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Invisibleveggie

Registered: 07/26/04
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Modafinil - the time-shifting drug
    #4374631 - 07/06/05 03:51 AM (11 years, 4 months ago)

Modafinil - the time-shifting drug
July 5, 2005 - gizmag.com

The wonders of pharmacology keep appearing regularly, each new drug seemingly too good to be true. In recent times there have been several killer apps for the drug industry - chemical substances that replace depression with a happy disposition or bolster a flagging sex drive to royal command performance (with encore) levels. Prozac and Viagra provided benefits so compelling they have entered everyday language and have a global following. Now there's another "drug-most-likely-to-succeed" - this one enables you to stay awake for 40+ hours with close to full mental capacity with few side effects.

Modafinil improves memory, and enhances one's mood, alertness and cognitive powers. The drug has a smoother feel than amphetamines and enables the user to stay awake and alert for 40 hours or more. Once the drug wears off, you just have to catch up on some sleep.

Marketed as 'Provigil', 'Aletec', and 'Vigicer', Modafinil is a psychostimulant approved by the US Federal Drug Administration for improving wakefulness in patients with excessive sleepiness associated with shift work sleep disorder, obstructive sleep apnea / hypopnea syndrome and narcolepsy.

Not surprisingly, a drug that enables people to stay awake for 40 hour periods at close to full mental capacity with no real side effects could quickly gain widespread usage as a time-shifting drug. Got a project to do, Particularly, when it is devoid of the jitteriness associated with most drugs commonly used in such circumstance such as dextroamphetamine, cocaine and the world's most popular drug, caffeine.

"Au natural", (without drugs) humans don't deal well with lack of sleep and thanks to our fast-paced lifestyle and ever-increasing job demands, sleep deprivation is a commonplace occurrence in modern culture.

Australian researchers recently found that people who drive after being awake for more than 17 hours performed worse than those with a blood alcohol level of .05 percent (the local blood alcohol limit). Tests the world over have found that sleep deprivation significantly reduces human performance capabilities, coordination, reaction time and judgment.

Twenty four hours without sleep is enough to reduce most humans to half their normal mental capacity and it declines rapidly from that point.

Not surprisingly, the military are showing the most interest in the drug.

A large part of battle fatigue is sleep deprivation. When the military is on the move, almost everybody is required to perform mission-critical tasks way after they should be asleep. From the personnel at command HQ to the soldiers at the front, two or three weeks of activity with just a few hours sleep per day is routine in combat situations.

For years the military has been exploring new methods to safely combat sleep deprivation and to prevent the associated degradation of performance.

A drug that can double the mental capacity and alertness of a fighting force has more than doubled its effectiveness.

On top of that, with military communications now in real-time, this is a drug that might keep a small fighting force in heavy contact going until the sky's open up and help arrives.

But likely candidates for the modafinil fan club aren't hard to find beyond the military, if the world's caffeine consumption is any indication.

Caffeine is a drug used across the planet for combating fatigue, restoring mental performance and enhancing exercise endurance. Caffeine occurs naturally in more than 60 plant species each contributing to a whopping global per capita consumption estimated at around 70 milligrams (mg.) per person per day some 20 years ago. That figure is growing.

More than half of all American adults consume 300 mg. or more of caffeine every day. Nine out of ten Americans consume caffeine every day.

The most prolific caffeine contributor is coffee, the second most valuable legally traded commodity on Earth (after oil) with annual global retail sales more than US$70 billion. Caffeine is also contained in tea, chocolate and caffeine-enhanced cold drinks such as Coca Cola, Pepsi Cola, Red Bull et al.

In recent times, the caffeine-enhanced softdrink market has burgeoned.

In 1970, the average american drank 36 gallons of coffee and 23 gallons of carbonated soft drinks. By the year 2000, coffee consumption had more than halved to 17 gallons and soft drinks had grown 130% to 53 gallons. Caffeine consumption has grown significantly and a large proportion of that caffeine was imbibed with the sole aim of performance enhancement.

Unfortunately, the benefits of caffeine are such that constant use builds immunity, leaving the jitteriness but not the enhanced performance and most of the world's habitual coffee consumption is used to stave off the effects of caffeine withdrawal. Modafinil does not appear to have such drawbacks, though users should be acutely aware that prolonged and regular use of the drug will lead to health issues.

