and ALE should also be avoided (McCabe, 1986), however other investigators feel major domestic (US) brands of beer is safe in small quantities (1/2 cup or less than 120 mL)
(Anon, 1989; Da Prada, 1988), but imported beer should not be consumed unless a specific brand is known to be safe.

WHISKEY and LIQUEURS such as Drambuie(R) and Chartreuse(R) have caused reactions.

NONALCOHOLIC BEVERAGES (alcohol- free beer and wines) may contain
tyramine and should be avoided (Anon, 1989; Stockley, 1993).

BANANA PEELS - a single case report implicates a BANANA as the-causative agent, which involved the consumption of whole stewed-green banana, including the peel. Ripe banana pulp contains 7-mcg/gram of tyramine compared to a peel which contains 65 mcg/gram-and 700 mcg of tyramine and dopamine, respectively (McCabe, 1986).

BEAN CURD - fermented bean curd, fermented soya bean, soya bean-pastes contain a significant amount of tyramine (Anon, 1989).

BROAD (FAVA) BEAN PODS - these beans contain dopa, not tyramine,-which is metabolized to dopamine and may cause a pressor reaction-and therefore should not be eaten particularly if overripe-(McCabe, 1986; Anon, 1989; Brown & Bryant, 1988).

CHEESE - tyramine content cannot be predicted based on appearance,-flavor, or variety and therefore should be avoided.

CREAM CHEESE and COTTAGE CHEESE have no detectable level of tyramine (McCabe,-1986; Anon, 1989, Brown & Bryant, 1988).

FISH - fresh fish (Anon, 1989; McCabe, 1986) and vacuum- packed-pickled fish or CAVIAR contain only small amounts of tyramine and-are safe if consumed promptly or refrigerated for short periods;-longer storage may be dangerous (Anon, 1989). Smoked, fermented,-pickled (Herring) and otherwise aged fish, meat, or any spoiled-food may contain high levels of tyramine and should be avoided-(Anon, 1989; Brown & Bryant, 1988).

GINSENG - some preparations have resulted in a headache,-tremulousness, and manic-like symptoms (Anon, 1989).

PROTEIN EXTRACTS - three brands of meat extract contained 95, 206,-and 304 mcg/gram of tyramine and therefore meat extracts should be-avoided (McCabe, 1986). Avoid liquid and powdered PROTEIN DIETARY-SUPPLEMENTS (Anon, 1989).

MEAT, nonfresh or liver - no detectable levels identified in fresh-chicken livers; high tyramine content found in spoiled or unfresh-livers (McCabe, 1986). Fresh meat is safe, caution suggested in-restaurants (Anon, 1989; Da Prada et al, 1988).

SAUSAGE, BOLOGNA, PEPPERONI and SALAMI contain large amounts of-tyramine (Anon, 1989; Da Prada et al, 1988; McCabe, 1986). No-detectable tyramine levels were identified in country CURED HAM-(McCabe, 1986).

SAUERKRAUT - tyramine content has varied from 20 to 95 mcg/gram-and should be avoided (McCabe, 1986).

SHRIMP PASTE - contain a large amount of tyramine (Anon, 1989).

SOUPS - should be avoided as protein extracts may be present; miso-soup is prepared from fermented bean curd and contain tyramine in-large amounts and should not be consumed (Anon, 1989).

YEAST, Brewer's or extracts - yeast extracts (Marmite) which are-spread on bread or mixed with water, Brewer's yeast, or yeast-vitamin supplements should not be consumed. Yeast used in baking-is safe (Anon, 1989; Da Prada et al, 1988; McCabe, 1986).--The foods to use with caution list categorizes foods that have been reported-to cause a hypertensive crisis if foods were consumed in large quantities,-stored for prolong periods, or if contamination occurred. Small servings-(1/2 cup, or less than 120 mL) of the following foods are not expected to-pose a risk for patients on MAOI therapy (McCabe, 1986).

Foods To Use With Caution:-

(1/2 cup or less than 120 mL)--Alcoholic beverages - see under foods to avoid.

AVOCADOS - contain tyramine, particularly overripe (Anon, 1989)-but may be used in small amounts if not overripened (McCabe,-1986).

CAFFEINE - contains a weak pressor agent, large amounts may cause-a reaction (Anon, 1989).

CHOCOLATE - is safe to ingest for most patients, unless consumed-in large amounts (Anon, 1989; McCabe, 1986).

DAIRY PRODUCTS - CREAM, SOUR CREAM, cottage cheese, cream cheese,-YOGURT, or MILK should pose little risk unless prolonged storage-or lack of sanitation standards exists (Anon, 1989; McCabe, 1986).

Products should not be used if close to the expiration date-(McCabe, 1986).

NUTS - large quantities of PEANUTS were implicated in a-hypertensive reaction and headache. COCONUTS and BRAZIL NUTS have-also been implicated, however no analysis of the tyramine content-was performed (McCabe, 1986).

RASPBERRIES - contain tyramine and small amounts are expected to-be safe (McCabe, 1986).

SOY SAUCE - has been reported to contain large amounts of tyramine-and reactions have been reported with teriyaki (Anon, 1989),-however analysis of soy sauce reveals a tyramine level of 1.76-mcg/mL and fermented meat may have contributed to the previously-reported reactions (McCabe, 1986).

SPINACH, New Zealand prickly or hot weather - large amounts have-resulted in a reaction (Anon, 1989; McCabe, 1986).

More than 200 foods contain tyramine in small quantities and have been-implicated in reactions with MAOI therapy, however the majority of the-previous reactions were due to the consumption of spoiled food. Evidence-does not support the restriction of the following foods listed if the food-is fresh (McCabe, 1986).

Foods With Insufficient Evidence For Restriction


(McCabe, 1986)--* anchovies - cream cheese - raisins-* beetroot - cucumbers - salad dressings-* chips with vinegar - egg, boiled - snails-* Coca Cola(R) - figs, canned - tomato juice-* cockles - fish, canned - wild game-* coffee - junket - worcestershire sauce-* corn, sweet - mushrooms - yeast-leavened bread-* cottage cheese - pineapple, fresh--Any protein FOOD, improperly stored or handled, can form pressor-amines through protein breakdown. Chicken and beef liver, liver-pate, and game generally contain high amine levels due to frequent-mishandling. Game is often allowed to partially decompose as part-of its preparation. Ayd (1986) reported that the freshness of the-food is a key issue with MAOIs and that as long as foods are-purchased from reputable shops and stored properly, the danger of-a hypertensive crisis is minimal. Some foods should be avoided,-the most dangerous being aged cheeses and yeast products used as-food supplements (Gilman et al, 1985).--With appropriate dietary restrictions, the incidence of-hypertensive crises has decreased to approximately 4% (Zisook,-1985). Treatment of a hypertensive reactions includes the=7F-administration of phentolamine (Anon, 1989) 2.5 to 5 milligrams-intravenously (slow) titrated against blood pressure (Zisook,=7F-1985; Lippman & Nash, 1990). One report has suggested that the use-of sublingual nifedipine 10 milligrams was effective in treating 2-hypertensive reactions following the ingestion of a-tyramine-containing food in a patient receiving MAOI therapy-(Clary & Schweizerr, 1987). Chlorpromazine also has alpha-blocking-properties and has been recommended as an agent for discretionary-use (patient-initiated treatment) in the setting of dietary-indiscretion (Lippman & Nash, 1990).

CONCLUSION:--Dietary restrictions are required for individuals receiving-monoamine oxidase inhibitor therapy to prevent a hypertensive-crisis and other side effects. The foods listed in the dietary-restrictions have been categorized into those foods that must be-avoided, foods that may be ingested in small quantities, and those-foods that were previous implicated in reactions but upon analyses-of fresh samples only a small tyramine content was identified and-should be safe to consume if freshness is considered.


--------------------
:mushroom2::mushroom2::mushroom2:"There is a world beyond ours, a world that is far away, nearby, and invisible. And there is where God lives, where the dead live, the spirits and the saints, a world where everything has already happened and everything is known. That world talks. It has a language of its own. I report what it says. The sacred mushroom takes me by the hand and brings me to the world where everything is known. It is they, the sacred mushrooms, that speak in a way I can understand.":mushroom2::mushroom2::mushroom2:

:sunny::mushroom2:Maria Sabina:mushroom2::sunny:

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Re: Syrian Rue and mushrooms [Re: sandman_130]
    #6359374 -

In other words, read the dietary restrictions before you do anything.


Your gonna have to calculate your extract and figure out a proper dose, i'm never tried it with extract.


But When I make syrian rue and mushrooms I take the rue in tea an hour before the mushrooms. and then I make a mushroom tea with more rue in it. I use the lemon juice method, you will find that if you pour grape juice into your lemon mush rue tea, it will turn it half lime green, and half red, very trippy, the colors dont run together at all.


--------------------
:mushroom2::mushroom2::mushroom2:"There is a world beyond ours, a world that is far away, nearby, and invisible. And there is where God lives, where the dead live, the spirits and the saints, a world where everything has already happened and everything is known. That world talks. It has a language of its own. I report what it says. The sacred mushroom takes me by the hand and brings me to the world where everything is known. It is they, the sacred mushrooms, that speak in a way I can understand.":mushroom2::mushroom2::mushroom2:

:sunny::mushroom2:Maria Sabina:mushroom2::sunny:

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Re: Syrian Rue and mushrooms [Re: sandman_130]
    #6359392 -

I was thinking about .2 grams of the rue, and 1 gram of mushrooms. Sounds good for a first try. How long cant I eat restricted items for? I was going to fast for until I am back to normal, how long do the maoi's effect you?


--------------------
Junkies United we stand , Devided we're sick as fuck.
-                  -                -
"Hallucinations are something heroin users are not at all accustomed to," said Const. Conor King, Victoria police drug expert. "They react like you or I would react if we took Aspirin and all of a sudden the TV got up and started walking across the room."
-                  -                -
Make drugs legal, or alcohol and tobacco illegal. Either way it's more fair.

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Re: Syrian Rue and mushrooms [Re: MustNotBe]
    #6359432 -

I had the same problem and would be interested in knowing the answer. Would ingesting 0.3g of Syrian Rue 10x extract be the same as 3g of regular Rue? I tried it one time with ayahuasca and barely tripped at all.


--------------------
Just say NO to the War on Drugs.

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Re: Syrian Rue and mushrooms [Re: MustNotBe]
    #6359442 -

I don't mean to make little of the diet precautions. Follow them by all means.

As far as the food goes, you probably don't need to worry your heart out, just try your best to follow the guide. But, everyone is different, so who knows. From all I've read and experienced, you're not going to be in any real danger having had a bit of meat, chocolate, or dairy the day before, or even the day of. Tyramine should be avoided, but some isn't going to kill you. It will be potentiated though... worst I've seen is a headache from cheese while a person was on rue. Cacti contain tyramine. Some avoid potentiating mescaline because of this, but it doesn't seem to be a realistic problem for anyone I've heard of.

*DO* take extreme precautions with any form of medication. Prescription or OTC. *DO* avoid alcohol days before, during, and the day after. As for the diet, I'd say follow it as completely as you can the day of. Follow it the day before, though it's not completely critical. A glass of milk for breakfast probably isn't reason to cancel your plans. But you probably don't want to eat a massive steak dinner.

Before an actual ayahuasca experience, people tend to fast anyway, sticking with things like rice and water. Ayahuasca in tea form is extremely hard on the stomach though, for many. Purge can often be unavoidable, so people make it as easy on themselves as possible.

You're wise to start low. Some people are more easily affected by rue. I know 2g was too high a starting point for me. Not sure that you'll feel .2, but it'll be good to see if you have some strange reaction I suppose.


--------------------
You're not like the others. You like the same things I do. Wax paper, boiled football leather... dog breath. We're not hitch-hiking anymore, we're riding!

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Re: Syrian Rue and mushrooms [Re: Koala Koolio]
    #6359534 -

I've tripped on rue + mushrooms twice in the last week, and I used the same dosage both times: 3g rue and about 3.5g mushrooms (dried). I don't use extracts, so I can't suggest dosage there.

As far as the taste is concerned, I used decaf instant coffee. Make your rue tea then add a bit of decaf instant. It worked well for me.

As the warnings above say, do NOT start off with too big a dose. You will trip HARD. Prior to my first MAOI + mushroom experience, I always sort of brushed aside the seriousness of the MAOI.. now I completely understand the warnings. I had a level 3/4 trip off of just 3-3.5g of mushrooms with the rue. And it lasted a long, long time.

I strongly suggest you remain with friends, people you are familiar with. Have relaxing music. Relaxing images. Be peaceful. If you don't relax, you will become very very anxious, which can make a wonderful experience turn sour.

Definitely not a party drug, not with rue at least. I enjoy mushrooms in party-like situations.. but not the combination. Rue + psilocybes is very very spiritual and very introspective.

I wish you the best, and enjoy yourself :smile:


--------------------
"Hence in the wise leader's plans, considerations of advantage and of disadvantage will be blended together." -Sun Tzu

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Re: Syrian Rue and mushrooms [Re: DrMario]
    #6361718 -

I'm a big proponent of fasting (for any occasion really) but as Koala said, you really don't need to worry too much about diet with such a low dose of maoi. All those diet precautions are for folks taking maoi's on the regular for legitimate reasons. SSRI's like prozac are much, much more dangerous.

Rue tends to make a lot of people feel a tad queasy and/or dizzy, so if you're one of the folks that already gets an upset tummy from shrooms alone; keep a bucket handy.

Have fun and report back.


--------------------
On storing pedro tea...

Brewmaster: Well, the mescaline will still be in there, but I'd be afraid of it conjealing and trying to escape after it grew in size from eating all the other shit in my fridge, and possibly my dogs if it got out.

Pithlit: sentient drugs, now that is an idea ...

OneMoreRobot: Idea? It's a fuckin' reality. You know Salvia? Nigga stole my TV.

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Re: Syrian Rue and mushrooms [Re: Brewmaster]
    #6361776 -

i drink regular coffee with it and no problems. also I fast for 6 hours before and 6 hours after taking the rue. eating rice is ok though a few hours after.
also I would use the dosage calculator...
http://www.shroomery.org/6257/Magic-Mushroom-Dosage-Calculator
different shrooms are different and you can attain different levels of a trip

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Re: Syrian Rue and mushrooms [Re: cpw1971]
    #6361848 -

"SSRI's like prozac are much, much more dangerous."

Not with mushrooms (effects will be decreased), or diet, but as far as mixing with an MAOI, yes... that could be a fatal mistake.


--------------------
You're not like the others. You like the same things I do. Wax paper, boiled football leather... dog breath. We're not hitch-hiking anymore, we're riding!

