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Invisibledr_gonz
Registered: 08/18/03
Posts: 44,654
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    #3707157 - 01/31/05 11:04 AM (19 years, 1 month ago)

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InvisibleRandalFlagg
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Re: Sexual side effects suck! -I want to come off Paxil [Re: dr_gonz]
    #3707564 - 01/31/05 01:00 PM (19 years, 1 month ago)

I was on Paxil and Wellbutrin at the same time. It was horrible. I had a BIG sexual side effect(I could not get off no matter how hard I tried). I don't know if the Paxil or the Wellbutrin caused that. It was not a fun month. Don't take that shit....it sucks.

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InvisibleEgo Death
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Re: Sexual side effects suck! -I want to come off Paxil [Re: dr_gonz]
    #3707630 - 01/31/05 01:27 PM (19 years, 1 month ago)

Sounds like a cure to premature ejaculation to me???


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InvisibleShroomismM
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Re: Sexual side effects suck! -I want to come off Paxil [Re: dr_gonz]
    #3709039 - 01/31/05 05:51 PM (19 years, 1 month ago)

I was on paxil and had the same problem.. could not ejaculate no matter how hard I tried. It was hell... especially since I was 16. Solution - get off paxil.


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Invisibledblaney
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Re: Sexual side effects suck! -I want to come off Paxil [Re: Shroomism]
    #3709155 - 01/31/05 06:07 PM (19 years, 1 month ago)

Yeah, there seem to be a lot of sexual side effects associated with SSRI's. Some doctors prescribe Wellbutrin simultaneously, as it is reported to help with the side effects, although clearly not in all cases. I would recommend slowly coming off of it, but that's just me and my dislike of SSRI's.

Shroomism...your avatar is definitely trippy.


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"What is in us that turns a deaf ear to the cries of human suffering?"

"Belief is a beautiful armor
But makes for the heaviest sword"
- John Mayer

Making the noise "penicillin" is no substitute for actually taking penicillin.

"This country, with its institutions, belongs to the people who inhabit it. Whenever they shall grow weary of the existing government, they can exercise their constitutional right of amending it, or their revolutionary right to dismember or overthrow it." -Abraham Lincoln

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Invisibledr_gonz
Registered: 08/18/03
Posts: 44,654
. [Re: dblaney]
    #3710272 - 01/31/05 08:56 PM (19 years, 1 month ago)

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OfflineDocPsilocybin
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Re: Sexual side effects suck! -I want to come off Paxil [Re: dr_gonz]
    #3711717 - 02/01/05 03:02 AM (19 years, 1 month ago)

Yeah, I was on SSRI's for awhile myself. Paxil, in fact. No good t'was. Should have seen my ex's face, twisted in pain, after a 45 minute blow job. She was not impressed!

I'm not sure if it's related but it still takes me a long time to get off. I can very easily have sex for half an hour or more. By all accounts from talking to my friends about the matter this is a rarity. Not sure if it's permanately altered my sex drive or something. Mmm... Damn reuptake inhibitors.


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You can't hold a man down without staying down with him.
-- Booker T. Washington

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InvisibleSociety
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Re: Sexual side effects suck! -I want to come off Paxil [Re: DocPsilocybin]
    #3717989 - 02/02/05 06:05 AM (19 years, 1 month ago)

This is even more discouraging that I was expected.  The first time I was on Lexapro (the drug that the man switched to) was when I was 15.  I was sexually active back then and I would never orgasm from oral secks and sometimes would have secks and go 60+ minutes before I said "I'm tired, this is boring, bye".

Fast forward a few years to the present where I've started taking Lexapro for a second time.  It's been an extrodinarily long time since I masturbated seeing how I cannot even sustain an erection. :frown:  Where is there hope for me?


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InvisibleEgo Death
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Re: Sexual side effects suck! -I want to come off Paxil [Re: Society]
    #3718432 - 02/02/05 09:59 AM (19 years, 1 month ago)

Viagra?


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OfflineCatalysis
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Re: Sexual side effects suck! -I want to come off Paxil [Re: dr_gonz]
    #3720496 - 02/02/05 06:29 PM (19 years, 1 month ago)

Quote:

Any advice?





Yes, talk to your psychiatrist/psychologist. The whole point of drugs is to improve your quality of life. If the drug significantly effects your quality of life, it is their responsibility to help you find a solution.

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InvisibleSociety
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Re: Sexual side effects suck! -I want to come off Paxil [Re: Catalysis]
    #3723611 - 02/03/05 06:16 AM (19 years, 1 month ago)

I personally don't like prescription drugs at all unless they are ABSOULUTELY necessary (which is why I started taking Lexapro again...). If Paxil has seemingly permanently affected your drive, then you MIGHT want look into / research / "talk to your doctor about" taking certain supplements or herbs. I don't have any first hand experience (yet), but there are a hell of a lot of drive improvers that have been used for ages of empires.

Ex: Peruvian Maca, Horny Goat Weed, Yohimbe, Ginko Biloba....


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Offlineballs
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Re: Sexual side effects suck! -I want to come off Paxil [Re: Society]
    #3728393 - 02/04/05 12:09 AM (19 years, 1 month ago)

did you have an attraction to animals?

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Offlinecanid
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Re: Sexual side effects suck! -I want to come off Paxil [Re: dr_gonz]
    #3731083 - 02/04/05 03:12 PM (19 years, 1 month ago)

i took paxil myself, and while te side effects sucked [acid reflux like effects and stomach problems, t is an effective drug if taken properly and for the right reasons.

i am by *NO* means a porponent of our society's pharmacutical overkill, but it seems to me that a lot of people who need strong help sell thier medcations short because there are unpleasant somatic effects ascociated with the drug. always evaluate the need for the medication, and do it honestly, then evaluate the proble4ms. only when the problems do outweigh the benefits should tey be the reason for comming off the medication. otherwise, a lack of need for the medication shoudl generaly be the reason to do so [wich i suspect is the true case in a lot of people anyway].

for a great many males, this one effect seems reason enough not to use the medication, and as long as your depression/anxiety/other issues can be resolved via another medication/herbal treatment or personaly; this would be good reason not to take it. if the latter resolution is true, you robably didn't need the paxil anymore anyway.