Almost any profession requires being switched on (mentally alert) at least some of the time, and if it's good enough for the most scientifically-analysed elite warriors on the planet, we suspect it'll be good enough for all other armed forces personnel, emergency and rescue workers, police, firefighters, and doctors, who are faced with very long hours of making potential life and death decisions ... and all those who need or choose to work long hours in their profession, from truck and taxi drivers, through to computer programmers.

Sportspeople are another likely marketplace - at the June 2003 United States Track and Field Championships, a star studded field of athletes tested positive for modafinil including sprinters Kelli White, Chris Phillips, Calvin Harrison and Chryste Gaines, hurdlers Sandra Glover and Eric Thomas and hammer thrower John McEwen. Modafinil now attracts a two year ban from all elite sports, but can be expected to proliferate at any level where drug testing does not occur.

Then there will be those who will take Modafinil for recreational purposes - it just might be the ultimate party drug with the user awake, alert and balanced and no problems remembering what happened or what got said the next morning.

So how good is it? Researchers recently had the opportunity to compare a group of America's finest with and without modafinil.

The testing was done using elite F-117A Nighthawk pilots - an F117-A Nighthawk is one of those black triangular stealth attack aircraft used with surgical precision by the US airforce in all recent wars.

Just over 60 Nighthawks were built and only one F-117A unit exists - the 49th Fighter Wing, at Holloman Air Force Base, N.M. The single-seater can fly at high subsonic speeds for unlimited distances with air refuelling. On their first deployment to Kuwait in 1992, a group of F-117s flew non-stop for 18.5 hours, a record for single-seat fighters that stands today.

With the right pilot aboard, the Nighthawk is a formidable weapon - a precision-strike aircraft with exceptional combat capabilities particularly suited for penetrating high-threat airspace with its stealth and speed and hitting critical targets with surgical accuracy using laser-guided weapons.

During Operation Desert Storm the Nighthawk flew approximately 1,300 sorties scoring direct hits on 1,600 high-value targets in Iraq. At US$45 million each, the Nighthawk is one of America's most effective weapons. When the United States declares war on you, the chances are the Nighthawk will be the first to tell you hostilities have begun. It was the ONLY U.S. or coalition aircraft to strike targets in downtown Baghdad and it led the first Allied air strike on Yugoslavia in March, 1999.

Our test group was the people who fly these aircraft - people who push the limits of human performance day-today using one of the most expensive and sophisticated aircraft on the planet. For the records, the F117-A is built by Lockheed Aeronautical Systems, is powered by two General Electric F404 non-afterburning engines is 19.4 metres long, 3.9 metres high, weighs 23,625 kilograms and has a wingspan of 13.2 metres.

The Laboratory and simulator tests studied the effects of being awake for 40 hours on alertness and flight performance.

The tests were repeated every five hours to help track the pilots' level of fatigue by monitoring body and brain activities. One test is a one-hour flight simulator mission. Researchers looked at the aviators' ability to monitor flight gauges and calculate basic mathematical equations. They also monitored eye movements and changes in pupil size.

While no one crashed or even came close to crashing, researchers said flight precision most noticeably changed between 33 hours and 38 hours into the test.

Armed with this initial data, the scientists returned to Holloman a few months later for the modafinil study.

Scientists said that while the pilots were on the medication, their performance "significantly improved," especially after 25 hours without sleep. The pilots also sustained brain activity at almost normal levels despite their sleeplessness.

During the simulator tests, modafinil "significantly" reduced the effects of fatigue during flight manoeuvres, researchers said.

Under the influence of modafinil, flight performance degraded by 15 to 30 percent. Performance by pilots without the medication degraded by 60 to 100 percent compared to fully rested performance levels.

The results of the testing were heavily conclusive - modafinil was effective for reducing the impact of fatigue.

International biopharmaceutical company Cephalon owns the worldwide rights to Modafinil.

Modafinil is available in more than 20 countries and is marketed under the brand name PROVIGIL in the United States, United Kingdom, Ireland, Italy, South Korea, Belgium and Luxembourg. Modafinil is available in other countries under the brand names, ALERTEC, MODIODAL, MODASOMIL, MODAVIGIL and VIGIL.

