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 DNKYD
Turtle!
Registered: 09/23/04
Posts: 12,326
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 Psilocin extraction questions 
#3769025 - 02/11/05 10:09 PM (18 years, 1 month ago) |
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Ok, I read this post on a/b extraction of psilocin. Here is my plan, using some parts from that post. I will use vinegar and distilled water at pH of 2 to soak my powdered mushrooms in. It will be in a hot water bath at 90?F for 45 minutes. Strain and save the solution. Repeat this a few more times.
Now, I won't do this part right here:
Quote:
7) We will now de-fat the acidic solution to ensure a purer finished product. Naphtha is what I will be recommending and using in this procedure. Pour the acidic liquid into a separatory funnel. Add 50mL of warm naphtha to the funnel. Turn the funnel upside down and right side up 10-20 times. Do this gently enough that great deals of bubbles don?t form. You?ll need to release the pressure in the funnel. Do this by turning the funnel so that the stopcock is aimed up and open it. I recommend doing this every 2-3 turns.
8) Allow the layers to settle out now. The bottom layer will be the acidic water solution containing the alkaloids and the top layer will be the naphtha containing the extracted fats.
9) Open the stopcock and save the water layer. The naphtha layer is to be discarded. Repeat the naphtha defatting once more to ensure complete defatting.
I will do these parts, replacing naptha with high-solvency acetone, or just regular acetone.
Quote:
10) Now it?s time to basify the solution and get our crystals! The DEA site that I gleaned some of this information from states that too high of a pH can damage the alkaloids that we want to extract. They recommend 8.0-8.5pH be used. Since we want this to be as ?gentle? as possible, we will use baking powder as our base. Prepare 200mL of distilled water and baking soda until the pH is about 8.0. Add to the acidic solution, stirring regularly, until the pH reaches 8.0. The crystals are now ?loose? in the solution and ripe for the plucking!
11) Again we will be using naphtha as our solvent but this time, since the crystals are not dissolved in the liquid, they will migrate to the naphtha layer. Put the basified liquid into the separatory funnel and add 75mL of naphtha. It?s pretty much the same as the defatting, except we want to keep BOTH layers, but keep them separate. Repeat this step 2-3 times saving the naphtha each time and re-extracting with fresh naphtha from the basified solution.
12) Now we have naphtha that has all of the alkaloids in it. The basified solution can be tossed. Just to make sure that we got all of the baking soda out we?ll add some water to the naphtha in the separatory funnel and wash it out again. You can shake the separatory funnel now as hard as you want to, as the layers will separate quite rapidly. Do this twice, tossing the water and keeping the naphtha.
13) Time to evaporate that naphtha and watch our crystals form! Put a fan blowing on the naphtha and some heat underneath if you can. Pyrex dishes are great for extractions because you can scrape the crystals off so easy. Don?t get it hotter than 90?F. Naphtha takes a while to evaporate but I guarantee you that it will do just that.
Will this yield pure/semi pure psilocin crystals?
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 p_knutt
amateur mushroomrancher
Registered: 01/27/04
Posts: 33
Loc: CT
Last seen: 16 years, 1 month
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 Re: Psilocin extraction questions [Re: DNKYD]
#3769496 - 02/12/05 12:07 AM (18 years, 1 month ago) |
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Forgive me if I sound like a chemistry teacher, but the reason step 7 is included is to get impurities out. The impurities will mix with the naphtha better than they do with the water, so when you pour off the naphtha, you get rid of a lot of the impurities. Skipping this step won't help you get pure psilocybin/psilocin.
Furthermore, your plan of replacing naphtha with acetone is a bad one.  Naphtha is non-polar, but acetone is polar. Naphtha was chosen because it does not mix with water. By using acetone instead, which does mix with water, you would really screw up the extraction. There would only be one layer of liquid, which would contain acetone, water, psilocybin/psilocin, and anything else that was polar at pH 2.0. I suppose you could try to evaporate off all the water and acetone, but your crystals (if you actually got any) would be pretty impure. 
I recommend a couple more chemistry classes before you start making up your own extraction techniques. If you do some reading and continue asking questions, you should be able to come up with something that works. Good luck! 
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DNKYD
Turtle!
Registered: 09/23/04
Posts: 12,326
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Re: Psilocin extraction questions [Re: p_knutt]
#3769566 - 02/12/05 12:29 AM (18 years, 1 month ago) |
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Aw damn. Thanks man. I don't want to use naptha because I've heard that it is unsafe to use in extractions. Any ideas on a safe nonpolar solvent that I could use for that step instead of naptha?
