This is exactly the type of info I'm looking for

Thanks Spidey 

I've just recently started taking Zoloft.  I've been on the treatment for 6 weeks now.  I started out @ 25mg/day and gradually want up to my current 100mg/day.  Zoloft is great, however it's not what I expected.  It helps all the time.  I'm no longer anxious or nervous when I get stoned, which is good cause I'm usually stoned all the time.

I've only had shrooms once before and it was a very small amount of someone's left overs.  I'de say over a gram, but not two.  It was a fun little trip.  I've also tripped on LSD several times.

I've always had an inherently curious nature, as most of us do

Spidey said:

Actually, Zoloft (Sertraline) does work on similar brain areas as Psilocybin and LSD.
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<br>Zoloft is in a catergory of antidepressants that are called SSRI's.
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<br>SSRI stands for Seritonin-Specific-Reuptake-Inhibitor.
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<br>What it does is potentiates serotonin neorotransmission by inhibiting its active presynaptic reuptake at the 5-HT sites, thus increasing seritonin neurotransmission throughout the brain.  (A Primer of Drug Action 8th edition, Robert M. Julien, MD., 1998, page, 200-204)
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<br>Conversely, LSD, Psilocybin, and other Seritonin-like psychedelics exhibit their action by decreasing seritonin neurotransmission; resulting in an inhibition of seritonin throughout the brain. (same source, page,358-360)
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<br>So, in a sense, Zoloft acts in an opposite way than LSD and psilocybin.  Therefore the two are counterproductive when taken together.
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