Modafinil is listed as a Schedule IV drug under the Controlled Substances Act. Schedule IV drugs as a class have a lower abuse potential than drugs listed in Schedule II or III. Other examples of Schedule IV drugs include Ambien, Xanax and Ativan. Examples of Schedule II drugs include Actiq, morphine, methadone and methylphenidate (Ritalin). Examples of Schedule III drugs include anabolic steroids, codeine and hydrocodone with aspirin or Tylenol, and some barbiturates.

Cephalon recently announced that it has filed an application with the U.S. Food and Drug Administration (FDA) requesting marketing approval of a new proprietary form of modafinil for the treatment of attention- deficit/hyperactivity disorder (ADHD) in children and adolescents between the ages of six and 17.


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OfflineLysergicRide
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Re: Modafinil - the time-shifting drug [Re: veggie]
    #4559016 - 08/20/05 02:28 PM (11 years, 3 months ago)

I have taken Modafinil/Provigil in the past and it WILL NOT let you stay up for 40 hours. Infact I've fallen asleep 3 or 4 hours after taking it. I have never taken Amphetamines, which I understand will truly let you stay up for a couple days and feel like you have tons of energy... But this drug will NOT do that. It will let a well rested person focus better and feel more alert but it is by no means a "safe meth" substitute


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The fool on the hill sees the sun going down... And the eyes in his head see the world spinning around

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OfflineMasema
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Re: Modafinil - the time-shifting drug [Re: LysergicRide]
    #6049255 - 09/11/06 10:31 AM (10 years, 2 months ago)

Just in case anyone searches and finds this reply about modafinil, in my experience modafinil can in fact keep you awake and alert for atleast 36 hours. One thing to realise about this drug is that it takes about four hours to take full effect, and it starts to wear off a bit after 12 hours. Therefore, to stay up for an extended period of time it must be taken about every 8 hours until about 12 hours before you intend to sleep. No, it does not work as well as methamphetamine, but then again it has nowhere near the addiction and side-effect potential as methamphetamine. It is weird because you do not feel stimulated per se, but really only as if you had sleep and are a little out of it (the lack of sleep does have SOME effect).


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OfflineCptnGarden
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Re: Modafinil - the time-shifting drug [Re: Masema]
    #6049919 - 09/11/06 03:12 PM (10 years, 2 months ago)

^ Masema in fijian means salt. sorry that was offtopic.


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OfflineMasema
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Re: Modafinil - the time-shifting drug [Re: CptnGarden]
    #6050813 - 09/11/06 07:24 PM (10 years, 2 months ago)

Thank you, that is actually pretty interesting to know. I always thought that Robert Jordan just had a genius streak with names (as well as a keen sense of how to screw up a good thing).


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Offlinedownlowfunk
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Re: Modafinil - the time-shifting drug [Re: Masema]
    #6051095 - 09/11/06 08:50 PM (10 years, 2 months ago)

I gotta say good clean acid in largerdoses will keep you up for 40+ hours. Hell some really killer Sativa will keep you up all night working as well. I would not be surprised to see the molecule of this drug to look very similar to LSD or Mescaline.


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OfflineLynxRufus
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Re: Modafinil - the time-shifting drug [Re: downlowfunk]
    #6051247 - 09/11/06 09:35 PM (10 years, 2 months ago)

Modafinil is affective in one hour on an empty stomach. It will not keep you awake for 40 hours. In fact, it will not keep you awake at all (once accustomed to it). No one is completely sure how it works, but basically it works when you need it to, as opposed to speeds 'always on' affects. You can relax and sleep at night, but if you are tired it and need to do something cognitively expensive (focusing, driving, thinking, being creative) it works wonders. Modafinil as a chemical is very speed-like, but lacks the dopaminergic rush associated with speed. A very potent combination is wellbutrin and modafinil. Low dose each and your day is splendid. Over do it and you may want to die.

Unfortunately the makers of Provigil (the US version of the pharmy that insurance companies cover) rake people over the coals and it is becoming increasingly hard to get. We're talking 400 USD a month here. People with sleep or hypersomnia disorders that actually need it (and see it as the one thing that can give them a happy life) are often left out in the cold cause insurance companies don't want to keep their end of the deal and the manufacturers are greedy bastard hellspawn.