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Re: Syrian Rue and mushrooms [Re: Koala Koolio]
    #6361889 -

That's what I meant, thanks for clarification.


--------------------
On storing pedro tea...

Brewmaster: Well, the mescaline will still be in there, but I'd be afraid of it conjealing and trying to escape after it grew in size from eating all the other shit in my fridge, and possibly my dogs if it got out.

Pithlit: sentient drugs, now that is an idea ...

OneMoreRobot: Idea? It's a fuckin' reality. You know Salvia? Nigga stole my TV.

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Re: Syrian Rue and mushrooms [Re: Brewmaster] * 1
    #28499586 -

syrian rue also potentiates vaporized DMT


--------------------
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Check out awesome music!

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Re: Syrian Rue and mushrooms [Re: TheLiesUnderneath]
    #28499587 -

Well hello.
I definitely belong here.
MAO makes alot of drugs get potentiated.
To a dangerous extent in some cases.
Do not take LSD while on this compound.
Here we are. I wrote out a lot of safety information.
Nobody die using this please.
I want this to say legal and safe for everyone.
https://www.shroomery.org/forums/showflat.php/Number/28497169/page/1

It’s not all scary though. Here’s my recipe for an amazing day.
https://www.shroomery.org/forums/showflat.php/Number/28447856

Edited by GenesisCorrupted (10/11/23 01:27 PM)

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted]
    #28499627 -

GenesisCorrupted said:
Well hello.
I definitely belong here.
MAO makes all drugs get potentiated.
To a dangerous extent in some cases.
Do not take LSD while on this compound.
Here we are. I wrote out a lot of safety information.
Nobody die using this please.
I want this to say legal and safe for everyone.
https://www.shroomery.org/forums/showflat.php/Number/28497169/page/1

It’s not all scary though. Here’s my recipe for an amazing day.
https://www.shroomery.org/forums/showflat.php/Number/28447856



Really? I never knew it potentiated LSD, but I'm fairly certain white grapefruit juice will. Syrian rue will induce a trip on its own, so you're definitely right in the sense that there might be synergistic properties


--------------------
Help the homeless

Subscribe to a Youtube channel that's making a difference

Check out awesome music!

Most importantly, love yourself, love life

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Re: Syrian Rue and mushrooms [Re: TheLiesUnderneath]
    #28499634 -

I guarantee it is dangerous to use LSD while under these compounds influence.
If you were to be so balls to the wall Cray Cray. You would only need to use an absolutely tiny amount as compared to the normal dose you would take.

For instance, if I was to take 6 g of mushrooms in a normal situation

I would now only take two. The Syrian rue will also make this affect last an entire goddamn day.
At least that’s the case for me. People say it only lasts 4 hours. It lasts 8-10 hours for me.

So just contemplate that. Under normal circumstances people can have an entire day long LSD trip.

What if that lasted for three or more days?
Under incredible intensity.
For that amount of time.
I could pretty much guarantee you’re going to be traumatized.

Edited by GenesisCorrupted (10/11/23 04:46 AM)

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted]
    #28499651 -

GenesisCorrupted said:
I guarantee it is dangerous to use LSD while under these compounds influence.
If you were to be so balls to the wall Cray Cray. You would only need to use an absolutely tiny amount as compared to the normal dose you would take.

For instance, if I was to take 6 g of mushrooms in a normal situation

I would now only take two. The Syrian rue will also make this affect last an entire goddamn day.
At least that’s the case for me. People say it only lasts 4 hours. It lasts 8-10 hours for me.

So just contemplate that. Under normal circumstances people can have an entire day long LSD trip.

What if that lasted for three or more days?
Under incredible intensity.
For that amount of time.
I could pretty much guarantee you’re going to be traumatized.




Yeah but what if you dose someone without them expecting it? Surely it'll get rid of some of the anxiety


--------------------
Help the homeless

Subscribe to a Youtube channel that's making a difference

Check out awesome music!

Most importantly, love yourself, love life

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted] * 2
    #28499881 -

GenesisCorrupted said:
MAO makes all drugs get potentiated.




This is simply untrue. Please read about MAOIs and RIMAs and stop spouting nonsense about them.

GenesisCorrupted said:
I guarantee it is dangerous to use LSD while under these compounds influence.




Also untrue. LSD and harmalas are not a dangerous combo. Please do not write misinformation on here. Recently you were telling people benzos will kill you on harmalas and now this.

Let's just stick to the truth rather than projecting our fear.

The mechanism by which this site provides harm reduction is by giving people the truth about substances. Knowledge is power. Fabricating things without really understanding the topics then presenting medical cautions with those untruths goes against that tenet.


--------------------
We are the music makers, the dreamers of dreams.

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Re: Syrian Rue and mushrooms [Re: Northerner]
    #28500058 -

I’ve been doing a ton of research on it.

https://pubmed.ncbi.nlm.nih.gov/34251464/

I’m not trying to pop off, but this is actually a dangerous combo. It can cause serotonin syndrome.
If you only took MAO and LSD. Maybe it would be more safe. But you definitely can’t add it on top of Ayahusca.
I’ve read multiple research papers that have literally stated that is a dangerous thing to take because it will be permeating into your system way harder and deeper.
I went back and corrected the trip killer article after I got input from the community. I’m not sure if you saw that I went back and changed that.
Can you please show me some articles to put my fears to bed?
Because the list has every single time that I found them on every single reference. Included SSRI, LSD, any blood pressure, medication, and melatonin. Those are the consistent ones. I don’t make these claims lightly.
I also have repeatedly stated that everyone is different.
Personally, I already have an OK amount of serotonin.
When I take anything that gives me more of it, I get quite happy.
If I was to take too much or add another chemical that produce serotonin…
Serotonin syndrome sets in. Now I’m sure not everyone is prone to this. Now for you Northerner perhaps this isn’t something that affects you.
But it can be dangerous. All I’m trying to do is be cautious. To educate people to the risks involved in having this combination of compounds in your brain.

Edited by GenesisCorrupted (10/11/23 12:35 PM)

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted]
    #28500097 -

GenesisCorrupted said:
But it can be dangerous. All I’m trying to do is be cautious. To educate people to the risks involved in having this combination of compounds in your brain.




I think it would be better for you if you posted links to your information. I notice that you constantly say that you have to find where you got your information from. How about you just post links to the information to back up your arguments. That way  a more informed discussion could be had.

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Re: Syrian Rue and mushrooms [Re: Kiwi89]
    #28500105 -

Clarifying statement
I don’t believe LSD is in of itself inherently toxic with MAO.
I believe that the amount of serotonin it produces when combined with an MAO is toxic.

I have responded to every evidence request. And included them above in the article that is getting the comment. I don’t actually respond to the comment directly with the evidence every time. But I can right now if you want.

https://pubmed.ncbi.nlm.nih.gov/34251464/

https://www.uspharmacist.com/article/drug-induced-serotonin-syndrome



This exists on a spectrum. Some people are much more prone to it than others. I am more prone to it than others. So I air on the side of caution.
I would love to see an article that says I can take my MAO and LSD. If that exists, I need to find that article.

Because so far every single thing that I’ve looked up is consistently telling me that is dangerous.
The only place that disagrees is this place and places like it.

Honestly, the Internet knows very little about MAO to begin with. If all of the stuff that I’ve been reading turned out to be propaganda. I need to be told that so I can stop trying to use it as a reference material.

But I have not been given any opposing evidence to dictate. The LSD would be safe on an MAO.

Edited by GenesisCorrupted (10/11/23 01:13 PM)

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted]
    #28500124 -

GenesisCorrupted said:
MAO makes all drugs get potentiated.




So that we do not get lost in the weeds, I think it will be helpful to address this comment first. Where in the two articles that you have just linked does it provide evidence for this statement?

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Re: Syrian Rue and mushrooms [Re: Kiwi89]
    #28500134 -



It just forces certain chemicals to stick around a lot longer before their naturally destroyed and sent away from your body. That’s the only reason you can use  Dmt while you’re on that compound. Otherwise, it would get absorbed and digested way to quickly wouldn’t even be able to experience it.

No, this may not apply to every single compound. But the list was expansive.
Here’s a list.
https://www.medicinenet.com/mao_inhibitors-oral/drug-class.htm

I always include a list when I make a claim like that. Obviously every single compound on earth will not interact with us. But it is a large enough and scary enough list. That it should shake people up and make them read an article about it.
I have corrected that statement though.

Sincerely,
Genesiscorrupted

Edited by GenesisCorrupted (10/11/23 01:28 PM)

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted] * 1
    #28500151 -

Harmalas are not the irreversible MAOI's being talked about in medical literature, they are RIMA's.

MAOI's are very well understood. They are the oldest form of medical antidepressant.

Please stop, you are making a fool out of yourself.

If you want clear and concise understanding of how harmalas interact with paychedelics please visit dmt-nexus.me . It is a very old project which has has many actual chemists on board exploring these questions.


--------------------
We are the music makers, the dreamers of dreams.

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted]
    #28500154 -

GenesisCorrupted said:
MAO makes all drugs get potentiated.




It would be more accurate, from the articles that you have linked so far to say that MAOI's interact with some other compounds. It is simply hyperbolic to say that they potentiate all drugs.


GenesisCorrupted said:
Do not take LSD while on this compound.




GenesisCorrupted said:
I guarantee it is dangerous to use LSD while under these compounds influence.




These two comment I think do need to be addressee next. Can you please show where the evidence is for this in the articles that you have linked.

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Re: Syrian Rue and mushrooms [Re: Northerner]
    #28500157 -

This is actually what I was talking about.
There isn’t enough information. If you try to search for anything involving these compound. You’re always sent to the same stupid scientific articles.
Earlier you mentioned RIMA.
This is literally the first time I’ve ever heard about it. I’m gonna go do some more reading. I don’t want to sound like a fool. I appreciate you bringing this to my attention.

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Re: Syrian Rue and mushrooms [Re: Kiwi89]
    #28500159 -

Kiwi89 said:
GenesisCorrupted said:
MAO makes all drugs get potentiated.




It would be more accurate, from the articles that you have linked so far to say that MAOI's interact with some other compounds. It is simply hyperbolic to say that they potentiate all drugs.


GenesisCorrupted said:
Do not take LSD while on this compound.




GenesisCorrupted said:
I guarantee it is dangerous to use LSD while under these compounds influence.




These two comment I think do need to be addressee next. Can you please show where the evidence is for this in the articles that you have linked.



I already shot my shot.
In principal. Because MAO forces you to not be able to get rid of serotonin in your brain as fast as we would normally.
Any drug that produces an excess of serotonin in your brain. Could potentially.
Cause serotonin syndrome.
LSD produces an enormous amount of serotonin, which on its own is completely fine.

The main scientific argument against getting to use LSD while using an MAO.
Was.
Due to the revelations that northerner has brought to my attention. This may have been misinterpreted or propaganda.

That, when using some thing that inhibits the natural dissolution of serotonin in the brain. Introducing some thing that produces an excess of serotonin can cause something called serotonin syndrome. Which can be dangerous. That’s all I was arguing for. That’s it.

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted]
    #28500163 -

There's a lot of information on this topic out there mate. But it's important that you understand it before trying to speak as an authority. Currently you don't even know what classes the drugs you are talking about are. You don't even appear to know the meaning of the acronyms you are using.

Spend a year hanging out with the Nexus crew, then come and tell us what you know as a journeyman.


--------------------
We are the music makers, the dreamers of dreams.

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Re: Syrian Rue and mushrooms [Re: Northerner] * 1
    #28500164 -

Northerner said:
Harmalas are not the irreversible MAOI's being talked about in medical literature, they are RIMA's.

MAOI's are very well understood. They are the oldest form of medical antidepressant.

Please stop, you are making a fool out of yourself.




This is the sort of stuff that is very difficult to learn. I have literally asked the doctor. They interchangeably used the terms MAO & MAOI. They never even mentioned RIMA.

There is a plethora of information. That is all wrong on this topic. I accidentally contributed to that disinformation by repeating wrong educational materials.
I literally feel ashamed.

Nobody should feel they have to.
But if I could have an article link directly underneath his comment. I feel like that would end the flow of where this conversation has gone quite well.

Edited by GenesisCorrupted (10/11/23 01:55 PM)

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted] * 3
    #28500165 -

I am so glad this 16 year old thread about "syrian rue and mushrooms" could be bumped for people to argue about combining LSD and ayahuasca.

:migraine:


--------------------
Good name is better than silver and gold
And no money can buy good name
I have a good name
And no money can buy my name
Do you have a good name?
Then no money should buy your name

Edited by ItAintGotNoGasInIt (10/11/23 01:55 PM)

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted] * 1
    #28500168 -

Go hang out on Nexus for a long while and read that treasure trove of info on harmalas and DMT. That is what they do, if you want to know about that.


--------------------
We are the music makers, the dreamers of dreams.

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Re: Syrian Rue and mushrooms [Re: ItAintGotNoGasInIt]
    #28500172 -

Your oversimplifying.
This was about MAO, and anything that produces an excess of serotonin (mush,lsd,dmt)
combined with anything else that also produces serotonin. Causing serotonin syndrome. That’s what this discussion was.
More information is necessary. But I feel like this was the correct place to discuss it.

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Re: Syrian Rue and mushrooms [Re: Northerner]
    #28500177 -

Northerner said:
Go hang out on Nexus for a long while and read that treasure trove of info on harmalas and DMT. That is what they do, if you want to know about that.



I absolutely want to know about that. But I am very curious. I was prescribed phenelzine.
Is that an MAO?
Because I thought this was a Harmmala that had been put down to his most concentrated form and put into a capsule.
Is this in no way related to the Syrian rue I was using before it?

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Re: Syrian Rue and mushrooms [Re: Northerner] * 1
    #28500180 -

LSD is not potentiated by MAO-A inhibition. However, Rue/Harmalas (among other things) does strongly inhibit CYP2D6 (which also metabolizes the Harmalas themselves, so they essentially inhibit their own metabolization which i think plays a role in the Harmala reverse tolerance that occurs with regular Harmala consumption), and LSD is apparently metabolized by CYP2D6 - https://www.nature.com/articles/s41598-021-90343-y - And so if you consume LSD at the same time as Harmalas/Rue, the Harmalas can inhibit CYP2D6 and thus potentiate the LSD, however the CYP inhibitions of Harmalas have two phases, the first phase is when you first consume the Harmalas, the second phase is halfway through when the Harmine and Harmaline metabolize into Harmol and Harmalol (i'm pretty sure), which depending on Harmalas dosage which plays into Harmala duration, the second phase of CYP2D6 inhibition can occur anywhere from 4 to 6 to 8 to 10 hours, possibly up to 12 hours after first taking the Harmalas, but the CYP inhibition depends on the Harmala dosage and duration and as the duration stretches out the CYP inhibition moves around from hour 6, to hour 8, to hour 10, possibly up to hour 12, as the Harmala dosage and duration increases.

