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OfflineAbermelin
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Psilocybin Metabolization
    #4107226 - 04/28/05 03:59 PM (11 years, 7 months ago)

Ive heard, since psilocybin is nearly identical to NN-DMT and is also a tryptamine like DMT , that the MAO enzyme in your stomach metabolizes the majoirty of psilocybin that you ingest causing a much weaker trip than if it were taken with an MAOI. Does anyone have any information on this? I would love to know whether it it entirely true, and if so, how much of the psilo gets metabolized.


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OfflineChuangTzu
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Re: Psilocybin Metabolization [Re: Abermelin]
    #4107265 - 04/28/05 04:14 PM (11 years, 7 months ago)

Shulgin hypothesizes somewhere in TIHKAL that as much as 60% (if I remember correctly) of the psilocin could be metabolized first-pass. I don't remember exactly where but if you look around in there you'll find it. I also seem to remember that he was just kind of pulling that figure out of his butt.


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Invisiblegdman
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Re: Psilocybin Metabolization [Re: Abermelin]
    #4107334 - 04/28/05 04:38 PM (11 years, 7 months ago)

The HO group on the 4 position allows for oral use without an MAO-i.


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Invisibledblaney
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Re: Psilocybin Metabolization [Re: Abermelin]
    #4107391 - 04/28/05 04:55 PM (11 years, 7 months ago)

Yeah, with an MAOI the trip will be several orders more intense.


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OfflineAbermelin
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Re: Psilocybin Metabolization [Re: dblaney]
    #4107641 - 04/28/05 05:59 PM (11 years, 7 months ago)

im not sure if shuglin would "pull a figure out of his butt". i think hes smarter than that. but thanks for the info. ill try to find a refernece to it in TIHKAL somewhere.


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OfflineChuangTzu
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Re: Psilocybin Metabolization [Re: Abermelin]
    #4109912 - 04/29/05 06:18 AM (11 years, 7 months ago)

Maybe it was more of an educated guess, but in any case he said something like "I suspect" or "I believe" and didn't mention whether any research had actually been done in that area.

And btw, it's "metabolism".


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OfflineAbermelin
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Re: Psilocybin Metabolization [Re: ChuangTzu]
    #4111222 - 04/29/05 03:21 PM (11 years, 7 months ago)

ill take shuglins educated guess over my own. of course hard evidence would be good.


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