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OfflineBleuboxo
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Registered: 04/05/01
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5-HTP
    #311965 - 05/08/01 01:56 AM (16 years, 6 months ago)

im currently doing 12 casings of B+....6 of them will get 2 pills in the casing ( coir )...and 6 of them will not. Im tired of people always talking about making shrooms more potent. Im gonna try this and see if it works. I will post results. Im sorry for the people that have tried, it doesnt imply to you. But if you have tried this tek, let us know the results!!

" Insanity is just a thread of reality...the make-as-you-go part of living, the bare second reflex of dying _Stavros Christou... by_"


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" Insanity is just a thread of reality...the make-as-you-go part of living, the bare second reflex of dying _Stavros Christou... by_"


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Offlinegray1
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Re: 5-HTP [Re: Bleuboxo]
    #312123 - 05/08/01 09:25 AM (16 years, 6 months ago)

i don't have any personal experience as to whether supplementing the substrate can increase potency. the presence of such a precursor may stimulate enzymes to make more, or if not to make more, to at least provide starting material to make the full potential from regular levels of biosynthesis.
however, it might turn out more practical to supplement with 5-htp yourself before you trip, as 5-htp is a direct precursor of serotonin, the neurotransmitter that is responsible for many of the characteristics of a mushroom trip.

c12h16n24ohdmt


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OfflineBleuboxo
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Re: 5-HTP [Re: gray1]
    #312196 - 05/08/01 11:43 AM (16 years, 6 months ago)

really? i already bought 20 capsules, it says it on the bottle something about seratonin. but in the future, whats the difference in L-tryptophan and 5-HTP? both are amino acids which people claim that shrooms get more potent this way. but if i take L-tryptophan and eat some shrooms will the same thing happen as eating 5-HTP and eating shrooms? how about it i take both of them and shrooms? thanks again.

" Insanity is just a thread of reality...the make-as-you-go part of living, the bare second reflex of dying _Stavros Christou... by_"


--------------------
" Insanity is just a thread of reality...the make-as-you-go part of living, the bare second reflex of dying _Stavros Christou... by_"


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Offlinegray1
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Re: 5-HTP [Re: Bleuboxo]
    #312210 - 05/08/01 12:00 PM (16 years, 6 months ago)

no need to take both, 5-HTP is a derivative of l-tryptophan, with an additional hydroxyl group on the 5th carbon atom, hence the name 5-hydroxy tryptophan. L-tryptophan is not availiable for sale in the US, though it is possible to mail order it especially through resources via the internet. where did you get yours? 5-HTP is availiable at gnc and healtfood stores. i would suggest giving your business to an independant healthfood store as the are most often more knowledgeable and have better quality/more variety of products. as a corporation, i really dislike GNC. they take advantage of the american publics' ignorance about supplementation and turn huge profits on their guillability (sp?)
for human purposes, supplementing with either won't increase the amount of trympamine or psilocybin/psilocin as the body doesn't naturally synthesize these molecules, however, in terms of increasing serotonin levels, 5-HTP would be better to take for several reasons, it is a more direct precursor of serotonin and crosses the blood brain barrier more readily. the body truns naturally available tryptophan into 5-HTP then 5-HTP into serotonin, then serotonin into melatonin...

i also posted a response to the super potent shroms are possible thread that you may be interested to read.

gray1

c12h16n24ohdmt


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OfflinePurplehaze32
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Registered: 04/02/01
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Re: 5-HTP [Re: gray1]
    #312213 - 05/08/01 12:04 PM (16 years, 6 months ago)

I dont think that mixing 5-htp in with your substrate would have much of an effect. Psilocybin is similar in structure to seratonin but not the same. Many people take 5-htp with substances such as MDMA. Again, rumor has it that doing this prolongs and heightens your experience but from personal experimentation, I found it just makes the following day alot better, no hangover etc because it replaces the seratonin your body has used. Now again, i'm no expert...

