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Registered: 12/20/04
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Tolerance with psychedelics
    #3823700 - 02/23/05 07:55 PM (13 years, 3 months ago)

Sorry if this has been posted before, I couldn't find the answer anywhere. I wanted to know if one takes a psychedelic will that one have a tolerance for other psychedelics? If so, how long?

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Re: Tolerance with psychedelics [Re: thedude100]
    #3823759 - 02/23/05 08:08 PM (13 years, 3 months ago)

i would say the only tolerance to be gained comes from the mental experience of a psychedelic. for example, if you have taken psilocybin or mescalin before, you will be more mentally prepared for the experience of LSD. however, i don't think they help build up any sort of chemical tolerance.

unless, of course, you count how they affect the various chemicals in your brain, in the sense that you will not trip as hard off a hit of LSD you take 3 hours after an initial trip wears off, as you would off the initial trip itself. i would also assume that this is true of eating ANY sort of hallucinogen within a short time of having eaten a prior one.

so to answer your question more precisely, unless you're talking about the span of a few hours, a day at the most, there is no built up tolerance.

unless, of course, i'm wrong.

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Re: Tolerance with psychedelics [Re: belowground]
    #3823846 - 02/23/05 08:24 PM (13 years, 3 months ago)

Hehe, tryptamines build up a cross tolerance with other tryptamines lasting for around 3-4 days. With phenethylamines it's not as clear. However with LSD, DMT, psilocybin, and other tryptamines there is a few day tolerance, but it is also not recommended to trip that often.

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Registered: 01/13/05
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Re: Tolerance with psychedelics [Re: thedude100]
    #3823852 - 02/23/05 08:25 PM (13 years, 3 months ago)

Interesting question, and fortunately the chemical part is easy enough to answer with erowid's fantastic vault. Some psychedelics do have tolerance and some dont.

The more elusive part of the question would have to be whether repeated exposure to psychedelics builds a "mental tolerance" where you might tend to filter out the feelings, visuals and thoughts. I think the answer is multi-faceted. Varying from person to person and settings.

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Mushrooms, Mycology and Psychedelics >> The Psychedelic Experience

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