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OfflineMasema
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Re: Modafinil - the time-shifting drug [Re: LynxRufus]
    #6051376 - 09/11/06 10:04 PM (10 years, 2 months ago)

Actually, in my experience it takes much more than one hour, even on an empty stomach, to feel the full effects of modafinil. According to www.rxlist.com under clinical pharmacolgy it states, "Absorption of PROVIGIL tablets is rapid, with peak plasma concentrations occurring at 2-4 hours . . . Food has no effect on overall PROVIGIL bioavailability; however, its absorption (tmax) may be delayed by approximately one hour if taken with food" (1). I know that it is said to not be 'always on' but that is not totally the case. It is a CNS stimulant, again from rxlist, "In addition to its wakefulness-promoting effects and increased locomotor activity in animals, in humans, PROVIGIL produces psychoactive and euphoric effects, alterations in mood, perception, thinking, and feelings typical of other CNS stimulants" (2). Provided there is continual dosage, it can and does keep one awake beyond 24 hours. It is not a subtle effect; it feels similar to other stimulants, i.e. increased heart rate, anxiety, etc. In fact on wikipedia it is stated that "one study on helicopter pilots suggested that 600 mg of modafinil given in three doses can be used to keep pilots alert with only 8 hours of sleep in an 88 hour period. Another study on fighter pilots showed that 300 mg modafinil given in three divided 100-mg doses sustained the flight control accuracy of sleep-deprived F-117 pilots to within about 27 percent of baseline levels (3).
The main difference here, I belive, is that it is possible to sleep with modafinil in your system, but it is not particularly easy. That is, it does not 'keep' one awake in the sense of methamphetamine, but it certainly does 'keep' one awake in the sense of allowing one to stay awake for extended periods of time, i.e. 36+ hours.

(1) http://www.rxlist.com/cgi/generic2/modafinil_cp.htm

(2) Ibid.

(3) http://en.wikipedia.org/wiki/Modafinil


Edited by Masema (09/11/06 10:07 PM)


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OfflineLynxRufus
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Re: Modafinil - the time-shifting drug [Re: Masema]
    #6051470 - 09/11/06 10:33 PM (10 years, 2 months ago)

Um, you can quote Greys Anatomy if it makes you feel better, lol.

But you feel the effects of 'wakefullness' within an hour on an empty stomach. Note how your quote states the term 'peak'. Note that a person does not automatically have an empty stomach just because they haven't eaten yet in the morning. A late snacker may have foods particles like grease in their stomach from a late night snack. A simple thing like this would naturally account for the 2 to 4 hour time discrepancy stated in your quote.

The actions of provigil, namely the always on part, are true and predictable based on phenomenological data as well as the advertised traits and published empirical data. Please refer to their published insert. In monkey trials, provigil was only found to be only mildly reinforcing.

Many many drugs produce the effects you have stated/quoted to some degree and in an often changing pattern. ie, benedryl changes our mental state and depending on dose and tolerance creates said effects, but on the opposite scale. 10 mg of percocet will have a very different effect on someone who uses pain killers regularly versus someone who never uses them.

Also, drug companies reports and interpretations of drug companies reports are written to the least common denominator. This means they report ALL effects even if the evidence does not support they will occur in most or even many people.

Provigil will give you the rush/speed effect more if you are just starting or changing your dose. but if you are taking as prescribed, then it will not. Note your wikipedia comments. The pilots did have sleep during those periods. The test does support the "on when you need it analogy". And 600 mg is not a standard dose (100 and 200 are common, 300 is rare, and 400 is reserved for high need patients and is expected to be supported by diagnostic criteria. 300 is rare because it is not in the 'double dose' factoring scale). Much like my benedryl analogy, if you take too much, you will trip your balls off. Yet that is not the purpose of the medication nor within its prescription range.

If provigil had a greater dopaminergic factor, it would be much more meth like. But it doesn't. When a person is acclimated to this medication (not recreational use or specific "I want to see 40 hours" use) then this medication has been clinically shown to allow sleep.