So basically, it's the CYP2D6 inhibition of Rue/Harmalas, which would potentiate LSD, not the MAO-A inhibition. But with that said, other strong CYP2D6 inhibitors would do the same, and anything that would induce the CYP2D6 enzyme would likely cause the LSD to be metabolized out of the system more quickly.


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Re: Syrian Rue and mushrooms [Re: Sabnock] * 2
    #28500188 -

Also LSD with MAO-A inhibition isn't going to cause Serotonin Syndrome because it doesn't raise Serotonin levels, particularly like SSRI's do. LSD and other Psychedelics are Serotonergic receptor agonists, though also binds to other receptors like Dopamine and Adrenergic receptors as well. Serotonin receptor stimulation isn't going to cause Serotonin Syndrome, or else all Psychedelics regardless of MAO-A inhibition would cause Serotonin Syndrome.

Also, 5-HTP for example can even be taken alongside Harmalas/MAO-A inhibition to raise Serotonin levels, it's actually quite nice, and it's safe, and has not been scientifically shown to cause Serotonin Syndrome in combination with MAOI's. I've been taking 5-HTP myself at 100mgs for the last say couple months and i take it either 2 hours before the Rue or about 6 hours into the Rue, and it's been great! Apparently i was rather low in Serotonin lol. Edit - Though it should be noted if you take 5-HTP you should take it alongside P5P B6 because B6 is needed by DOPA Decarboxylase to convert 5-HTP into Serotonin, whereas if you take 5-HTP without B6 it seems to feel more like 5-HTP than Serotonin, same with L-Dopa and Dopamine.


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Edited by Sabnock (10/11/23 02:23 PM)

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Re: Syrian Rue and mushrooms [Re: Sabnock] * 1
    #28500191 -

I've also taken Melatonin with Rue btw, it's fine too, but Melatonin aside from being partially metabolized by MAO-A iirc, also is metabolized by CYP1A2, which again the Harmalas also potently inhibit, just like for Caffeine and Theobromine and other things.


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Re: Syrian Rue and mushrooms [Re: Sabnock]
    #28500196 -

Now caffeine is the number one in a ton of articles.
Seriosly that is safe as well?
How can that not cause a hypertensive crises?
I swear i am going to call people and have this misinformation pulled of websites if these revelations keep coming.

Does Phenelzine still let me use dmt caps?

Edited by GenesisCorrupted (10/11/23 02:17 PM)

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted] * 1
    #28500203 -

GenesisCorrupted said:
Northerner said:
Harmalas are not the irreversible MAOI's being talked about in medical literature, they are RIMA's.

MAOI's are very well understood. They are the oldest form of medical antidepressant.

Please stop, you are making a fool out of yourself.




This is the sort of stuff that is very difficult to learn. I have literally asked the doctor. They interchangeably used the terms MAO & MAOI. They never even mentioned RIMA.

There is a plethora of information. That is all wrong on this topic. I accidentally contributed to that disinformation by repeating wrong educational materials.
I literally feel ashamed.



Don't feel too bad mate, i agree, a lot of the information about MAOI's applies moreso to the irreversible MAOI's, not reversible one's like Harmalas or Moclobemide, plus a lot of information is outdated on the subject and so now with RIMA's being more studied they're finding that RIMA's at least are actually rather safe, the only real thing they shouldn't be mixed with are strong SSRI's, as it's the SSRI's that are the actual issue, i myself have gotten Serotonin Syndrome just from being on SSRI's themselves, i've never gotten Serotonin Syndrome from Harmalas and i've taken them regularly since 2012.

And yes, Caffeine is safe, i drink it all the time with Harmalas actively in my system, like i said it's just metabolized by CYP1A2, if you take anything that inhibits CYP1A2, like Harmalas, and you take the Caffeine when the CYP1A2 inhibition is active, it will be potentiated which then you'd just have to reduce the dosage of Caffeine to account for the increase in dosage/bioavailability, or you can take the Caffeine either sometime before the Harmalas when CYP1A2 wouldn't be inhibited and the usual dosage of Caffeine will be fine, or you can take it at certain periods either during or after the Harmalas, when CYP1A2 isn't inhibited (which again happens in two phases/at certain hours within the Harmala effects/duration, so CYP1A2 isn't constantly inhibited, just inhibited for maybe an hour or so a couple times within the active Harmala effects.


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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted] * 1
    #28500207 -

Quote:
GenesisCorrupted said: Does Phenelzine still let me use dmt caps?



Phenelzine should technically knock out gut MAO-A and allow for oral DMT activation, yeah. I would not recommend Phenelzine though since it's irreversible and you have to avoid Tyramine, which isn't an issue with Harmalas/RIMA's. Plus you're more likely to run into interactions with things with irreversible inhibitors because they can knock out the MAO enzymes for approx 2 weeks or so.


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Re: Syrian Rue and mushrooms [Re: Sabnock]
    #28500212 -

:thumbup:

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Re: Syrian Rue and mushrooms [Re: Sabnock] * 1
    #28500222 -

I have this for the rest of the month. I’ve already been on the Dmt diet for like four months. So it won’t cause any interactions. But now that I know this. I will request an RIMA for the refill.
Then I get to fully enjoy a lot of things that have been falsely advertised as toxic poison to me.
I gave you a user review by the way. You’re like the most reliable source of information on these topics.
That’s how badly Google understands this topic.😂

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted]
    #28500229 -

GenesisCorrupted said:
I have this for the rest of the month. I’ve already been on the Dmt diet for like four months. So it won’t cause any interactions. But now that I know this. I will request an RIMA for the refill.
Then I get to fully enjoy a lot of things that have been falsely advertised as toxic poison to me.
I gave you a user review by the way. You’re like the most reliable source of information on these topics.
That’s how badly Google understands this topic.😂



Well i've done a lot of research and experimentation lol, and yet, some people still tell me i'm wrong sometimes lol. I mean idk everything, but i do know a good bit lol.

But yeah see if you can get a RIMA like Moclobemide, though it's not available here in the US it is available in Canada and Australia, but one can try to find it via an online pharmacy (which is where i had gotten my Moclobemide), or you can see if a psychiatrist will prescribe it and they can either maybe order it from Canada or overseas or you can send the prescription to an online pharmacy in Canada or overseas and have it shipped here, from what i've read.


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Re: Syrian Rue and mushrooms [Re: Sabnock] * 1
    #28500232 -

It would be worth it. Also, the psychiatrist I got is pretty cool. Otherwise he wouldn’t of even prescribed me an MAO. So I’m sure they would be willing to work with me in getting a medication that works better.

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted]
    #28500295 -

Triptamines and ketamine are safe but just don't take phenyethylamines even with reversible maois, because some phenylethylamines has some serotonin uptake inhibition activity. I actually try 150 mg moclo many times with with mdma, mescaline but dosage is really important (I prefer to not go over 150 mg and small amount of pea) but it may be dangerous for some people. Also I feel opoid mu receptor activity from peganum harmala if I go over 4 grams, i could not find literature about it, but i feel it.

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Re: Syrian Rue and mushrooms [Re: taskamil] * 1
    #28500310 -

taskamil said:
Triptamines and ketamine are safe but just don't take phenyethylamines even with reversible maois, because some phenylethylamines has some serotonin uptake inhibition activity. I actually try 150 mg moclo many times with with mdma, mescaline but dosage is really important (I prefer to not go over 150 mg and small amount of pea) but it may be dangerous for some people. Also I feel opoid mu receptor activity from peganum harmala if I go over 4 grams, i could not find literature about it, but i feel it.



Yeah Rue definitely interacts with the Opioid system, i can feel it too, to a degree, though it seems to be safer i'm pretty sure compared to actual Opiates, because i've taken Rue very regularly (daily for long periods of time) and let the Harmala reverse tolerance build up and so the dosage just gets stronger and stronger, at least for the Harmalas, while the background compounds are Rue-dosage dependent, the Harmalas are reverse tolerance-dependent, but if you take either high/heavy dosages of Harmalas, or about 4 grams or higher of Rue, there's definite pain relief and body relaxation there, even the next day or so, i'm pretty sure it's Harmaline-related because Harmine doesn't seem to have those properties that i've been able to tell and i've noticed it with Harmala extract which tells me it's coming from the Harmaline most likely, though some of Rue's other background compounds may well contribute as well. Either way, it doesn't seem to be unsafe or addictive or anything like actual Opioids so it likely has some sort of modulatory effect like positive allosteric modulation or indirect activation through some other mechanism. Plus if it had true full on Opioidergic properties it would cause some sort of withdrawal you would think, yet i've noticed no withdrawal at all from Rue, i've taken it daily in heavy dosages for years, and just stop taking it and over a few weeks to a couple months i slowly just return to baseline and any residual effects are then gone.

There's some studies that mention it interacts with the Opioid system, here's one - "These result showed that the alkaloid extract of Pgh contains active analgesic principles acting both centrally and peripherally. Furthermore, this antinociceptive effect has been avoided by naloxone at a dose of 1mg/kg in the first phase of formalin and hot plate tests indicating that this extract act partly through an opioid-mediated mechanism. In conclusion, the alkaloid extract of Peganum harmala seems to have both central and peripheral antinociceptive activities which may be mediated by opioid receptors." - https://pubmed.ncbi.nlm.nih.gov/18054186/

As for MDMA, it's definitely not advised to take that with Harmalas or Moclobemide, although it may well be doable so long as the dosage is controlled for. I've only had MDMA once at approx 100mgs, i had been taking my usual heavy dosages of Harmalas/Rue, and merely skipped taking it a day and took the MDMA, and the next day went back to the Rue, so i had Rue the day before and the day after the MDMA and had been dosing Harmalas/Rue on the regular, and yet didn't seem to have any issue, although the MDMA was rather strong and made my head felt like it was disappearing while having diarrhea, i didn't even really get anything good from the MDMA, i just felt really calm, but at the same time i do believe i was already low in Serotonin and had been for a long time in my life apparently, so idk maybe that's why i didn't get much of a good effect from the MDMA, either that or me taking the Rue around the same time did something but i think i was just low in Serotonin, which MDMA probably even made that worse lol. Granted i didn't have any negative interactions/reactions to the MDMA, it just felt strong and wasn't particularly fun or enjoyable and pleasurable.


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Re: Syrian Rue and mushrooms [Re: Sabnock] * 1
    #28500349 -

Yes I found new literature about harmaline efecting ventral tegmental area glutamatergic system and potenciates mu activity. So because of no direct agonist effect of mu receptors, there is no risk of withdrawal or any other opoid related side effects, probably it potenciates just internal opoid system. Actually because I don't like metylphenidate excess energy effects, harsh comedown and also become harder to find, I also started using rue 0.5 gram daily for one month for my adhd and makes me feel good and less distractive, more productive and good for general health. I am considering to go to 1 gram daily.

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Re: Syrian Rue and mushrooms [Re: Sabnock] * 1
    #28500350 -

Sabnock said:
taskamil said:
As for MDMA, it's definitely not advised to take that with Harmalas or Moclobemide, although it may well be doable .



I have been told and will be doing more research.

Mdma does both dangerous activites.
Ups heart rate. Hypertensive crises
And produces a lot of serotonin.
Serotonin syndrom.

Edited by GenesisCorrupted (10/11/23 04:16 PM)

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted] * 2
    #28500353 -

GenesisCorrupted said:
Sabnock said:
taskamil said:
As for MDMA, it's definitely not advised to take that with Harmalas or Moclobemide, although it may well be doable .



I have been told and will be doing more research.

Mdma does both dangerous activites.
Ups heart rate. Hypertensive crises
And produces a lot of serotonin.
Serotonin syndrom.



Yes it is dangerous but it can be doable at right dosages. There are death reports combining maoi with mdma just dont do if you are not sure about dosage or not sure about your substance.

You can read this article it is old but information there is valueable.

https://maps.org/news-letters/v06n3/06332ott.html

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Re: Syrian Rue and mushrooms [Re: Sabnock] * 1
    #28501157 -

I definitely feel the pain relief from Syrian Rue as well. I’ve thought to myself many times how it feels comparable to a small amount of opium, but with more positivity and energy.

Really cool to hear that it affects other people this way as well.

Northener introduced me to harmalas and they’ve done me a world of good since I started taking them.

One other interesting thing that I’ve noticed recently is that when I chew fresh seeds they seem to be a lot more stimulating than a harmala extract. I’m not sure what causes this so if anyone could enlighten me that would be great! Harmala extract still has all of the pain relieving and antidepressant qualities, but the fresh seeds have an extra energy boost as well.


--------------------
"God is an intelligible sphere, whose center is everywhere and whose circumference is nowhere."

Llamando la Mareacion

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Re: Syrian Rue and mushrooms [Re: Bardy] * 1
    #28501347 -

Good timing on this weird thread resurrection, I bought some powdered rue and plan on taking 2-3g rue + 2g liberty caps with it tomorrow or Saturday.
I've been reading conflicting stories about nausea caused by unextracted rue. Those with a lot of experience with it, how bad is it actually? I'll take them as separate teas 20-60 mins apart and I'll have some fresh ginger (helps with nausea apparently?) and a bucket for emotional support.


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Re: Syrian Rue and mushrooms [Re: Turvenuija] * 1
    #28501435 -

I definitely puked on rue + extracted dmt.  Experiences with harmine extracts + ACRB tea were much more gentle on my stomach.

Making tea from the liberty caps, rather than ingesting the mushrooms themselves, will help too.


--------------------
And if I only could
I'd make a deal with God
And I'd get him to swap our places
I'd be running up that road
Be running up that hill
With no problems

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Re: Syrian Rue and mushrooms [Re: tree frog]
    #28501498 -

Yeh I have a feeling I'm going to hurl, I get some nausea from shroom tea alone but that's fine, puking has never ruined trips for me. Get it over with, get the taste out and carry on. I'll look into extracting for the future, it doesn't look hard at all just time consuming.


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Re: Syrian Rue and mushrooms [Re: Turvenuija]
    #28501552 -

Turvenuija said:
Good timing on this weird thread resurrection, I bought some powdered rue and plan on taking 2-3g rue + 2g liberty caps with it tomorrow or Saturday.
I've been reading conflicting stories about nausea caused by unextracted rue. Those with a lot of experience with it, how bad is it actually? I'll take them as separate teas 20-60 mins apart and I'll have some fresh ginger (helps with nausea apparently?) and a bucket for emotional support.



