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InvisibleVoidOfsPg
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Marijuana use during conception results in failed pregnancy
    #5926295 - 08/02/06 06:13 PM (17 years, 9 months ago)

Women who use marijuana at the time of conception or very early in pregnancy face an increased risk of miscarriage or ectopic pregnancy, a new study suggests.

Marijuana’s active ingredient called tetrahydrocannabinol (THC) interferes with the body signaling system and prevents the implantation of the fertilized egg in the womb, the study said.

University of Nashville researchers warned that smoking marijuana at a delicate time immediately before or after conception might lead to miscarriages or ectopic pregnancies. The cannabinoid receptors, CB1 and CB2 are located in the brain and are also present in sperm, eggs, and newly formed embryos.

When the psychoactive ingredient of marijuana, tetrahydrocannabinol (THC), binds to these receptors a chain of events is set into motion. This culminates in the "high" experienced by smoking pot. During early pregnancy a molecule called anandamide, which occurs naturally, activates CB1 and CB2.

Anandamide is vital for normal embryonic development. It is synthesized by an enzyme called NAPE-PLD and is broken down by another enzyme called FAAH.

The current study led by Professor Sudhansu Dey of Vanderbilt University in Nashville, Tennessee, found that the production and breakdown of anandamide is a sensitive process and any alteration could lead to complications like preventing normal embryo development, transport into the womb and implantation.

The researchers studied the effect of THC in mice and found that affects the body in much the same way as high levels of anandamide. The signaling process goes haywire and thus prevents the embryo from being implanted in the womb.

In mice the researchers suppressed the activity of FAAH enzyme. This meant that high levels of anandamide accumulated in the body. These high levels of anandamide prevent the embryos from completing their passage to the uterus, thus compromising the pregnancy.

"Marijuana exposure may compromise pregnancy outcome," said Dey, the corresponding author of the study, published in the August issue of the Journal of Clinical Investigation.

"This is a major finding, that if you block FAAH and disturb anandamide levels, there is a compromised pregnancy outcome. This occurs very early during pregnancy, right from the start of fertilization. This may explain tubal pregnancies, it may be one cause of retention of embryos in the oviduct."

Dey said that all embryos in mice that were administered THC failed to reach the womb. "Our present findings have high clinical importance, since embryo retention in the fallopian tube is a significant cause of ectopic pregnancy in women, the incidence of which has markedly increased during the past decade," he added.

"I think the effect should not be permanent but smoking marijuana means the THC level might go up and interfere with early pregnancy, even before fertilization."

In an accompanying commentary in the same journal, Herbert Schuel from the State University of New York, said the study was thought provoking since many of the drugs currently in development or in use to suppress appetite or trigger weight-loss are known to have similar effects like THC on anandamide signaling.

Such drugs needed to be used with caution, he said. The present study "provides insight into normal mechanisms that regulate early development of the embryo and its transport through the oviduct to the uterus," he added.

Marijuana or pot is not freely available in the US, but it is still one of the most widely abused illicit drugs in the world, and often by pregnant women. Most drugs have some adverse effect on pregnancy, but marijuana tops that list.

Previous studies have suggested that pregnant women who smoke pot can pass on memory problems including attention deficiency to their offspring. Additionally, March of Dimes says that using marijuana in pregnancy is linked to low birth weight and to symptoms in the baby, such as excessive crying and shaking.

The conclusion reached by the study is that pregnant women are better off staying away from smoking pot. If you are already pregnant, there is no evidence that marijuana smoking in the past will harm your baby, but like many other factors, this is again unpredictable.

Ectopic pregnancies occur when the fertilized egg fails to reach the womb. There are many causes for this condition and marijuana is not the only one. However the fact that the drug is involved in this process means that the risk of ectopic pregnancy is enhanced.

Dey put it very aptly when he said that the effect of THC on fertilized egg "raises concern that the adverse effects of maternal use of marijuana could be seeded very early in pregnancy."

I personally dont think you should be doing any drugs while you're pregnant, but maybe this will discourage any of you who believe smoking weed is safe.

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InvisibleAfroshroomerican
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Re: Marijuana use during conception results in failed pregnancy [Re: VoidOfsPg]
    #5926313 - 08/02/06 06:20 PM (17 years, 9 months ago)

Good post indeed.

I don't think there are too many females here so many will just scoff at this.

However, I always thought weed, while fun, is kind of a bad drug.

Sure it doesn't fuck you up long term, but it just makes thinking during periods of heavy smoking sooo hard.

You always know who's the heavy pot smoker during mid-terms/finals because they get frustrated about how they can't remember what they read few minutes prior


--------------------
"We must learn to live together as brothers or perish together as fools."