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Attn PWN hunters: If you should come across a bluing Psilocybe matching P. pellicolusa please smell it.
If you detect a scent reminiscent of Anethole (anise) please preserve a specimen or two for study and please PM me.

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OfflineFungi_x
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Re: Sexual side effects suck! -I want to come off Paxil [Re: dr_gonz]
    #3750864 - 02/08/05 12:14 PM (19 years, 1 month ago)

I was on paxil it helped a little but the side affects were hell. I'm on Serzone now and I have noticed a increase in... well what paxil takes away. You may want to look in on it.

Peace, Fungi x

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InvisibleSociety
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Re: Sexual side effects suck! -I want to come off Paxil [Re: Fungi_x]
    #3752771 - 02/08/05 08:25 PM (19 years, 1 month ago)

Serzone isn't an SSRI and doens't have sexual side effects, so how does that work differently? I think I read something about how Serzone patients have somewhat (don't know if it's significant) increased risk of liver and hepatic failure.


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Invisibledr_gonz
Registered: 08/18/03
Posts: 44,654
. [Re: Society]
    #3760525 - 02/10/05 04:58 AM (19 years, 1 month ago)

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InvisibleSociety
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Re: Sexual side effects suck! -I want to come off Paxil [Re: dr_gonz]
    #3760615 - 02/10/05 06:02 AM (19 years, 1 month ago)

Yeah, I just lowered my dose of Lexapro for the third time and am down to 5mg. About a week ago, my secks drive came back like a blight.

SSRI's destroy sexual desire, no doubt.


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Offlinedutchmaster
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Re: Sexual side effects suck! -I want to come off Paxil [Re: Society]
    #3765606 - 02/11/05 06:09 AM (19 years, 1 month ago)

wellbutrin killed my sex drive when i was on it....i took myself off back in fall and my mind races worse than ever now and anxiety is killin me..shit sucks

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InvisibleSociety
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Re: Sexual side effects suck! -I want to come off Paxil [Re: dutchmaster]
    #3768809 - 02/11/05 09:16 PM (19 years, 1 month ago)

Did you quit "cold turkey" (not lowering the dose gradually over time)? When I did this with Lexapro the first time I quit, it seemingly produced permanent anxiety and other negative effects.


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OfflineFungi_x
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Re: Sexual side effects suck! -I want to come off Paxil [Re: Society]
    #3770360 - 02/12/05 08:22 AM (19 years, 1 month ago)

Quote:

SocietyRejects said:
Serzone isn't an SSRI and doens't have sexual side effects, so how does that work differently? I think I read something about how Serzone patients have somewhat (don't know if it's significant) increased risk of liver and hepatic failure.




I think its 1 in 100,000 will have adverse reactions. My doctor also told me most of the time people who had these complications were drinking heavily on the medication.

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OfflineLocus
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Re: Sexual side effects suck! and my experience with antidepressants [Re: dr_gonz]
    #3770426 - 02/12/05 09:05 AM (19 years, 1 month ago)

I am completely empathetic to all of you that have had or have sexual and/or other adverse side effects that come from taking antidepressants. I've probably tried more antidepressants than anyone here, or most people anywhere for that matter. I've gotten fucking every side effect in the book from antidepressants. Not even one didn't give me side effects. Sexually, like many of you, I couldn't even get a hard on most times. I'd try forever and couldn't come even if i did get it semi-hard. Anyway, the point is I know how you guys feel.

The thing is.. with me.. and a lot of other people out there that have problems concerning the need for antidepressants that truly do not have any other option, or people near this area of necessity.. have a big problem. Otherwise, they'll manage.

----My Experience in Brief----

With myself, my primary use of antidepressants are very different than most. Although, some people do use it for this as well, as antidepressants are prescribed for a lot of things. But the cause of my primary problem is unknown. I have many major problems that antidepressants cover along with that primary problem also, but most of the time despite how bad they are, they are usually manageable... unlike the primary. I can tell you what these particular things are and go into detail in another post if anyone is interested.

All of this is a very difficult subject for me as well though. I've been through hell when I was not on antidepressants ...and then I was in a different hell when I went on antidepressants ...and then again I went off them and went through my previous hell again with some differences, not good ones..

At this time it's been a few years since I was on an antidepressant, except for a few very short trials in this time that don't really count in comparison to my "antidepressant era".
Anyway, I'm still in fucking hell... I've been suicidal for many years now. I'm also young and have a long life ahead of me ...so I need a solution, you know? But there isn't one... The only relief out of the endless things I did try for that primary problem (which was just about every thing possible along with every doctor possible for years...) that actually worked was one high dose mix of two particular kinds of antidepressants along with the worst side effects of all and the longest duration on them. .(All the rest that I tried did not fix the primary problem)... So I'm still stuck at a standstill in my life. I don't know what to do and I haven't for years now.

Woah.. I didn't mean to make that drift into my own experience and troubles. I'm surprised I even got that out considering how much I hate this. I'll just split where I go into my own troubles with a mark. Anyway, I think it'd be nice if some of you could read my own part of this, I'd appreciate it I suppose, even though none of you can help me.


