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Offlinerunnerup
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Registered: 03/23/04
Posts: 708
Loc: USA
Last seen: 6 years, 8 months
NEW PAPER ON SALVINORIN A
    #3622893 - 01/13/05 12:41 PM (12 years, 7 months ago)

Just got this e-mail from Daniel Siebert. Dont know if anyone else got it.

NEW PAPER ON SALVINORIN A


Title #1: Studies Toward the Pharmacophore of Salvinorin A, a Potent Kappa
Opioid Receptor Agonist.

URL: http://sagewisdom.org/munroetal.pdf

Authors: Thomas Munro, Mark Rizzacasa, Bryan Roth, Beth Toth, and Feng Yan

Journal: Journal of Medicinal Chemistry. Epublished December 29, 2004 (ahead
of print)


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Offlinefresh313
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Registered: 09/02/03
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Re: NEW PAPER ON SALVINORIN A [Re: runnerup]
    #3627196 - 01/14/05 05:01 AM (12 years, 7 months ago)

how did they figure out that salvinorin is a k-opiod agonist??


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OfflinePsiloman
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Registered: 04/11/03
Posts: 1,116
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Re: NEW PAPER ON SALVINORIN A [Re: fresh313]
    #3627553 - 01/14/05 09:11 AM (12 years, 7 months ago)

They test it out on an array of receptors (dopamine,opioid,serotonine etc) and see where it "sticks".This can be done with cells expressing those receptors and radioligands.

On EXACTLY how they did it have a look at this paper http://sagewisdom.org/pnas.pdf .By the way,it requires some science knowledge to understand the "materials and methods" section.


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Mushrooms, Mycology and Psychedelics >> The Ethnobotanical Garden

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