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OfflineGainer
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LSD mushrooms cross-tolerance?
    #3635959 - 01/16/05 08:09 PM (13 years, 5 months ago)

I did acid for my first time the other night; i took two hits. The problem is i didn't trip very hard it lasted forever but it never got more intense than a really mild shroom trip. The night before i ate a lot of shrooms and tripped pretty hard i think thats why i didnt trip hard on the acid. I think i remember reading somewhere a while back that LSD and shrooms have a cross-tolerance but i dont remember where. It was definitely good acid though cause two guys that only took 1 1/2 each tripped much harder than me. Just wondering if anyone else has experienced this before.


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OfflineSynapticMisfire
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Re: LSD mushrooms cross-tolerance? [Re: Gainer]
    #3636032 - 01/16/05 08:29 PM (13 years, 5 months ago)

LSD is best described as a 5HT2/5HT1 receptor partial agonist. Psilocybin acts on the 5HT2 receptors as well, so a cross-tolerance is definitely possible.


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InvisibleDark_Star
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Re: LSD mushrooms cross-tolerance? [Re: Gainer]
    #3636119 - 01/16/05 08:53 PM (13 years, 5 months ago)

Yeah.....they are cross tolerant. I recommend waiting at least 2 weeks between trips, though 1-2 months is better for best results.


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OfflineAnnomM
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Re: LSD mushrooms cross-tolerance? [Re: Dark_Star]
    #3637548 - 01/17/05 02:57 AM (13 years, 5 months ago)

Quote:

Dark_Star said:
Yeah.....they are cross tolerant. I recommend waiting at least 2 weeks between trips, though 1-2 months is better for best results.



:thumbup:


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OfflineAnnoA
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Re: LSD mushrooms cross-tolerance? [Re: Gainer]
    #5056689 - 12/13/05 12:45 PM (12 years, 6 months ago)

Cross Tolerance between LSD and Psilocybin
Psychopharmacologia 1961
Isbell H, Wolbach AB, Wikler A, Miner EJ

http://research.lycaeum.org/index.rbx?id=1979

Quote:

In 2 series of experiments on 19 volunteers the development of tolerance to LSD and psilocybin was measured. LSD was given in increasing doses up to 1.5 mcg/kg over periods of 6 to 13 days; and on another occasion psilocybin in doses increasing up to 150 mcg/kg over a period of 6 to 7 days and 210 mcg/kg over 13 days. Cross tolerance to psilocybin was measured by administering 150 mcg/kg or 210 mcg/kg psilocybin to patients, who had been given chronic treatment with LSD. Cross tolerance to LSD was evaluated by "challenging" patients with 1.5 mcg/kg of LSD after they had been given chronic treatment with psilocybin. . "Direct" tolerance to LSD developed to a high degree. "Direct" tolerance to psilocybin also developed, although to a lesser degree. Patients tolerant to LSD were, to a considerable degree, also cross tolerant to psilocybin and patients tolerant to psilocybin were cross tolerant to LSD.




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Mushrooms, Mycology and Psychedelics >> The Psychedelic Experience

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