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Invisibledblaney
Human Being

Registered: 10/03/04
Posts: 7,894
Loc: Here & Now
Mescaline and LSD cross tolerance *DELETED*
    #4655398 - 09/13/05 04:30 PM (11 years, 10 months ago)

Post deleted by dblaney

Reason for deletion: .



--------------------
"What is in us that turns a deaf ear to the cries of human suffering?"

"Belief is a beautiful armor
But makes for the heaviest sword"
- John Mayer

Making the noise "penicillin" is no substitute for actually taking penicillin.

"This country, with its institutions, belongs to the people who inhabit it. Whenever they shall grow weary of the existing government, they can exercise their constitutional right of amending it, or their revolutionary right to dismember or overthrow it." -Abraham Lincoln


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OfflineThePredator
Your a eunich ifyou don't useunix!

Registered: 08/23/05
Posts: 542
Last seen: 11 years, 1 month
Re: Mescaline and LSD cross tolerance [Re: dblaney]
    #4656025 - 09/13/05 06:45 PM (11 years, 10 months ago)

Explain to me how a cross tolerance would work with these two? LSD-25 is a chemical very similar to seretonin and takes it place as an artificial receptor. Mescaline impairs the adrenyl glands causing a phychosis like high.


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Invisibledblaney
Human Being

Registered: 10/03/04
Posts: 7,894
Loc: Here & Now
Re: Mescaline and LSD cross tolerance [Re: ThePredator]
    #4656030 - 09/13/05 06:46 PM (11 years, 10 months ago)

Do you have a source for that man? That doesn't sound right to me.


--------------------
"What is in us that turns a deaf ear to the cries of human suffering?"

"Belief is a beautiful armor
But makes for the heaviest sword"
- John Mayer

Making the noise "penicillin" is no substitute for actually taking penicillin.

"This country, with its institutions, belongs to the people who inhabit it. Whenever they shall grow weary of the existing government, they can exercise their constitutional right of amending it, or their revolutionary right to dismember or overthrow it." -Abraham Lincoln


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Invisibledblaney
Human Being

Registered: 10/03/04
Posts: 7,894
Loc: Here & Now
Re: Mescaline and LSD cross tolerance [Re: dblaney]
    #4656037 - 09/13/05 06:48 PM (11 years, 10 months ago)

Quote:

Trained male Sprague-Dawley rats to discriminate intraperitoneally administered mescaline from saline in a 2-lever operant chamber for food reinforcement. Reward was contingent upon responses made greater than 15 sec apart on the appropriate lever paired with either drug or saline administration. Following the establishment of discriminative response control by mescaline, Ss were tested for stimulus generalization produced by mescaline after (a) blockade of peripheral and central serotonin (5-hydroxytryptamine, 5-HT) receptors with cinanserin, methysergide, or cyproheptadine; (b) blockade of peripheral 5-HT receptors with xylamidine tosylate; and (c) depletion of brain 5-HT with the tryptophan hydroxylase inhibitor p-chlorophenylalanine (PCPA). Results show that all 3 central 5-HT antagonists greatly reduced the discriminability of mescaline, while the peripheral antagonist xylamidine tosylate was without effect. These agents at the doses employed did not affect the discriminability of saline. Depletion of 5-HT with PCPA potentiated the effects of a subthreshold dose of mescaline and slightly reduced the discriminability of saline. Results indicate that mescaline produces its discriminative stimulus properties by directly stimulating central serotonergic receptors.



-Pharmacology, Biochemistry and Behavior
Vol 3 (No. 3) May-Jun 1975; 429-435
by Ronald G. Browne; Beng T. Ho
(http://www.erowid.org/chemicals/mescaline/mescaline_journal4.shtml)


--------------------
"What is in us that turns a deaf ear to the cries of human suffering?"

"Belief is a beautiful armor
But makes for the heaviest sword"
- John Mayer

Making the noise "penicillin" is no substitute for actually taking penicillin.

"This country, with its institutions, belongs to the people who inhabit it. Whenever they shall grow weary of the existing government, they can exercise their constitutional right of amending it, or their revolutionary right to dismember or overthrow it." -Abraham Lincoln


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OfflineThePredator
Your a eunich ifyou don't useunix!

Registered: 08/23/05
Posts: 542
Last seen: 11 years, 1 month
Re: Mescaline and LSD cross tolerance [Re: dblaney]
    #4656120 - 09/13/05 07:06 PM (11 years, 10 months ago)

http://www.mescaline.com/medsci/catsdopsero.html

Ah yes we are both right, it effects both of them (dopamine (specificly adrenal) and seretonin). So yes it would decrease a major part of its affect.