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p_knutt
amateur mushroomrancher
Registered: 01/27/04
Posts: 33
Loc: CT
Last seen: 16 years, 1 month
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Re: Psilocin extraction questions [Re: DNKYD]
#3788546 - 02/16/05 09:06 AM (18 years, 1 month ago) |
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I'm not really sure, off the top of my head. Let me ask my organic chem professor. I'll get back to you in a day or so...
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dblaney
Human Being
Registered: 10/03/04
Posts: 7,894
Loc: Here & Now
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Re: Psilocin extraction questions [Re: p_knutt]
#3789277 - 02/16/05 12:55 PM (18 years, 1 month ago) |
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Naptha is in my opinion, safe enough. However, I was under the impression that the psilocybin exists as an endogenous acid, hence rendering an A/B extraction useless. I think the easiest/best way is a simple alcohol extraction (methanol is recommended).
Good luck!
--------------------
"What is in us that turns a deaf ear to the cries of human suffering?"
"Belief is a beautiful armor
But makes for the heaviest sword"
- John Mayer
Making the noise "penicillin" is no substitute for actually taking penicillin.
"This country, with its institutions, belongs to the people who inhabit it. Whenever they shall grow weary of the existing government, they can exercise their constitutional right of amending it, or their revolutionary right to dismember or overthrow it." -Abraham Lincoln
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deadmoap
Trypping onTryptamines
 
Registered: 02/12/05
Posts: 63
Last seen: 12 years, 10 months
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Re: Psilocin extraction questions [Re: dblaney]
#3789824 - 02/16/05 03:23 PM (18 years, 1 month ago) |
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p_knutt took the words out of my mouth.
I imagine that you could substitute naphtha with any other nonpolar solvent like Coleman's White gas... or perhaps even vegetable oil. :p
IMO, naphtha (zippo lighter fluid) is safe. As long as everything is evaporated in the end, it doesn't make any difference.
I have a bottle of naphtha just sitting around in my room... but it's really fun to pour it on the floor all around the room and watch it make a trail of fire!  (Warning: don't try this with carpet; my floor is cement)
Edited by deadmoap (02/16/05 03:29 PM)
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DNKYD
Turtle!
Registered: 09/23/04
Posts: 12,326
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Re: Psilocin extraction questions [Re: dblaney]
#3789913 - 02/16/05 03:43 PM (18 years, 1 month ago) |
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Quote:
dblaney18 said:
Naptha is in my opinion, safe enough. However, I was under the impression that the psilocybin exists as an endogenous acid, hence rendering an A/B extraction useless. I think the easiest/best way is a simple alcohol extraction (methanol is recommended).
Good luck!
Using methanol gets the gooey shit. I heard that the gooey stuff does not disolve well into a solution. So if I got the goo and tried to soak it in naptha, would that get the impurities out? Then I could finish the rest of that extraction and get crystals?
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dblaney
Human Being
Registered: 10/03/04
Posts: 7,894
Loc: Here & Now
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Re: Psilocin extraction questions [Re: DNKYD]
#3790111 - 02/16/05 04:24 PM (18 years, 1 month ago) |
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Assuming that psilocybin is an acid, which is insoluble in NPS, then that could work. Although perhaps it would be easier to do something more like an LSA extraction, and just soak the fungal matter with naptha first, then extract into methanol, let the goodies settle at the bottom, and decant.
--------------------
"What is in us that turns a deaf ear to the cries of human suffering?"
"Belief is a beautiful armor
But makes for the heaviest sword"
- John Mayer
Making the noise "penicillin" is no substitute for actually taking penicillin.
"This country, with its institutions, belongs to the people who inhabit it. Whenever they shall grow weary of the existing government, they can exercise their constitutional right of amending it, or their revolutionary right to dismember or overthrow it." -Abraham Lincoln
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p_knutt
amateur mushroomrancher
Registered: 01/27/04
Posts: 33
Loc: CT
Last seen: 16 years, 1 month
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Re: Psilocin extraction questions [Re: DNKYD]
#3794192 - 02/17/05 04:14 PM (18 years, 1 month ago) |
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I talked to my professor, and he pretty much said "If you don't already know what's safe and what works, I'm not going to tell you and you shouldn't try it".
So I asked my TA. He said ether would be a good non-polar solvent to use, because it's easy to evaporate off. He mentioned that toluene is not carcinogenic, but he made it sound like ether would leave less residue.
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DNKYD
Turtle!
Registered: 09/23/04
Posts: 12,326
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Re: Psilocin extraction questions [Re: p_knutt]
#3795889 - 02/17/05 09:57 PM (18 years, 1 month ago) |
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Ok, I read the back of a denatured alcohol can and it said it only contains ethyl and methyl ether. I'm assuming this is safe to use since I can use methyl ether on its own. I'll evaporate some and see if it leaves residue. If it doesn't I'll try using that.
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