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The important thing is not to stop questioning. Curiosity has its own reason for existing. One cannot help but be in awe when he contemplates the mysteries of eternity, of life, of the marvelous structure of reality. It is enough if one tries merely to comprehend a little of this mystery every day. Never lose a holy curiosity. ~ Albert Einstein
"Fear is the great barrier to human growth." ~ Dr. Robert Monroe



~~~*Dosis sola facit venenum*~~~

*Check my profile to listen to my music* :smile:

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InvisibleSociety
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Re: Sexual side effects suck! and my experience with antidepressants [Re: Locus]
    #3770468 - 02/12/05 09:34 AM (19 years, 1 month ago)

It's great to hear your honesty. I'm almost completely off Lexapro (which was my SSRI giving me crap side effects), and my drive is coming back. When I was taking 15-20mg of this medicine, there was no WAY that I could obtain an erection. On top of this eminent flaw in an drug that I was hoping would help arouse my interest in females once again, I was even more miserable than before.

So how's the drive cumin' for you, drgonz?


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Invisibledr_gonz
Registered: 08/18/03
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. [Re: Society]
    #3772998 - 02/13/05 02:35 AM (19 years, 1 month ago)

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OfflineLocus
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Re: Sexual side effects suck! and my experience with antidepressants [Re: dr_gonz]
    #3777306 - 02/14/05 03:16 AM (19 years, 1 month ago)

Hey, I was actually thinking of trying St. Johns Wart soon as well drgonz. I'm fucking sick of living this way.. and although antidepressants may not work for my greatest problem - Physical Pain.. (because only that one mix worked for that... and caused dramatically horrid side effects of all sorts to cause just as much pain as i had before) it may help with my depression, ocd, anxiety, and so on..... I'm really hoping for the pain to be helped though. I'm not getting into details though so I won't bore you guys, hehe. Plus, it's difficult to talk about.

Anyway, so yeah, I think in a few weeks I'm going to start on St. John's Wart. I've done a lot of research on that and there has been more and more research being done that asseverates it's high quality of effectiveness, to work just as sufficiently as many of the pharmaceutical antidepressants out there. And with much less side effects.

And hey, if any of you guys ever want to talk to me about your troubles with antidepressants or anything correlated, I'm always here for ya.


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The important thing is not to stop questioning. Curiosity has its own reason for existing. One cannot help but be in awe when he contemplates the mysteries of eternity, of life, of the marvelous structure of reality. It is enough if one tries merely to comprehend a little of this mystery every day. Never lose a holy curiosity. ~ Albert Einstein
"Fear is the great barrier to human growth." ~ Dr. Robert Monroe



~~~*Dosis sola facit venenum*~~~

*Check my profile to listen to my music* :smile:

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InvisibleSociety
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Re: Sexual side effects suck! and my experience with antidepressants [Re: Locus]
    #3777508 - 02/14/05 05:59 AM (19 years, 1 month ago)

If I become extremely depressed/miserable when I'm off Lexapro completely, I'll probably give St. John's Wort a try. There's a crapload of research that's been done on it, it has almost complete absence of side effects (!), it's been around for ages of empires, et cetera. I recall that my mother used a smalled dose in the past and said it was somewhat efective. The only apparent, proven side effect is photosensitiviy, and the only way to have a negative reaction os apparently to take 30x the regular dose or have already existing issues with photosensitivity.. SJW is even being researched as an anti-inflamatory agent and for treating athritis.

Tru7h...


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Invisibledr_gonz
Registered: 08/18/03
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. [Re: Society]
    #3782753 - 02/15/05 09:33 AM (19 years, 1 month ago)

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OfflineLocus
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Re: Sexual side effects suck! and my experience with antidepressants [Re: dr_gonz]
    #3785016 - 02/15/05 06:26 PM (19 years, 1 month ago)

Thanks. It's good to know you're by my side drgonz :smile:
I'll let you know when I start St. John's Wart as well. And again, best of luck! Do keep me updated also :smile:

And the same to S.R. as well.


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The important thing is not to stop questioning. Curiosity has its own reason for existing. One cannot help but be in awe when he contemplates the mysteries of eternity, of life, of the marvelous structure of reality. It is enough if one tries merely to comprehend a little of this mystery every day. Never lose a holy curiosity. ~ Albert Einstein
"Fear is the great barrier to human growth." ~ Dr. Robert Monroe



~~~*Dosis sola facit venenum*~~~

*Check my profile to listen to my music* :smile:

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Offlinebugfungii24
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Re: Sexual side effects suck! -I want to come off Paxil [Re: Locus]
    #3790164 - 02/16/05 04:35 PM (19 years, 1 month ago)

Go on to a weaker SSRI like Zoloft or maybe try to reduce the dose to 10mg for the Paxil first if you really like that drug.

Forget the psych, they'll just tell you what the manual says.

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Invisibledr_gonz
Registered: 08/18/03
Posts: 44,654
. [Re: bugfungii24]
    #3792056 - 02/17/05 06:35 AM (19 years, 1 month ago)

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OfflineLocus
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Re: Sexual side effects suck! -I want to come off Paxil [Re: dr_gonz]
    #3793086 - 02/17/05 11:25 AM (19 years, 1 month ago)

hey buddy, you know there was just a new study done that said st johns wort is just as good as paxil. the study was specifically paxil vs s.j.w. and s.j.w. came up on top actually by a good deal i believe. and with basically no side effects (which is pretty well known anyway).


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The important thing is not to stop questioning. Curiosity has its own reason for existing. One cannot help but be in awe when he contemplates the mysteries of eternity, of life, of the marvelous structure of reality. It is enough if one tries merely to comprehend a little of this mystery every day. Never lose a holy curiosity. ~ Albert Einstein
"Fear is the great barrier to human growth." ~ Dr. Robert Monroe



~~~*Dosis sola facit venenum*~~~

*Check my profile to listen to my music* :smile:

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InvisibleSociety
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Re: Sexual side effects suck! -I want to come off Paxil [Re: Locus]
    #3793749 - 02/17/05 02:37 PM (19 years, 1 month ago)

Quote:

Go on to a weaker SSRI like Zoloft or maybe try to reduce the dose to 10mg for the Paxil first if you really like that drug.




Is Zoloft really a weaker SSRI? If it is, then I'm pretty sure it's compensated for with higher doses. With Lexapro, average doses usually are 10-20mg, but with Zoloft average doses seem to be around 60+mg. (If my memory is correct. [I have at least two friends in my area on Zoloft.])

