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Mushrooms, Mycology and Psychedelics >> The Psychedelic Experience

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Offlinemakedrugsfree
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difference in chem content
    #410942 - 10/02/01 05:24 AM (15 years, 2 months ago)

Could someone give me a simple explanation how the process works of converting these chem in our body to each of them. And maybe the affects of each (which are more % wise important).
PSILOCYBIN, PSILOCIN, and BAEOCYSTIN

Also which Psilocybe species do not work well with the standard PF tek?

Evil will always provail, because good is dumb.


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OfflineMarleyBob
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Re: difference in chem content [Re: makedrugsfree]
    #411534 - 10/02/01 07:40 PM (15 years, 2 months ago)

I dont understand your question.



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Offlinemakedrugsfree
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Re: difference in chem content [Re: makedrugsfree]
    #411661 - 10/02/01 09:36 PM (15 years, 2 months ago)

I've read that psilocybin is converted to psilocin (or vice versa) by our bodies. So do both chemicals affect us the same way? Are we only really affected by one of them because the other is converted to the second? If we are affected by both, then do they have different affects?

Evil will always provail, because good is dumb.


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Offlinedirk gently
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Re: difference in chem content [Re: makedrugsfree]
    #411686 - 10/02/01 09:53 PM (15 years, 2 months ago)

Its complicated. If you are trying to decide on a P.cubensis substrain based on some findings of their chemical content I would encourage you to not bother.

First off, its highly variable anyway. Even between flushes of the same colony. Secondly, the actual pharmacology/pharmcodynamics is not completely known with rerd to the relation of these compounds that may or may not be present in significant amounts when you eat mushroom X.

The general concensus is that psilocybin is converted to psilocin in your body. Enzymatically dephosphorylated I believe. It is not entirely clear as to whether or not psilocybin itself produces a drug effect as well as psilocin, or if its just psilocin thats doing it. IMO, those are the two chemicals that produce 99% of the drug effects. Some people think that baeocystin, norbaeocystin and a slew of other related compounds may produce significant effects or somehow change the effects of the psilocin. They are all present in much less quantity for the most part. To such an extent that the equivalent amount of pure chemical (baeocystin, for example) is not active (sub threshold or just not active at all).

The other thing to consider is that psilocin is much less stable than psilocybin. Drying, air oxidation, heat or other may effectively chemically change the psilocin to something thats inactive (Blueing of mushroom tissue is supposedly a psilocin breakdown product). Also, psilocybin is very water soluble. Psilocin, not so much (maybe, I forget now).

I'll just shut up now before I confuse you anymore than already.

Oh, for PF, use only psilocybe cubensis. Any variety.



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Offlinemakedrugsfree
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Re: difference in chem content [Re: dirk gently]
    #413270 - 10/04/01 04:32 AM (15 years, 2 months ago)

Thanks for your reply. Your information helped a lot.

>If you are trying to decide on a P.cubensis substrain ...

Well actually a psilocybe species, but I'll take it that what you said is good for that too.

Evil will always provail, because good is dumb.


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Mushrooms, Mycology and Psychedelics >> The Psychedelic Experience

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