--People must go out of their minds before they can come to their senses.-- Dr. Timmothy Leary


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--People must go out of their minds before they can come to their senses.-- Dr. Timmothy Leary


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Offlinegray1
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Re: 5-HTP [Re: Purplehaze32]
    #312234 - 05/08/01 12:29 PM (16 years, 6 months ago)

i would tend to agree with purplehaze32 that while the scientific basis is sound, supplementing your substrate will have minimal efects on mushroom potency. i find it much more interesting to experiemnt with the human physiological system by using molecules, vitamins, minerals, nutrients, etc that are involced in biosynthetic pathways involving psychoactive substances.
i have yet to supplement my natural cognition with 5-HTP and psiolcin/psilocybin at the same time, so the advice tha i am offering is just based on research of personal interest about nootropics, nutraceuticals, and imporving brain cognition, that i have been doing recently.

c12h16n24ohdmt


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OfflineBleuboxo
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Re: 5-HTP [Re: gray1]
    #312274 - 05/08/01 01:29 PM (16 years, 6 months ago)

i got mine from GNC, and they didnt ask for any ID or no company name or anything...thats strange, so should i take the pills an hour or two before the shrooms?

" Insanity is just a thread of reality...the make-as-you-go part of living, the bare second reflex of dying _Stavros Christou... by_"


--------------------
" Insanity is just a thread of reality...the make-as-you-go part of living, the bare second reflex of dying _Stavros Christou... by_"


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OfflineBleuboxo
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Re: 5-HTP [Re: Purplehaze32]
    #312278 - 05/08/01 01:31 PM (16 years, 6 months ago)

p.s. just wanted to say thanks for the info! i would have bought the whole 160 capsules and put them all in the substrate! i dont know i usually idiotic things like that just to see what will happen...me and my crazy experiements =)

" Insanity is just a thread of reality...the make-as-you-go part of living, the bare second reflex of dying _Stavros Christou... by_"


--------------------
" Insanity is just a thread of reality...the make-as-you-go part of living, the bare second reflex of dying _Stavros Christou... by_"


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Offlinegray1
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Re: 5-HTP [Re: Bleuboxo]
    #312303 - 05/08/01 02:10 PM (16 years, 6 months ago)

here is what i would do: 2 or more hours before eat a piece of fruit or two, drink a protein shake (i personally like designer protein natural flavor mixed in milk) and take a multivitamin.

30min to an hour before taking mushrooms, take the 5-HTP with a glass of water and nothing else. amino acids intercompete for metabloic enzymes and transportation mechanisms to cross the blood brain barrier, obviously you want to make the most possible available to 5-HTP

proper nutrition is key to brain functioning, and provides the physiological basis for a good trip.

c12h16n24ohdmt


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OfflineBleuboxo
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Re: 5-HTP [Re: gray1]
    #312625 - 05/08/01 09:32 PM (16 years, 6 months ago)

cool, i actually have some designer protein somewhere. about a gallon of chocolate powder! thanks alot for the info, you seem to know your stuff gray1! peace and good luck!

" Insanity is just a thread of reality...the make-as-you-go part of living, the bare second reflex of dying _Stavros Christou... by_"


--------------------
" Insanity is just a thread of reality...the make-as-you-go part of living, the bare second reflex of dying _Stavros Christou... by_"


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OfflineTonic
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Re: 5-HTP [Re: Bleuboxo]
    #312651 - 05/08/01 10:06 PM (16 years, 6 months ago)

Actually the idea behind the function of psilocin and also LSD is that they bind more strongly to serotonin receptors than serotonin itself does. And your brain then pulls back on serotonin release.

The best psychoactive effects of shrooms and acid are hypothesized to be a result of a lowered threshold for activation of the raphe nucleus in the brain, which is responsible for filtering commonplace or irrelevant information, since your brain's natural serotonin use is decreased. The raphe nucleus uses serotonin as its neurotransmitter, but perhaps psilocin is not as active in it. (There are all sorts of serotonin receptors). It's pretty complicated (feedback systems, etc..), but in general, they think that's how it works.