This is based off of my personal experience.
At first when your body has nothing to fear, Syrian Rue is fine.
In fact, it made me hungry multiple times.
But it does produce nausea I know for a fact.
Because physiologically I started getting more and more nauseous just by the smell of it.
Those last couple caps I had of Syrain Rue...
The smell of them was enough to turn my stomach and make me nauseous just being near the box that I kept them in.
That’s how powerfully the nausea works on you. The smell alone is enough.

I use pure harmalla extract or pills.
I’m so happy that I’m not using the actual Syrian rue pill capsules anymore.
Just keep marijuana nearby. You’re gonna need it.

I implore you to not make tea!!!
Get a scale it doesn’t have to be wildly accurate.
Measure out how much 3 Gelcaps Weigh on their own. Get the triple 000
Subtract that from the weight of your measured out Syrian rue seed. So that you’re right around 2 1/2 to 3 g.
It’ll take about 30 minutes for you to absorb the contents of those seeds.
Even with nothing being tasted at all.
You will still feel a little bit nauseous.
It won’t be bad enough to even need medicine until you try to put anything else on top of it that also produces nausea. Then you will have wild crazy ass nausea.
Here’s my reference material.
Mushrooms and Dmt both produce a similar amount of nausea when combined with this chem.


You do not want any of the flavor in your mouth at all…
Super duper better experience.
For comparison.
Imagine you left a tea bag of Earl Grey in a mug for three days….
Then somebody made you drink it.
Then, when you finally finish swallowing it. They put a gun up to your head and said you needed to suck on the teabag for a couple minutes.
That’s the aftertaste…
For all that is good in the world. For god sake. Just get some empty pill caps. Even empty some if you have some around the house that you’re not gonna use. Because the nausea that you have will be pretty significant. I didn’t realize how nauseous I was until the fourth time I tried to do it, and I got nauseous before I even finished picking up the Rue pills.
https://www.shroomery.org/forums/showflat.php/Number/28447856
This is my nausea free recipe
I can’t even imagine a worst way to use Syrian Rue.

Edited by GenesisCorrupted (10/12/23 12:45 PM)

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted]
    #28501596 -

GenesisCorrupted said:
Turvenuija said:
Good timing on this weird thread resurrection, I bought some powdered rue and plan on taking 2-3g rue + 2g liberty caps with it tomorrow or Saturday.
I've been reading conflicting stories about nausea caused by unextracted rue. Those with a lot of experience with it, how bad is it actually? I'll take them as separate teas 20-60 mins apart and I'll have some fresh ginger (helps with nausea apparently?) and a bucket for emotional support.



This is based off of my personal experience.
At first when your body has nothing to fear, Syrian Rue is fine.
In fact, it made me hungry multiple times.
But it does produce nausea I know for a fact.
Because physiologically I started getting more and more nauseous just by the smell of it.
Those last couple caps I had of Syrain Rue...
The smell of them was enough to turn my stomach and make me nauseous just being near the box that I kept them in.
That’s how powerfully the nausea works on you. The smell alone is enough to make your body start getting nauseous again.

I use pure harmalla extract or pills.
I’m so happy that I’m not using the actual Syrian rue pill capsule anymore.
Just keep marijuana nearby. You’re gonna need it.



Oh boy, i know this all too well lol. Same thing happened to me, just the smell of the Rue, the sight of the Rue powder, instantly would make me queasy and wanna gag and throw up lol. It can be rather deterring but i know the magick that Rue holds so i look past the nausea and vomiting and all that, but it is quite the pungent seed.

With that said, there are two ways that i go about dealing with the nausea/vomiting, i either take the Rue/Harmalas regularly (usually daily, at night, but a few times a week seems to also be fine ime) which will build up the reverse tolerance and with that the side-effects including the nausea/vomiting/diarrhea will go away and the bodyload will clean up and the motor impairment goes away and then even heavy dosages of Harmalas will feel pretty clean and are functional and won't cause anymore nausea/vomiting.

Or i use Limonene, which is a compound found in a wide variety of plants and essential oils, and is a major component of Lemon essential oil which people have touted as an anti-nausea remedy though they attributed it to Beta-Pinene, it's actually the Limonene, and so i recommend trying pure Limonene, get the pure oil form and not the supplement form because the supplement form is too high of a dosage at 500mgs to 1 gram, whereas you want more along the lines of 6 to 10 drops, 8 to 10 drops particularly seemed to help for me but 6 drops may even be enough, which would equate to about 108 to 180mgs, and so you just put the Limonene drops into a capsule using a dropper, and take it at the same time as the Rue/Harmalas, and it will remove most if not all of the nausea/vomiting ime, and i've gotten good feedback so far about it and that it works for others, so it might be something worth trying. The Limonene also seems to clean up some of the bodyload to a degree i think, it feels nice though ime.

As for things like Ginger or Zofran or Peppermint, they all act as Serotonin 3 receptor antagonists, which can be useful for nausea/vomiting, and some folks claim that it helps with the Aya or mushrooms or what not, but ime anytime i've tried Ginger or Zofran or Peppermint with Aya or even the Rue/Harmalas, idk, i find that it really doesn't help me with the nausea/vomiting but it also alters things in a really weird way that i don't particularly like or get benefit from. Plus with Peppermint, there's also other properties it has, including GABA-A receptor activity which on one hand may be useful but on the other hand i feel like it dulls things down, which is contrary to what Lemon Balm does for me through it's GABAergic properties which doesn't seem to dull things down but still relaxes things and smooths things out. So as far as GABAergic properties go, Lemon Balm is great, but Peppermint not so much, ime.

And yes, Cannabis is imo/ime definitely worth having around for gut discomfort and nausea, it's a great ally.

But yeah Rue seed powder encapsulated can be a bit more rough on the gut, at least at first, but if you build up the reverse tolerance and do away with the side-effects, and get your body used to it, and plus Rue/Harmalas have anti-microbial properties and so it'll interact with the gut microbiome which needs to get used to it, and then things feel better, even with the seed powder. But extracts are nice too, i much prefer the Rue seed itself over the extracts though because the seed itself has a lot more going on and feels more natural and magickal, whereas the extract feels more isolated and medicinal, which isn't an issue for me as i can certainly use that, but as far as extracts go i prefer homemade full spectrum freebased extract, which apparently you can't buy online that i've seen, some vendors list their Harmala extracts as full spectrum but they're not truly full spectrum, they're manske'd extracts which is basically just a pure Harmaline/Harmine mix, but the true full spectrum extract also has some other alkaloid from the Rue, but it doesn't get everything, it just adds a few more compounds to the mix and makes it feel better and closer to but lighter than the seed, so i recommend making your own full spectrum Rue extract and trying that out and comparing how it feels to the manske'd Harmala extract.


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Re: Syrian Rue and mushrooms [Re: Turvenuija] * 1
    #28501608 -

Turvenuija said:
Good timing on this weird thread resurrection, I bought some powdered rue and plan on taking 2-3g rue + 2g liberty caps with it tomorrow or Saturday.
I've been reading conflicting stories about nausea caused by unextracted rue. Those with a lot of experience with it, how bad is it actually? I'll take them as separate teas 20-60 mins apart and I'll have some fresh ginger (helps with nausea apparently?) and a bucket for emotional support.



Encapsulate the powdered Rue seed, tea is horrid lol. Encapsulate the powder, take the Rue capsules, then 30 minutes to an hour later drink the mushroom tea (i recommend an hour which seems to do good for me personally).

The nausea/vomiting from Rue can be pretty strong for sure, but it's really not that bad if you don't go too high on the dosage. Which i recommend 2.5 to 3 to 3.5 grams of Rue, but 2.5 grams at least, 2 grams is a bit low though it can work but 2.5 grams of Rue is better. And 2 grams of mushrooms is fine, though for the "full shebang" i do recommend trying 2.5 to 3.5 grams, which with proper potentiation would be near about 5 to 7 grams equivalent, ime, but again potency can vary so 2 grams can be a nice place to start i've just found 2 grams of mushrooms ime to be a little light.

But yeah the nausea/vomiting can also most certainly happen with Harmala extracts too, however the extracts are less likely to cause nausea or stomach discomfort, but with a high enough dosage can certainly still make you vomit lol, which is more of an easier purge compared to with the Rue seed but none the less, the Rue seed itself ime is where the real magick is, i've had great experiences/effects/benefits using extracts but i always end up going back to the seed itself as it seems to give me effects i don't get when using extracts.


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Re: Syrian Rue and mushrooms [Re: Bardy]
    #28501610 -

Bardy said:
I definitely feel the pain relief from Syrian Rue as well. I’ve thought to myself many times how it feels comparable to a small amount of opium, but with more positivity and energy.

Really cool to hear that it affects other people this way as well.

Northener introduced me to harmalas and they’ve done me a world of good since I started taking them.

One other interesting thing that I’ve noticed recently is that when I chew fresh seeds they seem to be a lot more stimulating than a harmala extract. I’m not sure what causes this so if anyone could enlighten me that would be great! Harmala extract still has all of the pain relieving and antidepressant qualities, but the fresh seeds have an extra energy boost as well.



I get the stimulation too, honestly to me it feels a bit more like it comes from the Harmaline, even though Harmaline can have a bit more sedative properties and Harmine is said to be a bit more stimulating, so it could be the Harmine but at the same time using pure Harmine or light roast Rue or Caapi doesn't seem to give me the stimulant effect i notice, which imo likely comes from Harmaline. Harmaline does have some actions as a GABA-A inverse agonist (which i've often used 3 to 4.5 grams of dried Lemon Balm leaf tea to counteract) which may perhaps lead to some stimulation, it also inhibits COMT which is involved in the metabolism of Dopamine and Noradrenaline but idk if that would contribute or not, i'm sure it has some other properties though that may be involved.


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Re: Syrian Rue and mushrooms [Re: Sabnock] * 1
    #28501620 -

I love when you weigh in on this topic.
I gotta get some of that limonene.
I’m very interested in trying it to ease the come up.
I find that the Ayahusca doesn’t produce an open eye visual for me unless I go into the very heavy dosage range. Is it just set & setting holding me back or am I not doing a big enough dose to get to where I’m trying to go to?
I’ll end up getting that thing where everything looks normal. Until you look at your phone. Then words try and get like Drifty…
Like every other letter, in a word, will start sliding down the screen as if it’s melting a little bit. Which is very cool. But it seems like my cell phone is one of the only things that even produces this.
Another time I was trying to watch knives out. Everything was completely normal until Daniel Craig turned once. Then there was a third eye behind his ear!

These are not the visuals that you are looking for!

Edited by GenesisCorrupted (10/12/23 12:59 PM)

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Re: Syrian Rue and mushrooms [Re: Sabnock]
    #28501624 -

Also, one fun fact that y'all might make use of, is that you can use either pure Harmine or properly light roasted Rue seed (which will break down the Harmaline content while sparing the Harmine content and some of the background compounds), and either take that for a bit, or mix it with the raw Rue or the Harmala/Rue extracts, and it will boost the Harmine concentration and raise Harmine above Harmaline so that Harmine is dominant and Harmaline is secondary, seems to feel better that way ime, and plus that's one reason why some folks don't like Rue because it's dominant in Harmaline, but if you raise the Harmine concentration, it feels better.

And, if you take the same dosages, like say you take 2 to 4 grams of properly light roasted Rue for the Harmine content, and you let the reverse tolerance to Harmine build up some, you can then switch to using the same dosage of raw Rue instead of the light roast (or pure Harmine extract), and the Harmine dosage will stay at the same level and will continue to be dominant even with Harmaline's reverse tolerance building up. This way, you can alter the ratio of Harmine to Harmaline. And you can mix light roast and raw Rue's (or add pure Harmine to the raw Rue) and use a little bit of raw Rue and then make up for the rest of it with light roast or pure Harmine.


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Re: Syrian Rue and mushrooms [Re: Sabnock]
    #28501627 -

Since I’ve been trying to experience EyeCandy
I wanted to use the harmaline because I heard it was harder hitting.
But if it’s body load and not visual. Then I’m going to get harmine next time. I had a choice.
I chose to get harmaline powder. It only has 2% harmine in it.
I could’ve gotten the exact opposite. 97% harmine. 2% harmaline.

They also offer mix. Where they offer some thing that they claim to be 50-50 split.
The people are youse are very good. They make whatever you really one of the three options. I just thought that harmaline was the way to go.

Edited by GenesisCorrupted (10/12/23 01:02 PM)

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Re: Syrian Rue and mushrooms [Re: Sabnock] * 1
    #28501629 -

I knew that you could roast them to release some of the chemicals and destroy some of the unpleasant compounds. I learned that from watching some dudes trying to make Yopo. But I don’t want to destroy any of my compounds. I’m just gonna get a better mix next time.

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted]
    #28501631 -

GenesisCorrupted said:
I love when you weigh in on this topic.
I gotta get some of that limonene.
I’m very interested in trying it to ease the come up.
I find that the Ayahusca doesn’t produce an open eye visual for me unless I go into the very heavy dosage range. Is it just set & setting holding me back or am I not doing a big enough dose to get to where I’m trying to go to?
I’ll end up getting that thing where everything looks normal. Until you look at your phone. Then words try and get like Drifty…
Like every other letter, in a word, will start sliding down the screen as if it’s melting a little bit. Which is very cool. But it seems like my cell phone is one of the only things that even produces this.
Another time I was trying to watch knives out. Everything was completely normal until Daniel Craig turned once. Then there was a third eye behind his ear!

These are not the visuals that you are looking for!




Yeah this stuff for me isn't particularly visual, lots of folks even with traditional Aya seem to not get much in the way of visuals, although some other folks get very obvious visuals and then act like visuals are supposed to be there when really this kind of medicine doesn't seem to be particularly visual at least for me, i get pretty much everything else but the visuals lol.

As far as the visuals go, it's mainly Harmala visuals like open eyed tracers and such, maybe some "lightness" where it feels like there's a mild light kinda lighting up the darkness in a way, idk, and there's some mental imagery that comes through to me sometimes that is mostly just random people doing random things, scenes that flash by rather quickly, almost like if you took snippets from a bunch of random movies and edited them together where it's just one quick glimpse scene after the other, it's kinda like that, i just see people, faces, them doing random things, idk what it is. Sometimes i'll also see like jungle imagery. But i really don't get much in the way of mental imagery/closed eyed visuals, they're fairly mild no matter the dosages of Harmalas/Rue or DMT, for me anyways.

Also ime there seem to be this thing i've noticed where at certain dosages of the Harmalas, things tend to be a bit more visual but beyond that certain dosage range it becomes less visual and more physical which definitely has it's benefits that i don't get from dosages below that. So there may be something to do with the dosage range of Harmalas playing into the visuals. Also i think extra Harmine makes things a bit more visual as well.

