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OfflinemotamanM
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Ministry warns against eating wild mushrooms
    #3266725 - 10/23/04 03:01 AM (12 years, 1 month ago)

http://www.japantoday.com/e/?content=news&cat=2&id=316501

Ministry warns against eating wild mushrooms


Saturday, October 23, 2004 at 00:24 JST
TOKYO ? The Health, Labor and Welfare Ministry warned people with kidney problems against consuming edible wild mushrooms called "sugihiratake" after several people died recently from acute brain disorder after eating them.

The ministry asked prefectural governments across Japan to issue warnings over the mushrooms with the Latin name of Pleurocybella porrigens and known as Angel's Wings in English. (Kyodo News)


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OfflinemotamanM
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Re: Ministry warns against eating wild mushrooms [Re: motaman]
    #3266727 - 10/23/04 03:02 AM (12 years, 1 month ago)

http://washingtontimes.com/upi-breaking/20041022-094320-3322r.htm

Deadly fever may be linked to mushrooms



AKITA, Japan, Oct. 22 (UPI) -- At least two more deaths from a mysterious brain fever have been reported in northern Japan.


Authorities are trying to determine if the disease that has claimed five lives is linked to the oyster mushroom, the Yomiuri Shimbun reported. The mushroom has been eaten in Japan for centuries, but experts say that hot weather and heavy rains this summer could have caused changes in its makeup that would make it dangerous.

The most recent deaths, a man in his 60s and a woman in her 40s, were in Akita Prefecture on the northwest coast of Honshu Island. Two more people have been hospitalized in the prefecture.

Several of the victims are known to have eaten oyster mushrooms recently.

National health officials advise that anyone with reduced kidney function avoid eating the mushrooms.


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OfflinemotamanM
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Mysterious mushrooms suspected in deaths of 5 kidney patie [Re: motaman]
    #3266733 - 10/23/04 03:05 AM (12 years, 1 month ago)

http://mdn.mainichi.co.jp/news/20041022p2a00m0dm009000c.html

Mysterious mushrooms suspected in deaths of 5 kidney patie




Five people died and eight suffered symptoms of an acute brain condition after they ate a type of mushroom in Niigata and Yamagata prefectures, it has been learned.

All of the victims had kidney disorders, and those affected had eaten the same type of mushroom, Pleurocybella porrigens, commonly known as "angel's wings," officials from the Ministry of Health, Labor and Welfare said.

The ministry has sent experts to examine an area of Niigata Prefecture where some of the mushrooms were collected, but the exact cause of the deaths remains unclear. Ministry officials are warning people with kidney disorders not to eat Pleurocybella porrigens.

After receiving a report on the apparent poisoning from Niigata prefectural authorities, the ministry sent workers from the National Institute of Infectious Diseases and the Japan Poison Information Center to examine the area.

The Japanese Society for Dialysis Therapy also plans to conduct an investigation of similar cases because many patients with serious kidney disorders receive dialysis treatment.

Acute encephalopathy, the condition that the five people died of, occurs when a person is infected with a virus or bacteria, and a toxic substance enters the body.

Ministry officials said it was hard to imagine that the mushrooms were the cause of the deaths because those who ate them did not show any signs of food poisoning such as vomiting. They added that there was probably a low possibility that their symptoms were caused by infections as their families and those around them had not shown any similar symptoms.

Officials said it was possible that a toxic mold on the mushrooms or chemical spray was responsible, but no such substance has been found.

Environmental Science Research Niigata plans to conduct animal and other tests in the future to determine whether angel wings can be toxic.

Noriyoshi Ohashi, managing director of the Japan Poison Information Center and deputy director of the Tsukuba Medical Center Hospital, said he would expect more patients if it was a case of food poisoning.

"It's a type of mushroom that's eaten widely locally, and if this was poisoning, one would expect there to be more patients. We can't say anything more until we carry out further investigations."

Ichiei Narita, an assistant professor at Niigata University, said in some cases those with kidney disorders were unable to expel toxic substances from their bodies, but he added that he had not heard of any increase in cases in which patients receiving dialysis treatment developed acute encephalopathy.

Akira Hishida, a professor at Hamamatsu University School of Medicine, said that it was still possible elements of the mushrooms had entered the bodies of the victims and seeped into their bloodstream without being expelled, thereby damaging brain cells. (Mainichi and wire reports, Japan, Oct. 22, 2004)


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OfflineTonyMontana
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Registered: 09/22/02
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Re: Mysterious mushrooms suspected in deaths of 5 kidney patie [Re: motaman]
    #3266951 - 10/23/04 05:36 AM (12 years, 1 month ago)

I am goin gto Japan in about six months.
All of this started just because the boxston red sox won the penant.  :shocked:


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"GULF COAST TEXAS SYRINGE! EVERYTHING IS BIG IN TEXAS! Dear Keeper, I send you these pictures and spores so you may pass on this wonderful strain to the world! My cat accidentally ate a spore print and washed it down with 'Keepers Brew' when I wasn't looking. He took a 'DUMP' in your Kit A and before I new what had happened I found these monsters! WHAT THE HELL IS IN THAT BREW!?!? $35.00 + S/H " - SporeTradingPost's 'Keeper': douchebag of the century! [a not so cleverly fabricated testimonial for his website that is only effective in making even his pretend customers look like morons]


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Invisibleveggie

Registered: 07/26/04
Posts: 13,985
Re: Ministry warns against eating wild mushrooms [Re: motaman]
    #3271350 - 10/24/04 02:32 PM (12 years, 1 month ago)

Deadly 'angel's wing' mushroom claims 8th victim
Mainichi Daily News

NIIGATA -- An elderly woman who had been hospitalized with an acute brain disease she suffered after eating "angel's wing" mushrooms, has died, prefectural government officials said Sunday.

The death has brought to eight the number of patients who died of an acute brain disease after eating the mushroom in Niigata, Yamagata and Akita prefectures.

A total of 19 people have suffered the disease after eating the mushroom, officially known as Pleurocybella porrigens.

The woman who died recently is a Niigata Prefecture resident in her 70s.

She was hospitalized in early October with the brain disease. She also suffered a kidney ailment and ate an angel's wing before being hospitalized.

Those who died earlier from similar symptoms are believed to be patients with kidney ailments who ate the mushroom.
(Compiled from Mainichi and wire reports, Japan, Oct. 24, 2004)


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OfflineAnnoA
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Re: Ministry warns against eating wild mushrooms [Re: motaman]
    #3275353 - 10/25/04 03:10 PM (12 years, 1 month ago)

Here is the bad boy:

Pleurocybella porrigens (Pers.:Fr.) Sing.



Habitat: Rotting wood, especially Cryptomeria japonica in Japan, frequently on partly burried moss-coverd branches forming dense clusters. Season fall.
Pileus: 2-10 across, white, the margin becoming wavy.
Flesh & Gills White.


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OfflinemotamanM
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'Mutant' mushrooms trigger deadly brain disease [Re: Anno]
    #3324104 - 11/05/04 12:52 PM (12 years, 1 month ago)

http://mdn.mainichi.co.jp/news/20041105p2a00m0dm011000c.html

'Mutant' mushrooms trigger deadly brain disease




A bumper crop of "angel's wing" mushrooms may be partially responsible for the outbreak of a deadly brain disease among patients with kidney ailments, experts have pointed out.

Extraordinarily large angel's wing mushrooms have been found across the country, giving rise to speculation that the environment in which such mushrooms grow has drastically changed, apparently causing them to contain toxic components.

A man in his 50s living in northern Niigata Prefecture, who had been undergoing artificial dialysis for more than 20 years suffered a brain disease after drinking miso soup containing an angel's wing on the morning of Oct. 6. Fortunately, he fully recovered after receiving an intravenous drip infusion.

"Until last year, I had eaten that type of mushroom, but it didn't cause me any problem. Maybe, I ate more this year than before," he said.

Angel's wing mushrooms, referred to scientifically as pleurocybella porrigens, grow in the stumps of pine and cedar trees.

This year, some of them had grown big enough to harvest by early September, a week or two earlier than usual, according to Noriyuki Matsumoto, a researcher at the Niigata Prefectural Government's forestry research institute.

Furthermore, this year's crop was nearly twice the amount of last year's. Angel's wing mushrooms usually grow to four to five centimeters, but this year many of them have grown as large as the palm of an adult's hand.

"It was hotter this summer than usual, and it rained a lot in August partly because a typhoon directly hit the archipelago. The environment in which the mushrooms grow was irregular," Matsumoto said.

Kanazawa University Prof. Tomihisa Ota specializing in mushrooms suspects that numerous kidney disease patients suffered brain diseases either because they ate excessive volumes of angel's wings or the toxic components in the mushrooms increased.

"A patient in Ishikawa Prefecture appears to have eaten that type of mushroom almost everyday. Patients ate more angel's wing mushrooms than usual because of the bumper crop, or toxic components in the mushrooms may have increased. I guess either of those factors has overly affected the patients' health," he said.

By Thursday, 46 cases of such brain illnesses had been reported in eight prefectures from Tohoku to Hokuriku regions in eastern Honshu, and 14 patients died, according to the Health, Labor and Welfare Ministry.

Most of the patients had serious kidney ailments and an overwhelming majority suffered the brain illness after eating such mushrooms. (Mainichi Shimbun, Japan, Nov. 5, 2004)


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Invisibleveggie

Registered: 07/26/04
Posts: 13,985
Update to Deadly 'Angels Wing' [Re: veggie]
    #3421372 - 11/29/04 12:09 AM (12 years, 11 days ago)

Mushrooms cause medical headaches
29 Nov 2004
Medical News Today

Close cooperation among experts from different fields of medicine is needed to solve a mysterious acute brain disease affecting people who ate sugihiratake mushrooms. Some people suffered from kidney disease.