The reason 5-HTP works with MDMA is because MDMA releases your brain's stored serotonin. Shrooms make you hang on to your stored serotonin, also why you tend to feel pretty great after a trip - because there's an excess. Taking 5-HTP probably makes that better.

I think it's entirely possible that adding 5-HTP to the substrate or casing would work. The serotonin and psilocin molecules are almost identical. The 5-HTP could make it easier to get there, provided shrooms have the proper metabolic pathways.



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OfflineBleuboxo
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Re: 5-HTP [Re: Tonic]
    #313063 - 05/09/01 01:22 PM (16 years, 6 months ago)

okay, about the substrate and 5-HTP...how do i give the mushrooms the correct metabolic pathways?

" Insanity is just a thread of reality...the make-as-you-go part of living, the bare second reflex of dying _Stavros Christou... by_"


--------------------
" Insanity is just a thread of reality...the make-as-you-go part of living, the bare second reflex of dying _Stavros Christou... by_"


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Offlinegray1
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Re: 5-HTP [Re: Bleuboxo]
    #313068 - 05/09/01 01:29 PM (16 years, 6 months ago)

the mushrooms inherently have the metabolic pathways needed to create psilocin and psilocybin, what you are attempting to do by adding 5-HTP as a precursor to the substrate is to provide the organism with the optimal growing conditions, in the same manner that you regulate temperature, humidity, other nutrients (eg. brf), growing substrate..., and you may even be stimulating the organism to produce psilocin and psilocybin by providing the precursor.

...how do i give the mushrooms the correct metabolic pathways?

you don't. the pathways are characteristic of the organism you choose. oyster msuhrooms don't have this metabolic pathway, p. cubensis do.

c12h16n24ohdmt


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OfflineThe Messiah
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Re: 5-HTP [Re: Bleuboxo]
    #313080 - 05/09/01 01:44 PM (16 years, 6 months ago)

you added 160 capsules to how much substrate? that seems a bit excessive. i don't think that the mycelia can even utilize all of it. just a thought, like to see how it turns out though =)

peace, -=To0dLeS=-
TM


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[green]peace[/green], [blue]~(To0dLeS)~[/blue]
TM


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OfflineBleuboxo
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Re: 5-HTP [Re: gray1]
    #313146 - 05/09/01 03:25 PM (16 years, 6 months ago)

no i didnt do that!! that is way too much, i bought 20 capsules of this stuff and was wondering when/time/how much to put in the substrate or the casing. gray1 informed me to put them in the casing. i guess ill try 6 casings and let you guys know how it turns out.

casings:
1-1/2 pill
2-1 pill
3-3 pills
4-4 pills
5-4 pills
6-7 1/2 pills

chart__

" Insanity is just a thread of reality...the make-as-you-go part of living, the bare second reflex of dying _Stavros Christou... by_"


--------------------
" Insanity is just a thread of reality...the make-as-you-go part of living, the bare second reflex of dying _Stavros Christou... by_"


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Offlinegray1
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Re: 5-HTP [Re: Bleuboxo]
    #313165 - 05/09/01 03:53 PM (16 years, 6 months ago)

and you're also going to cultivate 6 batches without any additional nutrients, right? definately need to have a control. try and treat each cultivation exactly the same.
how are you going to judge the difference in potency? obviously it's going to be subjective, unlesas you plan on extracting compounds from the mushrooms and analyzing based on weight of extract. that would be slightly more scientific


c12h16n24ohdmt


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OfflineTonic
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Re: 5-HTP [Re: gray1]
    #313167 - 05/09/01 03:54 PM (16 years, 6 months ago)

> the mushrooms inherently have the metabolic pathways needed to create psilocin and psilocybin

Yes, but not necessarily from 5-HTP. It's a good experiment.



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Mushrooms, Mycology and Psychedelics >> Mushroom Cultivation

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