Another thought i've had is that perhaps if someone doesn't get visuals, maybe they're low in certain vitamins, particularly the B vitamins, ime. I've begun to supplement with B vitamins the last few months because i apparently wasn't getting enough from my diet, and i have noticed some visual activity picking up recently, so i'm not sure if that's because of the raised Harmine concentration or if it's because of the vitamins, but i do think in any case, B vitamins are really important and you want to make sure you're getting those. Magnesium too, as Harmalas seem to use up or deplete Magnesium, which for me causes cramping and heart palpitations and then i know i'm low and have to supplement.


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Edited by Sabnock (10/12/23 01:25 PM)

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Re: Syrian Rue and mushrooms [Re: Sabnock] * 1
    #28501636 -

Fascinating.
I have definitely had some open eye visuals on this before. Some of the most beautiful shit I’ve ever seen in my life.
But yes, it is very difficult to use as a visual drug.
It gets me really energetic.
So it is difficult for me to get to relax and close my eyes and try to experience these visuals. Then like you say.
It is as you’ve been teleported to 1000 verandas in 15 minutes.
You can see all this incredible stuff. But it’s like you’re being sent through so many different universes, so quickly. Sometimes you don’t even get the time to really appreciate them.
I want to be able to spend some time in some of these places that I got sent to on that drug.
I know people have had breakthroughs with DMT. But that only seems to be with free base.

Edited by GenesisCorrupted (10/12/23 01:15 PM)

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted] * 1
    #28501638 -

GenesisCorrupted said:
Since I’ve been trying to experience EyeCandy
I wanted to use the harmaline because I heard it was harder hitting.
But if it’s body load and not visual. Then I’m going to get harmine next time. I had a choice.
I chose to get harmaline powder. It only has 2% harmine in it.
I could’ve gotten the exact opposite. 97% harmine. 2% harmaline.

They also offer mix. Where they offer some thing that they claim to be 50-50 split.
The people are youse are very good. They make whatever you really one of the three options. I just thought that harmaline was the way to go.



One day you might try making your own Rue extracts, it's really easy to do, just takes a day of boiling and reducing and filtering and basing and cleaning. Basically just brew up 100 grams of whole Rue seed in a big pot filled a few inches from the top with water, let it boil at medium to medium high heat where it's actually boiling and not simmering but not overboiling or boiling too hard, just a nice rolling boil ya know, and when the water gets down enough to where it's just covering the seed, pour the liquid through a filter of some kind and put the liquid in another pot, and then reboil the seeds again with fresh water doing the same thing and then filtering it off into the pot with the first boil, and continue to do a total of 4 to 6 separate boils, which takes a few hours or so but it's worth it.

And when all boils are done and filtered and combined you reduce the brew down to 400mls, and when it cools down to room temp you add a splash of vinegar which i use approx 100mls of vinegar, and then you take 30 grams of washing soda and dissolve it into 100mls of hot water and then add/stir that into the vinegarized Rue brew and the crude full spectrum extract will precipitate out, which once it's all precipitated and mostly fallen to the bottom you can filter it off and collect it. Then you can clean it up a time or two or three by dissolving the extract in fresh warm vinegar water (100mls of vinegar, 300mls of warm water), once it's all dissolved as much as possible, filter it which will filter out a bunch of black plant gunk, and then rebase the filtered liquid with 30 grams of washing soda dissolved into 100mls of hot water added/stirred to the liquid which will precipitate out a cleaner full spectrum extract, do that a time or two or so more and you will have a pure/clean full spectrum freebased Rue extract, which can then be filtered off and dried and used.

And this should be able to be used with light roast Rue as well, so that you can get an extract with just Harmine and not Harmaline, though it should still be full spectrum technically, and then one could do a manske extraction on the light roast extract to collect pure Harmine, technically it should work, haven't tried it personally yet but i'm going to at some point because it should very well work just the same as extracting from raw Rue. Or you can just do a manske on the full spectrum extract and then use ammonia and a pH meter to separate Harmaline and Harmine, but i think doing the light roast thing would maybe be easier.


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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted]
    #28501641 -

GenesisCorrupted said:
Fascinating.
I have definitely had some open eye visuals on this before. Some of the most beautiful shit I’ve ever seen in my life.
But yes, it is very difficult to use as a visual drug.
It gets me really energetic.
So it is difficult for me to get to relax and close my eyes and try to experience these visuals. Then like you say.
It is as you’ve been teleported to 1000 verandas in 15 minutes.
You can see all this incredible stuff. But it’s like you’re being sent through so many different universes, so quickly. Sometimes you don’t even get the time to really appreciate them.
I want to be able to spend some time in some of these places that I got sent to on that drug.
I know people have had breakthroughs with DMT. But that only seems to be with free base.



There's also the potential in smoking Changa or pure DMT while on Aya/Psilo-huasca, which may be more in the way of visual, perhaps. I have a good bit of experience with smoked DMT particularly in the form of Changa, but i still haven't really experienced most of what it's capable of, i still need to explore it much further but combining it with oral Aya/Psilo-huasca imo would be interesting and more likely to induce visions/visuals.


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Re: Syrian Rue and mushrooms [Re: Sabnock] * 1
    #28501678 -

My dreams are incredibly prophetic. I have been given mission statements. Told what books to write. All of my inspiration for writing kind of stems from them. That’s why Dmt is such an amazing compound to me. It lets me directly go into the dream realm while getting to remember all of it.

I am incredibly interested in getting some of these Dmt cartridges. But I’ve been told that the concentration can vary so wildly that I seem to have no choice, but to make it myself.
&pp=ygUhSSdtIGhpdHRpbmcgbXkgRE1UIGNhcnQgcmlnaHQgbm93

Edited by GenesisCorrupted (10/12/23 02:02 PM)

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted]
    #28501701 -

Ait you convinced me, I ordered some capsules. They won't make it for the weekend though, do you think it's feasible to simply mix the powder into a glass of juice for example? I really want to test them out tomorrow since it's my only window of opportunity for quite a while I think. I also think 2g is on the low side but if we assume it roughly doubles the intensity of shrooms while adding their own twist, I think it's enough for a test run. I have cubes growing but it'll be another 6 weeks before I can even dream about a harvest so after that I can do stronger doses at will.
Also, when you folks have thrown up have you purged any of the shrooms or does that usually happen before you even get to drinking/consuming the mushrooms/dmt? I wouldn't want to waste any, my dose already being on the low side. Thanks a ton for the tips and info, I'll bookmark this and refer to it when I'm ready to do it properly.


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Re: Syrian Rue and mushrooms [Re: Turvenuija]
    #28501707 -

OK quite honestly. You get 3.

I know that sounds really fatalistic.
Three times.
After that, your body will know what’s been causing the nausea and will actively fight you to not eat any more of those seeds.
But for those first three trips. You won’t even know why you’re nauseous. Neither will your body.
So you can sneakily use Syrian Rue seeds. Just directly drinking them in water even.

But I swear to God…
After that third time, the jig is up. Your body will know those seeds have been causing your nausea. And just the smell alone. Will be enough to make you feel queasy.

I wouldn’t suggest doing it more than once. Because then it will just be a one off thing. And your body won’t really associate the nausea directly to the compound.
But after you start, just using it in caps. The nausea won’t really be a thing anymore. But the smell…
Will always make you feel sick after that fourth time trying it.

Edited by GenesisCorrupted (10/12/23 02:21 PM)

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted] * 1
    #28501804 -

I get what you mean, smelling and especially tasting dried shrooms and the smell of the brewing tea makes me gag, wasn't always that way. Rue sounds like that to the power of 10. I'll do it once this way like you said.


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Re: Syrian Rue and mushrooms [Re: Turvenuija]
    #28501812 -

Have the dosage ready in a small cup of water. Have a very large cup of water with flavor in it beside it. Have a 3rd cup of water to pour into the first initial cup to get the remainder.

So first drink a cup with a seeds at the bottom as quickly as you can after stirring it.
Immediately drink a chaser
Then pour the 3rd cup into the 1st cup to drink the remainder.
Then take one last long draw of the chaser.
You’ll be fine after that.
You literally wouldn’t be nauseous at all if you didn’t do anything else either. It’s really odd. But the Syrian rue seems to only make you incredibly nauseous when combined with something else. You are nauseous while on it. But at such a low and manageable level that you can almost completely ignore it.
But when combined with DMT or mushrooms, yeah, that marijuana is going to come in clutch.

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Re: Syrian Rue and mushrooms [Re: Sabnock] * 1
    #28501822 -

Sabnock said:
Bardy said:
I definitely feel the pain relief from Syrian Rue as well. I’ve thought to myself many times how it feels comparable to a small amount of opium, but with more positivity and energy.

Really cool to hear that it affects other people this way as well.

Northener introduced me to harmalas and they’ve done me a world of good since I started taking them.

One other interesting thing that I’ve noticed recently is that when I chew fresh seeds they seem to be a lot more stimulating than a harmala extract. I’m not sure what causes this so if anyone could enlighten me that would be great! Harmala extract still has all of the pain relieving and antidepressant qualities, but the fresh seeds have an extra energy boost as well.



I get the stimulation too, honestly to me it feels a bit more like it comes from the Harmaline, even though Harmaline can have a bit more sedative properties and Harmine is said to be a bit more stimulating, so it could be the Harmine but at the same time using pure Harmine or light roast Rue or Caapi doesn't seem to give me the stimulant effect i notice, which imo likely comes from Harmaline. Harmaline does have some actions as a GABA-A inverse agonist (which i've often used 3 to 4.5 grams of dried Lemon Balm leaf tea to counteract) which may perhaps lead to some stimulation, it also inhibits COMT which is involved in the metabolism of Dopamine and Noradrenaline but idk if that would contribute or not, i'm sure it has some other properties though that may be involved.



I read somewhere a while ago that Rue causes histamine to be released somewhere in the brain, and that may have something to do with the stimulant properties as well.

Unfortunately can’t remember where I read that.

Thanks for passing on the knowledge 👍


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"God is an intelligible sphere, whose center is everywhere and whose circumference is nowhere."

Llamando la Mareacion

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Re: Syrian Rue and mushrooms [Re: Bardy]
    #28501847 -

Bardy said:
Sabnock said:
Bardy said:
I definitely feel the pain relief from Syrian Rue as well. I’ve thought to myself many times how it feels comparable to a small amount of opium, but with more positivity and energy.

Really cool to hear that it affects other people this way as well.

Northener introduced me to harmalas and they’ve done me a world of good since I started taking them.

One other interesting thing that I’ve noticed recently is that when I chew fresh seeds they seem to be a lot more stimulating than a harmala extract. I’m not sure what causes this so if anyone could enlighten me that would be great! Harmala extract still has all of the pain relieving and antidepressant qualities, but the fresh seeds have an extra energy boost as well.



I get the stimulation too, honestly to me it feels a bit more like it comes from the Harmaline, even though Harmaline can have a bit more sedative properties and Harmine is said to be a bit more stimulating, so it could be the Harmine but at the same time using pure Harmine or light roast Rue or Caapi doesn't seem to give me the stimulant effect i notice, which imo likely comes from Harmaline. Harmaline does have some actions as a GABA-A inverse agonist (which i've often used 3 to 4.5 grams of dried Lemon Balm leaf tea to counteract) which may perhaps lead to some stimulation, it also inhibits COMT which is involved in the metabolism of Dopamine and Noradrenaline but idk if that would contribute or not, i'm sure it has some other properties though that may be involved.



I read somewhere a while ago that Rue causes histamine to be released somewhere in the brain, and that may have something to do with the stimulant properties as well.

Unfortunately can’t remember where I read that.

Thanks for passing on the knowledge 👍



Yeah that was likely from me too lol, Harmaline apparently can inhibit Histamine N-Methyltransferase which can raise levels of Histamine to some degree, may even bring about some allergy sensitivities maybe but i haven't had any issue that i know of, the only thing is that sometimes my nose will get congested and stuffed up, idk if that's the increase in Histamine or from the Harmalas' vasodilation, but i hate stuffy noses, doesn't happen all the time, so i think it's just allergies, and anti-histamines seem to maybe help with the nasal congestion and so it may help with the allergies in general. As far as anti-histamines go, i think Cetirizine is probably the best bet because it's not metabolized by any of the CYP enzymes that Harmalas inhibit, whereas Loratadine is metabolized by CYP2D6 which would be potentiated if taken with the Harmalas but taken sometime before the Harmalas shouldn't be potentiated, Diphenhydramine can also be used, though it's also metabolized by CYP2D6 so the same applies.

Idk if it contributes to the stimulation but maybe, i know Histamine is considered to be a "wakefulness" compound and helps aid alertness.


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Re: Syrian Rue and mushrooms [Re: Sabnock]
    #28501850 -

Oh my gosh, this happens every time during my come up.
I got a little bit of a runny nose.
I also have some temperature shifts.
Sometimes getting pretty warm. Sometimes getting quite cold and needing to bundle up.
I thought of it as just part of the drug starting up my brain. But the fact that it is related to a histamine would make a lot of sense for the congestion.

Edited by GenesisCorrupted (10/12/23 03:38 PM)

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Re: Syrian Rue and mushrooms [Re: Turvenuija]
    #28501853 -

Turvenuija said:
Ait you convinced me, I ordered some capsules. They won't make it for the weekend though, do you think it's feasible to simply mix the powder into a glass of juice for example? I really want to test them out tomorrow since it's my only window of opportunity for quite a while I think. I also think 2g is on the low side but if we assume it roughly doubles the intensity of shrooms while adding their own twist, I think it's enough for a test run. I have cubes growing but it'll be another 6 weeks before I can even dream about a harvest so after that I can do stronger doses at will.
Also, when you folks have thrown up have you purged any of the shrooms or does that usually happen before you even get to drinking/consuming the mushrooms/dmt? I wouldn't want to waste any, my dose already being on the low side. Thanks a ton for the tips and info, I'll bookmark this and refer to it when I'm ready to do it properly.



Do you happen to have any like supplements that you're not using or can spare some of for the capsules? If you do you can just empty out the capsules and fill em' up with the Rue powder. If you don't have any supplement capsules to empty out and fill up with the powder, then you can technically toss n' wash the powder with some sort of drink, but i imagine it's going to taste rather nasty, but it's doable, some people have done it that way, i haven't though, i'd instantly gag lol. Or you can just make a tea but again it may taste pretty bitter but if you can drink it on down it'd be easier i think than toss n' washing the powder.

Also for the mushrooms, if you're eating the mushrooms themselves, take them 30 minutes after the Rue, if you're drinking a mushroom tea drink it an hour after the Rue, mushrooms take a bit more time to digest whereas tea is absorbed pretty instantly.