There seems to be a lot of varying research on SJW; most seems to support SJW as being a herbal remedy that's comparable to the antidepressant effectiveness of an SSRI without the side effects. In my Internet research, I've found that the only real issue with St. John's Wort is that it can increase photosensitivty. This side effect, however, only seems to effect people with already apparent issues with light and such as it's been shown that in order to have an adverse reaction, one must take AT LEAST 30x the regular daily dose.


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Invisibledr_gonz
Registered: 08/18/03
Posts: 44,654
. [Re: Locus]
    #3794984 - 02/17/05 07:34 PM (19 years, 1 month ago)

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OfflineLocus
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Re: Sexual side effects suck! -I want to come off Paxil [Re: dr_gonz]
    #3797224 - 02/18/05 04:53 AM (19 years, 1 month ago)

Yeah, I had a better article on this, but the link to it isn't working right now. So I found another article with same basic gist of it anyhow... http://www.hbcprotocols.com/sjw-news1.html

Eh, I'm barely getting by man. But I'm hopeful about trying St. John's Wort soon... it'd be really cool if it helped me out. I certainly hope it works for you also. How are you doin?


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The important thing is not to stop questioning. Curiosity has its own reason for existing. One cannot help but be in awe when he contemplates the mysteries of eternity, of life, of the marvelous structure of reality. It is enough if one tries merely to comprehend a little of this mystery every day. Never lose a holy curiosity. ~ Albert Einstein
"Fear is the great barrier to human growth." ~ Dr. Robert Monroe



~~~*Dosis sola facit venenum*~~~

*Check my profile to listen to my music* :smile:

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Offlinechrism
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Re: Sexual side effects suck! -I want to come off Paxil [Re: dr_gonz]
    #3797529 - 02/18/05 08:06 AM (19 years, 1 month ago)

Quote:

drgonz said:
Hey everyone.

I'm looking for some personal opinions. I've been on Paxil for over 2 years now, at 20mg daily. I just can't deal with the sexual side effects anymore, which in turn depresses me (ironic?)

This guy had a similar problem:

http://www.rxlist.com/rxboard/celexa.pl?read=2508

Any advice?




Paxil sucks. I was miserable as soon as the side effects kicked in. I stopped taking it after a week or two. Told the doctor " I'd rather have sex" He suggested St. John's Wort and I have never looked back. Been taking it for five years now.

Do some research first regarding dosage, interactions, etc.. The herb must be standardized and will take at least 6 weeks to begin to work.

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Offlinebugfungii24
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Re: Sexual side effects suck! -I want to come off Paxil [Re: Society]
    #3797567 - 02/18/05 08:29 AM (19 years, 1 month ago)

The dosage is usually between 50mg and 150mg, it's much easier to control the dosage. You could be right about the relative strengths, but I distinctly remember reading that paroxetine has the highest affinity to the receptor site. I also haven't looked in to the relative toxicities of the SSRI's, you? :smile:

I've read those reports that SJW is comparable to popular antidepressants too, however in practice is doesn't work I found-especially for anxiety.

Your lucky if you get better at all. Many of the people who get better in several monthes or weeks I believe had little wrong with them to begin with... and it was more true to say that they were going through "a phase". For those people SJW is probably appropriate.

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OfflineLocus
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Re: Sexual side effects suck! -I want to come off Paxil [Re: bugfungii24]
    #3799440 - 02/18/05 04:37 PM (19 years, 1 month ago)

different antidepressants work differently for each and every person. your experience doesn't stand for everyone elses. look at the post above yours..


--------------------

The important thing is not to stop questioning. Curiosity has its own reason for existing. One cannot help but be in awe when he contemplates the mysteries of eternity, of life, of the marvelous structure of reality. It is enough if one tries merely to comprehend a little of this mystery every day. Never lose a holy curiosity. ~ Albert Einstein
"Fear is the great barrier to human growth." ~ Dr. Robert Monroe



~~~*Dosis sola facit venenum*~~~

*Check my profile to listen to my music* :smile:

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InvisibleSociety
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Re: Sexual side effects suck! -I want to come off Paxil [Re: Locus]
    #3801009 - 02/18/05 09:30 PM (19 years, 1 month ago)

It is unfortunate, though, when people get prescribed a medicine because of phase they are going through. The first time I got Lexapro was because of a teenage phase, and now I'm permanetly skrewed up.

I'm currently in hopes that the end of this SSRI withdrawal will bring mental clarity and energy.


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Re: Sexual side effects suck! -I want to come off Paxil [Re: Society]
    #3802597 - 02/19/05 04:26 AM (19 years, 1 month ago)

May I ask in what way do you now have permanent damage?


--------------------

The important thing is not to stop questioning. Curiosity has its own reason for existing. One cannot help but be in awe when he contemplates the mysteries of eternity, of life, of the marvelous structure of reality. It is enough if one tries merely to comprehend a little of this mystery every day. Never lose a holy curiosity. ~ Albert Einstein
"Fear is the great barrier to human growth." ~ Dr. Robert Monroe



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Re: Sexual side effects suck! -I want to come off Paxil [Re: Locus]
    #3802776 - 02/19/05 08:37 AM (19 years, 1 month ago)

I wish I could explain it, but there are things SERIOUSLY mentally wrong with me, and NONE of these exist before I took Lexapro the first time. Once I quit cold turkey that first time years ago,... barfgh just read the topic I posted of my screaming in frustration.

I really can't blame usage of a drug 100% for my problems, though.


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Re: Sexual side effects suck! -I want to come off Paxil [Re: Locus]
    #3803891 - 02/19/05 04:18 PM (19 years, 1 month ago)

Quote:

Locus said:
different antidepressants work differently for each and every person. your experience doesn't stand for everyone elses. look at the post above yours..



That's true. However, all MAOI antiudepressants (including SJW) have many potentially dangerous interactions.

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Re: Sexual side effects suck! -I want to come off Paxil [Re: dr_gonz]
    #3828316 - 02/24/05 03:51 PM (19 years, 27 days ago)

I would like to invite you to join a new Yahoo discussion group focused on the sexual side effects of SSRIs and antidotes to these effects.

