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Every trip is a little different, and different batches of shrooms can vary... but cubes are cubes.
Set and setting has more to do with it than anything...
But I notice differences between strains... the thing is the differences are likely placebo, because different folks have different opinions of different strains. This is why I think set and setting are more important.
But, if you find a favorite strain, GREAT! I have a few.
Now, different species of mushrooms can give different trips... but the variations aren't as big as with different strains of pot.