When you throw up, yes, you can throw up the Rue seed powder, and the mushrooms, but usually i've been able to keep things down long enough for things to get absorbed, it isn't usually an issue unless you get into higher/heavier Harmala dosage territory. Which Rue at 2 to 3 grams usually doesn't cause nausea or vomiting ime, especially 2 to 2.5 grams, 3.5 grams to 4.5 grams may cause nausea/vomiting if you take that same dosage a few times, since the reverse tolerance will build up and the dosage gets stronger and stronger at the same dosage. And the reverse tolerance builds up quicker and stronger with higher Rue/Harmala dosages, and it builds up slower and weaker with lower to moderate dosages, so if you dose high on the Rue a few days in a row, the dosage will get pretty strong, if you dose a moderate dose of the Rue for a few days the reverse tolerance won't build up as strongly and won't cause nausea/vomiting as quickly, if you take a lighter Rue dose there doesn't seem to be any nausea/vomiting even when taken regularly ime.


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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted]
    #28501857 -

GenesisCorrupted said:
Oh my gosh, this happens every time during my come up.
I got a little bit of a runny nose.
I also have some temperature shifts.
Sometimes getting pretty warm. Sometimes getting quite cold and needing to bundle up.
I thought of it as just part of the drug starting up my brain. But the fact that it is related to a histamine would make a lot of sense for the congestion.



There's also Serotonin to think about as well since Serotonin is involved in temp regulation. Which i've found that taking 5-HTP with P5P B6 once a day seems to help stabilize my body temp and seems to help a good bit with counteracting the hot/cold flashes during the come up. Idk if that's due to Histamine at all, but maybe. There's also the possibility that because of the Harmalas' anti-microbial properties, it may be interacting with the microbiome temporarily which may cause certain microbes to come out a bitmore and that may also contribute to the hot/cold flashes, similarly to if you have some sort of infection or something you can have hot/cold flashes and shivering/shaking, idk if that's related or if it says something about the microbiome but just something i've noticed over the years.

Edit - Certain vitamins may also be involved, because i've apparently been low in B vitamins especially Folate, and so i've been anemic, and anemia can cause temp shifts and cold intolerances and such, so that's something to maybe think about as well, you can tell if you're low in Folate by looking at your fingernail moons, if your fingernail moons aren't like in the middle of your fingernail on all/most fingers, then you're low in Folate, Folate and fingernail moons seem to be connected from my observations.


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Re: Syrian Rue and mushrooms [Re: Sabnock] * 1
    #28501861 -

Hilariously enough.
Each time that I have done this. If I have been recovering from something.
I always feel like I am completely cured after I’ve taken this.

Like every time I’ve ever used Ayahusca. I have felt better after the come down than I did when I took it.
It always feelt like it just cleared out my system to a weird extent.

Edited by GenesisCorrupted (10/12/23 03:50 PM)

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted] * 1
    #28501865 -

GenesisCorrupted said:
Hilariously enough.
Each time that I have done this. If I have been recovering from something.
I always feel like I am completely cured after I’ve taken this.

Like every time I’ve ever used a Ayahusca I have felt better after the come down than I did when I took it.
It always feelt like it just cleared out my system to a weird extent.



Yup same here, and i think/believe/feel like it can even kill off the rona/covid, at least ime. Harmalas, Rue in particular, have/has anti-bacterial, anti-fungal, anti-viral and anti-parasitic properties, and the last few years anytime i've gotten sick i've taken Rue at 3 to 4 grams for about 4 days and i'm not longer sick, it seems to work, and i'm not vaccinated and i've caught the rona once like early on and it was rough, anytime since then though i start getting sick, i take Rue, it kills off whatever is making me sick, and i feel better on day 4 or 5 and back to normal. But it needs to be 3 to 4 grams of Rue, anything below that i think is not strong enough, and Harmala extracts may work but i think Rue has other things as well besides Harmalas that helps, so Rue ideally is better.

I do feel like it like cleans you out to some degree, or it could just be the active properties doing something to help us feel better.


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Re: Syrian Rue and mushrooms [Re: Sabnock] * 1
    #28501888 -

I don’t know if it has any effect on pushing it away.
But I know, for a fact, it did help me recover from Covid.
This last one rocked me. I have never gotten that sick from Covid before.
But after it was just dragging out for like the third week. I decided to do another trip. Afterwards it was done.
Like done.
I am still waiting to get my booster. But there is no doubt that this does have some anti-viral or bacterial qualities to it.
In my opinion. By no means should anyone reference this in any scientific capacity.

Edited by GenesisCorrupted (10/12/23 04:08 PM)

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted]
    #28501917 -

GenesisCorrupted said:
I don’t know if it has any effect on pushing it away.
But I know, for a fact, it did help me recover from Covid.
This last one rocked me. I have never gotten that sick from Covid before.
But after it was just dragging out for like the third week. I decided to do another trip. Afterwards it was done.
Like done.
I am still waiting to get my booster. But there is no doubt that this does have some anti-viral or bacterial qualities to it.
In my opinion. By no means should anyone reference this in any scientific capacity.



Indeed. I'm not saying it's a sure thing that it kills off covid, but ime it seems to, so i figure if someone is sick, they're gonna be down and out for a bit anyways, may as well give the Rue a try and see if it helps. I've suggested it in a few places so far, and i'm always eager for some feedback about my observations to see if anyone else notices the same things. So it's a possibility it helps, it may not, but i think it does, people just need to test it out and see and report back.


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Re: Syrian Rue and mushrooms [Re: Sabnock] * 1
    #28501960 -

You should make a thread. Try and collect all the experiences of people feeling better after taking a Ayahusca, MOA, or RIMA.
There isn’t nearly enough information on it. We just did a lot of discussion that doesn’t exist anywhere on Google.

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted] * 2
    #28501984 -

Great read :thumbup:

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Re: Syrian Rue and mushrooms [Re: Rockman] * 1
    #28502043 -

GC, if you were on your third week of Covid then you cannot attribute harmalas to be the cause of you getting better… your body should be able to fight it off within that timeframe anyway. Stop jumping to conclusions. There are more possibilities.

Sabnok, interesting you mention the allergies… this year has been my first time ever regularly doing harmalas and it has also coincided with my first ever year of bad allergies. I can’t for sure chalk it up to being The harmalas because I’ve also recently moved to a new state with different seasons and plants, but I have wondered if the harmalas could be exacerbating the stuffiness/itchiness in my nose.

Maybe I’ll try to go next allergy season without any harmalas to see if my allergies improve.


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"God is an intelligible sphere, whose center is everywhere and whose circumference is nowhere."

Llamando la Mareacion

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Re: Syrian Rue and mushrooms [Re: Bardy] * 1
    #28502048 -

I was waiting for a long time.
I’m not a scientist.
I felt sick.
Afterwords, I felt great.
Typically drugs lower your immune system.
So, with most drugs, I feel a little worse than I did before using them.
This was not the case with Ayahusca
By no means, am I trying to fuel any sort of weird conspiracy theory involving medicine.
Also, wasn’t an assumption. It was physically observable.

Edited by GenesisCorrupted (10/12/23 05:44 PM)

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted]
    #28502065 -

Maybe it's just pollen season Bardy and once the rain starts the allergies will go away?


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We are the music makers, the dreamers of dreams.

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted]
    #28502072 -

GC, You said you know for a fact it helped you recover. You keep using definite language like this and then when someone calls you out on it you act like you never said anything definite lol. You do not know for a fact that it helped you recover at all.

Northerner, yeah you’re probably right. I’ve heard from other people that this year was apparently a bad one for pollen in the area. Other people who have never had any allergies have been in the same boat as me… makes more sense.


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"God is an intelligible sphere, whose center is everywhere and whose circumference is nowhere."

Llamando la Mareacion

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Re: Syrian Rue and mushrooms [Re: Bardy]
    #28502086 -

For me. I can guarantee it’s gonna make me feel better afterwards.
I always say that everyone is different
I am not a scientist.
Do not take this as scientific advice.
I will be more careful.
But I always put disclaimers on these claims.
GenesisCorrupted said:
I don’t know if it has any effect on pushing it away.
But I know, for a fact, it did help me recover from Covid.
This last one rocked me.
I am still waiting to get my booster. But there is no doubt that this does have some anti-viral or bacterial qualities to it.
In my opinion. By no means should anyone reference this in any scientific capacity.



This is the entire quote without something being taken out of context.
I am trying to be more clear with my writing, though. So I appreciate the input.

Edited by GenesisCorrupted (10/12/23 06:09 PM)

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted]
    #28502107 -

I know you’re not a scientist, but just because we’re not scientists doesn’t mean we should go around claiming that harmalas cured our Covid without any good evidence. It’s all good man 👍 I don’t mean any offence, it’s all in the spirit of discussion.


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"God is an intelligible sphere, whose center is everywhere and whose circumference is nowhere."

Llamando la Mareacion

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Re: Syrian Rue and mushrooms [Re: Bardy]
    #28502115 -

For the record. I was on Ayahusca before I caught it too.

But I have done 17 trips of Ayahusca.
Every single time. I have felt better afterwards than I did before.
It seems to just make me feel better afterwards.
I’m also on a very strict diet because I do MAO. Which I’m sure has something to do with me feeling better.
I appreciate you.
Thanks for checking to make sure nobody is trying to spread any vaccine misinformation.
😎

Edited by GenesisCorrupted (10/12/23 06:20 PM)

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted] * 1
    #28502159 -

Yeah that’s normal to feel better after a trip, pretty sure that happens for everyone.

Even if you take harmalas just by themselves you’ll feel better afterwards as well, generally speaking.

I’m yet to have a full trip experience combining a psychedelic and harmalas. Maybe I will one day but I feel like psychedelics are strong enough for me without them.

Thanks man, appreciate it 😊

And Sabnock, you’re full of good info on harmalas. I’m just as keen on them as you are haha


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"God is an intelligible sphere, whose center is everywhere and whose circumference is nowhere."

Llamando la Mareacion

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Re: Syrian Rue and mushrooms [Re: Bardy]
    #28502335 -

As for the covid thing, again i just want to make note and say that i don't know for certain if it helps or not, but in my observations and experiments, it seems to be a consistent effect. Basically it goes like this, if i take Rue daily, i don't tend to get sick from viral infections (so far), if i don't take the Rue i eventually end up getting sick and i can definitely feel that i'm getting sick, and so i take the Rue usually at 4 grams but 4 grams is pretty damn strong lol, 3 to 3.5 grams of Rue may be fine though, i just go for 4 because i wanna make damn sure i get a full dose, but i take the Rue and the sick feeling goes away in 3 to 4 days, i'll take the Rue one night, the next day i'm feeling a little better so i take it again, the day after i feel almost back to normal and take it again, and on the 4th day i'm pretty much 100% back to normal but i'll take it again once more, and so 4 or 5 i feel 100% back to normal and no longer sick.

Harmaline has been shown to have active properties against herpes and influenza as far as it's anti-viral properties go, i'm not sure how truly effective it would be against those, but it is promising for potentially being useful against corona, plus like i said i don't think it's just the Harmalas, i could be wrong but i do believe that there are background compounds in Rue that are beneficial in that area, and 3 to 4 grams seems to be about the level where the background compounds definitely imo/ime contribute. So idk if Harmala extracts or full spectrum Rue extract would work just as well, perhaps next time i get sick and have some extract whipped up i'll give it a go with that at about say 200mgs maybe and see how it goes.

All we can really do right now is just observe and learn and use our intuition and try to figure out what's going on, at least until this is scientifically studied more, if it ever is anyways. But ime and from my own personal observations, i can't deny that it happens consistently, it seems to work, i get a certain feeling from corona compared to the typical flu so when i've gotten sick with corona a few times i know it was definitely corona, and when i take the Rue, it just knocks out whatever it is within a few days and i'm 100% back to normal and no longer feel sick and don't have any of the weird symptoms, heck even my taste and smell will go away when i get corona yet it'll come back when i dose the Rue, so i'm pretty sure that it's been corona rather than influenza. Idk if it's the anti-microbial properties (although i do suspect that to be the case), or if it's somehow activating/stimulating the immune system or something, idk, but i can't deny that it seems to work.

Again, this is not to be taken as some sort of proven fact and i don't want people risking their lives for some experimentation if they really need like an actually proven treatment like an anti-viral pill or something or ya know, the vaccine, personally though i'm pretty good at figuring things out and while i'm not always right, i do seem to be most often right lol, and so idk, my gut tells me to stick with the Rue. And like i said, it seems to act as some sort of preventative as well, because if i take Rue daily at the right dosage, i don't get sick, but if i stop taking Rue, i definitely get sick lol, so it seems that not only can Rue possibly help prevent you from getting it, it may also help to kill it off.

Again, not scientifically proven, not a risk worth taking if one like needs a hospital/doctor, i'm just my own doctor because i'm smart enough and the doctors i've seen apparently don't know much at all, whether general practitioners or psychiatrists, they just want to prescribe pills, they don't really do any detective work or try to figure out what's going on, like i said i was even low in my B vitamins especially Folate and it's been obvious to me for a long while now, yet everything "seemed" fine on my bloodwork last time i went to the doctor, but idk what all they can see from the bloodwork, but in any case i had/have the signs of being low in Folate and such and you would think a doctor would pick up on malnutrition but apparently not. Maybe i just live in an area with shitty doctors, idk.

Edit - Also due to Rue feeling rather rough at 4 grams especially if dosed regularly and the reverse tolerance builds up, this is one reason why it can be a good thing to have other things in the mix with the Rue in order to alter it's effects or clean up it's bodyload. Many different plants and supplements for example can be mixed with Rue to alter it in various ways, Harmalas and DMT are very malleable and can be altered pretty easily depending on what's in the mix. So like using 3 to 4.5 grams of dried Lemon Balm leaf tea can help clean up the Rue's bodyload and can help it feel better if using 4 grams of Rue because of the cleaner bodyload. Although to add to that, adding something to the Rue may alter it's anti-microbial properties, alter meaning it may either contribute to/enhance the anti-microbial properties, or it may reduce the effectiveness by interfering with the active mechanisms, i've seen lots and lots of personal evidence/observation of different things with anti-microbial properties kinda contradicting one another, and so i know Rue on it's own seems to work, Rue with Lemon Balm may still work, but with other things idk, would just have to mix things together and see what all happens, that's what i do.


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Edited by Sabnock (10/12/23 08:23 PM)

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Re: Syrian Rue and mushrooms [Re: Bardy]
    #28502345 -

Quote:
Bardy said: And Sabnock, you’re full of good info on harmalas. I’m just as keen on them as you are haha



Thanks, i've definitely learned a lot about this stuff by working with it so much and really paying attention and looking into things, figuring things out, experimenting around and trying different things. A lot of people don't really understand this medicine, so i just like to share what all i've come across in my studying and experimentations.