Here is the link:

http://health.groups.yahoo.com/group/ssrisex/

In particular, it appears that for some people the sexual side effects of SSRIs do not go away immediately after quitting the drugs, and can last for considerable time afterwards  :shocked::mad2::sad:. We would like to discover the reason for this persistent sexual dysfunction and find a cure.

Best regards,

Vornan

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Re: Sexual side effects suck! -I want to come off Paxil [Re: Vornan]
    #3829213 - 02/24/05 07:08 PM (19 years, 27 days ago)

Quote:

MAOI antiudepressants (including SJW)




I'm pretty sure that St John's Wort is not a MAOI.

I quit Lexapro and I still experience sexual side effects. While I've had some relief from the side effects, I still am not the way I used to be. I fucking hate SSRIs with a passion.

There are numerous safe herbal treatments for a sexual dysfuction.
-Horny Goat Weed
-Peruvian Maca Root
-Deer Antler Velvet
-Yohimbe (Thought its a MAOI so you should not each foods with trymamines [sp] like chocolate and cheese adn you should not take it if you have high blood pressure)
-Ginko Biloba (for improved blood flow)

You should read up on these.


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Re: Sexual side effects suck! -I want to come off Paxil [Re: Society]
    #3829801 - 02/24/05 08:24 PM (19 years, 27 days ago)

SJW is contraindicated with SSRI's, and I've also heard (from an emergency room Dr) that St John's wort and the Atkin's diet are contraindicated.

Seafood is good for libido because ocean inhabitants concentrate iodine in they're tissues, and iodine is the precursor TSH requires for preparing thyroid hormones.
It's also long acting too, because of the long half-life of thyroid hormones.

Paroxetine's too strong for basically anyone. But the sexual side-effects aren't a significant draw-back in the scheme of things, weight gain is, and so are movement disorders, suicidal or homicidal thoughts.


St John's wort and depression: slight efficacy at best, many drug interactions.

(1) St John's wort has been widely used for centuries as a herbal remedy. Dozens of trials, of variable quality, have examined the therapeutic value of St John's wort. Published meta-analyses show that St John's wort extracts are more effective than placebo in patients with mild and moderate depression. (2) Trials show that St John's wort is about as effective as tricyclic and serotonin reuptake inhibitor antidepressants. (3) There is insufficient evidence to determine the efficacy of St John's wort in patients with more severe depression. (4) Few, mostly minor adverse effects have been reported, but there may be a small risk of serotonin syndrome and cutaneous photosensitisation. (5) Some components of St John's wort interfere with CYP3A4, one of the main cytochrome P450 isoenzymes. CYP3A4 is involved in the metabolism of many commonly used drugs. St John's wort reduces the efficacy of several drug groups including: immunosuppressants (risk of graft rejection), oral contraceptives (risk of pregnancy), oral anticoagulants (risk of thrombosis), and HIV protease inhibitors. It can also reduce the bioavailability of digoxin. (6) In practice, St John's wort is an inappropriate treatment for severe depression. It is, however, an acceptable option for short-term management of transient depressed mood when there is no risk of drug interactions and when the patient is properly informed of this risk. (7) In short, the risk-benefit balance of St John's wort is no better than that of standard antidepressants, mainly because of the risk of drug interactions.

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Re: Sexual side effects suck! -I want to come off Paxil [Re: bugfungii24]
    #3830348 - 02/24/05 09:37 PM (19 years, 27 days ago)

Actually SJW is an SSRI, and questionably has MAOI properties as well. Generally drug interactions with SJW are uncommon, and a lot of the info you posted above is questionable.


--------------------

The important thing is not to stop questioning. Curiosity has its own reason for existing. One cannot help but be in awe when he contemplates the mysteries of eternity, of life, of the marvelous structure of reality. It is enough if one tries merely to comprehend a little of this mystery every day. Never lose a holy curiosity. ~ Albert Einstein
"Fear is the great barrier to human growth." ~ Dr. Robert Monroe



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Re: Sexual side effects suck! -I want to come off Paxil [Re: Locus]
    #3830407 - 02/24/05 09:46 PM (19 years, 27 days ago)

I was on paxil for a while and didn't enjoy the side effects either. I switched to zoloft recently. Much more subtle..simular ups, and fewer downs. I've been sexually inactive since I started it, so I don't know how it is on that end of things, but I bet it's not as bad as paxil. SRRI's are fucking addictive..it's hard to stay off of them once you start.

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Re: Sexual side effects suck! -I want to come off Paxil [Re: Locus]
    #3831587 - 02/25/05 02:37 AM (19 years, 27 days ago)

Quote:

Locus said:
Actually SJW is an SSRI, and questionably has MAOI properties as well. Generally drug interactions with SJW are uncommon, and a lot of the info you posted above is questionable.





St. John's wort is an SSRI? No it isn't, it likely blocks 5-HT1A receptors to some  extent but it isn't selective. Actually, it may not even block it, but I can look in to that too. But it isn't an SSRI.

As for interactions with medicines, it isn't the simple fact that mixing an MAOI with an SSRI can lead to serotonin syndrome ? it's the fact that SSRI's ALONE can lead to serotonin syndrome and using SJW willy nilly brings you one step closer. If, on top of this the patient has other undiagnosed conditions such as OCD, bi-polar disorder, tourette's  or schizophrenia which already have associated catecholamine elevations, then you can run in to problems. These aforementioned conditions may also mimic serotinin syndrome states. (which is dangerous in itself)

Also one of the reasons that SSRI's are given to young people is because young people tend to dabble in drugs

SJW is reasonably assumed to be contraindicated with any manic condition too, btw.