Note your word "allowing" in the sense of "allowing" to stay awake. Yep, like I said in my last post. Its there when you need it.


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OfflineLynxRufus
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Re: Modafinil - the time-shifting drug [Re: LynxRufus]
    #6051488 - 09/11/06 10:39 PM (10 years, 2 months ago)

I forgot to say that I am not in total disagreement with you. I should point that out in case you didn't infer it from my response. Yeah, if you don't have a tolerance and you start chucking pills, get ready for a long response (clinically speaking, an expected 15 hour response from the initial dose alone.) Some people may also be more reactive to this drug than others, but these people do not conform to the bell curve normative data presented to us by the folks who brought us provigil.


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OfflineMasema
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Re: Modafinil - the time-shifting drug [Re: LynxRufus]
    #6051830 - 09/12/06 12:21 AM (10 years, 2 months ago)

I see, I believe I became stuck on the sentence "It will not keep you awake for 40 hours. In fact, it will not keep you awake at all (once accustomed to it)." I took this to mean that it does not allow a person to stay awake for an extended period of time, atleast beyond the first few doses, and that is has no use beyond helping someone who is tired and needs to perform a cognitively demanding task. This conflicted with my research and experience with modafinil. Yet, if what you meant was that either one dose will not keep you awake for 40 hours, and/or that chronic use will not keep one awake at all, then I can see what you mean. My point in my original post was simply to inform people such as myself - people who on a infrequent basis need to stay awake for an extended period of time, an 'all-nighter' - that modafinil does in fact help you stay awake. This is in contrast with the first reply to this thread which said otherwise. Certainly this would not be the case for a habitual user, such as a shift worker or a narcoleptic. In fact, I have noticed deminished effects after taking modafinil for about a week with intermittent sleep (finals).


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Offline76degrees
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Re: Modafinil - the time-shifting drug [Re: Masema]
    #6052519 - 09/12/06 08:47 AM (10 years, 2 months ago)

I know a better way to fight sleep deprivation. It's called takeafuckingnap. That stuff works like a charm everytime :smile:


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The world is changed. I feel it in the water. I feel it in the earth. I smell it in the air. Much that once was is lost, for none now live who remember it.


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OfflineCosmicFunGuy
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Re: Modafinil - the time-shifting drug [Re: 76degrees]
    #6054015 - 09/12/06 06:08 PM (10 years, 2 months ago)

What does a pill that keeps you up for 40 hrs have to do with time shifting? It just makes you stay up time doesn't change.

If you want to experience a time shift or even exist outside of time ditch the pharmecuticals eat some acid....

THE TITLE OF THIS TOPIC IS DECIEVING!!!! PHARMECUTICALS ARE NOT THE WAY TO SHIFT TIME! :cool:


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♫ ♪ In the garden of many fields, there is no me or you. There is no right or wrong. There is no up or down. There is no black or white. Everyone is the plow man. Everyone is the seed. Everyone harvests and everyone yields. In the garden of many fields, everyone is one with one love and one love is one with everyone. ♪ ♫
lyrics from: Transglobal Underground - Eyeway Souljah (from Psychic Karaoke)


Edited by tickettothemoon (09/12/06 06:10 PM)


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Offlinejunior2521
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Re: Modafinil - the time-shifting drug [Re: CosmicFunGuy]
    #6054743 - 09/12/06 09:22 PM (10 years, 2 months ago)

Crazy shit.. Has ne one actually tried this?


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OfflineSerratedFrond
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Re: Modafinil - the time-shifting drug [Re: junior2521]
    #6054831 - 09/12/06 09:50 PM (10 years, 2 months ago)

Both Lynx and Masema sound as if they have.

This could be used in glorious ways if one was impetuous enough.


--------------------

Genesis 1:29
AsalamAlakum ~ SF


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OfflineGumbyM
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Re: Modafinil - the time-shifting drug [Re: veggie]
    #8491793 - 06/06/08 08:54 AM (8 years, 5 months ago)

Bumping an old post after doing a search.

I've been looking for an alternative medication for ADHD for a while because adderal gives me a bad case of hyperhydrosis (sweating too much), even after playing around with dosages. It also causes me to be quite shaky and causes some minor tremors, which is not acceptable because I need pinpoint fine motor skills for my work (genetics and other lab work).

