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trippinalice
Yes
Registered: 02/18/04
Posts: 47
Loc: nz
Last seen: 15 years, 7 months
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Extracted mescaline dosage?
#5670830 - 05/24/06 11:27 PM (17 years, 8 months ago) |
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When doing an acid/base mescaline extraction in particular the one posted by Ekstaza 'Mescaline extraction made easy' not long ago(very nice post btw) you extract the hydrochloride salts of all the alkaloids in the cactus right not just the mescaline? I remember reading somewhere that mescaline makes up about half the alkaloid content of the San Pedro. My question is, say you wanted to take 300mg mescaline would you have to eat about 600mg of the extracted alkaloids?
Anyone who has done this extraction, how mush have you been eating?
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Mezcal
Registered: 08/11/05
Posts: 1,980
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Re: Extracted mescaline dosage? [Re: trippinalice]
#5671077 - 05/25/06 12:29 AM (17 years, 8 months ago) |
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My guess is that over 95% of the SP alkaloids are mescaline.
I don't have a reference for you, but I hope others can also support this theory.
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Koala Koolio
TTAGGGTTAGGGTTAGGGTTAGGG

Registered: 01/07/04
Posts: 7,752
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Re: Extracted mescaline dosage? [Re: Mezcal]
#5671139 - 05/25/06 12:45 AM (17 years, 8 months ago) |
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Yep. I remember, a long while back, people used to estimate 50%. Most consider this to be ridiculously far off these days. Estimates range from 90-98% or so. No way to say for sure without extensive testing, and of course alkaloids will differ between species and clones.
-------------------- You're not like the others. You like the same things I do. Wax paper, boiled football leather... dog breath. We're not hitch-hiking anymore, we're riding!
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trippinalice
Yes
Registered: 02/18/04
Posts: 47
Loc: nz
Last seen: 15 years, 7 months
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Re: Extracted mescaline dosage? [Re: trippinalice]
#5671589 - 05/25/06 04:57 AM (17 years, 8 months ago) |
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Over 90%! thats way higher than I would expect. What are those estimates based on?
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Mezcal
Registered: 08/11/05
Posts: 1,980
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Re: Extracted mescaline dosage? [Re: trippinalice]
#5671811 - 05/25/06 07:50 AM (17 years, 8 months ago) |
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Quote:
Lloydia. 1977 Nov-Dec;40(6):585-90. Related Articles, Links
Cactus alkaloids. XXXVI. Mescaline and related compounds from Trichocereus peruvianus.
Pardanani JH, McLaughlin JL, Kondrat RW, Cooks RG.
Agurell has previously detected (tlc, glc-ms) tyramine, 3-methoxytyramine, and two unknown alkaloids in the Peruvian cactus, Trichocereus peruvianus Br. and R. The presence of mescaline in other similar Trichocereus species prompted us to reinvestigate this species, which is commercially available in the United States. The nonphenolic alkaloid extracts yielded an abundance of crystalline mescaline hydrochloride (0.82% yield) and a trace of 3,4-dimethoxyphenethylamine (tlc-ms). Crystalline tyramine hydrochloride, 3-methoxytyramine hydrochloride, and 3,5 dimethoxy-4-hydroxphenethylamine hydrochloride were isolated from the phenolic alkaloid extracts; the last compound has not been previously crystallized from nature, although it is the immediate biosynthetic precursor of mescaline. Crystalline 2-chloromescaline hydrochloride was isolated drom the nonphenolic extracts; but, as determined by mass-analyzed ion kinetic energy spectrometry, this new compound is an extraction artifact. Both 2-chloromescaline and 2.6-dichloromescaline hydrochlorides were prepared synthetically from mescaline. This cactus species has a mescaline content equal or superior to peyote and should be legally controlled as an item of drug abuse.
PMID: 600028 [PubMed - indexed for MEDLINE]
According to this article, it seems like mescaline is by and large the principal alkaloid, along with some tyramine and some other possibly active precursors to mescaline.
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