The Japanese Society of Nephrology recently held a meeting in Tokyo to discuss the mysterious disease. A report presented by Prof. Fumitake Gejo of Niigata University's Faculty of Medicine, who is also president of the academic society, caused surprise among attendees.

Gejo reported on two patients who developed the disease last year and seven years ago. Both were women in their 60s who also suffered from kidney disease.

One of them developed the disease last year after eating the sugihiratake mushrooms, known as angel's wings in English.

Last year, the woman's symptoms, including palsy in her limbs and disturbed consciousness, were light. But after eating the same mushrooms again this year, she suffered serious symptoms and was hospitalized.

The other patient died seven years ago seven days after hospitalization. Doctors were informed by the woman's husband that she had eaten the mushrooms.

Both cases showed that the brain disease--developed mainly by kidney disease sufferers--had been overlooked until recently.

Gejo called the disease Sugihiratake Brain Fever. Because of the mushroom's popularity as a cooking ingredient in areas where patients were found, a large number of medical experts doubted whether the mushroom had caused the disease, noting the paucity of cases compared with the mushroom's popularity.

But the theory has gained credibility as past cases have come to light.

The problem first surfaced this year in Niigata Prefecture. Similar cases were found later in Akita, Yamagata and other prefectures.

As of Nov. 16, the Health, Labor and Welfare Ministry had received reports that 55 people had developed the disease in nine prefectures, and 16 had died.

===

Law revision led to more reporting

Why were more cases than in the past reported this year? According to the ministry, one possible reason is that a revision of the Infectious Disease Prevention Law in November last year changed the system of collecting information on acute brain diseases.

Before the change, such diseases were monitored by fixed-point observation and only designated medical institutions were required to report cases to the ministry.

Under the old system, cases of the brain disease could be found only sporadically. But now, all medical institutions are required to report cases of the disease to the ministry.

The change in policy was designed to catch signs of breakout of unknown infectious diseases as brain fever and other brain diseases are often caused by infection with disease-causing microbes.

It is possible that the new measure shed light on the disease--caused by eating the mushrooms--that had previously gone unnoticed.

Medical experts have suggested various causes of the disease--poison discharged by parasitic germs in the mushrooms, harmful substances contained in the mushrooms, or some element from the forest that adhered to the mushrooms.

In response to the crisis, the ministry's emergency research team will soon start work.

Prior to the team's work, the National Institute of Health Science collected samples of the mushroom to analyze the mushroom's constituents--the focus of attention.

The institute has collected raw samples, leftovers of meals containing the mushroom that were eaten by patients, and mushrooms preserved with salt.

However, it is common for an analysis of such poisonous components to start after having narrowed down candidates to a certain range.

Tamio Maitani, head of the institute's Foods Division, said, "This time, it's difficult to determine what components should be targeted in the analysis."

"In cases involving health foods, it's not unusual for the substances that caused the problems to have not been identified even if they harmed humans. The mushroom in question is a similar case," he said.

The current epidemic was found by the system designed to detect infectious diseases. At the same time, a doctor specializing in kidney disease first noticed that past cases suspected of developing the brain disease were caused by the mushroom.

Cooperation between different branches of medicine will be vital in resolving the mystery of the mushroom and the disease.


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Invisibleveggie

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Re: Update to Deadly 'Angels Wing' [Re: veggie]
    #3749811 - 02/08/05 05:27 AM (11 years, 9 months ago)

Mice killed by sugihiratake extract provide clue to mystery brain fever
February 8, 2005
Daily Yomiuri

When mice are injected extract of the edible sugihiratake mushroom, they suffer a toxic reaction that causes kidney failure, Prof. Tomihisa Ota, a specialist in natural products chemistry at Kanazawa University Graduate School of Natural Science and Technology, announced.

It is expected the research will provide a clue to help identify the cause a series of mysterious cases of brain fever in kidney patients who ate sugihiratake (angel wing) mushrooms last autumn in the Tohoku and Hokuriku regions.

The research team led by Prof. Ota obtained the extract by heating sugihiratake gathered last autumn in Tohoku and Hokuriku to 90 C for 30 minutes.

The team injected mice with one milligram of extract per gram of body weight. Seven of the ten mice injected died within 24 hours.

The mice are suspected to have died of shock caused by damage to red blood cells and kidney failure.

Toxicity was not identified in essence extracted by heating it to 100 C.

According to Prof. Ota, a toxic sugar-protein not destroyed by heating the mushroom to the temperature of miso soup was suspected of being contained in the mushrooms or in organisms attached to them.

It is possible the toxic substance entered the bloodstream, destroyed red blood cells and produced a toxic effect, Ota said.


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