--------------------


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Offlinegnrm23
Carpal Tunnel
Registered: 08/30/99
Posts: 6,481
Loc: n. e. OH, USSA
Last seen: 24 days, 23 hours
Re: Mescaline and LSD cross tolerance [Re: dblaney]
    #4656138 - 09/13/05 07:11 PM (11 years, 10 months ago)

mescaline, psilocybin, & lsd-25 have all been described as developing a "partial cross-tolerance"...
you could probably take a couple hundred ug of lsd & still feel it behind a (non-felt) dose of mescaline...
(although you might notice a "mescaline-tinge" to the trip, as the (sub-threshold dose?) of mesc has a pretty-long half life...)

& mescaline does not get you high by poisoning your adrenal glands...
(although some of the minor alkaloids in _peyote cactus_ could be classed as "poisons" heh...)


--------------------
old enough to know better
not old enough to care


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Invisibledblaney
Human Being

Registered: 10/03/04
Posts: 7,894
Loc: Here & Now
Re: Mescaline and LSD cross tolerance [Re: gnrm23]
    #4656143 - 09/13/05 07:12 PM (11 years, 10 months ago)

:thumbup: thanks much to both of you


--------------------
"What is in us that turns a deaf ear to the cries of human suffering?"

"Belief is a beautiful armor
But makes for the heaviest sword"
- John Mayer

Making the noise "penicillin" is no substitute for actually taking penicillin.

"This country, with its institutions, belongs to the people who inhabit it. Whenever they shall grow weary of the existing government, they can exercise their constitutional right of amending it, or their revolutionary right to dismember or overthrow it." -Abraham Lincoln


Post Extras: Print Post  Remind Me! Notify Moderator
OfflineDivided_Sky
Ten ThousandThings

Registered: 11/02/03
Posts: 3,171
Loc: The Shining Void
Last seen: 9 years, 1 month
Re: Mescaline and LSD cross tolerance [Re: dblaney]
    #4656216 - 09/13/05 07:28 PM (11 years, 10 months ago)

I have seen first hand that there is a cross tolerance between mescaline and SHROOMS. Shroom hard one night, and you'll barely feel any mescaline the next.


--------------------
1. "After an hour I wasn't feeling anything so I decided to take another..."
2. "We were feeling pretty good so we decided to smoke a few bowls..."
3. "I had to be real quiet because my parents were asleep upstairs..."


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OfflineThePredator
Your a eunich ifyou don't useunix!

Registered: 08/23/05
Posts: 542
Last seen: 11 years, 1 month
Re: Mescaline and LSD cross tolerance [Re: Divided_Sky]
    #4656390 - 09/13/05 08:05 PM (11 years, 10 months ago)

I never said it poisened them, I said it impared them, meaning the production ofhteir own epinephdrine and noraphedrine.


--------------------


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OfflineDivided_Sky
Ten ThousandThings

Registered: 11/02/03
Posts: 3,171
Loc: The Shining Void
Last seen: 9 years, 1 month
Re: Mescaline and LSD cross tolerance [Re: ThePredator]
    #4656655 - 09/13/05 09:18 PM (11 years, 10 months ago)

Apparently adrenochrome (what adrenaline becomes when it decays from being around for too long) is very close chemically and subjectively to mescaline.


--------------------
1. "After an hour I wasn't feeling anything so I decided to take another..."
2. "We were feeling pretty good so we decided to smoke a few bowls..."
3. "I had to be real quiet because my parents were asleep upstairs..."


Post Extras: Print Post  Remind Me! Notify Moderator
Invisibledblaney
Human Being

Registered: 10/03/04
Posts: 7,894
Loc: Here & Now
Re: Mescaline and LSD cross tolerance [Re: Divided_Sky]
    #4656659 - 09/13/05 09:20 PM (11 years, 10 months ago)

Yeah, though strangely enough adrenochrome has appears to not be psychoactive when taken orally (don't know about other routes).


--------------------
"What is in us that turns a deaf ear to the cries of human suffering?"

"Belief is a beautiful armor
But makes for the heaviest sword"
- John Mayer

Making the noise "penicillin" is no substitute for actually taking penicillin.

"This country, with its institutions, belongs to the people who inhabit it. Whenever they shall grow weary of the existing government, they can exercise their constitutional right of amending it, or their revolutionary right to dismember or overthrow it." -Abraham Lincoln


Post Extras: Print Post  Remind Me! Notify Moderator
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