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Amazon Shop for: Salvia

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Offlineheidegger
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Registered: 02/03/03
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Last seen: 10 years, 23 days
Short Review of Kappa Opioid Receptor Pharmacology -> Salvia
    #3083026 - 09/02/04 03:46 PM (12 years, 3 months ago)

A short review of the pharmacology of kappa opioid receptors
(You know, salvinorin A works by binding to kappa opioid receptors)


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Offlinemonoamine
umask 077(nonefor you)

Registered: 09/07/02
Posts: 3,095
Loc: Jacksonville,FL
Last seen: 11 years, 2 months
Re: Short Review of Kappa Opioid Receptor Pharmacology -> Sa [Re: heidegger]
    #3084586 - 09/02/04 10:48 PM (12 years, 3 months ago)

The medicine I'm taking right now (buprenorphine),is a kappa antagonist. I'm going to try a heavy dose of Salvia while on it. If that theory about Salvia is indeed correct,it shouldn't work.

I'm only heard of a couple people doing this,and the results were inconclusive.

By the way,I've noticed a slight anti depressant effect from the buprenorphine that isn't mu opioid related,which supports that paper.

This probably belongs more in Other Drugs....


--------------------
People think that if you just say the word "hallucinations" it explains everything you want it to explain and eventually whatever it is you can't explain will just go away.It's just a word,it doesn't explain anything...
Douglas Adams


Edited by monoamine (09/02/04 10:51 PM)


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OfflineSeussA
Error: divide byzero

Folding@home Statistics
Registered: 04/27/01
Posts: 23,480
Loc: Caribbean
Last seen: 23 days, 11 hours
Re: Short Review of Kappa Opioid Receptor Pharmacology -> Sa [Re: monoamine]
    #3086398 - 09/03/04 09:29 AM (12 years, 3 months ago)

Good read...

> This probably belongs more in Other Drugs....

Either/or... it can stay.  :smile:


--------------------
Just another spore in the wind.


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OfflineRandolph_Carter
НơĻ?ĢΉō

Registered: 06/14/00
Posts: 29,281
Loc: Shroomery B-list.
Last seen: 6 years, 6 months
Re: Short Review of Kappa Opioid Receptor Pharmacology -> Sa [Re: monoamine]
    #3086738 - 09/03/04 11:48 AM (12 years, 3 months ago)

If it was in other drugs it would've been dead and buried by now.


--------------------
"..all those molecules thrashing their kinky little tails, hot for destiny and the street."  Gibson


Nuke baby seals for Jesus!

(This has been a +1 production.)


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Invisibleredgreenvines
irregular verb
 User Gallery

Registered: 04/08/04
Posts: 19,681
Re: Short Review of Kappa Opioid Receptor Pharmacology -> Sa [Re: monoamine]
    #3086872 - 09/03/04 12:28 PM (12 years, 3 months ago)

I am very interested in your results.

if the KOR produces the effect - it would have to do it by excitation of a general neural pathway or by dampening fadeout effects of mental frame sets.

I find this salvia effect (all entheogens too) includes a general
lengthening of neural signal fadeout, thus expanding the flood of input - seeminly opening dimensions and suporting views of fractals and other mental frame overlay experiences.

I have seen no real indication as to how the KOR does this, but it might do so by increasing or decreasing a circuit "governor" that does generalized signal flow management.

I might expect that smaller amounts of salvia would now get you as far as 1 or 2 levels past what that same dose did for you before.


Quote:

monoamine said:
The medicine I'm taking right now (buprenorphine),is a kappa antagonist. I'm going to try a heavy dose of Salvia while on it. If that theory about Salvia is indeed correct,it shouldn't work.

I'm only heard of a couple people doing this,and the results were inconclusive.

By the way,I've noticed a slight anti depressant effect from the buprenorphine that isn't mu opioid related,which supports that paper.

This probably belongs more in Other Drugs....




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OfflineAnnomM
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Registered: 12/22/02
Posts: 6,364
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Re: Short Review of Kappa Opioid Receptor Pharmacology -> Sa [Re: Randolph_Carter]
    #3138722 - 09/15/04 02:59 PM (12 years, 2 months ago)

Quote:

Randolph Carter said:
If it was in other drugs it would've been dead and buried by now.




Move this to ODD!!! It's a high-quality-post! We need that in ODD!!!!


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InvisibleTeragon
Noddy

Registered: 02/21/01
Posts: 36,253
Loc: Lost in the Patterns
Re: Short Review of Kappa Opioid Receptor Pharmacology -> Sa [Re: monoamine]
    #3164755 - 09/22/04 02:38 PM (12 years, 2 months ago)

Hey monamine-

I've noticed a slight anti depressant effect from the buprenorphine that isn't mu opioid related

Is it not mu-opioid related b/c you can tell physically or b/c you assume?

Buprenorphine does stimulate mu-opioid receptors to a certain extent (ceiling effect) and this could be responsible for your rise in mood. Although an experienced opiate user could tell the difference(between any mu or different-receptor effects), and I'm assuming you are one, b/c of your script.

Are you using buprenorphine for maintenance? If so I'd love to hear how it is going. If not, then how'd you get a script? Also, if you aren't using for maintenance, then buprenorphine would have a very different affect on you then me. I'd be very interested to hear anything about how it is going. Thanks bro.


--------------------
need that cash to feed them jones.


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