I've looked in to why it might be contraindicated with the Atkin's diet, and sure enough here it is:

Depression, among other non-cognitive symptoms, is common in patients with dementia. The effect of Hypericum perforatum (St. John's Wort) extract, with well-documented antidepressant activity, was tested on memory retrieval 24 h after training on a one-trial passive avoidance task in mice. Acute administration of Hypericum extract (4.0, 8.0, 12.0, and 25.0 mg/kg i.p.) before retrieval testing increased the step-down latency during the test session. The same doses of Hypericum extract, on the other hand, failed to reverse scopolamine-induced amnesia of a two-trial passive avoidance task. The involvement of serotonergic, adrenergic, and dopaminergic mechanisms in the facilitatory effect of Hypericum extract on retrieval memory was investigated. Pretreatment of the animals with serotonergic 5-HT1A receptor antagonist (-)-pindolol (0.3, 1.0, and 3.0 mg/kg), serotonergic 5-HT2A receptor blocker spiperone (0.01, 0.03, and 0.1 mg/kg), alpha adrenoceptor antagonist phentolamine (1, 5, and 10 mg/kg), beta receptor antagonist propranolol (5, 7.5, and 10 mg/kg), dopaminergic D1 receptor antagonist SCH 23390 (0.01, 0.05, and 0.1 mg/kg), and dopaminergic D2 receptor antagonist sulpiride (5, 7.5, and 10 mg/kg) revealed the involvement of adrenergic and serotonergic 5-HT1A receptors in the facilitatory effect of Hypericum extract on retrieval memory.

It's because of the fact that the Atkin's diet inherently increases dopamine and adrenal hormones, due to the fact that it lowers blood glucose levels, and St. John's wort also likely increases adrenal activity.

St John's wort-drug interactions
1.???????? TGA, TGA alert to doctors and pharmacists and complementary health practitioners. Important interactions between St John's wort (Hypericum perforatum) preparations and prescriptions medicines. 2000.
2.???????? Moschella, C. and B. Jaber, Interaction between cyclosporine and Hypericum perforatum (St. John's wort) after organ transplantation. American Journal of Kidney Diseases, 2001. 38(5): p. 1105-1107.
3.???????? Karliova, M., et al., Interaction of Hypericum perforatum (St John's wort) with cyclosporin A metabolism in a patient after liver transplantation. Journal of Hepatology, 2000. 33: p. 853-855.
4.???????? Mai, I., et al., Hazardous pharmacokinetic interaction of St John's wort (Hypericum perforatum) with the immunosuppressant cyclosporin. International Journal of Clinical Pharmacology and Therapeutics, 2000. 38(10): p. 500-502.
5.???????? Mandelbaum, A., et al., Unexpained decrease of cyclosporin trough levels in a compliant renal transplant patient. Nephrology Dialysis Transplantation, 2000. 15: p. 1473-1474.
6.???????? Rey, J. and G. Walter, Hypericum perforatum (St John's wort) in depression: pest or blessing? Med J Aust, 1998. 169: p. 583-586.
7.???????? Turton-Weeks, S., et al., St John's wort: a hidden risk for transplant patients. Progress in Transplantation, 2001. 11(2): p. 116-120.
8.???????? Barone, G., et al., Herbal supplements: a potential for drug interactions in transplant recipients. Transplantation, 2001. 71(2): p. 239-241.
9.???????? Breidenbach, T., et al., Drug interaction of St John's wort and cyclosporin. Lancet, 2000a. 355: p. 1912.
10.?????? Breidenbach, T., et al., Profound drop of cyclosporin A whole blood trough levels caused by St John's wort (hypericum perforatum). Transplantation, 2000b. 69(10): p. 2229-30.
11.?????? Ahmed, S., N. Banner, and S. Dubrey, Low cyclosporin-A level due to Saint-John's wort in heart transplant patients. Journal of Heart and Lung Transplantation, 2001. 20(7): p. 795.
12.?????? Ruschitzka, F., et al., Acute heart transplant rejection due to Saint John's wort. Lancet, 2000. 355: p. 548-549.
13.?????? Bolley, R., et al., Tacrolimus-induced nephrotoxicity unmasked by induction of the CYP3A4 system with St John's wort. Transplantation, 2002. 73(6): p. 1009-1011.
14.?????? Piscitelli, S., et al., Indinavir concentrations and St. John's wort. Lancet, 2000. 355: p. 547-548.
15.?????? Johne, A., et al., Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum). Clin Pharmacol Ther, 1999. 66: p. 338-345.
16.?????? Johne, A., Decreased plasma levels of amitryptyline and its metabolites on comedication with an extract from St. John's wort (Hypericum perforatum). Journal of Clinical Psychopharmacology, 2002. 22(1): p. 46-54.
17.?????? Lantz, M., E. Buchalter, and V. Giambanco, St John's wort and antidepressant drug interactions in the elderly. Journal of Geriatric Psychiatry and Neurology, 1999. 12: p. 7-10.
18.?????? Spinella, M. and L. Eaton, Hypomania induced by herbal and pharmaceutical psychotropic medicines following mild traumatic brain injury. Brain Injury, 2002. 16(4): p. 359-367.
19.?????? Gordon, J., SSRIs and St John's wort: possible toxicity? Am Family Phys, 1998. 57: p. 950-953.
20.?????? Will-Shahab, L., et al., St John's wort extract (Ze 117) does not alter the kinetics of a low-dose oral contraceptive. in press.
21.?????? Schwarz, U., B. Buschel, and W. Kirch, Unwanted pregnancy on self-medication with St John's wort despite hormonal contraception. British Journal of Clinical Pharmacology, 2003. 55: p. 112-113.
22.?????? Ernst, E., Second thoughts about the safety of St John's wort. Lancet, 1999. 354: p. 2014-2016.
23.?????? Schultz, V., Incidence and clinical relevance of the interactions and side effects of hypericum preparations. Phytomedicine., 2001. 8(2): p. 152-60.
24.?????? Maurer, A., A. Johne, and S. Bauer, Interaction of St John's wort with phenprocoumon (abstract). Eur J Clin Pharmacol, 1999. 55: p. A22.
25.?????? Yue, Q., C. Bergquist, and B. Gerden, Safety of St John's wort (Hypericum perforatum). Lancet, 2000. 355: p. 576-577.
26.?????? Carson, S., et al., Inhibitory effect of methanolic souloution of St. John's wort (Hypericum perforatum) on cytochrome P450 3A4 activity in human liver microsomes. Clin Pharmacol Ther, 2000. [abstract].
27.?????? Obach, R., Inhibition of human cytochrome P450 enzymes by constituents of St John's wort, an herbal preparation used in the treatment of depression. J Pharmacol Exp Ther, 2000. 294: p. 88-95.
28.?????? Budzinski, J.W., et al., An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine., 2000. 7(4): p. 273-82.
29.?????? Zou, L., M. Harkey, and G. Henderson, Effects of herbal components on cDNA-expressed cytochrome P450 enzyme catalytic activity. LIfe Sciences, 2002. 71: p. 1579-89.
30.?????? Noldner, M. and S. Chatterjee, Effects of two different extracts of SJW on Cytochrome P450 activities. Pharmacopsychiatry, 2001. 34(Suppl.1): p. S108-S110.
31.?????? Ereshefsky, B. Determination of St John's wort differential metabolism at CYP2D6 and CYP3A4, using dextromethorphan probe methodology. in Poster no. 130 presented at the 39th Annual Meeting of the New Clinical Drug Evaluation Unit Program. 1999. Florida.
32.?????? Gewertz, N. Determination of the differential effects of St John's wort on the CYP1A2 and NAT2 metabolic pathways using caffiene probe methodology. in Poster no. 131 presented at the 39th Annual Meeting of the New Clinical Drug Evaluation Unit Program. 1999. Florida.
33.?????? Markowitz, J., Effect of St John's wort (Hypericum perforatum) on cytochrome P450 2D6 and 3A4 activity in healthy volunteers. Life Sci, 2000. 66(9): p. 133-139.
34.?????? Roby, C., G. Anderson, and E. Kantor, St John's wort: Effect on CYP3A4 activity. Clin Pharmacol Ther, 2000. 67: p. 451-457.
35.?????? Durr, D., et al., St John's wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4. Clinical Pharmacology and Therapeutics, 2000. 68: p. 598-604.
36.?????? Bray, B., et al., St. John's wort extract induces CYP3A and CYP2E1 in Swiss Webster Mouse. Toxicological Sciences, 2002. 66: p. 27-33.
37.?????? Gurley, B.J., et al., Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans. Clinical Pharmacology & Therapeutics., 2002. 72(3): p. 276-87.
38.?????? Moore, L., et al., St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. Proc Natl Acad Sci USA, 2000. 97(13): p. 7500-7502.
39.?????? Wentworth, J., St John's wort, a herbal antidepressant, activates the steroid X receptor. J Endocrinol, 2000. 166(3): p. R11-R16.
40.?????? Hennessy, M., et al., St John's wort increases expression of P-glycoprotein: Implications for drug interactions. Br J Clin Pharmacol, 2002. 53: p. 75-82.
41.?????? Perloff, M., et al., Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure. British Journal of Pharmacology, 2001. 134(8): p. 1601-1608.
42.?????? Wang, Z., et al., Effect of St John's wort on the pharmacokinetics of fexofenadine. Clinical Pharmacology and Therapeutics, 2002. 71(6): p. 414-420.
43.?????? Barnes, J., L. Anderson, and J. Phillipson, Herbal Medicines. 2nd Edition ed. 2002, London: Pharmaceutical Press.
44.?????? Narhsted, A. Active constituents and quality of St. John's wort preparations. in Evidence-based herbal medicines: from tradition to clinic. 2002. Herbal Medicines Research and Education Centre, University of Sydney.

