Home | Community | Message Board


This site includes paid links. Please support our sponsors.


Welcome to the Shroomery Message Board! You are experiencing a small sample of what the site has to offer. Please login or register to post messages and view our exclusive members-only content. You'll gain access to additional forums, file attachments, board customizations, encrypted private messages, and much more!

Shop: PhytoExtractum Maeng Da Thai Kratom Leaf Powder   Original Sensible Seeds Autoflowering Cannabis Seeds   Bridgetown Botanicals Bridgetown Botanicals   Kraken Kratom Kratom Capsules for Sale

Jump to first unread post Pages: 1
OfflineSirTripAlot
Semper Fidelis
Male User Gallery

Registered: 01/11/05
Posts: 7,460
Loc: Harmless (Mostly)
Last seen: 1 hour, 56 minutes
20,000 X pills????
    #5476561 - 04/03/06 08:45 PM (17 years, 9 months ago)

The strange case of the man who took 40,000 ecstasy pills in nine years

? Usage increased to 25 tablets a day at peak
? Memory problems and paranoia may be lasting

David McCandless
Tuesday April 4, 2006
The Guardian


Doctors from London University have revealed details of what they believe is the largest amount of ecstasy ever consumed by a single person. Consultants from the addiction centre at St George's Medical School, London, have published a case report of a British man estimated to have taken around 40,000 pills of MDMA, the active ingredient in ecstasy, over nine years. The heaviest previous lifetime intake on record is 2,000 pills.
Though the man, who is now 37, stopped taking the drug seven years ago, he still suffers from severe physical and mental health side-effects, including extreme memory problems, paranoia, hallucinations and depression. He also suffers from painful muscle rigidity around his neck and jaw which often prevents him from opening his mouth. The doctors believe many of these symptoms may be permanent.

The man, known as Mr A in the report in the scientific journal Psychosomatics, started using ecstasy at 21. For the first two years his use was an average of five pills per weekend. Gradually this escalated until he was taking around three and a half pills a day. At the peak, the man was taking an estimated 25 pills every day for four years. After several severe collapses at parties, Mr A decided to stop taking ecstasy. For several months, he still felt he was under the influence of the drug, despite being bedridden.

Hallucinations

His condition deteriorated and he began to experience recurrent tunnel vision and other problems including hallucinations, paranoia and muscle rigidity. "He came to us after deciding that he couldn't go on any more," said Dr Christos Kouimtsidis, the consultant psychiatrist at St George's Medical School in Tooting who treated him for five months. "He was having trouble functioning in everyday life."

The doctors discovered that the man was suffering from severe short-term memory problems of a type usually only seen in lifetime alcoholics. But evaluating the full extent of his condition was difficult as his concentration and attention was so impaired he was unable to follow the simple tasks involved in the test.

"This was an exceptional case. His long- term memory was fine but he could not remember day to day things - the time, the day, what was in his supermarket trolley," said Dr Kouimtsidis. "More worryingly, he did not seem aware himself that he had these memory problems."

With no mental illness in his family and no prior psychiatric history, the doctors concluded that his unique condition was direct result of his intense ecstasy use.

"This is obviously an extreme case so we should not blow any observations out of proportion," says Dr Kouimtsidis. "But if this is what is happening to very heavy users, it might be an indication that daily use of ecstasy over a long period of time can lead to irreversible memory problems and other cognitive deficits."

For 10 years, MDMA has been suspected of causing these kinds of effects in heavy users. It is thought to be due to its disruption of the regulation of serotonin, a brain chemical believed to play a role in mood and memory. It remains unclear whether these effects are the result of permanent neurotoxic damage or just temporary reversible alterations in the brain.

A study today in a special MDMA issue of the British Journal of Psychopharmacology, suggests long-term side-effects may be temporary. The researchers from the University Of Louisiana could find no significant relationship between depression and recreational ecstasy use.

In the case of Mr A, a structural MRI brain scan failed to show any obvious damage or atrophy in his brain. However, these results, says Dr Kouimtsidis, are difficult to interpret. "A scan of this type is not sensitive enough," he said.

Such limitations in brain scanning technology, along with ethical and legal barriers to giving MDMA to human test subjects, have limited direct observation of the drug's effects in humans.

Instead, scientists have had to use recreational drug users as subjects in their studies. Conclusions from this are often flawed because few, if any, drugs users use ecstasy in isolation.

Cannabis user

Mr A was also a heavy cannabis user, and when he was encouraged to decrease his use, his paranoia and hallucinations disappeared and his anxiety abated. But his memory and concentration problems remained, leading the doctors to suspect that these may be permanent disabilities.

When he was admitted to a specialist brain injury unit and put on anti-psychotic medication, he did start to show some improvement. "Unfortunately, he discharged himself before we were able to complete the assessment," says Dr Kouimtsidis. "We continued to support him. But he started to use cannabis again and he dropped out. We tried to re-engage him but we lost him about a year ago."

The Guardian made several attempts to find the man without success.

Effects of ecstasy

MDMA is one the most intensely studied recreational drugs in history. But despite thousands of research papers and studies, scientific evidence on the side-effects remains inconclusive.

Death by overdose

Undoubtedly, large amounts of ecstasy can lead to over-heating which in turn, in rare cases, can trigger fatal heat stroke. Many factors contribute: number and strength of pills taken, environment, alcohol-consumption, body weight - but women seem more at risk. The bulk of ecstasy-related deaths around the world have been young women.

Water-poisoning

Panicking users, fearing they are overdosing, drink too much water and provoke hyponaetraemia (water-poisoning). Leah Betts died after drinking 14 pints in just 90 minutes. The recommended amount of water to drink per hour is one pint.

