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kit_kat
Vixen


Registered: 01/05/06
Posts: 249
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Celexa (and other SSRIs) and other drugs
#5939933 - 08/07/06 06:00 AM (17 years, 5 months ago) |
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Does anyone know how safe it is to do shrooms or ecstasy while on an SSRI like celexa. I've drank on it and smoked weed without any problems.
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barfightlard
tales of theinexpressible



Registered: 01/29/03 
Posts: 8,670
Loc: Canoodia
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Re: Celexa (and other SSRIs) and other drugs [Re: kit_kat]
#5940522 - 08/07/06 11:29 AM (17 years, 5 months ago) |
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Effects of shrooms and E are greatly diminished while your on any SSRI.
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"What business is it of yours what I do, read, buy, see, say, think, who I fuck, what I take into my body - as long as I do not harm another human being on this planet?" - Bill Hicks
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kit_kat
Vixen


Registered: 01/05/06
Posts: 249
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Re: Celexa (and other SSRIs) and other drugs [Re: barfightlard]
#5940853 - 08/07/06 01:29 PM (17 years, 5 months ago) |
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how sad... why is that?
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ZippoZ
Knomadic


Registered: 06/17/03
Posts: 13,227
Loc: Pongyang, North Korea
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Re: Celexa (and other SSRIs) and other drugs [Re: kit_kat]
#5940862 - 08/07/06 01:33 PM (17 years, 5 months ago) |
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It has to do with the pre existing effects on your seritonin system. I believe that it is partially inhibited by the drugs due to similar receptor affinity (the drugs both share the same receptor on the brain, and only so many can get through the barrier)
-------------------- PEACE
zippoz "in times of widespread chaos and confusion, it has been the duty of more advanced human beings - artists, scientists, clowns, and philosophers - to create order. In such times as ours however, when there is too much order, too much m management, too much programming and control, it becomes the duty of superior men and women and women to fling their favorite monkey wrenches into the machinery. To relieve the repression of the human spirit, they must sow doubt and disruption" "People do it every day, they talk to themselves ... they see themselves as they'd like to be, they don't have the courage you have, to just run with it."
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Fractalated
There's no onehome up there...

Registered: 07/22/06
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Re: Celexa (and other SSRIs) and other drugs [Re: barfightlard]
#5941577 - 08/07/06 05:51 PM (17 years, 5 months ago) |
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Exactly right. It would be a waste to do either while using an SSRI. You would need to give you body about a week or two after discontinuing use before you could really get full effects.
-------------------- "Now that the principalities and the powers stockpile weapons of mass destruction, contaminate the earth with their feverish industry, release floods of images to trigger insatiable desires, treat animals and humans as commodities and functions of a market, the devil must be grinning from ear to ear."
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badchad
Mad Scientist

Registered: 03/02/05
Posts: 13,372
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Re: Celexa (and other SSRIs) and other drugs [Re: Fractalated]
#5941831 - 08/07/06 07:13 PM (17 years, 5 months ago) |
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It's thought to occur via receptor desensitization.
The SSRI will increase your levels of serotonin. The increased serotonin will (obviously) stimulate your serotonon receptors. To compensate, they will be downregulated (internalized).
Since both drugs (to some degree) work through these receptors, the absence of them decreases the effects.
-------------------- ...the whole experience is (and is as) a profound piece of knowledge. It is an indellible experience; it is forever known. I have known myself in a way I doubt I would have ever occurred except as it did. Smith, P. Bull. Menninger Clinic (1959) 23:20-27; p. 27. ...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely. Osmond, H. Annals, NY Acad Science (1957) 66:418-434; p.436
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kit_kat
Vixen


Registered: 01/05/06
Posts: 249
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Re: Celexa (and other SSRIs) and other drugs [Re: badchad]
#5943263 - 08/08/06 05:07 AM (17 years, 5 months ago) |
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Quote:
badchad said: It's thought to occur via receptor desensitization.
The SSRI will increase your levels of serotonin. The increased serotonin will (obviously) stimulate your serotonon receptors. To compensate, they will be downregulated (internalized).
Since both drugs (to some degree) work through these receptors, the absence of them decreases the effects.
Sounds scary...
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kit_kat
Vixen


Registered: 01/05/06
Posts: 249
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Re: Celexa (and other SSRIs) and other drugs [Re: kit_kat]
#5955808 - 08/12/06 06:54 AM (17 years, 5 months ago) |
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fuckk... i wanna do some e
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Cerebro
Spawnmaster C


Registered: 09/13/06
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Re: Celexa (and other SSRIs) and other drugs [Re: kit_kat]
#6210432 - 10/25/06 12:21 PM (17 years, 3 months ago) |
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I've always wanted to try the salvia with the celexa, and weed. I think it would be interesting because salvia is a drug which doesn't effect serotonin. I like it. It made me feel alright, I guess.
Edited by Cerebro (01/27/07 08:52 PM)
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some1whoisntme
Stranger

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Re: Celexa (and other SSRIs) and other drugs [Re: Cerebro]
#6213559 - 10/26/06 10:17 AM (17 years, 3 months ago) |
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I'd be hella careful with the SSRI/MDMA combo, and by hella careful I mean don't do it. Not only would it be a waste, it's also possible to get serotonin syndrome this way. I have done both salvia and weed while on an SSRI, even at the same time, and enjoyed both throughly.
-------------------- "Ignore the distortion you're forced to percieve and believe that what supercedes is love, but who agrees?"
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EarthDroid
Old Crank(Veteran)

Registered: 01/25/06
Posts: 409
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Re: Celexa (and other SSRIs) and other drugs [Re: some1whoisntme]
#6213573 - 10/26/06 10:22 AM (17 years, 3 months ago) |
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You can't get serotonin syndrome from mixing them, the effects would just be greatly diminished. This is because SSRI's block the reuptake receptors of the brain, the same reuptakes that take MDMA up in order for it to do its tricks. In otherwords the MDMA wouldn't be able to get into the receptors to work.
As for psilocybin, it has been shown that SSRI's don't diminish the effects much at all, so it would work. LSD on the otherhand would be greatly diminished by SSRI's.
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