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April 16, 1943: Dr. Albert Hoffman, a Swiss chemist who had created the synthetic drug LSD-25 in 1938, discovered its hallucinogenic effects on this date in 1943.
Hoffman accidentally consumed some of the substance, formally known as lysergic acid diethylamide, and went home because of a slight dizziness and restlessness. At home he lay down and was disturbed by unusual sensations and hallucinations. Hoffman recorded these experiences in his notes.
He intentionally took the drug again to check his reactions. When he published a report announcing his discovery, LSD made its way into the array of so-called "mind-expanding" drugs. After its use as a recreational drug became more widespread in the 1960s, the manufacture, sale, possession and use of LSD was made illegal in the U.S. in 1965.
Quote: With the laboratory goal of working towards isolation of the active principles of known medicinal plants, Hofmann worked with Mediterranean squill (Scilla maritima) for several years, before moving on to the study of Claviceps purpurea (ergot) and ergot alkaloids.
Over the next few years, he worked his way through the lysergic acid derivatives, eventually synthesizing LSD-25 for the first time in 1938. After minimal testing, LSD-25 was set aside as he continued with other derivatives. Four years later, on April 16, 1943, he re-synthesized LSD-25 because he felt he might have missed something the first time around. That day, he became the first human to experience the effects of LSD after accidentally ingesting a minute amount. Three days later, on April 19, 1943, he decided to verify his results by intentionally ingesting 250 ug of LSD. This day has become known as "Bicycle Day" as Hofmann experienced an incredible bicycle ride on his way home from the lab.