~Martin Luther King Jr.~

<passitbobbie> if I just showed you a closeup of my ass
<passitbobbie> youd think it was female

"You owe errrbody up in here an apology fow youwe shit, HO!" - classic

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InvisibleVoidOfsPg
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Re: Marijuana use during conception results in failed pregnancy [Re: Afroshroomerican]
    #5926338 - 08/02/06 06:26 PM (17 years, 9 months ago)

Yeah I'm finally coming up on the end of my sack i've had for over a month now and I think I'm gonna try to stop before this semester. I know I can't perform as well as I could when I smoke. Plus I'm kinda getting burnt out on it. :shrug:

I posted this just because I've read a few threads a while back talking about pregnant women doing drugs and it pissed me off.

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InvisibleAfroshroomerican
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Re: Marijuana use during conception results in failed pregnancy [Re: VoidOfsPg]
    #5926368 - 08/02/06 06:37 PM (17 years, 9 months ago)

Yeah man. I hope you do quit before the semester. I liked weed a little to much and I used to sit in physics class and not understand a damn thing.

Then I stopped and finished off with an A- in it.

Weed is not good for those who care about their grades imo.


--------------------
"We must learn to live together as brothers or perish together as fools."

~Martin Luther King Jr.~

<passitbobbie> if I just showed you a closeup of my ass
<passitbobbie> youd think it was female

"You owe errrbody up in here an apology fow youwe shit, HO!" - classic

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Offlineabsolute zero
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Re: Marijuana use during conception results in failed pregnancy [Re: VoidOfsPg]
    #5926545 - 08/02/06 07:23 PM (17 years, 9 months ago)

Quote:

VoidOfsPg said:
I personally dont think you should be doing any drugs while you're pregnant, but maybe this will discourage any of you who believe smoking weed is safe.




I agree that women should be very careful about the substances and foods they take into their body during pregnancy... They shouldn't use ANY drugs, as this is a VERY important time in the development of their offspring...

I don't really think that this is proof that cannabis is dangerous :shrug:




Quote:

Afroshroomerican said:
You always know who's the heavy pot smoker during mid-terms/finals because they get frustrated about how they can't remember what they read few minutes prior




We can assume and say many things, but just because we do, doesn't mean there is truth to them.

Last fall, while I was attending (took spring semester off due to financial constraints of working my own way through college), I was a weekday smoker at the time. I would go down to the labs each day and write code for hours on end while under the influence. I didn't get baked before my exams, but I had a hit or two... I was one of the first ones out of the classroom because I knew the material...



Quote:

Afroshroomerican said:
Weed is not good for those who care about their grades imo.




My gpa for the semester was a 3.5....

Don't get me wrong, some people just aren't able to pull it off... but what holds true for one, does not necessarily hold true for another...


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InvisibletrendalM
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Re: Marijuana use during conception results in failed pregnancy [Re: Afroshroomerican]
    #5926561 - 08/02/06 07:27 PM (17 years, 9 months ago)

Quote:

Afroshroomerican said:
However, I always thought weed, while fun, is kind of a bad drug.

Sure it doesn't fuck you up long term, but it just makes thinking during periods of heavy smoking sooo hard.

You always know who's the heavy pot smoker during mid-terms/finals because they get frustrated about how they can't remember what they read few minutes prior




That says much more about the user than it does about the drug itself. I've known daily pot smokers who had great grades in school. I've also known people who never had a toke in their life who couldn't get a B anywhere in school.

Stop generalizing an entire group of people.


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Once, men turned their thinking over to machines in the hope that this would set them free.
But that only permitted other men with machines to enslave them.

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InvisibleAfroshroomerican
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Re: Marijuana use during conception results in failed pregnancy [Re: trendal]
    #5926585 - 08/02/06 07:35 PM (17 years, 9 months ago)

Quote:

Afroshroomerican said:
Yeah man. I hope you do quit before the semester. I liked weed a little to much and I used to sit in physics class and not understand a damn thing.

Then I stopped and finished off with an A- in it.

Weed is not good for those who care about their grades imo.





Well sorry if I offended people:

But we do know it causes problems with short term memory.

Let's face it. It's not totally harmless. Nothing is. Memory problems is a side effect. Fact.

Yes I'm sure that there are people who can't get a B average even if they don't toke. Do you think they'd get higher if they did? They'd probably drop down to a C

Lastly, I said IMO--meaning In My Opinion. And from what I have seen the heavy pot smokers DO have a problem with memorizing things.

Sure some may pull off a 3.0+. Great for them. They'd probably have closer 4.0 if they didn't toke everyday.


--------------------
"We must learn to live together as brothers or perish together as fools."