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Re: Syrian Rue and mushrooms [Re: Sabnock]
    #28502405 -

The only problem I see is that with a lot of viral infections they tend to resolve themselves completely within 3-5 days without any treatment anyway. Of course, in a study with a population of 1 there is no way to tell whether the treatment actually did anything or not, so it is just an anecdote (which I know you’ve already acknowledged).

Also, harmalas make you feel good, so they would be an effective treatment in reducing some of the symptoms of common viral infections such as lethargy or low mood and pain. So it could possibly just be masking symptoms and allowing your body to get over the infection naturally. Just another thing to consider.


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"God is an intelligible sphere, whose center is everywhere and whose circumference is nowhere."

Llamando la Mareacion

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Re: Syrian Rue and mushrooms [Re: Bardy]
    #28502409 -

Bardy said:
The only problem I see is that with a lot of viral infections they tend to resolve themselves completely within 3-5 days without any treatment anyway. Of course, in a study with a population of 1 there is no way to tell whether the treatment actually did anything or not, so it is just an anecdote (which I know you’ve already acknowledged).

Also, harmalas make you feel good, so they would be an effective treatment in reducing some of the symptoms of common viral infections such as lethargy or low mood and pain. So it could possibly just be masking symptoms and allowing your body to get over the infection naturally. Just another thing to consider.



Precisely it makes you feel better.
But why wouldn’t I go back to feeling sick like I did before. But better?
That’s the only reason I said that.
I found it remarkable enough to say it that confidently to.

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted] * 1
    #28502586 -

Because your immune system is killing the virus. It’s possible the Rue has some anti viral properties, I have no idea, but it’s also possible that while you’re feeling good from the Rue your body is just going about it’s normal immune response and killing the virus. Then by the time you’ve stopped taking the Rue your immune system has managed to fight it all away.

It could be just working in a similar manner to taking cold and flu medication (just treating the symptoms and not actually killing the virus itself).

Maybe it helps your immune system work faster in some way as well? Who knows…

All I’m doing is trying to highlight that there are many other possible ways that harmalas might be making you feel better. It’s not clear how, or if, it even works for treating viruses.

Do you see where I’m coming from?


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"God is an intelligible sphere, whose center is everywhere and whose circumference is nowhere."

Llamando la Mareacion

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Re: Syrian Rue and mushrooms [Re: Bardy]
    #28502591 -

ah
But here’s the rub.
We both used drugs. We know for a fact that drugs always lower your immune system.

https://www.hiv.va.gov/patient/daily/alcohol-drugs/immune-system.asp

I was in fact, still sick. Runny nose, coughing throat having trouble sleeping temperature shifts. The whole 9 yard. Now the symptoms were lessened. From when I had first gotten sick. But I was definitely still sick.
So I have been waiting like two weeks to do this stuff.
All of the symptoms I was suffering were the same as what I would, to a very minute degree experience when I tried Ayahusca. So I figured what the hell.

So my immune system went down.
Just a little bit. But it did get lowered.
Now, when I came back. I was no longer on the compound.
I should have been as sick as I was going into it. If not just slightly worse.
Now, as you said, it is possible that because of my serotonin. Maybe my body was operating at a high level of awesome. Maybe that boosted my mood. Enough that my immune system kicked up a notch.
But the drug did lower it. So at the very least. I feel like the effect would leave me about where my immune was already overall.

I was not sick at all after I came back to my recollection.
I am not a doctor or a scientist.
But I would never lie about that stuff. That was my experience.
I also do remember reading that DMT did have some immune boosting affects. Here’s an article.
http://www.actionchildren.org/incredible-things-about-mimosa-hostilis/

Edited by GenesisCorrupted (10/12/23 11:42 PM)

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted] * 2
    #28502632 -

You just contradicted yourself in your comment.

At the start you said “we know for a fact drugs lower your immune system”, then at the end you said “I read that DMT had some immune boosting effects”.

Take a break man, give your mind a rest ✌️


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"God is an intelligible sphere, whose center is everywhere and whose circumference is nowhere."

Llamando la Mareacion

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Re: Syrian Rue and mushrooms [Re: Bardy]
    #28502644 -

Well, every drug that makes you get high does
That doesn’t need an article. That was unrelated.
Like not getting enough sleep is enough to lower your immune system sometimes.

https://www.hiv.va.gov/patient/daily/alcohol-drugs/immune-system.asp

But yes, I do suspect that DMT could have their own articles written that they also do you lower your immune system. But there’s new research being done all the time. Maybe it actually is in fact, boosting it.
I’m debating whether or not it does with you. I’m not sure it does. I’m just telling you my experience with it.

So what I’m saying is. That because it makes you high. It does lower your immune system. But separately of that. This compound could have things that are actively boosting your immune system at the same time.

Edited by GenesisCorrupted (10/14/23 12:33 AM)

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted]
    #28502647 -

Unfortunately, there isn’t very much on psychedelics. So I’m just using the concept to go off of here.
If it makes you get high enough that you were inebriated. Or you’re tripping. Or you’re seeing some thing. Or your mood is altered. For the most part. That is going to lower your immune system.
Even steroidal cream can lower your immune system.

https://www.edgewoodhealthnetwork.com/resources/blog/how-do-drugs-and-alcohol-affect-the-immune-system/

Edited by GenesisCorrupted (10/12/23 11:46 PM)

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted] * 1
    #28502649 -

Back in my heavy druggie days I always used to cure colds with methcathinone. Not that the cat cures the cold, but 2 days of being high and feeling great while my body fought off the cold was way better than 2 days of feeling like shit. :tongue2:


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We are the music makers, the dreamers of dreams.

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Re: Syrian Rue and mushrooms [Re: Northerner]
    #28502654 -

Northerner said:
Back in my heavy druggie days I always used to cure colds with methcathinone. Not that the cat cures the cold, but 2 days of being high and feeling great while my body fought off the cold was way better than 2 days of feeling like shit. :tongue2:




“ I only know that I know nothing”

That was some wisdom right there though.

Edited by GenesisCorrupted (10/12/23 11:54 PM)

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted] * 1
    #28502734 -

GenesisCorrupted said:
You should make a thread. Try and collect all the experiences of people feeling better after taking a Ayahusca, MOA, or RIMA.
There isn’t nearly enough information on it. We just did a lot of discussion that doesn’t exist anywhere on Google.



In fact there is psilohuasca thread about combining rue and shrooms.

:rocket::rocket::rocket:

For the first timers if you taken raw rue, I strongly recommend not to exceed 2 grams or 2.5 of syrian rue because of strong weird side effects like retrograd amnesia, motion sickness, tinnitus and diarrae. Once you get used to effects you can take more.

:rocket::rocket::rocket:

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted] * 1
    #28502804 -

GenesisCorrupted said:
Unfortunately, there isn’t very much on psychedelics. So I’m just using the concept to go off of here.
If it makes you get high enough that you were inebriated. Or you’re tripping. Or you’re seeing some thing. Or your mood is altered. For the most part. That is going to lower your immune system.



It's stress causing this.  Drugs don't lower your immune system as a general rule, some in fact boost it as mentioned above.  Some will lower it.

But both positive and negative stress (excitement and anxiety) pulls us out of homeostasis (a calm, awake state).  This calm awake state is the best place for the body and mind to heal.

So, I would put forth, rather or not psychedelics improve or lower the immune system, is going to depend on rather it increases or lowers your stress.  And that's going to mostly depend on set and setting.


--------------------
And if I only could
I'd make a deal with God
And I'd get him to swap our places
I'd be running up that road
Be running up that hill
With no problems

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Re: Syrian Rue and mushrooms [Re: tree frog] * 2
    #28502896 -

Preparing the shroom tea now and the rue is about to go down the hatch. I'm a little scared but it's all part of the fun. Here I go then.


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Re: Syrian Rue and mushrooms [Re: Turvenuija]
    #28502899 -

Turvenuija said:
Preparing the shroom tea now and the rue is about to go down the hatch. I'm a little scared but it's all part of the fun. Here I go then.



Enjoy the ride!


--------------------
And if I only could
I'd make a deal with God
And I'd get him to swap our places
I'd be running up that road
Be running up that hill
With no problems

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Re: Syrian Rue and mushrooms [Re: Turvenuija]
    #28502900 -

You are going to have an amazing day.
You do have a trip sitter though, right?

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Re: Syrian Rue and mushrooms [Re: Turvenuija] * 1
    #28502936 -

The rue feels nice, it has a calming effect. All the jitters melted away, I just drank my tea. Let's see what all the fuss is about!


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Re: Syrian Rue and mushrooms [Re: Turvenuija] * 1
    #28502941 -

That is instantly observable. You will just feel like you are fine.
This is the oldest antidepressant.

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Re: Syrian Rue and mushrooms [Re: Turvenuija] * 1
    #28502942 -

GenesisCorrupted said:
You are going to have an amazing day.
You do have a trip sitter though, right?



Never had one, everyone I know is against drugs so I won't even ask. In the beginning I probably could've used one but now I can handle things. I won't be replying for a while, have a good day people!


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Re: Syrian Rue and mushrooms [Re: Turvenuija] * 2
    #28503323 -

Wow, what an experience or so I'd say if I could remember a thing :lol: Somehow I had 0 nausea which unusual for me. I'm so glad I tried rue though, never tripping without it if I can help it.


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Re: Syrian Rue and mushrooms [Re: Turvenuija]
    #28503334 -

Turvenuija said:
Wow, what an experience or so I'd say if I could remember a thing :lol: Somehow I had 0 nausea which unusual for me. I'm so glad I tried rue though, never tripping without it if I can help it.



Awesome news.
Your body will get hip to the jive next time though.
😂

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Re: Syrian Rue and mushrooms [Re: Turvenuija]
    #28503352 -

Turvenuija said:
Wow, what an experience or so I'd say if I could remember a thing :lol: Somehow I had 0 nausea which unusual for me. I'm so glad I tried rue though, never tripping without it if I can help it.




So about six hours?

I'm wanting to do a psiluasca circle with some friends.  Dose maois and make a pot of mushroom tea people can sip on.

Would be good to know how long we'll be in for lol


--------------------
And if I only could
I'd make a deal with God
And I'd get him to swap our places
I'd be running up that road
Be running up that hill
With no problems

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Re: Syrian Rue and mushrooms [Re: tree frog]
    #28503368 -

Hard to say exactly since I'm still coming down, the peak lasted for 3-4 hours I think and then I started sobering up, the effects linger for far longer than usual which makes sense. Maybe I should've redosed some rue to keep the peak going?


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Re: Syrian Rue and mushrooms [Re: Turvenuija]
    #28503373 -

I have taken 3g rue.
When prepped and dieting beforehand.
My trips have lasted longer than 8 hours before.
Thats why a trip sitter isn’t a bad suggestion until you know how potent your ingredients are.

Heres a cautionary tale…
https://www.shroomery.org/forums/showflat.php/Number/28429684

I even had a sitter but didnt know i would be energized.
I was prepped for a chill time lol.
Turns out I have ADD or ADHD.

Edited by GenesisCorrupted (10/13/23 05:38 PM)

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Re: Syrian Rue and mushrooms [Re: Bardy]
    #28503592 -

Bardy said:
The only problem I see is that with a lot of viral infections they tend to resolve themselves completely within 3-5 days without any treatment anyway. Of course, in a study with a population of 1 there is no way to tell whether the treatment actually did anything or not, so it is just an anecdote (which I know you’ve already acknowledged).

Also, harmalas make you feel good, so they would be an effective treatment in reducing some of the symptoms of common viral infections such as lethargy or low mood and pain. So it could possibly just be masking symptoms and allowing your body to get over the infection naturally. Just another thing to consider.



Maybe some folks recover in 3 to 4 days, but for one they've shown that with other anti-viral treatments that one can recover from covid in about 3 to 4 days, and also when i've gotten sick from covid it's been like a 2 week or so thing, the only way i'm no longer sick in a shorter timeframe than that seems to be when i take the Rue.

Also if it was just feeling good/better, i'd know, Rue doesn't exactly make me feel good/better, to me it's just an MAOI with a few other properties, it can feel rather healthy in general but i'm well accustomed to the effects of Rue having dosed it for a long time now and when i get sick i know and when the Rue seems to help me not be sick i know, there's a different feeling there, i can feel the sickness, and then i can no longer feel it. I really don't think the Rue is making me feel better in and of itself, and personally the timeframe of about 3 to 4 days does line up with the timeframe for other anti-virals from what i've read, so i'm pretty sure it has something to do with the anti-microbial properties, which the anti-microbial properties are pretty strong ime.

Just an observation i know, but idk i feel like there's something to it.

Also if it were something as simple as having more Serotonin, Dopamine and Noradrenaline, i would notice the same effect most likely from 5-HTP and L-Dopa with the P5P B6 but while i definitely get my neurotransmitters from them they don't make covid go away lol. So the Rue's MAO-A inhibition at least is imo not likely to contribute to me feeling/getting better.


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Re: Syrian Rue and mushrooms [Re: Turvenuija] * 3
    #28503609 -

Turvenuija said:
Wow, what an experience or so I'd say if I could remember a thing :lol: Somehow I had 0 nausea which unusual for me. I'm so glad I tried rue though, never tripping without it if I can help it.



Yup, many people seem to like how the Harmalas impact the mushroom experience. Psilohuasca is essentially/basically Ayahuasca, but using mushrooms instead of DMT, same medicine, some slight differences, but can be very DMT-esque, it reminds me of something someone said before in that it's like the Harmalas brings out the DMT part of the molecule, to me it feels almost just like DMT but a bit lighter, less serious, a bit more relaxed, likely due to the lack of Adrenergic action that Psilocin has compared to DMT which is very Adrenergic. But all in all it's still Ayahuasca none the less, which i know it's Rue and Aya is Caapi but i see the Harmalas as being "the Huasca" and so for me Caapi and Rue are like different flavors/variations of the same underlying medicine and as such is basically the same thing, with some differences, still takes you where need to go.

Another thing for me is that for some odd reason, i find that Psilohuasca makes mushrooms and even 4-ACO-DMT feel way more mushroomy than straight mushrooms, even with 4-ACO-DMT i would feel this mushroom-like feel and i'd keep seeing visuals of mushrooms growing, and Psilohuasca using 4-ACO-DMT feels pretty much the same to me as Psilohuasca using mushrooms, the come up of 4-ACO may be a little different but once it metabolizes into Psilocin in the body, which i can feel when it happens, it from that moment is just the same as the Psilocin in mushrooms.