I talked to my doctor about it and he said he thought it would be a great idea to give it a try, so he called it in to the pharmacy. I went to the pharmacy to pick it up and they told me that insurance wasn't going to cover it until the doctor personally called them and gave them a reason why I needed the drug. After seeing the price without insurance I could understand why... It was fucking $365 for a 30 day supply. That is just insane.

I haven't heard anything since then, but I'm going to call him today and see what he's doing about it. I'll update this post if I ever manage to get my hands on some.

By the way, that article has to be the most long winded superfluous piece of journalism I have ever read. Where the hell was this guy's copy editor?


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Invisibleveggie

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Re: Modafinil - the time-shifting drug [Re: Gumby]
    #8492049 - 06/06/08 11:19 AM (8 years, 5 months ago)

That's a crazy price. I've seen much cheaper on those 'buy without a prescription' sites, but who knows what you are getting.

Anyway, on the PROVIGIL (modafinil) website, there is a coupon for a free 7 day supply. You could get that first and see if it is even going to work for you. Good luck.


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OfflineJohn Smith
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Re: Modafinil - the time-shifting drug [Re: veggie]
    #8493255 - 06/06/08 05:58 PM (8 years, 5 months ago)

double standards ftw

(not you veggie, the whole concept of good drugs vs bad drugs)


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OfflineTriggerFun
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Re: Modafinil - the time-shifting drug [Re: CosmicFunGuy]
    #15149227 - 09/28/11 09:52 PM (5 years, 2 months ago)

Quote:

CosmicFunGuy said:
What does a pill that keeps you up for 40 hrs have to do with time shifting? It just makes you stay up time doesn't change.

If you want to experience a time shift or even exist outside of time ditch the pharmecuticals eat some acid....

THE TITLE OF THIS TOPIC IS DECIEVING!!!! PHARMECUTICALS ARE NOT THE WAY TO SHIFT TIME! :cool:




To throw my two cents in:

First of all, LSD is pharmacological in nature, as it requires synthesis in a lab to create, and if our scheduling were different, would exist in a pill in a pharmacy as well.  LSD in fact, as you all probably know, takes a hell of a lot of really good chemistry to pull off, so it's fundamentally the same as anything sold via a pill (strictly from a chemistry standpoint).

That being said I have taken my fair amounts of acid, meth, coke, shrooms, mescaline, dmt, a few trips of salvia, and every other drug that really isn't belonging in the "wakefulness promoting" category (opiates, benzos, you get it) - and though lsd and similar psychedelics are the shit, there really is some merit to this drug as a "time-shifter." 

I've used it for a long time (get a legal Rx), and when i take larger than proper doses if you will, I experience a familiar rush thru some system in my neo-cortex.  It's definitely got a little dopamine and other catecholamine flavor to it, but it also seems to encourage deeper and more abstract mental connections, leading to break-thru's not totally unlike acid (though much more difficult on average to obtain

It's also highly synergistic with cannabis in my opinion, at which point you can really call upon your mind to dance for you.  No b.s., i hallucinated as heavy as a 5 day meth run or the 13th hour of some killer acid when I threw pot in the mix.

As my brain chemistry stands, modafinil can pull off some amazing things without relatively frequent re-dosing, well past hour 40.  When the psychedelic state is at maximum with modafinil hours become minutes - and when I do nothing but meditate on it I can create lucid dream states or even full on sleep if such is desired.

It's just something to consider I guess - few drugs positively surprise me the way lsd, shrooms, or cannabis do, but if i had to extend that list much further, modafinil would be there.

It's a psycho-stimulant, and at times it can create real psychedelic effects.


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My avatar is my beautiful and young (well - 24 years old makes her a physical specimen and kind-hearted genius), pyschonaut apprentice - and wife of almost 5 years. :heart::grin:


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OfflineSWEDEN
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Re: Modafinil - the time-shifting drug [Re: TriggerFun]
    #15150391 - 09/29/11 01:21 AM (5 years, 2 months ago)

Whoa, speaking of time-shifting, here's a blast from the past. 6 year-old thread :crazy2:

But you have piqued my curiosity! I must try some of this "modafinil".


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