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OfflineSirFrancisBacon
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Registered: 03/14/05
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Natural-born painkiller found in human saliva
    #6281135 - 11/14/06 12:14 AM (17 years, 3 months ago)

http://www.newscientist.com/article.ns?id=dn10514&feedId=online-news_rss20

Natural-born painkiller found in human saliva

* 22:00 13 November 2006
* NewScientist.com news service
* Andy Coghlan

Saliva from humans has yielded a natural painkiller up to six times more powerful than morphine, researchers say.

The substance, dubbed opiorphin, may spawn a new generation of natural painkillers that relieve pain as well as morphine but without the addictive and psychological side effects of the traditional drug.

When the researchers injected a pain-inducing chemical into rats’ paws, 1 gram of opiorphin per kilogram of body weight achieved the same painkilling effect as 3 grams of morphine.

The substance was so successful at blocking pain that, in a test involving a platform of upended pins, the rats needed six times as much morphine as opiorphin to render them oblivious to the pain of standing on the needle points.
Anti-depressive angle

“Its pain-suppressive effect is like that of morphine,” says Catherine Rougeot at the Pasteur Institute in Paris, France, who led the research. “But we have to test its side effects as it is not a pure painkiller,” she says. “It may also be an anti-depressive molecule.”

Rougeot and colleagues discovered that opiorphin works in nerve cells of the spine by stopping the usual destruction of natural pain-killing opiates there, called enkephalins.

Opiorphin is such a simple molecule that it should be possible to synthesise it and produce large quantities without having to isolate it from saliva, Rougeot explains. Alternatively, it might be possible to find drugs which trigger patients’ bodies to produce more of the molecule themselves.

Journal reference: Proceedings of the National Academy of Sciences (vol 103, p 17979)


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Offlinetools_n_corpses
why did i choosethis name
Male
Registered: 09/27/06
Posts: 172
Last seen: 16 years, 3 months
Re: Natural-born painkiller found in human saliva [Re: SirFrancisBacon]
    #6281411 - 11/14/06 03:29 AM (17 years, 3 months ago)

How do I extract it? And will my saliva become an illegal substance? It's already enough trouble draining all the DMT from my brain every morning.


--------------------
"Misery only doth exist, none miserable,

No doer is there; naught save the deed is found.

Nirvana is, but not the man who seeks it.

The Path exists, but not the traveler on it.
"


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Offlineflower_child
Dawson
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Registered: 12/13/05
Posts: 677
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Re: Natural-born painkiller found in human saliva [Re: tools_n_corpses]
    #6281436 - 11/14/06 04:28 AM (17 years, 3 months ago)

They make mice stand on needle points?

Well that's kind of fucked up.


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Today while walking up the stairs
I met a man who wasn't there
He wasn't there again today
Oh how I wish he'd stay away


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Offlinecookeman
Live and let live
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Registered: 10/26/05
Posts: 1,077
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Re: Natural-born painkiller found in human saliva [Re: flower_child]
    #6281453 - 11/14/06 05:04 AM (17 years, 3 months ago)

Anything it takes to make spit illegal. :rofl: that's kinda weird that it took that long to figure this out if it's legit


--------------------
“Let’s put it this way – to lump psychedelic mushrooms into the same group as methamphetamine is like lumping the Bible into the same group as Mein Kampf.
I mean shit; they’re both books, right?”

Joe Rogan


R.I.P. - "Bones" - One of the greatest people I've ever had the pleasure of getting to know and become friends with.


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OfflineApJunkie
part-time Ninja
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Registered: 08/17/06
Posts: 2,735
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Re: Natural-born painkiller found in human saliva [Re: cookeman]
    #6281865 - 11/14/06 10:03 AM (17 years, 3 months ago)

so wait, my mommys kisses really DID make it better?


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InvisibleEgo Death
Justadropofwaterinanendlesssea
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Registered: 04/27/03
Posts: 10,447
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Re: Natural-born painkiller found in human saliva [Re: SirFrancisBacon]
    #6282009 - 11/14/06 11:04 AM (17 years, 3 months ago)

>opiorphin

What a shat name. Makes it sound like an opiod.


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OfflineJorsher
Psychonaut
Male

Registered: 08/28/06
Posts: 691
Loc: Earth
Last seen: 13 years, 2 months
Re: Natural-born painkiller found in human saliva [Re: Ego Death]
    #6282070 - 11/14/06 11:18 AM (17 years, 3 months ago)

Hurry up and synthesize please. Thanks


--------------------
5 shroom me!


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OfflineOjom
member
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Folding@home Statistics
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Re: Natural-born painkiller found in human saliva [Re: flower_child]
    #6282118 - 11/14/06 11:34 AM (17 years, 3 months ago)

Quote:

flower_child said:
They make mice stand on needle points?

