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1) painkillers are very soft tranquilizers. They do cause the liver (and kidneys) to do overtime. So combining this with LSD/mushrooms isn't a big problem; as LSD/mushrooms don't require much to be broken down in the bloodstream. ( If the liver doesn't break down the active substances in your blood; that may cause bad effects on your body. ) So for safety reasons, it's best to just skip the painkillers.
2) antibiotics require a steady blood stream to work; so I'm guessing not a big problem there. And even if taking LSD/mushrooms would alter that blood stream; it would just make the antibiotics a little bit ineffective.
The only thing I didn't find, is warnings or bad experiences mixing those drugs.
(I found one report on Erowid; AMT + antibiotics ; but nothing he wrote could really be atoned to the antibiotics; to me it seems like he just had some nausea and a bad trip. )
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