Regards little Locus! :cool:

Edited by bugfungii24 (02/25/05 02:40 AM)

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OfflineVornan
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Re: Sexual side effects suck! -I want to come off Paxil [Re: Society]
    #3835634 - 02/26/05 01:21 AM (19 years, 26 days ago)

When did you quit lexapro? Sometimes it just takes a very long time to normalize. Are you taking anything now?

Vornan

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Re: Sexual side effects suck! -I want to come off Paxil [Re: bugfungii24]
    #3835875 - 02/26/05 05:22 AM (19 years, 25 days ago)

I have read differently, and that St. John's Wort has a mix of both SSRI and MAOI properties. Therefore, it's contraindictations are questionable, along with research and experience. And from the experiences of many it's side effects are usually not very common and certainly not as common as pharmaceutical antidepressants. I don't know what your deal is trying to make it look so bad.


--------------------

The important thing is not to stop questioning. Curiosity has its own reason for existing. One cannot help but be in awe when he contemplates the mysteries of eternity, of life, of the marvelous structure of reality. It is enough if one tries merely to comprehend a little of this mystery every day. Never lose a holy curiosity. ~ Albert Einstein
"Fear is the great barrier to human growth." ~ Dr. Robert Monroe



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*Check my profile to listen to my music* :smile:

Edited by Locus (02/26/05 05:29 AM)

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OfflineNewAgeDiciple
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Re: Sexual side effects suck! -I want to come off Paxil [Re: Ego Death]
    #3837017 - 02/26/05 12:54 PM (19 years, 25 days ago)

Quote:

danoEoboy said:
Sounds like a cure to premature ejaculation to me???




Classic example of the glass half-empty half-full phenomenon. It's these differing ideas that keep this place spinning.  :thumbup:


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Re: Sexual side effects suck! -I want to come off Paxil [Re: NewAgeDiciple]
    #3837285 - 02/26/05 02:01 PM (19 years, 25 days ago)

i too had the same problem with paxil. it might be cool that you can "stay in the game" for hours on end but you can tell it lowers your sex drive.. thats why i have been off paxil for years.. but now i dont have a girl so it doesnt matter


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Offlinebugfungii24
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Re: Sexual side effects suck! -I want to come off Paxil [Re: danlennon3]
    #3840536 - 02/27/05 08:55 AM (19 years, 24 days ago)

Quote:

danlennon3 said:
i too had the same problem with paxil. it might be cool that you can "stay in the game" for hours on end but you can tell it lowers your sex drive.. thats why i have been off paxil for years.. but now i dont have a girl so it doesnt matter




I lost my girlfriend because of paroxetine (I always knew she was a slut at heart, it was just a matter of time) in part. Both because of the sexual side-effects, and because I was then ear marked as a mental case. She was a young bitch, she had ignorant and immature ideas.