Well that's kind of fucked up.




Indeed


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Offlinededjam
Electro Penguin
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Re: Natural-born painkiller found in human saliva [Re: Ojom]
    #6282387 - 11/14/06 01:00 PM (17 years, 3 months ago)

Ok, so time to start collecting spit while waiting on an extraction technique lol


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OfflinegrimR
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Registered: 03/29/06
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Re: Natural-born painkiller found in human saliva [Re: dedjam]
    #6282528 - 11/14/06 01:47 PM (17 years, 3 months ago)

Wonder what the % it is in the saliva... I can see it now can o' spit for 20 bucks all day buzz.


--------------------
- grimR


-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-
http://egolost.com 
"I am already given to the power that rules my fate. And I cling to nothing, so I will have nothing to defend. I have no thoughts, so I will see. I fear nothing, so I will remember myself."

- Don Juan teachings


Edited by grimR (11/14/06 01:48 PM)


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OfflineLily_Morgan
I'm #1 !!
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Registered: 07/05/06
Posts: 437
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Re: Natural-born painkiller found in human saliva [Re: grimR]
    #6283266 - 11/14/06 05:06 PM (17 years, 3 months ago)

Keep in mind that this isn't like morphine times 6 as far as being stoned. It's not going to fuck you up. It's just going to take away pain if you're actually having pain. Don't get all excited...


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Offlinedrugsaregoodmmk
Stranger
Male
Registered: 08/14/06
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Last seen: 16 years, 4 days
Re: Natural-born painkiller found in human saliva [Re: Lily_Morgan]
    #6283387 - 11/14/06 05:52 PM (17 years, 3 months ago)

how do you know!?


--------------------
"Guess who's back in the mutha fuckin house with a fat dick for ya mutha fuckin mouth"- Snoop Dogg


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InvisibleBrainiac
Rogue Scientist
Male

Registered: 04/29/06
Posts: 13,259
Loc: 與您的女朋 Flag
Re: Natural-born painkiller found in human saliva [Re: drugsaregoodmmk]
    #6283408 - 11/14/06 05:58 PM (17 years, 3 months ago)

I won't to be the first one to try it. Where do I sign up for it.


--------------------
:Awesketch:

:cool: Fair is Fair :devil:


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OfflineDadeMurphy
H4x0r

Registered: 01/29/03
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Re: Natural-born painkiller found in human saliva [Re: Ego Death]
    #6283643 - 11/14/06 07:27 PM (17 years, 3 months ago)

">opiorphin

What a shat name. Makes it sound like an opiod. "

That's intentional dude, it is like an opioid. It's an endogenous peptide that activates opioid receptors - this group of molecules are known as endorphins (and enkephalins), hence the name.


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--------------------------------------------------



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InvisibleStein
Stranger
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Registered: 07/02/03
Posts: 35,129
Re: Natural-born painkiller found in human saliva [Re: SirFrancisBacon]
    #6285033 - 11/15/06 06:06 AM (17 years, 3 months ago)

No wonder humans fall in love after swapping spit.

I have a feeling there's a whole lot more that will come from this study.

is pussy juice saliva?


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InvisibleOneMoreRobot3021
Male

Registered: 06/06/03
Posts: 61,024
Loc: the sky
Re: Natural-born painkiller found in human saliva [Re: Stein]
    #6285409 - 11/15/06 09:42 AM (17 years, 3 months ago)

Sure


--------------------
Acid doesn't give you truths; it builds machines that push the envelope of perception. Whatever revelations came to me then have dissolved like skywriting. All I really know is that those few years saddled me with a faith in the redemptive potential of the imagination which, however flat, stale and unprofitable the world seems to me now, I cannot for the life of me shake.

-Erik Davis


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InvisibleS33D
this side up
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Registered: 11/13/05
Posts: 511
Loc: skylabONE
Re: Natural-born painkiller found in human saliva [Re: OneMoreRobot3021]
    #6287093 - 11/15/06 06:56 PM (17 years, 3 months ago)

I got a cure for the common cold in my seamen.

any takers? :blowme:


--------------------
If my calculations are correct, when this baby hits eighty-eight miles per hour... you're gonna see some serious shit.
~Dr. Emmett Brown


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Offlinemycotard
Tard
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Registered: 11/27/05
Posts: 53
Loc: wherever
Last seen: 17 years, 2 months
Re: Natural-born painkiller found in human saliva [Re: S33D]
    #6287804 - 11/15/06 10:07 PM (17 years, 3 months ago)

semen actually makes a person's skin glow when they ingest it. if women want to keep their youthful appearance, it is wise to ingest fresh sperm.


--------------------
dude, that lowcrawler is smokin all ur shit bro!!!

whoa, that aint my shit bro. It's yours!!!


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