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InvisibleveggieM

Registered: 07/25/04
Posts: 17,504
Study finds how grapefruit juice affects drugs
    #5608771 - 05/09/06 01:23 PM (17 years, 8 months ago)

Study finds how grapefruit juice affects drugs
May 9, 2006 - reuters.com

WASHINGTON (Reuters) - U.S. researchers said they have identified the compound in grapefruit juice that affects how some drugs are absorbed in the body and said on Tuesday it might be used to help lower dosages for some patients.

Grapefruit juice is known for its effects on drug metabolism and is avoided by some patients while other deliberately take their drugs with the juice.

The reason is an intestinal enzyme called CYP3A, which partially destroys drugs as they are absorbed. Grapefruit juice, like no other fruit juice, interferes with CYP3A, so the body ends up absorbing more of the drug.

Dr. Paul Watkins of the University of North Carolina at Chapel Hill and colleagues say they have identified the substance in grapefruit juice that is responsible -- furanocoumarin.

"It should now be possible to market the furanocoumarin-free grapefruit juice to patients who would otherwise need to avoid grapefruit," Watkins said in a statement.

"In addition, it should be possible to screen new foods for the potential for drug interactions by determining whether they contain furanocoumarins," Watkins said.

"Finally, it may be possible to add furanocoumarins to formulations of certain drugs that tend to be poorly or erratically absorbed to improve their oral delivery."

To test the theory that furanocoumarin was the responsible compound, Watkins and colleagues filtered it out grapefruit juice, which they discovered was then less bitter but otherwise unaltered.

Then they tested 18 men and women taking various drugs on a regular basis including aspirin and birth control pills.

Each fasted in the hospital and got a single dose of the blood pressure drug felopidine, sold under the brand name Plendil, along with either normal grapefruit juice, furanocoumarin-free juice or orange juice.

They then ate and drank normally and blood was taken regularly all day.

In each volunteer, the normal grapefruit juice made between 6 percent to 230 percent more Plendil available in the blood, the researchers reported in the American Journal of Clinical Nutrition. The furanocoumarin-free grapefruit juice and orange juice had no such effect, they reported.


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OfflineMicrocosmatrix
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Registered: 10/20/05
Posts: 11,293
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Re: Study finds how grapefruit juice affects drugs [Re: veggie]
    #5609522 - 05/09/06 05:02 PM (17 years, 8 months ago)

Great, but does it work with opiates, LSD, Mushrooms, etc. etc.???


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InvisibleBanez
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Registered: 09/23/05
Posts: 15,181
Re: Study finds how grapefruit juice affects drugs [Re: Microcosmatrix]
    #5609599 - 05/09/06 05:28 PM (17 years, 8 months ago)

when doing shrooms, whenever i drink orange juice its like that


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OfflineMicrocosmatrix
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Registered: 10/20/05
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Last seen: 17 years, 1 month
Re: Study finds how grapefruit juice affects drugs [Re: Banez]
    #5609761 - 05/09/06 06:25 PM (17 years, 8 months ago)

Yeah, and OJ and LSD seems to work great. Any citrus does.

But this is grapefruit specific so I wonder how good it really is. next percocet I'm gonna find out.


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OfflineCUBErt
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Registered: 08/24/05
Posts: 1,067
Loc: Southern CA
Last seen: 14 years, 3 months
Re: Study finds how grapefruit juice affects drugs [Re: Microcosmatrix]
    #5610294 - 05/09/06 08:23 PM (17 years, 8 months ago)

Quote:

Microcosmatrix said:
Great, but does it work with opiates, LSD, Mushrooms, etc. etc.???




Its supposed to work especially strong with opiates and benzodiazepines.. those are the only ones I know for sure.


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OfflineNortherNathan
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Registered: 02/02/04
Posts: 17
Loc: bottom of the lake
Last seen: 16 years, 6 months
Re: Study finds how grapefruit juice affects drugs [Re: CUBErt]
    #6293628 - 11/17/06 11:18 AM (17 years, 2 months ago)

Hey this is an old thread but... no one mentioned anything about interaction with DXM. I once read on a DXM site about this particular enzyme that GF juice interferes with. Apparently certain individuals might lack this enzyme and as a result can have extremely intense experiences from low doses of DXM. On the Dex site, though, it said that it interferes with the absorption of the drug in the brain, rather than the intestine.
    Anyway, of course I tried it on several occassions and there certainly is a noticeable difference. Drank 1 to 2 quarts of 100% white grapefruit juice throughout the day of the trip and usually fasted, dosed as usual in the evening. The trip does not come on any quicker, but the qualitative experience is changed. Found that I would lose myself easier in the trip, and couldn't recall the experience afterwards (though that often happens anyway with DXM). 
  Hope this helps.  :grin:


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