Toxic reactions

Much of the reports of toxic reactions are muddled with overdose or water-poisoning deaths. There is no clear evidence that some people suffer allergic reactions to ecstasy. However, around 10% of Western users do lack a key liver enzyme CYP2D6 needed to break down MDMA. This may make them more sensitive to the effects and more prone to accidental overdose.

Depression

Many weekend users report a mid-week mood dip. This is suspected to be related MDMA's effect on serotonin, but hard evidence is lacking. In heavy users, dips can turn to crashes and depression. However studies suggest this effect reverses after a 2-3 month abstinence.

Positive effects

Users still claim "long lasting improvements in self-awareness, self-esteem, openness and insight into personal problems", reports the study from the University Of Louisiana. In the US, research continues into the use of MDMA-assisted psychotherapy to treat Post Traumatic Stress Disorder.


--------------------
“I must not fear.
Fear is the mind-killer.
Fear is the little-death that brings total obliteration.
I will face my fear. I will permit it to pass over me and through me.
And when it has gone past I will turn the inner eye to see its path.
Where the fear has gone there will be nothing. Only I will remain.”


Extras: Filter Print Post Top
Invisiblegogrowgo123
all the same

Registered: 10/18/05
Posts: 249
Re: 20,000 X pills???? [Re: SirTripAlot]
    #5476668 - 04/03/06 09:07 PM (17 years, 9 months ago)

shit id think 25 pills in one day would kill you. how the fuck to you get the money and hookup for all that stuff. if thats all true i hope that guy can somewhat recover.


--------------------
"For everything to be consummated, for me to feel less alone, I had only to wish that there be a large crowd of spectators the day of my execution and that they greet me with cries of hate."


Extras: Filter Print Post Top
OfflineinoculatedGreif
greif struken
Male User Gallery

Registered: 03/14/06
Posts: 663
Last seen: 17 years, 5 months
Re: 20,000 X pills???? [Re: gogrowgo123]
    #5477064 - 04/03/06 10:48 PM (17 years, 9 months ago)

why? either he has a death wish, or he loves the stuff. let em have it.


--------------------
one branch of man turns away what has made us who we are, the other,excepts it for how its made man. which path do you choose?
-------------------------------------
Man takes advantage of who he is,nature is his home, where he evolved from. So why does he turn it down, defy, and mutalate his birth ground? why does he spread disease, murder his native animals,rape and torture his land, and still feel descent of who he is? live a life that is not true? excepts an artificial home?


Extras: Filter Print Post Top
OfflineDreamer987
The VerbalHerman Munster
Female

Registered: 04/15/03
Posts: 5,326
Loc: Texas
Last seen: 16 years, 1 month
Re: 20,000 X pills???? [Re: inoculatedGreif]
    #5477825 - 04/04/06 02:00 AM (17 years, 9 months ago)

Have some compassion. The man made some huge mistakes, but addiction is a bitch.
I pray that he can recover alittle bit, and mabey learn to be happy again.


--------------------


Extras: Filter Print Post Top
Invisiblemoog
Stranger

Registered: 02/15/05
Posts: 1,296
Re: 20,000 X pills???? [Re: SirTripAlot]
    #5480738 - 04/04/06 09:26 PM (17 years, 9 months ago)

There was just another story in the news forum about some guy taking 13 E pills and dying of a heart attack. I call shenanigans on this guy's story.


Extras: Filter Print Post Top
OfflineCherk
Fashionable
Male User Gallery

Registered: 10/25/02
Posts: 46,493
Loc: International Flag
Last seen: 1 year, 2 months
Re: 20,000 X pills???? [Re: SirTripAlot]
    #5481038 - 04/04/06 10:41 PM (17 years, 9 months ago)

lol


--------------------
I have considered such matters.

SIKE


Extras: Filter Print Post Top
Jump to top Pages: 1

Shop: PhytoExtractum Maeng Da Thai Kratom Leaf Powder   Original Sensible Seeds Autoflowering Cannabis Seeds   Bridgetown Botanicals Bridgetown Botanicals   Kraken Kratom Kratom Capsules for Sale


Similar ThreadsPosterViewsRepliesLast post
* is this because of ecstasy? nightkrawler 865 11 07/31/05 06:20 PM
by Kada
* Laced Ecstasy (Please Help Me) StrandedVoyager 1,334 7 11/01/05 09:23 PM
by D_M_X
* I think I'm addicted to ecstasy StrandedVoyager 4,591 12 07/19/05 04:24 PM
by RESTLESS
* What pills should i ask from my Doc? Jalruza 959 10 12/04/04 10:34 AM
by Supernova
* Mushroom/Ecstasy/Mescaline Interactions with combo of Lithium & Lamictal janeyjanejane 6,450 3 12/24/11 09:39 PM
by leira7
* Condom broke, GF refuses Morning After Pill
( 1 2 all )
encryptor 5,170 26 04/08/06 12:09 AM
by downforpot
* My idea for an effective weight-loss pill... NewbieS 958 8 09/21/05 02:43 PM
by Twister
* my dad needs help... big pill problem *DELETED* RebelSteve33 1,183 7 08/08/03 02:14 AM
by RebelSteve33

Extra information
You cannot start new topics / You cannot reply to topics
HTML is disabled / BBCode is enabled
Moderator: CherryBom, Rose, mndfreeze, yogabunny, feevers, CookieCrumbs, Northerner
708 topic views. 0 members, 1 guests and 2 web crawlers are browsing this forum.
[ Show Images Only | Sort by Score | Print Topic ]
Search this thread:

Copyright 1997-2024 Mind Media. Some rights reserved.

Generated in 0.022 seconds spending 0.007 seconds on 15 queries.