Also the duration should be closer to about 9 to 12 hours, but that depends on dosages and timing, so long as gut MAO-A is fully inhibited when the mushrooms are consumed, the Psilocin should be properly potentiated and lengthened in duration, if it's shorter than about 9 to 12 hours, could be the Rue dose, could be the mushroom dose, could be the timing between them as well as one's digestion, but once you hit the gut's MAO-A inhibition right it'll extend out to 9 to 12 hours. Another thing is the CYP2D6 enzyme which some folks have lower or higher amounts of, and if one is higher in CYP2D6 they would have a reduced duration most likely for the Harmalas and would metabolize them out faster, whereas those low in CYP2D6 wouldn't need as much of a dosage and would likely have a longer duration of Harmala effects. But yeah once you get the hang of the dosages and timing you should get the full duration.

Overall i take it that it went well? Personally i love the combo, and i can't wait to work with it more in the future whenever i more fully dive back into experimentation mode again. One thing i wanna try out more, that i've only done once, is take mushrooms with my normal dose of Acacia or Mimosa and the Rue, and some Lemon Balm, because one time i took like i think 600 to 800mgs of potent mushroom powder capsules 30 minutes after my Rue and then an hour into the Rue i drank my Acacia and my i think 4 gram Lemon Balm tea, and even that low of a dose of mushrooms synergized with and added to/enhanced  the Acacia/DMT, it was a very lovely combination, and very smooth too with the Lemon Balm in the mix.

Psilohusca is definitely worth exploring further, i just wish it didn't have tolerance unlike DMT lol.


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Re: Syrian Rue and mushrooms [Re: Sabnock]
    #28503801 -

Sabnock said:
Turvenuija said:
Wow, what an experience or so I'd say if I could remember a thing :lol: Somehow I had 0 nausea which unusual for me. I'm so glad I tried rue though, never tripping without it if I can help it.



Yup, many people seem to like how the Harmalas impact the mushroom experience. Psilohuasca is essentially/basically Ayahuasca, but using mushrooms instead of DMT, same medicine, some slight differences, but can be very DMT-esque, it reminds me of something someone said before in that it's like the Harmalas brings out the DMT part of the molecule, to me it feels almost just like DMT but a bit lighter, less serious, a bit more relaxed, likely due to the lack of Adrenergic action that Psilocin has compared to DMT which is very Adrenergic. But all in all it's still Ayahuasca none the less, which i know it's Rue and Aya is Caapi but i see the Harmalas as being "the Huasca" and so for me Caapi and Rue are like different flavors/variations of the same underlying medicine and as such is basically the same thing, with some differences, still takes you where need to go.




I've heard you say that a lot comparing psilohuasca and ayahuasca, I've taken psilohuasca regularly for a few years now but I've been a bit scared of taking oral dmt - any advice you can give for someone experienced with psilohusca trying oral DMT, anything I should be aware of about how they differ? I wouldn't be working with traditional DMT sources but I have brewed MHRB and ACRB and have caapi as well, dunno, after vaping DMT a few times the strength of it has me tentative about taking the dive on oral DMT.

How much does oral dmt differ or not from the psilohuasca experience? I've always been comfortable with psilohuasca and never had any problems even taking 5g+ of shrooms and 3.5g+ of syrian rue(though I normally prefer about 4-4.5g shrooms and 3-3.5g of rue) so I don't know if I am getting worked up over nothing and psyching myself out listening to people who say how intense ayahuasca is or that think you need a shaman hitting you with palm fronds and singing icaros for hours to have ayahuasca go well, obviously I don't believe that, but still, I'd appreciate any insight you could provide.


--------------------
Good name is better than silver and gold
And no money can buy good name
I have a good name
And no money can buy my name
Do you have a good name?
Then no money should buy your name

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Re: Syrian Rue and mushrooms [Re: MustNotBe] * 1
    #28503858 -

Did I miss something? Why revive a 16 year old thread when the psilohuasca thread is newer and contains actual trip reports and everything? I thought it was against the rules to necropost especially if there's a more up to date thread already.

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Re: Syrian Rue and mushrooms [Re: ItAintGotNoGasInIt] * 1
    #28503885 -

Quote:
ItAintGotNoGasInIt said: I've heard you say that a lot comparing psilohuasca and ayahuasca, I've taken psilohuasca regularly for a few years now but I've been a bit scared of taking oral dmt - any advice you can give for someone experienced with psilohusca trying oral DMT, anything I should be aware of about how they differ? I wouldn't be working with traditional DMT sources but I have brewed MHRB and ACRB and have caapi as well, dunno, after vaping DMT a few times the strength of it has me tentative about taking the dive on oral DMT.

How much does oral dmt differ or not from the psilohuasca experience? I've always been comfortable with psilohuasca and never had any problems even taking 5g+ of shrooms and 3.5g+ of syrian rue(though I normally prefer about 4-4.5g shrooms and 3-3.5g of rue) so I don't know if I am getting worked up over nothing and psyching myself out listening to people who say how intense ayahuasca is or that think you need a shaman hitting you with palm fronds and singing icaros for hours to have ayahuasca go well, obviously I don't believe that, but still, I'd appreciate any insight you could provide.



I'd say go for the Acacia, it's ime better/higher quality than Mimosa even though Mimosa is no doubt good too, i find Acacia to be more mystical and sacred personally, feels better too and also has NMT in it as well. As for how oral DMT and Psilocin in the Huasca differ, they feel pretty similar/the same for the most part, but Psilocin has more of a mushroomy feel + the DMT feel, and the DMT is sharper and more Adrenergically intense.

If you want to take oral DMT, i highly recommend taking a dose of Acacia (or Mimosa) tea, diluting it to like a small Coffee cups worth of liquid, you can warm it up in the microwave and add sweetness to it as well if desired, and then sip on the tea for 10 to 15 minutes, drinking it all within 10 to 15 minutes, just space the sips out enough so that you finish it by 10 to 15 minutes, doing so will allow the DMT to come on much more smoothly and less intensely, even to the point of having little to no intensity at all during the come up. If you still find it a bit too intense, you can also make a tea from 3 to 4.5 grams of dried Lemon Balm leaf, and either drink that right before or after the Acacia, or mix it with the Acacia and drink them together at the same time.

Though Acacia or Mimosa teas are more palatable when you clean them up by freezing/thawing/filtering the bulk Acacia or Mimosa tea a few good times and then on the last freeze/thaw you use a syringe or turkey baster to siphon off the clean tea away from any tea at the bottom with any remaining plant crud, which will leave you with a very clean Acacia or Mimosa tea that is rather palatable and not difficult to drink, then you can try adding the Lemon Balm to the Acacia tea, and not only will it counteract Harmaline's GABA-A inverse agonism by inhibiting GABA Transaminase and raising GABA levels and in doing so will clean up the Rue/Harmala bodyload, but will also remove the intensity from the oral DMT and smooth out the come up, as well as add anti-anxiety and relaxative properties to the mix. All of my most mystical/spiritual/religious experiences were with Lemon Balm in the mix, it doesn't seem to dull things down from 3 to 4.5 grams of dried leaf, ime.

As for vaping DMT, try Changa, and sip the smoked DMT, basically you smoke some Harmalas, then you smoke a few puffs of some Changa or DMT-enhanced leaf, once the intense come up happens sit the pipe down for a couple minutes and wait for the come up to pass and then once the come up has passed and the effects are stable, continue to smoke the DMT and then it will hit so smoothly and gently and you can work your way into deep territory, comfortably. It seems whether smoking or drinking, sipping on the DMT is the better way to go ime.

But yeah Ayahuasca and Psilohuasca feel very similar, it's just DMT has Alpha Adrenergic agonism while Psilocin doesn't, so it's the Alpha Adrenergic agonism that makes it so intense. You could technically take an Alpha Adrenergic receptor antagonist of some sort and then the DMT's Adrenergic intensity should go away, imo, but no need to do that when you can just "sip" on the DMT.


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Re: Syrian Rue and mushrooms [Re: Sabnock] * 2
    #28503960 -

Sabnock said:
Turvenuija said:
Wow, what an experience or so I'd say if I could remember a thing :lol: Somehow I had 0 nausea which unusual for me. I'm so glad I tried rue though, never tripping without it if I can help it.



Yup, many people seem to like how the Harmalas impact the mushroom experience. Psilohuasca is essentially/basically Ayahuasca, but using mushrooms instead of DMT, same medicine, some slight differences, but can be very DMT-esque, it reminds me of something someone said before in that it's like the Harmalas brings out the DMT part of the molecule, to me it feels almost just like DMT but a bit lighter, less serious, a bit more relaxed, likely due to the lack of Adrenergic action that Psilocin has compared to DMT which is very Adrenergic. But all in all it's still Ayahuasca none the less, which i know it's Rue and Aya is Caapi but i see the Harmalas as being "the Huasca" and so for me Caapi and Rue are like different flavors/variations of the same underlying medicine and as such is basically the same thing, with some differences, still takes you where need to go.

Another thing for me is that for some odd reason, i find that Psilohuasca makes mushrooms and even 4-ACO-DMT feel way more mushroomy than straight mushrooms, even with 4-ACO-DMT i would feel this mushroom-like feel and i'd keep seeing visuals of mushrooms growing, and Psilohuasca using 4-ACO-DMT feels pretty much the same to me as Psilohuasca using mushrooms, the come up of 4-ACO may be a little different but once it metabolizes into Psilocin in the body, which i can feel when it happens, it from that moment is just the same as the Psilocin in mushrooms.

Also the duration should be closer to about 9 to 12 hours, but that depends on dosages and timing, so long as gut MAO-A is fully inhibited when the mushrooms are consumed, the Psilocin should be properly potentiated and lengthened in duration, if it's shorter than about 9 to 12 hours, could be the Rue dose, could be the mushroom dose, could be the timing between them as well as one's digestion, but once you hit the gut's MAO-A inhibition right it'll extend out to 9 to 12 hours. Another thing is the CYP2D6 enzyme which some folks have lower or higher amounts of, and if one is higher in CYP2D6 they would have a reduced duration most likely for the Harmalas and would metabolize them out faster, whereas those low in CYP2D6 wouldn't need as much of a dosage and would likely have a longer duration of Harmala effects. But yeah once you get the hang of the dosages and timing you should get the full duration.

Overall i take it that it went well? Personally i love the combo, and i can't wait to work with it more in the future whenever i more fully dive back into experimentation mode again. One thing i wanna try out more, that i've only done once, is take mushrooms with my normal dose of Acacia or Mimosa and the Rue, and some Lemon Balm, because one time i took like i think 600 to 800mgs of potent mushroom powder capsules 30 minutes after my Rue and then an hour into the Rue i drank my Acacia and my i think 4 gram Lemon Balm tea, and even that low of a dose of mushrooms synergized with and added to/enhanced  the Acacia/DMT, it was a very lovely combination, and very smooth too with the Lemon Balm in the mix.

Psilohusca is definitely worth exploring further, i just wish it didn't have tolerance unlike DMT lol.



It was very DMT-esque, like a dream. I felt that I rediscovered something very important that I've seen and forgotten before. I would guess I didn't take enough rue and the timing was off, my scale is very cheap and old by now and I have no idea if it's accurate enough, I'll buy a better scale soon.

Went very smoothly overall, for years I've had an issue with mushrooms alone where I struggle to dive in, when I close my eyes I start seeing dark rooms and very mundane things like furniture and people's backs from annoying angles where it's hard to tell what I'm looking at and I get stuck in thought loops fearing that I'll never experience those amazing trips I used to have. This used to derail the whole experience and I was unable to explore closed eye visuals at all. Rue threw that nonsense out the window and I got exactly what I wanted with just 2 grams of shrooms, I can't wait to find out what stronger doses have in store.


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Re: Syrian Rue and mushrooms [Re: Turvenuija]
    #28503961 -

If lightly ground. I find that three of the triple zero empty pill capsules will almost always be a gram every time.
I’m not talking about dust. I’m talking about almost entirely intact seeds.
As long as you get the consistency that you’re looking for. You will know how many pills to take.

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted] * 1
    #28504017 -

GenesisCorrupted said:
If lightly ground. I find that three of the triple zero empty pill capsules will almost always be a gram every time.
I’m not talking about dust. I’m talking about almost entirely intact seeds.
As long as you get the consistency that you’re looking for. You will know how many pills to take.



Yeah i use size 00 capsules and grind the seed into a powder using a coffee grinder and pack the powder in the capsules, i can fit a gram into each capsule just by filling it up completely and packing it, the cap doesn't go on all the way though but it works lol, size 000 capsules would likely be better though.


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Re: Syrian Rue and mushrooms [Re: Sabnock] * 1
    #28504510 -

I just grind the seeds and drink it with water, just small diarrhae, not bad taste, it gets good once you get used to. One teaspoon is almost 1 gr...Sometimes I combine with ginkgo biloba extract 80 mg and sometimes an acetylcholinesterase inhibitor like rivastigmine 1.5 mg makes trip more expanded and rememberable...more rememberable experience means alot to me, remembering more information and states to digest and replicate when I am sober.

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Re: Syrian Rue and mushrooms [Re: taskamil] * 1
    #28504520 -

Yeah, that really bummed me out when he said he couldn’t remember his trip.
Even as crazy as things can get when you do too much Ayahusca. I have been able to remember everything.
There’s no harm in taking some omega oil right before the trip. It probably would be better absorbed.

Edited by GenesisCorrupted (10/14/23 04:25 PM)

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted] * 2
    #28505510 -

Ah don't be, I'm not. The memory is in there somewhere, just dormant and inaccessible.
Every time I trip I open doors and recognise I've been here before and it feels like coming home every time. "Wait hang on, ah that's what it was. Everything is clear again..." and so on.
It does make it hard to apply much to my everyday life but I believe as long as my subconsciousness learns something I'll be fine.


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Re: Syrian Rue and mushrooms [Re: Turvenuija] * 1
    #28505571 -

Yup i've noticed that too, it's like when i take Aya again it all comes right back to my memory and i remember, and i start back where i left off pretty much, it's like an ongoing process even if i haven't taken it for years lol.


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Re: Syrian Rue and mushrooms [Re: Sabnock] * 1
    #28505576 -

This is a personal experience. It probably wouldn’t work for everyone.
But did you listen to any music while you were tripping?
My third trip was heavy enough that I did have some blanks in my memory. But a song went off on my phone during the trip. As soon as I heard it again the next day. Immediate total recall.

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Re: Syrian Rue and mushrooms [Re: GenesisCorrupted] * 1
    #28505605 -

I've never tripped without music, I should probably try that sometime too. Listening to the same music even years later does instantly bring me back, I get a very trippy feeling and flashbacks start playing in my mind.
I don't get the whole picture from it, there's always so many sights, ideas and thoughts synchronizing while tripping that it just doesn't fit inside a sober mind which I'm sure is relatable to many.
I try to save my favorite trip songs for trips so I don't ruin them by listening too much, but every now and then I do listen to get some reminders when life has me down.


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