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Gainer
Syzurp


Registered: 10/20/04
Posts: 1,468
Loc: Ðirty §outh
Last seen: 26 days, 39 minutes
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LSD mushrooms cross-tolerance?
#3635959 - 01/16/05 06:09 PM (19 years, 1 month ago) |
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I did acid for my first time the other night; i took two hits. The problem is i didn't trip very hard it lasted forever but it never got more intense than a really mild shroom trip. The night before i ate a lot of shrooms and tripped pretty hard i think thats why i didnt trip hard on the acid. I think i remember reading somewhere a while back that LSD and shrooms have a cross-tolerance but i dont remember where. It was definitely good acid though cause two guys that only took 1 1/2 each tripped much harder than me. Just wondering if anyone else has experienced this before.
-------------------- "I mean, it's like a koala bear crapped a rainbow in my brain!" -Captain Murphy "Quit being a bitch and pill me up" -Dr. Quinn "Smoke that bitch" "I am not Stormy, I am He who smokes Bitches!" -Stormy
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SynapticMisfire
Stranger

Registered: 01/04/05
Posts: 85
Last seen: 9 years, 6 months
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Re: LSD mushrooms cross-tolerance? [Re: Gainer]
#3636032 - 01/16/05 06:29 PM (19 years, 1 month ago) |
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LSD is best described as a 5HT2/5HT1 receptor partial agonist. Psilocybin acts on the 5HT2 receptors as well, so a cross-tolerance is definitely possible.
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Dark_Star
train driver pervading a desktop


Registered: 08/20/04
Posts: 31,859
Loc: Uranus
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Re: LSD mushrooms cross-tolerance? [Re: Gainer]
#3636119 - 01/16/05 06:53 PM (19 years, 1 month ago) |
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Yeah.....they are cross tolerant. I recommend waiting at least 2 weeks between trips, though 1-2 months is better for best results.
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Annom
※※※※※※



Registered: 12/22/02
Posts: 6,367
Loc: Europe
Last seen: 8 months, 27 days
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Re: LSD mushrooms cross-tolerance? [Re: Dark_Star]
#3637548 - 01/17/05 12:57 AM (19 years, 1 month ago) |
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Quote:
Dark_Star said: Yeah.....they are cross tolerant. I recommend waiting at least 2 weeks between trips, though 1-2 months is better for best results.
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Anno
Experimenter



Registered: 06/17/99
Posts: 24,166
Loc: my room
Last seen: 14 hours, 43 minutes
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Re: LSD mushrooms cross-tolerance? [Re: Gainer]
#5056689 - 12/13/05 10:45 AM (18 years, 2 months ago) |
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Cross Tolerance between LSD and Psilocybin Psychopharmacologia 1961 Isbell H, Wolbach AB, Wikler A, Miner EJ
http://research.lycaeum.org/index.rbx?id=1979
Quote:
In 2 series of experiments on 19 volunteers the development of tolerance to LSD and psilocybin was measured. LSD was given in increasing doses up to 1.5 mcg/kg over periods of 6 to 13 days; and on another occasion psilocybin in doses increasing up to 150 mcg/kg over a period of 6 to 7 days and 210 mcg/kg over 13 days. Cross tolerance to psilocybin was measured by administering 150 mcg/kg or 210 mcg/kg psilocybin to patients, who had been given chronic treatment with LSD. Cross tolerance to LSD was evaluated by "challenging" patients with 1.5 mcg/kg of LSD after they had been given chronic treatment with psilocybin. . "Direct" tolerance to LSD developed to a high degree. "Direct" tolerance to psilocybin also developed, although to a lesser degree. Patients tolerant to LSD were, to a considerable degree, also cross tolerant to psilocybin and patients tolerant to psilocybin were cross tolerant to LSD.
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