To Swami and Xyrico,
---I found this material on a physics discussion forum. These guys are far more eloquent than I, so I shall let them explain. I believe it will be useful in answering your questions:---
"By taking Creatine or vitamin Q-10 for ATP synthesis, one is also taking an external source. In fact we are drug addicts to 20 essential amino acids, which we require from food, to produce the brain drugs of: Dopamine, Noreadrenaline, Serotonin et al. These are EXTERNAL SOURCES, and drugs unto themselves, they are highly PSYCHOACTIVE, not only that, but presently, we are also addicted to them.
The highest amount of serotonin in the body are found in the pineal. Serotonin can be converted to tryptamine (DMT is N-dimethyltryptamine). The pineal appears to have this ability. Methyltransferases, enzymes that convert serotonin, melatonin, or tryptamine into psychedelic compounds, reside in unusually high concentrations in the pineal. Finally, the pineal produces the potentially mind-altering substances, beta-carbolines. Beta-carbolines inhibit the breakdown of DMT by the body's MAOs. These compounds enhance and prolong the effects of DMT."
---So that debunks the issue of external vs. natural. Many of these compounds are produced in the human brain! ---
"I believe it's an open question as to what significance such altered states of consciousness possess. The common response that they are meaningless since they are just caused by chemicals in the brain is ridiculous; everything we perceive is caused by chemicals in our brains, but clearly we ascribe some significance to our everyday perceptions.
Personally, I do not think such experiences are really literally the doorway to 'other worlds.' However, they are quite enlightening as to the nature of consciousness itself. The typical person who is limited to the experiences of 'normal' wakefulness and varying stages of dreaming is correspondingly limited in his notion of what consciousness is and what consciousness can be.
Why is the 'natural' more epistemically priveleged than the 'artificial'? If someone's brain naturally produced a rush of DMT in response to a natural experience, would that experience be more meaningful than the one where DMT is artificially introduced? If tomorrow everyone's brains started producing massive amounts of DMT, and the only way to return to previous brain states was by ingesting some artificially contrived pill, would that be an exercise in self deception or a restoring of sanity? What about so called 'smart drugs'-- if there really is any benefit to be had from them, is this benefit automatically deflated and shown to be misguided because it stems from an artificial source?
I personally see a distinction to be made, but it's certainly not about natural vs. artificial. Everyday experiences are taken to be veridical, ie being true representations of external reality, in virtue of their functional covariance with causal agents detectable by independent means (such as light, heat, etc.) In the hallucinatory experience, the isomorphism between information in internal brain states and external stimuli typically becomes degraded, and so in this sense such states can be said to be less veridical.
However, there may still be a functional covariance with factors other than those typically encountered in everyday experience, and in this sense altered states may be taken to be veridical representations of these new factors. For instance, at the very least, visual hallucinations are a case where visual experience covaries with internally generated activation of brain states, and in this sense visual hallucinations can be taken to be veridical representations of the visual brain processes themselves, as divorced from the causal chains of organization that normally shape them and artificially restrict our notions of them. This is surely insightful insofar as the workings of the brain are essentially invisible in everyday experience, and all we 'see' is an apparently concrete external world in a fit of naive realism.
Thus the significance of psychedelic experiences at the very least lives up to its name-- 'mind revealing.' And depending on the metaphysical nature of consciousness, it could be something more significant than one's own brain that one is gaining new insight into."
---So you see, there are legitimate reasons to seek these experiences. Further, altered states of consciousness hardly require the use of chemicals. The same can be achieved through meditation, art, novel ideas, alternative languages, hypnosis, sensory deprivation, as well as chemical compounds.
For instance, watch the following flash presentation. You will feel a definite change in perspective after having viewed it, yet you ingested no chemicals. The only "mind altering agent" in this case is a pattern of acoustic and electromagnetic frequencies observed through the normal channels of your sensory apparatus:
http://w1.736.telia.com/~u73602493/flashback.html
So please, open your mind. Psychedelic experiences are your birthright as a human being. To believe the current propaganda is to cut yourself off from a realm of experience as profound and as nourishing as that of having really good sex! You wouldn't want to go your whole lifetime without ever having sex, would you? 
That's it. I've had my say. May love and truth find you where ever you are!---
"We teach what we know, but we reproduce what we are." - John Maxwell
"Before you can know anything directly, non-verbally, you must know the knower. So far, you took the mind for the knower, but it is not so. The mind clogs you up with images and ideas, which leave scars in memory. You take remembering to be knowledge. True knowledge is ever fresh, new, unexpected. It wells up from within. When you know what you are, you also are what you know. Between knowing and being there is no gap." - Nisargadatta Maharaj
"Men occasionally stumble over the truth, but most of them pick themselves up and hurry off as if nothing had happened." ~ Winston Churchill
"No man really becomes a fool until he stops asking questions." ~ Charles P. Steinmetz
"The mind is its own place, and in itself, can make heaven of Hell, and a hell of Heaven." -John Milton
"I never submitted the whole system of my opinions to the creed of any party of men whatever, in religion, in philosophy, in politics or in anything else, where I was capable of thinking for myself. Such an addiction is the last degradation of a free and moral agent. If I could not go to Heaven but with a party, I would not go there at all." -Thomas Jefferson
"Somewhere defined in aimless words, Somewhere within my angry herd of stampeding emotions Love was running blind." ? Michael Hedges
?Reality is but a serotonin-induced hallucination" - Terence McKenna
"Earth's crammed with heaven, And every common bush afire with God; And only he who sees takes off his shoes; The rest sit round it and pluck blackberries." - Elizabeth Barrett Browning
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