~Martin Luther King Jr.~

<passitbobbie> if I just showed you a closeup of my ass
<passitbobbie> youd think it was female

"You owe errrbody up in here an apology fow youwe shit, HO!" - classic

Edited by Afroshroomerican (08/02/06 07:38 PM)

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InvisibleZippoZM
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Re: Marijuana use during conception results in failed pregnancy [Re: Afroshroomerican]
    #5926644 - 08/02/06 07:53 PM (17 years, 9 months ago)

dude its a bias study funded by the march of dimes, a right to life group


--------------------
PEACE

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"in times of widespread chaos and confusion, it has been the duty of more advanced human beings - artists, scientists, clowns, and philosophers - to create order. In such times as ours however, when there is too much order, too much m management, too much programming and control, it becomes the duty of superior men and women and women to fling their favorite monkey wrenches into the machinery. To relieve the repression of the human spirit, they must sow doubt and disruption"

"People do it every day, they talk to themselves ... they see themselves as they'd like to be, they don't have the courage you have, to just run with it."

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InvisibleVoidOfsPg
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Re: Marijuana use during conception results in failed pregnancy [Re: ZippoZ]
    #5926661 - 08/02/06 07:57 PM (17 years, 9 months ago)

So do you think they altered the results to suit their biased opinion? I doubt it.

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Offlineabsolute zero
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Re: Marijuana use during conception results in failed pregnancy [Re: VoidOfsPg]
    #5926741 - 08/02/06 08:20 PM (17 years, 9 months ago)

Quote:

VoidOfsPg said:
So do you think they altered the results to suit their biased opinion? I doubt it.




Not purposely, but knowing they have an agenda is a good reason to be suspicious...

This study may be completely legitimate, but I'd wait til some other studies take place to see the results duplicated before placing much stock in it...


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InvisibleAmatoxin
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Re: Marijuana use during conception results in failed pregnancy [Re: absolute zero]
    #5926826 - 08/02/06 08:57 PM (17 years, 9 months ago)

Quote:

absolute_zero said:
I don't really think that this is proof that cannabis is dangerous :shrug:




Tell that to the the doctors and nurses at your local psychiatric ward  :crazy:


--------------------




Sectioned Under The Mental Health Act Sat 20-10-07 to Thurs 01-11-07 for playing TECHNO music

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OfflineGr8fulJ420
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Re: Marijuana use during conception results in failed pregnancy [Re: Amatoxin]
    #5926915 - 08/02/06 09:28 PM (17 years, 9 months ago)

Quote:

Amatoxin said:
Quote:

absolute_zero said:
I don't really think that this is proof that cannabis is dangerous :shrug:




Tell that to the the doctors and nurses at your local psychiatric ward  :crazy:




Watch out, kids! Today's reefer is way stronger than the grass your parents were experimenting with back in the day. Reefer madness is back!

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Offlineabsolute zero
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Re: Marijuana use during conception results in failed pregnancy [Re: Amatoxin]
    #5927020 - 08/02/06 09:52 PM (17 years, 9 months ago)

Quote:

Amatoxin said:
Tell that to the the doctors and nurses at your local psychiatric ward  :crazy:




For some reason, I don't see myself having a psychotic break or anything like that due to cannabis... I'm sure weed could help bring out underlying conditions in certain individuals, but then again, many things could help those conditions start to manifest...

I couldn't really see cannabis causing psychosis in a mentally healthy individual...

So, yes, there are probably some rare cases where that's the case, but then again, its probably about as likely as getting struck by lightning...



Hehe, I also probably can't speak on the same level as a college-level psychology student either... so you'll have to dumb it down a bit for me :smile:


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Invisibleeligal
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Re: Marijuana use during conception results in failed pregnancy [Re: absolute zero]
    #5927073 - 08/02/06 10:01 PM (17 years, 9 months ago)

Quote:

absolute_zero said:
Quote:

VoidOfsPg said:
So do you think they altered the results to suit their biased opinion? I doubt it.




Not purposely, but knowing they have an agenda is a good reason to be suspicious...

This study may be completely legitimate, but I'd wait til some other studies take place to see the results duplicated before placing much stock in it...





if its your child, would you really just ignore this study?


--------------------
\m/ Spanksta \m/

"do you have the freedom to do with your nervous system what you want?"

"MolokoMilkPlus said:
I'll respect you if you let me give you a blow job"

"tactik said:
respect the can."


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Offlineabsolute zero
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Re: Marijuana use during conception results in failed pregnancy [Re: eligal]
    #5927099 - 08/02/06 10:06 PM (17 years, 9 months ago)

Quote:

eligal said:
if its your child, would you really just ignore this study?




*sigh*

Quote:

absolute_zero said:
Quote:

VoidOfsPg said:
I personally dont think you should be doing any drugs while you're pregnant, but maybe this will discourage any of you who believe smoking weed is safe.




I agree that women should be very careful about the substances and foods they take into their body during pregnancy... They shouldn't use ANY drugs, as this is a VERY important time in the development of their offspring...





*double sigh*


It should also be noted that medical studies make the news every other day saying certain things are healthy and certain things are unhealthy... a single isolated study is not enough to draw broad conclusions...


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