I went psycho after that. I remember once when I was tearing my hair out, making threats with Hit em Up as background music. (not too loud, because then she couldn't hear the threats)

Locus, yes your right it has less side effects to the usual antidepressants. :wink:

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InvisibleSociety
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Re: Sexual side effects suck! -I want to come off Paxil [Re: Vornan]
    #3842786 - 02/27/05 06:05 PM (19 years, 24 days ago)

Quote:

Vornan said:
When did you quit lexapro?  Sometimes it just takes a very long time to normalize.  Are you taking anything now?

Vornan




I quit taking it because I was tired of being in a lethargic, antisocial daze of fatigue and COMPLETE loss of sexual desire.  I started taking 900mg of St. John's Wort a few days ago...  I feel A LOT better although it's probably mainly due the the fact the SSRI withdrawal is withdrawing.  :tongue2:

Quote:

St. John's Wort has a mix of both SSRI and MAOI properties.


 

From what I have learned to the extent I have read, it has serotonin reuptake properties and it's controversial whether it's mildly an MAOI because it exhibits slight properties.  On the bottle it says not to take with an MAOI such as Yohimbe and Ephedra, though.


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Re: Sexual side effects suck! -I want to come off Paxil [Re: Society]
    #3844317 - 02/27/05 09:54 PM (19 years, 24 days ago)

Quote:

...although it's probably mainly due the the fact the SSRI withdrawal is withdrawing...




I'd say so, SSRI's have an inhibitory effect on dopamine, and when they are stopped, the dopamine system becomes more active.

You aren't supposed to swap those medications so quickly, your supposed to wait 14 days. It states as much on the leaflet issued with the box.

Ill find out more about the chemical properties.

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Re: Sexual side effects suck! -I want to come off Paxil [Re: bugfungii24]
    #3845588 - 02/28/05 06:20 AM (19 years, 23 days ago)

Yeah, it was probably a horrible idea to quit Lexapro and start taking St Johns Wort about 5 days later, but I was thinking so irrationally because of the withdrawal that it sounded like a good idea.  :rolleyes: Go figure. I just hope I don't get screwed up from this.... and I hope my sexual drive comes completely back.


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Offlinebugfungii24
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Re: Sexual side effects suck! -I want to come off Paxil [Re: Society]
    #3847672 - 02/28/05 04:14 PM (19 years, 23 days ago)

The sex drive will definetly come back. SSRI's are designed to have lasting effects with respect to taming obsessions and compulsions, aswell as depressive thoughts. Weight gained on SSRI's (if it is gained) takes longer to lose for this reason. (decreased "obsession" for maintaining diet and exercise)

But the libido will definetly return, whether it's tomorrow or in 15-20 days isn't important. You have to wait for orgasm to be physiologically more possible, and for the resumption of that compulsion.

It blocks the reuptake of dopamine, noradrenaline, glutamate, and GABA, GABA A and B mostly.

Also what's important is the quality of the SJW you use, it should be high in hyperforin ? if it isn't, then it's good for the rubbish.

The anti-depressant effect is dosage dependent too.

Oh yeah, SocialRejects, the great Internet is also communicating to me that it's supposed to have a calming effect, so if your aggitated/edgy, I'd probably stop taking it for a while. Careful!

You know SJW sounds alright!

Ill find out more about the dosage and the hyperforin contents and get started. (after tapering off Zoloft)

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Re: Sexual side effects suck! -I want to come off Paxil [Re: bugfungii24]
    #3861226 - 03/03/05 03:23 AM (19 years, 21 days ago)

Quote:

bugfungii24 said:

You know SJW sounds alright!

Ill find out more about the dosage and the hyperforin contents and get started. (after tapering off Zoloft)




alright now man, that sounds better  :thumbup:


--------------------

The important thing is not to stop questioning. Curiosity has its own reason for existing. One cannot help but be in awe when he contemplates the mysteries of eternity, of life, of the marvelous structure of reality. It is enough if one tries merely to comprehend a little of this mystery every day. Never lose a holy curiosity. ~ Albert Einstein
"Fear is the great barrier to human growth." ~ Dr. Robert Monroe



~~~*Dosis sola facit venenum*~~~

*Check my profile to listen to my music* :smile:

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InvisibleJoeChip
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Re: Sexual side effects suck! -I want to come off Paxil [Re: Locus]
    #3903820 - 03/11/05 03:42 PM (19 years, 12 days ago)

I take zoloft and the sexual side effects suck; but they're nowhere near as bad as prozac was for me. The 'zac was basically 6 months of impotentcy.

I was on St. John's wort but that didn't really do anything except make me get really pissed off and angry at everything even little things. Prozac did that too. Zoloft also did that to me but then it went away.


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I am Ubik. Before the universe was, I am. I made the suns. I made the worlds. I created the lives and the places they inhabit; I move them here, I put them there. They go as I say, they do as I tell them. I am the word and my name is never spoken, the name which no one knows. I am called Ubik, but that is not my name. I am. I shall always be.

Edited by JoeChip (03/11/05 03:44 PM)

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InvisibleSociety
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Registered: 07/03/04
Posts: 14,303
Re: Sexual side effects suck! -I want to come off Paxil [Re: JoeChip]
    #3906373 - 03/12/05 09:46 AM (19 years, 11 days ago)

I've been on SJW for a few weeks now. I have no idea if it's doing anything, but I can atleast get an erection- something I couldn't do when taking SSRIs.


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Delicious Pizza

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