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The game is Switch!, also known as Panic!, and it was released for SegaCD. I just tried the game for the first time this evening, so I cannot attest through experience that it can be played while tripping. But the controls consist entirely of pushing buttons, after which some VERY strange things happen, and another button is pushed. The sound effects are incredible, the animation is delightful; I cannot say enough good things about it. The style is very surrealist, bringing to mind the films of Luis Bunuel (with even more blunt and bizarre absurdities).