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InvisibleLoosifa
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Registered: 05/26/04
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Psilocybin / mescaline cross tolerance?
    #3072522 - 08/31/04 05:04 AM (12 years, 5 months ago)

My humble apologies if this is in FAQ... I couldn't find it.
I've been doing mushrooms too often, and have built up a tolerance.  Having been curious about San Pedro and Peyote for a while, I thought the answer might be to try that.  Will I have developed a cross tolerance between all hallucinogens?  Anyone got advice??  Cheers. :smirk:


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OfflineDadeMurphy
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Re: Psilocybin / mescaline cross tolerance? [Re: Loosifa]
    #3072537 - 08/31/04 05:09 AM (12 years, 5 months ago)

Almost definately not. Psilocybin/Psilocin (Tryptamines) are quite different chemicals from Mescaline (Phenethylamine) or LSD (Lysergamide). They do all act on 5-ht2 but not in similar enough ways to be cross-tolerant


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OfflineDadeMurphy
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Re: Psilocybin / mescaline cross tolerance? [Re: Loosifa]
    #3072543 - 08/31/04 05:11 AM (12 years, 5 months ago)

On a side note tolerance to shrooms should subside after about a week or less. If you can leave that long between your trips you should be fine.


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InvisibleLoosifa
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Re: Psilocybin / mescaline cross tolerance? [Re: DadeMurphy]
    #3072589 - 08/31/04 05:28 AM (12 years, 5 months ago)

Thanks for that.... what joy!! However maybe I should not be so damn greedy.... I love that world and find it hard to not be in it.
This is what I get for working at McDonalds (booo... hiss..).


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LURK


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InvisibleMerkin
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Re: Psilocybin / mescaline cross tolerance? [Re: Loosifa]
    #3072714 - 08/31/04 06:30 AM (12 years, 5 months ago)

abuser -_-


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Wheels of cheese wheeels of cheeeeese!!!


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OfflineAnnoA
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Re: Psilocybin / mescaline cross tolerance? [Re: DadeMurphy]
    #3072797 - 08/31/04 07:21 AM (12 years, 5 months ago)

>Psilocybin/Psilocin (Tryptamines) are quite different chemicals from Mescaline
>(Phenethylamine) or LSD (Lysergamide).

There is a cross tolerance between psilocybin and LSD.


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InvisibleHermes_br
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Re: Psilocybin / mescaline cross tolerance? [Re: Loosifa]
    #3072987 - 08/31/04 09:41 AM (12 years, 5 months ago)

from: http://www.drugtext.org/library/books/recreationaldrugs/mescaline.htm

Quote:

While tolerance develops rapidly--within three to six days-mescaline is not considered either physiologically or psychologically addicting, since withdrawal symptoms do not occur. A cross-tolerance to LSD and psilocybin exists. Overdose is unlikely unless mescaline is combined with other drugs such as barbiturates, physostigmine, and insulin. Hyperin sulinism may result from the combination of mescaline and insulin.




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OfflineShroomyTunes
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Re: Psilocybin / mescaline cross tolerance? [Re: Hermes_br]
    #3073152 - 08/31/04 11:19 AM (12 years, 5 months ago)

In the How Hallucinogens Work report it says that LSD, psilocin, DMT, mescaline and DOM have cross tolerance with eachother...To what degree this affects psilocin and mescaline, I'm not sure. It may be negligible.


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