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Offlinehybridphil
Student

Registered: 03/04/04
Posts: 323
Loc: Milky Way....they'll neve...
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5-HTP & MAOI?
    #5740072 - 06/11/06 10:51 PM (17 years, 7 months ago)

I had injested approximately the equivalent of 3 grams of syrian rue seeds of harmala alkaloids. It was a crude extraction, but I took some with some mushrooms for a very nice trip. I was wondering if I was to take 5-HTP, would it have any interaction with the MAOI? It said on the bottle to consult your doctor if taking a MAOI but I was wondering if it could have some adverse effect?


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OfflineDucky
Governor ofRhythm
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Registered: 05/09/06
Posts: 71
Loc: on a boat somewhere
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Re: 5-HTP & MAOI? [Re: hybridphil]
    #5740427 - 06/12/06 12:48 AM (17 years, 7 months ago)

What did the label say?

Dude, it's generally a good idea to follow that kind of info. I wouldn't suggest taking any 5htp for a week or two (probably the latter to be safe) after any sort of MAOI. The combination of those two types of things are very dangerous! Taking some 5htp right now would probably raise your blood pressure so high that after being hospitalized for it (if you even made it there), you'd be lucky if you got away with just some serious internal injuries. Your choice tho.


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"Whoa! ...did you just see that too?"


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OfflineOverSoul
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Registered: 04/23/06
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Re: 5-HTP & MAOI? [Re: Ducky]
    #5740752 - 06/12/06 04:45 AM (17 years, 7 months ago)

Didn't the FDA ban Tryptophan a while ago?


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Invisiblepac_man
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Registered: 05/01/06
Posts: 200
Re: 5-HTP & MAOI? [Re: OverSoul]
    #5740879 - 06/12/06 07:41 AM (17 years, 7 months ago)

.


Edited by pac_man (06/17/06 09:37 AM)


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OfflineEarthDroid
Old Crank(Veteran)

Registered: 01/25/06
Posts: 409
Last seen: 17 years, 1 month
Re: 5-HTP & MAOI? [Re: OverSoul]
    #5740882 - 06/12/06 07:44 AM (17 years, 7 months ago)

They banned it because a batch that was sent out was contaminated, it's not banned anymore.


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InvisibleEntropymancer
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Registered: 07/16/05
Posts: 10,207
Re: 5-HTP & MAOI? [Re: EarthDroid]
    #5742582 - 06/12/06 04:53 PM (17 years, 7 months ago)

Quote:

EarthDroid said:
They banned it because a batch that was sent out was contaminated, it's not banned anymore.




It's still not available in the US. They basically used that one bad batch as an excuse to ban tryptophan (for who knows what reason, maybe they were afraid of it being used as a tryptamine precursor). Now the closest thing you can get is 5-HTP.

As to 5-HTP and MAOIs, it's not going to be a huge issue if you're talking about rue/caapi MAOIs. It would probably be a bad idea to take it within 8-12 hrs of consuming the MAOI, but there's no reason to avoid it for weeks. Not to downplay the risks involved, but rue and caapi are not going to be lurking in your system readyto bust some serotonin syndome out on your ass. Think about how long an ayahuasca experience lasts; that's a good estimate for how long after consuming the rue that you need to be concerned with dietary costraints.

And really, who knows, 5-HTP might be psychoactively interesting at some dose with a harmala extract. After all, your intention consuming rue with mushrooms is to make an indole chemical more interesting; the same principle may apply to 5-HTP, another indole. As far as I know, this is unexplored territory, and thus would carry some potential risks, and ought to be researched further.


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